Supplement encyclopedia

LINOLENIC ACID

Alpha-linolenic acid (ALA) is an essential plant-derived omega-3 fatty acid. It should not be confused with alpha-lipoic acid.

Recheck the conclusions and examine the sources before choosing a supplement.

Main conclusion

Potential benefits

ALA is an essential plant-derived omega-3 that can be obtained from food. Specific oils show preliminary signals for skin and an individual verbal-fluency test; the experiments described found no overall strength gain or reduction in fatigue. [1] [2] [3] [4] [5]

What was studied

Strength alongside training: 12 weeks; resistance training three times weekly; Verbal fluency and attention: 12 weeks; Skin hydration and comfort: Eight weeks; Everyday fatigue: 12 weeks; Bowel comfort and regularity during training: Eight weeks. [1] [2] [3] [4] [5]

How to obtain it from food

The main dietary ALA sources are flaxseed, rapeseed and soybean oils, flax and chia seeds, and walnuts. As a reference, obtaining 1.6 g of ALA from the verified set requires approximately 3 g of flaxseed oil (27 kcal), 7 g of flax seeds (37 kcal) or 9 g of chia (44 kcal). [1] [2]

Effects and studied questions

Goal or questionResultConfidenceStudiesPopulation studiedKey sources
Strength alongside trainingThese data do not justify preferring flaxseed oil for strength gains.No overall additional advantage in strength or body composition was obtained. Individual differences in muscle thickness depended on sex and the muscle measured.2/51One direct trial described; the count refers to the named publication, not the entire literature.Alpha-linolenic acid supplementation and resistance training in older adults ↗51 previously untrained older adults: 28 men and 23 women
  1. Alpha-linolenic acid supplementation and resistance training in older adults ↗
Verbal fluency and attentionA small narrow effect on the test is possible; it is too early to expect overall memory improvement.Change in one verbal-fluency subscale: +0.30 versus +0.03 points. There was no convincing between-group difference in the numerous other cognitive measures.2/51One direct trial described; the count refers to the named publication, not the entire literature.Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults ↗60 adults aged 65–80 without a diagnosed cognitive disorder or depression
  1. Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults ↗
Skin hydration and comfortFor skin, consider the specific product composition; the data remain preliminary.Improvements in individual hydration and itching ratings were reported. These are results for a special DAG oil; they cannot be applied to every ALA capsule.2/51One direct trial described; the count refers to the named publication, not the entire literature.Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study ↗60 adults with mild skin discomfort; 58 in the per-protocol analysis
  1. Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study ↗
Everyday fatigueThere is no convincing advantage of these oils for reducing fatigue.No convincing between-group differences in subjective fatigue or the POMS2 measure were found; minimum p values were 0.102 and 0.15. This experiment provides no numerically confirmed energy gain.2/51One direct trial described; the count refers to the named publication, not the entire literature.The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial ↗120 Japanese women aged 45–65
  1. The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial ↗
Bowel comfort and regularity during trainingThere is a preliminary signal in intensively training women for a specific oil-containing jelly.Changes in the constipation scale differed between groups (p=0.035); 9 g differed from control (p=0.020), while 3 g did not (p=0.073). The scale was assessed by the difference from the minimum value during the period, rather than only at the end of treatment.1/51One direct trial described; the count refers to the named publication, not the entire literature.Effect of 8-week intake of the n-3 fatty acid-rich perilla oil on the gut function and as a fuel source for female athletes: a randomised trial ↗36 Japanese female volleyball athletes, 12 per group
  1. Effect of 8-week intake of the n-3 fatty acid-rich perilla oil on the gut function and as a fuel source for female athletes: a randomised trial ↗

The study count refers to the cited source. Reviews with overlapping trials and outcomes from one study are not added together.

Guidance for each goal

Strength alongside training

Confidence2/5

These data do not justify preferring flaxseed oil for strength gains.

Study findings. No overall additional advantage in strength or body composition was obtained. Individual differences in muscle thickness depended on sex and the muscle measured.

Studied regimen30 mL/day, approximately 14 g of ALAFlaxseed oil
Duration and population12 weeks; resistance training three times weekly51 previously untrained older adults: 28 men and 23 women

The confidence scale assesses the reliability of this conclusion, not the probability of an individual result.

Verbal fluency and attention

Confidence2/5

A small narrow effect on the test is possible; it is too early to expect overall memory improvement.

Study findings. Change in one verbal-fluency subscale: +0.30 versus +0.03 points. There was no convincing between-group difference in the numerous other cognitive measures.

Studied regimen3.7 g of oil/day, including 2.2 g of ALAFlaxseed oil
Duration and population12 weeks60 adults aged 65–80 without a diagnosed cognitive disorder or depression

The confidence scale assesses the reliability of this conclusion, not the probability of an individual result.

Skin hydration and comfort

Confidence2/5

For skin, consider the specific product composition; the data remain preliminary.

Study findings. Improvements in individual hydration and itching ratings were reported. These are results for a special DAG oil; they cannot be applied to every ALA capsule.

Studied regimen2.5 g of oil/day, containing 0.9 g of ALA as part of DAGFlaxseed oil enriched with diacylglycerols (DAG)
Duration and populationEight weeks60 adults with mild skin discomfort; 58 in the per-protocol analysis

The confidence scale assesses the reliability of this conclusion, not the probability of an individual result.

Everyday fatigue

Confidence2/5

There is no convincing advantage of these oils for reducing fatigue.

Study findings. No convincing between-group differences in subjective fatigue or the POMS2 measure were found; minimum p values were 0.102 and 0.15. This experiment provides no numerically confirmed energy gain.

Studied regimen0.97, 1.36 or 2.13 g of ALA/dayEdible oil blends
Duration and population12 weeks120 Japanese women aged 45–65

The confidence scale assesses the reliability of this conclusion, not the probability of an individual result.

Bowel comfort and regularity during training

Confidence1/5

There is a preliminary signal in intensively training women for a specific oil-containing jelly.

Study findings. Changes in the constipation scale differed between groups (p=0.035); 9 g differed from control (p=0.020), while 3 g did not (p=0.073). The scale was assessed by the difference from the minimum value during the period, rather than only at the end of treatment.

Studied regimen3 or 9 g of oil/day; this is oil weight, not pure ALAPerilla oil in jelly
Duration and populationEight weeks36 Japanese female volleyball athletes, 12 per group

The confidence scale assesses the reliability of this conclusion, not the probability of an individual result.

How to read the confidence scale 1–5

The rating considers study quality, directness and applicability to the stated group and regimen. It is an editorial scale, not the probability of an individual result.

Total intake reference values
GroupAmountType
Men aged 19 and over1.6 g/dayAI_total_intake
Women aged 19 and over1.1 g/dayAI_total_intake
Pregnancy1.4 g/dayAI_total_intake
Breastfeeding1.3 g/dayAI_total_intake

Omega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗

Safety and limitations

Flaxseed oil may cause digestive complaints and allergy. With medicines affecting coagulation, the combination needs checking; the clinical magnitude of bleeding risk for ALA has not been established. Dietary intake during pregnancy and safety of concentrated supplements are different questions. Dietary ALA reference values concern the entire diet. No UL has been established for ALA; this does not permit unlimited intake. With medicines affecting coagulation, supplement compatibility should be checked separately.

Omega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗ · Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease ↗ · Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial ↗ · Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed ↗

Forms

Flaxseed, perilla, rapeseed and soybean oils: Fatty-acid mixtures; oil weight is not equivalent to ALA weight. Whole or ground seeds: Also contain protein, fiber and other components. DAG-enriched flaxseed oil: A special formulation studied for individual skin and nasal symptoms. EPA/DHA and alpha-lipoic acid: Different substances; they do not replace ALA when assessing its dietary intake and effects.

Food sources

The main dietary ALA sources are flaxseed, rapeseed and soybean oils, flax and chia seeds, and walnuts. As a reference, obtaining 1.6 g of ALA from the verified set requires approximately 3 g of flaxseed oil (27 kcal), 7 g of flax seeds (37 kcal) or 9 g of chia (44 kcal). ALA is distinguished here from EPA/DHA and the measure “18:3, unspecified.” Reference values mean adequate total intake, not supplementation on top of the diet. Contributions from minor sources are retained, but do not make them practical top food sources.

FoodGroupAmountServingCaloriesSources
Flaxseed oilcold-pressedOils53.368 g / 100 g13.6 g · 7.258048 g · 120.22399999999999 kcal884 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Rapeseed oiledible canola oilOils9.137 g / 100 g14 g · 1.27918 g · 123.76 kcal884 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Soybean oiledible, for salads and cookingOils6.789 g / 100 g13.6 g · 0.923304 g · 120.22399999999999 kcal884 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Chia seedsdriedSeeds and nuts17.83 g / 100 g28.35 g · 5.054804999999999 g · 137.781 kcal486 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Black walnutsdried kernelsSeeds and nuts2.677 g / 100 g28.35 g · 0.7589295 g · 175.4865 kcal619 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Edamamefrozen, preparedLegumes0.358 g / 100 g77.5 g · 0.27745 g · 93.775 kcal121 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Pumpkin seedsdried shelled kernelsSeeds and nuts0.12 g / 100 g30 g · 0.036 g · 167.7 kcal559 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Pine nutsdried kernelsSeeds and nuts0.112 g / 100 g30 g · 0.0336 g · 201.9 kcal673 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Peanut buttersmooth, with saltSpreads0.027 g / 100 g20 g · 0.0054 g · 119.6 kcal598 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
2% milkfluid, with vitamins A and DDairy products0.008 g / 100 g200 g · 0.016 g · 100 kcal50 kcal / 100 gUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Flax seedsseeds or edible kernelsSeeds and nuts22.815533980582522 g / 100 g10.3 g · 2.35 g · 55.00200000000001 kcal534 kcal / 100 gOmega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗
USDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Walnutsseeds or edible kernelsSeeds and nuts9.065255731922399 g / 100 g28.35 g · 2.57 g · 185.40900000000002 kcal654 kcal / 100 gOmega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗
USDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Amount comparison

Fewer calories among portions of a suitable size: Flaxseed oil — 3 g, about 27 kcal; Flax seeds — 8 g, about 43 kcal; Chia seeds — 9 g, about 44 kcal.

A reference for total intake from all sources; this is not a supplement dose for a specific effect. The top list is calculated from the verified set using up to 2.5 of the listed servings. Omega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗

FoodSubstance and kcal per 100 gMen aged 19 and over: 1.6 gSource
Flaxseed oilcold-pressedOils53.37 g884 kcal3 g≈27 kcalUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Flax seedsseeds or edible kernelsSeeds and nuts22.82 g534 kcal8 g≈43 kcalOmega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗
USDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Chia seedsdriedSeeds and nuts17.83 g486 kcal9 g≈44 kcalUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Walnutsseeds or edible kernelsSeeds and nuts9.07 g654 kcal18 g≈118 kcalOmega-3 Fatty Acids — Health Professional Fact Sheet (NIH ODS) ↗
USDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Rapeseed oiledible canola oilOils9.14 g884 kcal18 g≈159 kcalUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Soybean oiledible, for salads and cookingOils6.79 g884 kcal24 g≈212 kcalUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Black walnutsdried kernelsSeeds and nuts2.68 g619 kcal60 g≈371 kcalUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Edamamefrozen, preparedLegumes0.36 g121 kcal447 g≈541 kcal · large amountUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Pumpkin seedsdried shelled kernelsSeeds and nuts0.12 g559 kcal1,334 g≈7,457 kcal · large amountUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Pine nutsdried kernelsSeeds and nuts0.11 g673 kcal1,429 g≈9,617 kcal · large amountUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
2% milkfluid, with vitamins A and DDairy products0.01 g50 kcal20,000 g≈10,000 kcal · large amountUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗
Peanut buttersmooth, with saltSpreads0.03 g598 kcal5,926 g≈35,437 kcal · large amountUSDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗

USDA National Nutrient Database for Standard Reference, Release 28 (SR28): ASCII data and documentation ↗

Studies

PublicationWhat was studiedParticipantsForm and doseResult
Alpha-linolenic acid supplementation and resistance training in older adults ↗Strength alongside training51 previously untrained older adults: 28 men and 23 womenFlaxseed oil: 30 mL/day, approximately 14 g of ALA. 12 weeks; resistance training three times weeklyNo overall additional advantage in strength or body composition was obtained. Individual differences in muscle thickness depended on sex and the muscle measured.
Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults ↗Verbal fluency and attention60 adults aged 65–80 without a diagnosed cognitive disorder or depressionFlaxseed oil: 3.7 g of oil/day, including 2.2 g of ALA. 12 weeksChange in one verbal-fluency subscale: +0.30 versus +0.03 points. There was no convincing between-group difference in the numerous other cognitive measures.
Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study ↗Skin hydration and comfort60 adults with mild skin discomfort; 58 in the per-protocol analysisFlaxseed oil enriched with diacylglycerols (DAG): 2.5 g of oil/day, containing 0.9 g of ALA as part of DAG. Eight weeksImprovements in individual hydration and itching ratings were reported. These are results for a special DAG oil; they cannot be applied to every ALA capsule.
The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial ↗Everyday fatigue120 Japanese women aged 45–65Edible oil blends: 0.97, 1.36 or 2.13 g of ALA/day. 12 weeksNo convincing between-group differences in subjective fatigue or the POMS2 measure were found; minimum p values were 0.102 and 0.15. This experiment provides no numerically confirmed energy gain.
Effect of 8-week intake of the n-3 fatty acid-rich perilla oil on the gut function and as a fuel source for female athletes: a randomised trial ↗Bowel comfort and regularity during training36 Japanese female volleyball athletes, 12 per groupPerilla oil in jelly: 3 or 9 g of oil/day; this is oil weight, not pure ALA. Eight weeksChanges in the constipation scale differed between groups (p=0.035); 9 g differed from control (p=0.020), while 3 g did not (p=0.073). The scale was assessed by the difference from the minimum value during the period, rather than only at the end of treatment.