Виагра

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Виагра

Property Description
Active ingredient Sildenafil (as Sildenafil citrate)
Form Film-coated oral tablet
Pharmacological class Phosphodiesterase type 5 (PDE5) inhibitor
Common use Facilitates increased blood flow to specific tissues
Origin Synthetic organic compound

Identity and Composition of Виагра

Виагра is a highly recognized prescription-only brand-name medicine whose active ingredient is Sildenafil, supplied as the salt form Sildenafil citrate. This drug is a synthetic organic compound, chemically synthesized rather than naturally derived, and is prepared for oral administration as a film-coated oral tablet. The standardization of this single-ingredient composition ensures predictable delivery of Sildenafil. The unique, diamond-shaped appearance of the tablet is a distinguishing feature specific to the Виагра brand.

Pharmacological Classification and Type

The drug is definitively classified as a Phosphodiesterase type 5 (PDE5) inhibitor. This pharmacological class dictates the drug’s highly selective function: it specifically targets and blocks the cGMP-specific PDE5 enzyme. Sildenafil's efficacy in this class is clinically recognized, and its specialized action, focused on a single enzyme, differentiates it from other, less specific vascular agents.

General Purpose of Sildenafil

The general purpose of Sildenafil is to modulate the body’s internal signaling pathways to promote localized smooth muscle relaxation and increased blood flow. The drug functions by sustaining the presence of the critical messenger substance, cGMP, which in turn allows vascular muscles in the target area to remain relaxed. This physiological action facilitates the necessary hemodynamic conditions required for achieving a complete and sustained physical response following appropriate stimulation. The primary target patient group for Виагра is adult males seeking to restore or improve this specific physical function.

Regulatory References

  1. National Institutes of Health (NIH)

What side effects are possible with Виагра?

Possible Side Effects and Safety Information

The official safety profile for Sildenafil (Viagra) is structured by classifying potential effects according to their frequency and the body system affected, based on regulatory documentation from authorities like the EMA and FDA. As a vasodilator, many observed adverse reactions are related to this property.


Frequency-Classified Adverse Reactions

The most frequently observed effects in clinical trials are classified as Very Common (ge 1/10), notably headache.

Effects classified as Common (ge 1/100 to <1/10) include flushing, dizziness, dyspepsia, nasal congestion, and various visual disturbances (e.g., color tinge, blurred vision). Less frequent effects are classified as Uncommon (e.g., palpitations, vomiting, skin rash) or Rare.


Serious Adverse Reactions and Safety Constraints

The label documents rare but clinically significant risks, including a prolonged erection lasting over four hours (Priapism), a sudden decrease or loss of vision (such as Non-arteritic Anterior Ischemic Optic Neuropathy, or NAION), and sudden loss of hearing. Post-marketing reports also include serious cardiovascular events, such as stroke or myocardial infarction.

Sildenafil is strictly contraindicated for use with nitrates in any form or the guanylate cyclase stimulator riociguat. Usage is also contraindicated in patients with severe hepatic impairment or a history of NAION. The label advises caution for individuals with anatomical deformation of the penis or conditions predisposing to Priapism, such as sickle cell anaemia.

Overdose and Emergency Response

Overdose Scope

Category Description (Strictly Label-Derived)
Documented overdose presentations Overdose is associated with an increased incidence and severity of known adverse reactions. Manifestations include marked hypotension, headache, flushing, and visual disturbance, such as blurred vision or altered color perception.
Physiological systems affected (as stated in label) The drug's effects target the Cardiovascular system, causing systemic vasodilation, and the Urogenital system (risk of priapism). Severe outcomes may involve Ocular and Otic functions.
Dose-related factors Exposures exceeding recommended dose levels result in a magnification of known adverse effects due to elevated plasma concentrations.
Population-specific overdose notes Effects may be increased in patients with severe hepatic or renal impairment due to reduced drug clearance.
When immediate medical help is required (label-derived phrasing only) Seek immediate medical assistance if an erection lasts longer than 4 hours. Stop taking the medicine and seek immediate medical attention for sudden loss of vision or sudden decrease or loss of hearing.

Overdose Management

Category Description (Strictly Label-Derived)
Severity classification The profile identifies serious or life-threatening outcomes, including priapism and sudden vision loss, that require urgent intervention.
Antidote and procedure No specific antidote is known for overdose. Treatment is restricted to symptomatic and supportive measures, as hemodialysis is not expected to accelerate clearance.

Connection to the overall overdose profile: Regulatory documents define the Sildenafil overdose profile by detailing the expected magnification of common effects and linking specific, time-critical manifestations (e.g., prolonged erection) directly to mandated emergency actions. The official management approach confirms that intervention is strictly symptomatic and supportive treatment, with no specific antidote identified.

Therapeutic Uses of Виагра

Sildenafil (Виагра) is applied in contexts marked by increased discomfort or tension. The medication is commonly used across two distinct therapeutic domains.

Supporting the Management of Erectile Function

This therapeutic domain is centered on addressing Erectile Dysfunction (ED), which involves the inability to obtain or sustain an erection firm enough to support functional stability. It helps address symptom clusters that create noticeable functional strain and supports patients during episodes of heightened discomfort. It is relevant for easing symptoms that interfere with daily comfort.

Quick Fact: Relief for Functional Strain Sildenafil is relevant for managing symptoms that interfere with daily comfort, specifically supporting the physiological process needed for penile rigidity.

Managing Functional Capacity in Pulmonary Conditions

Sildenafil's active ingredient is also relevant in conditions characterized by periods of heightened symptoms, such as Pulmonary Arterial Hypertension (PAH), a condition marked by increased physiological stress. The medication is applied in situations where symptoms, such as shortness of breath and fatigue, interfere with daily functioning. This use may assist with managing symptoms that interfere with daily functioning, and supports the patient during difficult episodes by easing distress and helping improve day-to-day comfort during symptomatic periods in both adult and pediatric patients with this condition.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Who Can and Cannot Use Виагра? - Official Regulatory Information

The eligibility for Виагра (sildenafil for erectile dysfunction) is strictly defined by government regulatory bodies based on age, sex, existing medical conditions, and concomitant medication use. It is approved exclusively for adult men aged 18 years and older.


Absolute Contraindications

Viagra must not be used by individuals with the following conditions or circumstances, as they pose a risk of severe, life-threatening hypotension or other serious adverse events:

  • Concomitant use with any form of nitrate medication (e.g., nitroglycerin) or nitric oxide donors.
  • Concomitant use with guanylate cyclase stimulators (e.g., riociguat).
  • Severe cardiovascular disease, which makes sexual activity inadvisable (e.g., unstable angina, severe cardiac failure, or recent stroke/myocardial infarction within the last 6 months).
  • Severe hepatic impairment or hypotension (low blood pressure, typically <90/50 mmHg).
  • Known hypersensitivity to sildenafil or any component of the tablet.

Population-Specific Restrictions

Population Group Regulatory Status / Restriction
Pediatric Population Not indicated for use (under 18 years of age).
Women Not indicated for use for the ED indication.
Severe Renal/Hepatic Impairment Requires a lower starting dose (e.g., 25 mg) due to reduced drug clearance and potential for higher plasma levels.
Conditions Predisposing to Priapism Use requires caution (e.g., sickle cell anemia, multiple myeloma, anatomical penile deformation).
Ocular Conditions Contraindicated if there is a history of vision loss due to Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION).

What should I know about interactions with other medicines?

Viagra (sildenafil) can interact with a variety of medications, which may lead to serious health risks, primarily due to additive effects on lowering blood pressure. It is crucial to inform your healthcare provider about all medicines, over-the-counter products, and supplements you are currently taking.

Major Contraindications

Sildenafil is contraindicated (must not be taken) with the following classes of drugs, as the combination can cause a severe, potentially life-threatening drop in blood pressure:

  • Nitrates: Medicines used for chest pain (angina), such as nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. This also includes recreational drugs known as "poppers" (amyl or butyl nitrite).
  • Guanylate Cyclase (GC) Stimulators: Medicines like riociguat, which are used to treat pulmonary hypertension.

Interactions Requiring Caution and Dose Adjustment

Consult your healthcare provider regarding potential dose adjustments if you are taking the following:

  • Alpha-Blockers: Medications such as doxazosin or tamsulosin, often used for high blood pressure or an enlarged prostate, can have an additive blood-pressure-lowering effect. Sildenafil should be initiated at the lowest dose (25 mg) after a patient is stable on alpha-blocker therapy.
  • CYP3A4 Inhibitors: Certain medications inhibit the enzyme that metabolizes sildenafil, leading to increased levels of sildenafil in the body and a higher risk of side effects. Examples include certain HIV protease inhibitors (like ritonavir) and some antifungal drugs (like ketoconazole and itraconazole). A reduced starting dose of sildenafil is typically recommended.
  • Other Erectile Dysfunction or Pulmonary Arterial Hypertension (PAH) Treatments: Sildenafil should not be used in combination with other PDE5 inhibitors (e.g., tadalafil, vardenafil) or other sildenafil-containing products (like Revatio) to treat erectile dysfunction, as this can increase the risk of side effects.

Finally, excessive alcohol consumption or the intake of large amounts of grapefruit juice may also increase the risk of side effects by affecting sildenafil levels or contributing to a drop in blood pressure.

Mechanism of Action

Selective Inhibition of the PDE5 Enzyme

The drug operates by acting as a selective inhibitor of the cGMP-specific phosphodiesterase type 5 ( PDE5) enzyme, which is concentrated in the smooth muscle of specific peripheral tissues. This molecular action prevents the hydrolysis of the key chemical messenger, cyclic guanosine monophosphate ( cGMP), sustaining its concentration.


Amplifying the Nitric Oxide ( NO) / cGMP Signaling Axis

Sildenafil modulates the NO/ cGMP pathway, a cascade initiated by the natural release of Nitric Oxide during arousal. By sustaining cGMP levels, the drug amplifies this signal, leading directly to the relaxation of arterial and smooth muscle tissue. This results in vasodilation and an increase in localized blood flow.


Mechanistic Constraints and PDE6 Cross-Reactivity

The entire mechanism is physiologically constrained: it is strictly contingent upon the prior release of NO triggered by stimulation. Without this initial signal, Sildenafil cannot potentiate the cGMP pathway. Furthermore, the molecule exhibits limited off-target activity against the retinal enzyme PDE6, which is the specific biological basis for potential alterations in visual signaling via PDE6 inhibition.

Dosage and Administration Information

Official Administration Guidelines for Sildenafil

Sildenafil is administered orally, available as film-coated tablets in 25 mg, 50 mg, and 100 mg strengths. An oral suspension form and an intravenous route are also approved for the treatment of Pulmonary Arterial Hypertension (PAH). The official dosing schedule differs significantly based on the intended condition:

Dosing for Erectile Dysfunction (ED)

Regimen Feature Official Guideline (Maximum Once Daily)
Recommended Dose 50 mg, taken as needed.
Dose Range May be increased to 100 mg or decreased to 25 mg.
Timing Approximately one hour before sexual activity, or within a range of 30 minutes to 4 hours.
Food Constraint May be taken with or without food, but a high-fat meal may delay the onset of activity.

Dosing for Pulmonary Arterial Hypertension (PAH)

Regimen Feature Official Guideline
Standard Dose 20 mg.
Frequency Three times a day (TID), with doses taken approximately 4 to 6 hours apart.
Maximum Dose Titration up to a maximum of 80 mg TID may be permitted in adults.
Preparation Oral suspension must be shaken well for at least 10 seconds before each use.

Population-Specific Considerations

A lower starting dose of 25 mg should be considered for patients with certain characteristics, including those over 65 years of age, or those with severe renal impairment (creatinine clearance <30 mL/min) or hepatic impairment (e.g., cirrhosis). Additionally, patients on alpha-blocker therapy should initiate Sildenafil at the 25 mg dose. These requirements define the specific conditions under which the medicine must be introduced and maintained.

Recent Clinical Evidence

️ Sildenafil: Summary of Clinical Evidence for Erectile Dysfunction

Sildenafil, marketed under the brand name Viagra, is a widely studied oral treatment for male erectile dysfunction (ED). Its clinical utility has been assessed across numerous randomized, double-blind, placebo-controlled trials, meta-analyses, and long-term open-label extension studies in diverse patient populations.

Efficacy and Patient Response

Clinical evidence consistently shows that sildenafil use is associated with improved erectile function compared to placebo in men with ED of various etiologies (including organic, psychogenic, and mixed).

  • Improvement in Function: Pooled data from multiple clinical trials indicate that a significantly greater percentage of men receiving sildenafil report improvements in their erections compared to those receiving placebo. For instance, in several pre-marketing studies, between 46.5% and 87% of patients across different subgroups reported improved erections following treatment, versus 11.3% to 41.3% in the placebo groups.
  • Successful Intercourse: Trial data has also shown an increased percentage of successful attempts at sexual intercourse reported by participants using sildenafil (ranging from approximately 53% to 80%) compared to placebo (14% to 34.5%).
  • Subpopulations: Studies have assessed sildenafil's use in difficult-to-treat patient groups, including men with diabetes mellitus and those who have undergone radical prostatectomy. Evidence suggests a measurable benefit for erectile function may be observed even in these populations.
Clinical Trial Outcome Sildenafil Response Placebo Response
Global Efficacy Question (Improvement in erections) Significant improvement reported in a majority of trials Lower rates reported
Successful Intercourse Attempts Increased percentage reported Lower percentage reported

Tolerability and Long-Term Use

Sildenafil is generally characterized by a positive tolerability profile in clinical settings. The most commonly reported side effects across clinical trials include headache, flushing, and dyspepsia, with the overall discontinuation rate due to adverse events typically being low. Long-term studies, some extending up to four years, have suggested that the effectiveness and safety profile of sildenafil may be maintained over extended periods of use.

Frequently Asked Questions (FAQ)

Common questions about Виагра (FAQ)


Q: What is the main goal or purpose of taking Виагра?

According to official regulatory documents, the primary purpose of the medication is to treat erectile dysfunction in men. It is also indicated for the treatment of pulmonary arterial hypertension (PAH), which is a specific type of high blood pressure affecting the lungs, and can be used for this purpose in both men and women.

Q: Is Виагра the same as the generic name sildenafil?

Sildenafil is the generic name for the active ingredient contained in the brand-name medicine Виагра. Official labeling confirms that both the brand-name product and the generic versions contain the same active compound, sildenafil citrate.

Q: Is Виагра considered a prescription-only medicine?

In the United States and many other regions, the medicine is generally available only by prescription from a healthcare provider. However, in some countries and regions, certain formulations may be available from a pharmacist after a mandatory health consultation.

Q: How long can the effects of Виагра last?

Clinical studies have examined the duration of the effect for erectile dysfunction for up to 4 hours after dosing. Official product information suggests that the response may diminish during this time compared to the initial peak.

Q: How quickly is Виагра expected to start working after it's taken?

Official information on the drug’s pharmacokinetics indicates that the highest concentration in the bloodstream is usually reached within 30 to 120 minutes, with the median time being about one hour. For treating erectile dysfunction, the effect is typically experienced within 30 to 60 minutes after taking the tablet.

Q: Does Виагра work immediately, or do I need to be stimulated?

The medicine does not cause an erection automatically upon ingestion. The drug's mechanism of action indicates that sexual stimulation is generally required for the effect to occur.

Q: Is it true that Виагра can cause a temporary change in color vision?

Abnormal vision is a listed potential side effect in official product information. This includes blurred vision and temporary, often mild, changes in color perception. This is related to the drug's activity on an enzyme present in the eye.

Q: Can alcohol consumption affect how Виагра works?

Authoritative medical sources suggest that consuming alcohol while taking this medicine may be associated with an increased risk of low blood pressure and could intensify common side effects like headache and dizziness.

Q: Are there specific heart conditions that prevent someone from using Виагра?

The medicine is absolutely contraindicated for patients taking any form of nitrate medicine, which is often used to treat chest pain (angina). The concurrent use of nitrates is associated with a risk of a significant and dangerous decrease in blood pressure.

Q: Do people who take nitrates for chest pain need to avoid Виагра?

Regulatory guidelines describe that the use of sildenafil is absolutely contraindicated for individuals taking any form of nitrate medication. This is due to the high risk of severe hypotension.

Q: What should be done if an erection lasts longer than expected after taking Виагра?

An erection lasting 4 hours or more (priapism) is considered a medical emergency. Official warnings state that this condition can cause permanent damage to the penis. This condition is described as requiring prompt medical evaluation.

Q: Is it normal to feel a headache after using Виагра?

Yes, headache is listed in official documentation as one of the most commonly reported side effects. This reaction is generally considered common when using the medication.

Q: Can people who have had a stroke or heart attack use Виагра?

Use of the medicine after a stroke or heart attack is a matter that requires medical guidance. It is recommended that individuals with a history of stroke or heart attack consult with a healthcare provider to assess cardiovascular risk and ensure appropriate use.

Q: Is Виагра known to interact with herbal supplements?

Official patient information advises patients to report all medicines, including any herbal products and dietary supplements, to their healthcare provider before beginning sildenafil. This ensures that any potential interactions are considered.

Q: Is it only men with certain health conditions who can be prescribed Виагра?

While the medicine is indicated for treating erectile dysfunction in men, it is also indicated for treating pulmonary arterial hypertension (PAH). The PAH indication permits its use in both men and women.

Q: What types of medications are listed as having serious interactions with Виагра?

Major interacting classes include all forms of nitrate medicines, certain HIV protease inhibitors, and certain alpha-blockers. These interactions can cause dangerously low blood pressure or significantly affect sildenafil concentration.

Q: What are the most commonly reported non-serious side effects of Виагра?

Commonly reported side effects include headache, flushing (a feeling of warmth or redness), heartburn or indigestion, nausea, and a stuffy or runny nose. These are usually considered mild and manageable reactions.

Q: Is it possible for a woman to be prescribed Виагра for any reason?

Yes, sildenafil is indicated for use in women for the treatment of pulmonary arterial hypertension (PAH). This treatment uses the drug's effect on blood vessels in the lungs.

Q: Are there any age limits for who can use Виагра?

Dosing guidelines specifically mention considerations for adult patients aged 65 years and older, who may require a specific starting dose. Sildenafil is also approved for pediatric patients (ages 1 to 17) for the treatment of pulmonary arterial hypertension, which is a separate indication.

Q: Is it true that taking Виагра can cause a stuffy nose or flushing?

Yes, flushing, described as a warm or tingly feeling, and a stuffy or runny nose are listed in regulatory documents as common potential side effects of the medication.

Q: Why is it important to have a medical evaluation before starting Виагра?

A medical evaluation is important to review underlying health conditions and current medications. This assessment helps determine appropriate use and rule out contraindications, as required by regulatory guidance.

Q: Can Виагра affect blood pressure levels?

Yes, official labeling notes that the medicine can cause a mild and temporary drop in blood pressure. The effect is most notable approximately one to two hours after dosing.

Q: Are vision or hearing problems a known potential side effect listed in official documents?

Sudden vision loss, changes in vision, sudden decrease in hearing, or hearing loss are reported as urgent side effects. These are serious potential reactions that require immediate medical attention.

Q: Does Виагра affect fertility or sperm count?

Studies examining the effect of a single, standard dose of sildenafil on seminal parameters in healthy male volunteers did not show a statistically significant change in sperm count, motility, or abnormality percentages when compared to a placebo.

Q: Is there a specific mechanism described for how Виагра interacts with other medicines?

Sildenafil is predominantly metabolized (cleared from the body) by the hepatic isoenzyme CYP3A4. Drug interactions occur when other medications either block or speed up the function of this enzyme, affecting the concentration of sildenafil in the bloodstream.

Q: Why do official sources sometimes mention caution when taking Виагра with ritonavir?

Ritonavir is an HIV protease inhibitor that acts as a strong inhibitor of the CYP3A4 enzyme. This significantly slows the removal of sildenafil from the body. Due to the resulting increase in drug levels, the regulatory guidance for this combination includes specific dosage considerations.

Q: Can a patient with diabetes use Виагра?

Use is possible, but official documentation notes that medical review and monitoring are generally advised, as these individuals may have an increased risk of certain side effects.

Q: Are there any foods or drinks officially listed to be strictly avoided while using Виагра?

Grapefruit or grapefruit juice can raise the amount of sildenafil in the blood by interfering with its metabolism. Official guidance describes that avoidance or limitation of grapefruit may be an appropriate precaution.

Q: Does taking Виагра cause an increase in sexual desire?

Official information states that the medicine does not function as a cure for erectile dysfunction, nor does it increase sexual desire or act as a treatment for low libido.

Q: Is it possible to buy Виагра without a prescription in some places?

While it is a prescription medicine in the U.S., some countries and regions permit the sale of sildenafil from a registered pharmacy following a mandatory health consultation with a pharmacist. This is sometimes referred to as 'Pharmacy Medicine' status.

Q: Does the medication have any known effect on other body systems besides the vascular system?

In addition to its primary effect on vascular smooth muscle, the medicine has minor inhibitory action on the PDE6 enzyme, which is present in the eye’s photoreceptors. This secondary action is linked to the potential for visual side effects.

Q: Is it normal to feel a bit dizzy or lightheaded after taking Виагра?

Dizziness or a lightheaded feeling is listed as a common potential side effect, likely related to the drug’s effect on blood pressure.

Q: What official guidance exists on continuing to use Виагра if minor side effects occur?

Official guidance emphasizes seeking immediate medical attention for urgent or serious side effects. For common or minor side effects, patients are generally advised to discuss these symptoms with their prescribing healthcare provider.

Q: Can Виагра be taken by men who have undergone prostate surgery?

Use after prostate surgery requires specific medical guidance. Medical guidance is necessary for use after prostate surgery, particularly for patients taking alpha-blockers, as specific dosage considerations apply due to the risk of hypotension.

Q: Is the use of Виагра described differently for men with or without diabetes?

While the general use is not described differently, regulatory information notes that individuals with diabetes are considered to be at an increased risk for certain rare, serious side effects, meaning specific medical monitoring may be advised.

Q: What is the difference between brand-name Виагра and generic sildenafil, according to official labeling?

Brand-name Виагра and generic sildenafil share the same active ingredient, sildenafil citrate. The main difference noted on official labeling includes the inactive ingredients, such as coloring agents and binders, which vary between brand and generic versions.

Q: Is it advised to stop taking Виагра abruptly?

For patients using the medicine to treat pulmonary arterial hypertension (PAH), official instructions advise against abruptly discontinuing the medication without consulting a healthcare provider.

Q: What are the ingredients in Виагра besides sildenafil?

In addition to the active ingredient sildenafil citrate, the tablets contain various inactive ingredients. These typically include microcrystalline cellulose, lactose, titanium dioxide, and specific coloring agents.

How should Виагра be stored and disposed of?

How to Store and Dispose of Sildenafil (Виагра)

Official regulatory guidelines define precise requirements for storing and disposing of this medication to maintain its stability and ensure public safety.

Storage and Handling Requirements

Requirement Official Statement
Temperature Store at controlled room temperature, 20 C to 25 C (68 F to 77 F).
Protection Keep the medication in its original, tightly closed container and protect it from moisture.
Child Safety Keep this medicine out of the sight and reach of children.

Disposal Instructions

Unused or expired tablets must be discarded according to official instructions. If a drug take-back program is available, utilize it for disposal. If a take-back option is not available, mix the uncrushed tablets with an undesirable substance, seal the mixture in a bag, and discard it in household trash. Do not flush this medication down a toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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