Инванз

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Инванз

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Инванз

Quick Facts about Инванз

Property Description
Active Ingredient Ertapenem
Form Lyophilised Powder for Solution for Injection
Pharmacological Class Carbapenem (Specialized beta-Lactam Antibiotic)
Common Use Treating serious bacterial infections
Origin Synthetic

What type of medicine is Инванз and to which class does it belong?

Инванз is a specialized, synthetic, and prescription-only medicine used to treat moderate to severe infections caused by bacteria. It belongs to the carbapenem class of antibiotics, a high-potency subgroup of the broader beta-Lactam antibiotics. Ertapenem is effective against a broad array of common Gram-positive and Gram-negative bacteria that cause infections. This specialized class is utilized for its activity against various multi-drug resistant strains, often serving as a choice when standard therapies are not suitable.

What is the composition of Инванз and in what form is it supplied?

The single active ingredient in Инванз is ertapenem, which is supplied as the sodium salt. The product comes as a sterile, white-to-off-white lyophilised powder (freeze-dried powder) in a vial, designed to be mixed with a diluent to form a solution. The formulation of ertapenem provides a sustained antibacterial concentration, which allows for once-daily dosing in adults, a feature that assists in patient management. This medicine is administered only via parenteral injection, either into a vein (intravenous infusion) or into the muscle (intramuscular injection).

What is the general purpose of this medicine?

The primary purpose of Инванз is to eliminate a wide variety of harmful bacteria throughout the body. It achieves this by directly interfering with the bacteria's ability to build and maintain their protective cell walls, a process known as bactericidal action. Due to its broad spectrum and stability against certain bacterial defense enzymes, a typical use for Инванз involves treating serious infections, such as severe community-acquired pneumonia. This activity makes it a tool for addressing severe or complicated bacterial illnesses.

What side effects are possible with Инванз?

Possible Side Effects and Safety Information

The safety profile for Ertapenem (Инванз) is systematically documented by regulatory authorities, classifying adverse reactions by frequency and the body system affected. These classifications structure the official understanding of the medicine’s risk profile.


Adverse Reaction Classification

Side effects are officially categorized into tiers based on their reported incidence in clinical trials:

  • Very Common (ge 1/10): Reactions at the infusion or injection site, such as pain, phlebitis, or thrombophlebitis.
  • Common (ge 1/100 to < 1/10): Includes gastrointestinal effects like diarrhea and nausea, as well as headache, rash, and documented increases in liver enzymes (transaminases).
  • Uncommon (ge 1/1,000 to < 1/100): May include seizures, dizziness, and more serious gastrointestinal issues like Clostridioides difficile-associated diarrhea (CDAD).

Serious Safety Considerations

Official labeling documents specific serious adverse reactions. These include potentially life-threatening anaphylaxis and other severe hypersensitivity reactions. The medicine is also associated with Central Nervous System (CNS) effects, specifically seizures and altered mental status, a risk that is greater in patients with pre-existing CNS disorders or compromised renal function.

Safety Restrictions and Special Populations

Ertapenem is contraindicated in individuals with known hypersensitivity to any carbapenem or a severe hypersensitivity reaction to any other beta-lactam antibiotic. Due to its primary elimination by the kidneys, the risk of toxicity is increased in patients with renal impairment, necessitating caution and often requiring adjustment of the administered amount. A specific safety restriction advises against its co-administration with valproic acid or divalproex sodium, as this combination may lead to a loss of seizure control.

Overdose and Emergency Response

Officially documented information on Ertapenem overdose primarily addresses the reported clinical manifestations and the required immediate emergency response. Common symptoms reported in the regulatory context of overdose include nausea, diarrhea, and dizziness.

Domain Official Regulatory Statement
Documented Manifestations Clinical manifestations explicitly documented include nausea, diarrhea, and dizziness.
Severe Outcomes/Triggers Seizure, collapse, trouble breathing, or inability to be awakened are signs that require immediate medical attention.
Emergency Actions The medicine should be discontinued, and general supportive treatment must be initiated. Contact a Poison Control Helpline or emergency services for guidance.
Treatment & Antidote Treatment is strictly symptomatic and supportive, as no specific information is available on the treatment of overdosage, implying no specific antidote is known. The drug is eliminated via the kidneys, and haemodialysis is listed as a procedural option for removal.
Population Note Patients with impaired renal function are identified as having an increased risk of toxic central nervous system reactions due to slower drug clearance, which is a key consideration in overdose scenarios.

The official regulatory profile requires the immediate discontinuation of the drug and the provision of general supportive care until the medicine is naturally cleared by the kidneys. This profile emphasizes the need for urgent help if severe neurological signs are observed, ensuring the documented risks are addressed by mandated emergency procedures.

Therapeutic Uses of Инванз

What Инванз Treats: Main Uses and Benefits

Quick Fact: Relief for Systemic and Localized Symptoms

Инванз is for managing infections that are classified as moderate to severe and are caused by susceptible bacteria. This specialized antibiotic is commonly used when short-term symptomatic assistance is needed to address significant physiological strain. It is considered relevant in contexts involving bacteria that may be resistant to other therapies.

Severe Abdominal, Pelvic, and Skin Infections

This medicine is applied across domains where additional symptomatic support is needed for serious infections, including complicated intra-abdominal infections, severe acute pelvic infections, and complicated skin and soft tissue infections (such as diabetic foot infections). It helps address symptom clusters such as high, debilitating fever, and significant, localized pain, which supports the patient during difficult episodes by easing distress.

Community-Acquired Illnesses and High-Risk Scenarios

Инванз is relevant in contexts involving heightened systemic burden, such as the treatment of serious community-acquired pneumonia (CAP) and complicated infections of the urinary tract (like acute pyelonephritis). It is commonly used as initial empiric therapy when severe infection is suspected or used for surgical prophylaxis in specific high-risk procedures, which assists with maintaining functional stability by offering supportive coverage against complicated bacterial threats.

Regulatory References

  1. NIH DailyMed official labeling information

Eligibility and Restrictions for Use

Who Can and Cannot Use Инванз?

Eligibility for using Ertapenem (Инванз) is strictly defined by regulatory authorities based on patient population status, allergies, and organ function. This medicine must not be used by individuals with a known hypersensitivity or severe allergic reaction to Ertapenem, any other carbapenem antibacterial agent, or any other beta-lactam antibiotic, such as penicillins or cephalosporins. Additionally, the intramuscular (IM) formulation is contraindicated in patients allergic to amide-type local anesthetics, like lidocaine.

Age and Physiological Restrictions

Category Eligibility Status (Regulatory Basis)
Established Age Patients 3 months of age and older.
Infants (< 3 months) Use is not established due to insufficient safety and efficacy data.
Severe Renal Impairment Not recommended or conditional use required (creatinine clearance leq 30 mL/ min/1.73 m^2) due to lack of adequate data.
Pregnancy Should not be used unless potential benefit clearly outweighs risk to the fetus.
Lactation Not recommended due to potential adverse effects on the nursing infant.

Eligibility for use in patients with a history of certain Central Nervous System (CNS) disorders requires caution. Use in pediatric patients specifically for meningitis is not indicated.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Ertapenem (Инванз) documents specific pharmacokinetic interactions and constraints vital for safe administration.

Specific Drug-Drug Interaction Patterns:

  • Co-administration with Valproic Acid or its derivatives is generally not recommended because this combination is officially documented to substantially reduce the serum concentration of the anti-convulsant medicine. This pharmacokinetic outcome is formally noted as a risk in the regulatory labels.
  • The combination of Ertapenem with Probenecid is also not recommended. This is due to an established interaction where Probenecid inhibits the active tubular secretion of Ertapenem in the kidney, which results in an officially documented increase in the antibiotic's systemic exposure.
  • Regulatory data provides a crucial statement of non-interaction, affirming that Ertapenem is not an inhibitor of major CYP enzymes, including 3A4 and 2D6, nor does it interact with the P-glycoprotein transporter system. This means interactions related to these metabolic pathways are officially considered unlikely.

Administration Constraints and Restrictions:

  • The official label strictly mandates that the product MUST NOT be mixed with or co-infused with any other medications. This restriction also extends to diluents, as solutions containing Dextrose (alpha-D-Glucose) MUST NOT be used for reconstitution.
  • For individuals with mild or moderate renal insufficiency, the clearance is affected, and an officially observed increased systemic exposure of Ertapenem is noted in the regulatory documents.

Mechanism of Action

Targeted Disruption of Bacterial Cell Wall Synthesis

The mechanism of Ertapenem (Инванз) centers on the rapid, covalent inhibition of Penicillin-Binding Proteins (PBPs), which are crucial enzymes in bacteria. By binding irreversibly to these targets, the drug blocks the transpeptidation step, which is the final process in constructing the rigid, protective bacterial cell wall. This structural failure causes the cell to lose its osmotic integrity, leading to lysis and bacterial cell death.

Functional Limitations of the Mechanism

The functional range of this mechanism is inherently constrained by specific bacterial defenses. The mechanism is functionally nullified when bacteria produce carbapenemase enzymes, which chemically destroy the drug before it can reach the PBPs. Furthermore, certain bacterial species like Pseudomonas aeruginosa possess altered cell structures that prevent the drug from penetrating the outer membrane, directly limiting the drug's access to its intended molecular targets.

Dosage and Administration Information

How Инванз is used: Official Administration Guidelines

Инванз (Ertapenem) is supplied as a lyophilised powder for injection and is administered exclusively via parenteral routes, either as an intravenous (IV) infusion or by deep intramuscular (IM) injection. The official use is structured around a precise, once-daily schedule and requires specific preparation and timing.

Administration and Dosing Schedule

Patient Group Standard Daily Dose Administration Schedule
Adults (and Adolescents ge 13 years) 1 gram (g) Once daily (q24h)
Pediatric Patients (3 months to 12 years) 15 mg/kg (Max. 1 g daily) Twice daily (q12h)
Surgical Prophylaxis (Adults) 1 gram (g) single dose Administered 1 hour prior to incision

Standard treatment duration typically ranges from 3 to 14 days, though the overall course may be extended for certain complicated infections, such as diabetic foot infections, up to four weeks. IV administration should be infused over a period of 30 minutes. Intravenous administration is approved for up to 14 days, while intramuscular injection is limited to a maximum of 7 days.

Dosage Adjustments and Preparation

The dosage must be adjusted for adult patients with reduced kidney function. For patients with creatinine clearance le 30 mL/min/1.73 m^2, including those on hemodialysis, the dose is reduced to 500 mg once daily. A supplemental dose of 150 mg is required following hemodialysis if the daily dose was given within six hours prior to the session.

For proper preparation, the powder must be reconstituted and diluted using specific, non-dextrose-containing solutions. Importantly, the medication must not be mixed or co-infused with other medications.

Recent Clinical Evidence

Research evidence / Overview of Studies for Инванз

The research on Инванз (Ertapenem) is primarily based on formal clinical trials, mostly Randomized Controlled Trials (RCTs). These studies' design involved examining the regimen alongside other standard therapies or measuring the outcomes in a defined group of patients. The research contributes data used in the medicine's regulatory review. Findings describe group patterns, not personal outcomes.


Evidence from Studies on Complicated Infections

Research for this antibiotic has been applied in studies examining patient-reported experiences related to several serious infections. The core evidence for these uses comes from comparative clinical trials involving large groups of adults and children. These studies monitored outcomes related to physical discomfort and systemic or functional imbalance.

Research for Complicated Intra-abdominal Infections

Studies explored this antibiotic's use for treating complicated infections inside the abdomen. Researchers utilized major RCTs focused on measuring the clinical success rate (resolution of infection signs) and monitoring the status of the bacteria causing the infection. Findings describe patterns observed in the studies, reporting short-term outcomes. However, there is limited information for patients with the most severe, high-risk intra-abdominal conditions, as results apply mainly to the populations studied in the trials.

Research for Community-Acquired Pneumonia

The antibiotic was studied for severe community-acquired pneumonia (CAP) in hospitalized patients. These large comparative trials monitored outcomes reflecting daily functioning and capturing phases of heightened symptom activity. Studies report how symptoms evolved in the observed populations, such as the time to fever subside, and looked at whether the infection-causing bacteria were eradicated. Evidence is limited for patients who had milder CAP that did not require hospitalization.


Evidence in Specific Patient Populations

Research has explored the use of the antibiotic in populations beyond the general adult patient group, providing context but not individual predictions. For pediatric patients, studies explored short-term symptom changes in children aged 3 months and older for most of the approved complicated infections. These studies help show what has been observed in children, which is considered alongside data from adult trials. Studies have also evaluated its performance against infections caused by bacteria that may be resistant to certain other antibiotics; however, evidence quality varies across studies for these resistant infections, with some findings coming from smaller observational studies.

Key Studies & References

  1. Use of ertapenem in the treatment of infections caused by extended-spectrum β-lactamase-producing bacteria: a systematic review and meta-analysis

Frequently Asked Questions (FAQ)

Common questions about Инванз (FAQ)

Q: What is the main difference between Инванз and other medicines used for the same purpose?

A: Official product information describes Ertapenem as a specialized antibiotic within the carbapenem class. A distinguishing feature noted in regulatory documents is that the drug is formulated and studied for a once-daily dosing regimen in adults, which is supported by how the body processes the medication.

Q: Can people who have diabetes use Инванз?

A: Yes, the medicine's approved uses, as described in regulatory documents, include treating complicated skin and skin structure infections, specifically listing diabetic foot infections in adults. Eligibility for use in any individual, however, depends on their overall medical status.

Q: What is the shelf life of Инванз before it is prepared for use?

A: Official instructions specify the storage requirements for unopened vials, such as keeping the powder at 25 C (77 F). The precise shelf life (expiration date) is marked on the packaging of each individual vial, as it is determined by the manufacturer for that specific batch.

Q: Is Инванз meant to replace other treatments or be used alongside them?

A: Official use involves using this medicine to treat specific bacterial infections. Regulatory-associated guidance indicates that it is sometimes used to transition patients from intravenous treatment to a suitable oral antibiotic to complete their course of therapy.

Q: Is the chemical structure of Инванз unique compared to similar drugs?

A: Official product information defines Ertapenem as a specialized, synthetic drug within the carbapenem class of antibiotics. While regulatory documents provide the full chemical structure, they do not contain statements that compare its structural uniqueness against other similar drugs.

Q: What is the average duration of action for one dose of Инванз?

A: Studies described in regulatory documents show that the half-life of Ertapenem in young, healthy adults is approximately 4 hours. This pharmacological property supports the official once-daily dosing schedule for adults, as the dose is designed to maintain necessary drug levels over 24 hours.

Q: How quickly can a person expect to notice the effects of Инванз?

A: Information associated with regulatory documentation suggests that patients typically begin to feel better during the first few days of receiving the medicine. Healthcare providers typically advise that the full prescribed course should be completed, even if symptoms improve quickly.

Q: What happens if a person misses a scheduled dose of Инванз?

A: Official regulatory documents contain specific patient counseling information regarding a missed dose. These instructions describe the steps to follow if a dose is remembered shortly after it was due, and they also specify that a double dose is not to be used to compensate for a missed dose.

Q: Is it true that Инванз might cause changes in body weight?

A: Regulatory-associated safety information includes reports of unusual weight loss as an observed adverse reaction. This is classified as a rare side effect that has been reported during the use of the medicine.

Q: Does Инванз have any known interactions with common over-the-counter pain relievers?

A: Official labeling documents specific drug-drug interactions with Valproic Acid and Probenecid. While interactions with common over-the-counter pain relievers are not specifically listed, regulatory patient counseling always advises informing a doctor about all nonprescription medicines being used.

Q: Are there any specific types of food or drinks that should be avoided while using Инванз?

A: The official product label generally advises that patients continue their normal diet unless their doctor provides alternative instructions. The primary restriction noted is related to the drug's preparation, specifying that the powder must not be mixed with diluents that contain Dextrose (alpha-D-Glucose).

Q: Is it normal to feel tired after receiving an injection of Инванз?

A: Regulatory safety information indicates that unusual tiredness or weakness has been reported as an observed side effect in adult patients. Safety information generally notes that any concerns about side effects may be discussed with a healthcare provider.

Q: What is the longest period of time people have been studied while using Инванз?

A: The duration of the core safety and efficacy data collection generally aligns with the maximum approved treatment periods. These periods are typically up to 14 days for intravenous infusion and up to 7 days for intramuscular injection, though longer courses have been studied for specific complicated infections.

Q: Are there any known requirements for blood tests or monitoring while on Инванз?

A: Official labeling advises that various laboratory tests may be conducted during the course of treatment. This monitoring may include blood tests to check liver function and blood cell counts, especially in outpatients.

Q: Do regulatory agencies classify Инванз as a high-risk medication?

A: Ertapenem is a prescription-only antibiotic belonging to the specialized carbapenem class. The official label includes specific Warnings and Precautions sections outlining the potential for serious events, such as seizures and severe allergic reactions, which require careful use and management by a healthcare professional.

Q: Is Инванз used to treat all stages of the condition it targets?

A: Regulatory documents indicate that the medicine is primarily used for the treatment of moderate to severe infections caused by susceptible bacteria. For specific complicated conditions, the medicine has not been studied in the most severe instances, such as diabetic foot infections that involve bone infection (osteomyelitis).

Q: Does using Инванз affect a person's ability to drive or operate machinery?

A: Regulatory information notes the potential for Central Nervous System (CNS) effects, including dizziness and confusion. Because of this potential, patients experiencing these effects are typically cautioned against performing skilled activities such as driving or operating machinery.

Q: Is it possible for Инванз to interact with herbal supplements?

A: Specific interactions with herbal supplements are not listed in the core regulatory label. However, official patient counseling always emphasizes informing a doctor about all prescription medicines, nonprescription medicines, and herbal or nutritional products being used.

Q: Can a person use Инванз if they have a history of heart problems?

A: Heart problems are not listed as an official restriction for use. However, the regulatory label notes that cardiovascular events such as fast heart rate (tachycardia) and high blood pressure have been observed as serious adverse reactions in clinical trials.

Q: What should a patient do if they accidentally receive more than the standard amount of Инванз?

A: Official regulatory documents include patient counseling that specifies the steps to be taken in the event of a suspected overdose. These instructions specify immediately seeking emergency medical care or contacting a poison control center.

Q: Does Инванз interact with common vitamins like Vitamin D or B12?

A: Specific interactions with common vitamins like D or B12 are not listed in the regulatory documents. As with all medications, patients are generally advised to inform their healthcare provider about all vitamins, supplements, and other products they are taking.

Q: Are the side effects of Инванз different for older adults compared to younger adults?

A: Regulatory studies did not observe overall differences in how the drug worked or its safety profile between older adult patients and younger adults. However, a greater sensitivity in some older individuals cannot be ruled out, particularly due to the potential for decreased kidney function.

Q: Can a person get a fever after receiving Инванз?

A: Yes, regulatory-associated safety information lists fever as a reported adverse reaction. This is one of the possible effects observed during the use of the medicine.

Q: What is the official definition of the condition Инванз is approved to treat?

A: Official indications state that the medicine is approved for the treatment of moderate to severe infections that are caused by specific, susceptible bacteria. Examples of approved uses include complicated intra-abdominal infections and community-acquired pneumonia.

Q: Are there any known interactions between Инванз and common cold or flu medications?

A: The official label specifically highlights interactions with Valproic Acid and Probenecid. Specific interactions with general cold or flu medicines are not listed, but official guidance requires informing your doctor of all nonprescription medicines being used.

Q: Is it true that Инванз may affect cholesterol levels?

A: The regulatory label documents that changes in various laboratory test results were observed during clinical trials. These reported adverse changes include both increases and decreases in serum lipids (such as cholesterol levels).

Q: Do people typically stop taking their other medications when starting Инванз?

A: The continuation of other medications is a decision made by a healthcare provider. However, for patients taking certain anti-seizure medicines like Valproic Acid, regulatory labeling states that anticonvulsant therapy for this patient population is typically continued while receiving Ertapenem, due to a known interaction.

Q: What evidence exists about using Инванз in people with liver impairment?

A: Regulatory documents indicate that no dosage adjustment is considered necessary for adult patients who have hepatic (liver) impairment. This is different from the guidance provided for patients with impaired kidney function.

Q: Can people with high blood pressure use Инванз?

A: High blood pressure (hypertension) is not listed as an official restriction or contraindication for use. However, regulatory safety data notes that hypertension has been reported as an uncommon adverse reaction observed during clinical trials.

Q: Are there any specific patient populations that were excluded from the main clinical trials for Инванз?

A: Yes, regulatory documents note that the medicine has not been studied in certain specific populations. Examples include patients with severe, high-risk intra-abdominal conditions and diabetic foot infections that involve bone infection (osteomyelitis).

Q: Does the body metabolize Инванз quickly or slowly?

A: Official pharmacokinetic information indicates that the body only partially metabolizes the medicine. The majority of the drug is primarily eliminated from the body by the kidneys as the active parent compound.

How should Инванз be stored and disposed of?

How to Store and Dispose of Инванз?

The storage and stability requirements for Инванз (Ertapenem) are strictly defined by regulatory labeling to maintain product integrity.

Storage Conditions

Item Requirement
Unopened Vials Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).
Protection Store in the original container to protect the lyophilized powder.
Child Safety Must be kept out of the sight and reach of children.

Stability After Preparation

The reconstituted solution must not be frozen. The stability depends on the method of administration:

  • Intramuscular (IM): Use within 1 hour of preparation.
  • Intravenous (IV) Infusion: Stable for 6 hours at room temperature or 24 hours if refrigerated (5°C).

Disposal Requirements

Unused product or waste material must be disposed of in accordance with local requirements. The medicine should not be disposed of by flushing it down a toilet or pouring it into a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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