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Oliinyk Elizabeth Ivanovna 、薬局による医学的評価、 最終更新日:21.03.2022
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Cevamec (ivermectin) is indicated for the treatment of the following infections:
Strongyloidiasis of the intestinal tract. Cevamec (ivermectin) is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis.
This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of ivermectin. (See CLINICAL PHARMACOLOGY, Clinical Studies.)
Onchocerciasis. Cevamec (ivermectin) is indicated for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus.
This indication is based on randomized, double-blind, placebo-controlled and comparative studies conducted in 1427 patients in onchocerciasis-endemic areas of West Africa. The comparative studies used diethylcarbamazine citrate (DEC-C).
NOTE: Cevamec (ivermectin) has no activity against adult Onchocerca volvulus parasites. The adult parasites reside in subcutaneous nodules which are infrequently palpable. Surgical excision of these nodules (nodulectomy) may be considered in the management of patients with onchocerciasis, since this procedure will eliminate the microfilariae-producing adult parasites.
Strongyloidiasis
The recommended dosage of Cevamec (ivermectin) for the treatment of strongyloidiasis is a single oral dose designed to provide approximately 200 mcg of ivermectin per kg of body weight. See Table 1 for dosage guidelines. Patients should take tablets on an empty stomach with water. (See CLINICAL PHARMACOLOGY, Pharmacokinetics.) In general, additional doses are not necessary. However, follow-up stool examinations should be performed to verify eradication of infection. (See CLINICAL PHARMACOLOGY, Clinical Studies.)
Table 1: Dosage Guidelines for Cevamec (ivermectin) for Strongyloidiasis
Body Weight (kg) | Single Oral Dose Number of 3-mg Tablets |
15-24 | 1 tablet |
25-35 | 2 tablets |
36-50 | 3 tablets |
51-65 | 4 tablets |
66-79 | 5 tablets |
≥ 80 | 200 mcg/kg |
Onchocerciasis
The recommended dosage of Cevamec (ivermectin) for the treatment of onchocerciasis is a single oral dose designed to provide approximately 150 mcg of ivermectin per kg of body weight. See Table 2 for dosage guidelines. Patients should take tablets on an empty stomach with water. (See CLINICAL PHARMACOLOGY, Pharmacokinetics.) In mass distribution campaigns in international treatment programs, the most commonly used dose interval is 12 months. For the treatment of individual patients, retreatment may be considered at intervals as short as 3 months.
Table 2: Dosage Guidelines for Cevamec (ivermectin) for Onchocerciasis
Body Weight (kg) | Single Oral Dose Number of 3-mg Tablets |
15-25 | 1 tablet |
26-44 | 2 tablets |
45-64 | 3 tablets |
65-84 | 4 tablets |
≥ 85 | 150 mcg/kg |
However, we will provide data for each active ingredient