Avage

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Avage

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Treatment option: Keratoses, Wrinkles

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Avage

Quick Facts

Property Description
Active ingredient Tazarotene
Form Cream, Gel, Foam
Pharmacological class Retinoid (Acetylenic Retinoid)
Common use Modulating skin cell growth and appearance
Origin Synthetic

What Type of Medicine is Avage? A Synthetic Retinoid Prodrug

Avage is a prescription-only topical medication containing the active ingredient Tazarotene, a Retinoid. Retinoids are a specialized class of synthetic or natural compounds chemically related to Vitamin A. Avage functions by influencing dermatological cell cycles.

Tazarotene is specifically a third-generation acetylenic retinoid and functions as a prodrug (a compound that becomes active only after metabolism). This means the molecule applied topically is initially inactive and requires rapid conversion by skin enzymes to its biologically potent metabolite, Tazarotenic Acid. This activation ensures the drug’s action is focused primarily within the skin tissue.

Composition and Form: Topical Application

This preparation is a synthetic compound formulated exclusively for topical administration to the skin. While Avage is the trade name primarily associated with a cream preparation, the active ingredient Tazarotene is available under other brands and in other dosage form(s), including gel and foam formulations.

The topical route is an inherent differentiator, ensuring the drug concentrates its effect locally where it is needed. This localized delivery results in low systemic absorption after application. This reduced systemic exposure is a characteristic of this topical formulation in comparison to oral retinoid treatments.

General Therapeutic Purpose

The fundamental purpose of Avage is to address underlying cellular dynamics by normalizing skin cell function. Tazarotenic Acid works by binding to nuclear receptors within skin cells, which influences gene expression to help restore the proper pattern of cellular differentiation and limit excessive cell proliferation. This corrective action is central to the drug’s general therapeutic benefit in improving the structure and appearance of the skin.

Regulatory References

  1. clinical data reviewed by the NIH

What side effects are possible with Avage?

Official Adverse Reactions and Safety Profile

The safety profile of Avage (Tazarotene) is primarily defined by the occurrence of local application site reactions, which are classified in official regulatory documents under Skin and Subcutaneous Tissue Disorders. These reactions constitute the most frequent effects observed during clinical use.

Frequency Classification of Adverse Reactions

The following effects are commonly documented, with incidence rates consistent with Very Common or Common frequency categories:

  • Skin and Subcutaneous Tissue Disorders: Pruritus (itching), Burning or Stinging sensation, Erythema (redness), Desquamation (peeling/flaking), Dry Skin, Skin Irritation, and local Skin Pain.

Time-related regulatory data indicates that the maximum severity of localized irritation, such as burning or peeling, generally peaked at the second week of therapy and then decreased thereafter.

Serious Safety Constraints

The most critical safety consideration documented in prescribing information is the potential for Embryofetal Toxicity (teratogenicity). Consequently, the medication is Contraindicated in pregnant females. Females of child-bearing potential must use effective methods of contraception throughout the period of use.

Additional regulatory warnings address Photosensitivity. The drug augments susceptibility to sunburn, and caution is required when used alongside other systemic drugs known to be photosensitizers, due to the risk of augmented sensitivity.

Safety-Related Limitations

Official documents advise against application on compromised skin, stating that the drug should not be used on eczematous or sunburned skin due to the potential for severe irritation. Furthermore, a caution exists regarding the potential for a cumulative irritant effect when Tazarotene is used simultaneously with other highly drying or irritating topical products.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation for Avage (Tazarotene) strictly defines overdose scenarios and mandated emergency responses, distinguishing between localized and systemic exposure.

Overdose Exposure Documented Manifestations Emergency Action
Excessive Topical Use Marked redness, peeling, or discomfort. Symptomatic treatment is generally sufficient.
Oral Ingestion Signs and symptoms associated with hypervitaminosis A (excessive intake of Vitamin A). Seek immediate medical attention. Close patient monitoring and supportive measures are required.

Regulatory Action and Monitoring

Urgent medical attention is required for all cases involving oral ingestion of the drug. In this systemic context, regulatory guidance mandates that the patient must be monitored closely in a clinical setting.

The official overdose profile emphasizes that management is strictly supportive. In the absence of a known specific antidote, administering appropriate supportive measures is the official procedural step required. The product labeling does not document population-specific risks (e.g., pediatric or geriatric) associated with overdose severity. This information establishes the documented manifestations and the mandatory clinical steps required by regulatory authorities.

Therapeutic Uses of Avage

What Avage Treats: Main Uses and Benefits

The topical therapeutic role of Avage (Tazarotene) is commonly used for managing symptoms across three distinct dermatological domains associated with certain physiological processes or solar damage. The medication is applied where additional symptomatic support is needed to help manage symptoms that interfere with daily functioning. It is commonly used for managing the symptoms of stable plaque psoriasis, providing relief for mild to moderate acne vulgaris, and addressing specific signs of facial photodamage.

The treatment supports symptomatic relief that helps improve day-to-day comfort during periods of heightened symptoms. The medication may assist with managing symptom clusters related to redness, scaling, acne lesions, fine wrinkling, and mottled hyperpigmentation. The treatment's role is to provide support that helps ease the overall symptom burden associated with these chronic or aesthetic concerns. The clinical context is generally one of long-term management where the drug contributes to easing the overall symptom load and assists with maintaining functional stability when symptoms are more noticeable.


Quick Fact: Relief for Chronic Skin Manifestations

Property Description
Primary Therapeutic Goal Symptomatic relief and management of chronic skin changes.
Symptoms Eased Redness, scaling, acne lesions, and facial fine lines.
Typical Context Long-term support in conditions characterized by recurrent or episodic manifestations.
Patient Benefit Supports day-to-day comfort and stability in visible skin appearance.

Regulatory References

  1. DailyMed, a service of the U.S. National Library of Medicine

Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Avage? — official regulatory information

The eligibility for Avage (Tazarotene) is defined by regulatory authorities based on population characteristics and specific pre-existing conditions.


Eligibility scope

Scope Detail and Regulatory Wording
Populations for whom use is allowed (as stated in label) Adults and adolescents 12 years of age and older (for certain indications). Adolescents 17 years and older are eligible for facial photodamage treatment.
Populations for whom use is not recommended (if applicable) Children under 12 years of age (safety and effectiveness have not been established). Older adults 65 years and older (safety for facial photodamage is not established).
Populations for whom use is contraindicated Pregnant Females (due to risk of embryofetal toxicity). Individuals with a known hypersensitivity to Tazarotene or any component.
Pregnancy and lactation eligibility status (if explicitly documented) Pregnancy is an absolute contraindication. Lactation requires a decision to discontinue nursing or discontinue the drug as excretion into human milk is unknown.
Eligibility-related restrictions Females of childbearing potential must use effective contraception and obtain a negative pregnancy test prior to treatment. The product must not be used on sunburned skin until fully recovered, or on eczematous skin.

Eligibility classifications (high-level)

Classification Detail
Eligibility severity classification (as defined in official documents) Contraindicated (Pregnancy, Hypersensitivity). Use Not Established (Children under 12). Conditional Use (Females of childbearing potential, Sun exposure).

Resulting eligibility structure

Official regulatory documents define who can and cannot use the medicine by establishing absolute contraindications for pregnancy and allergy, reflecting Tazarotene’s classification as a retinoid. Eligibility is further structured by age-based limitations where safety is not established and by mandatory conditional restrictions (contraception, sun avoidance) to mitigate specific documented risks.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation structures the interaction profile of Avage (Tazarotene topical) around local effects and additive risks, consistent with its low systemic absorption.

Interaction Classifications

Classification Official Regulatory Statement
Interaction Severity Contraindicated (in pregnancy status, due to drug properties); Requires Caution/Avoidance (due to additive risks); Requires Administration Management (due to chemical instability).
Interaction-Context Primarily pharmacodynamic (additive irritancy, additive phototoxicity) and chemical (local degradation risk).

Official Interaction Statements

  • Contraindicated Status: Avage is contraindicated in pregnancy. The drug is a retinoid, and this restriction is tied to the class and the teratogenic risk observed in animal studies.
  • Photosensitizing Agents: Co-administration with systemic photosensitizing agents (including specific classes like Tetracyclines, Thiazides, and Sulfonamides) increases the possibility of augmented photosensitivity.
  • Topical Agents: Concomitant use with topical products that have a strong drying effect should be avoided due to the potential for a cumulative irritant effect.
  • Benzoyl Peroxide: This oxidizing agent may cause chemical degradation of tazarotene and potentially reduce efficacy. If co-administered, the products must be applied at different times of the day.
  • Population Notes: Females of child-bearing potential must obtain a negative pregnancy test prior to initiation and utilize effective contraception throughout treatment.

The regulatory profile defines strict rules for co-administration, requiring specific timing and avoidance rules to mitigate additive pharmacodynamic and chemical risks on the skin surface. The low systemic exposure of the active metabolite means that the profile lacks formally documented systemic pharmacokinetic interactions.

Mechanism of Action

Retinoid Receptor Activation and Gene Modulation

Avage (tazarotene) is a prodrug that undergoes rapid conversion to its active metabolite, tazarotenic acid, within the skin. Tazarotenic acid acts as a selective agonist (ligand) for nuclear Retinoic Acid Receptors (RARs), specifically RARbeta and RARgamma. This binding event engages the nuclear receptor system, which is a key step in regulating gene transcription.

Binding to the RARs enables the receptor complex to interact with DNA (Retinoid Response Elements), thereby initiating or suppressing the transcription of specific genes. This targeted gene modulation modifies the growth (proliferation) and maturation (differentiation) of keratinocytes, the skin's primary cells, resulting in changes toward a regulated cellular state. The resulting cascade also affects systems associated with physiological responses by suppressing the expression of certain pro-inflammatory mediators and regulating factors involved in dermal tissue remodeling.

Dosage and Administration Information

How Avage is Used: Administration Guidelines

Standardized administration guidelines for Tazarotene (Avage and other topical formulations) outline the required route, frequency, dosing pattern, and procedural steps for use.


Administration Scope

Entity Administration Summary
Route and Form Topical (Dermatologic) Use Only. Not for ophthalmic, oral, or intravaginal application.
Dosing Frequency Once daily, typically applied in the evening or at bedtime.
Application Preparation The skin must be cleansed and dried before application. Hands must be washed thoroughly after application.
Duration Pattern Safety and effectiveness of daily use beyond 52 weeks have not been established for facial photodamage.

Standard Labeled Regimens

The dosing rules depend on the specific dermatologic context and prescribed formulation:

  • For Facial Photodamage: A pea-sized amount of 0.1% cream is applied to lightly cover the entire affected face once daily.
  • For Plaque Psoriasis: A thin film of 0.05% or 0.1% strength is applied only to the psoriatic lesions. Treatment may commence with the lower strength and adjust to the higher strength based on tolerance.
  • For Acne Vulgaris: A thin layer of the prescribed strength (0.045% or 0.1% lotion, cream, or gel) is applied to cover the entire area where acne lesions appear.

Population and Procedural Constraints

The use is indicated for pediatric patients 9 or 12 years of age and older, depending on the formulation. Procedural constraints also specify that for females of reproductive potential, a negative pregnancy test is a prerequisite, and therapy should be initiated during a menstrual period. Consistent use of effective sunscreens and protective clothing is a required component of the use protocol.

Recent Clinical Evidence

Research evidence / Overview of studies for Avage (Tazarotene)


1. Evidence for use in Facial Photodamage

Research examining Tazarotene for facial photodamage primarily involved randomized, controlled trials. These studies, which typically lasted several months, explored how symptoms change over time by tracking specific outcomes, including fine facial wrinkling, mottled hyperpigmentation, and tactile roughness. Findings describe patterns observed in the studies related to changes in investigator-graded scores for these signs when Tazarotene was studied compared to a non-active control (vehicle).

Research describes changes measured during the study period, including some findings related to the skin's microscopic structure. However, evidence is largely derived from populations with lighter skin tones, meaning limited information exists regarding observed patterns in individuals with darker or non-Caucasian skin types. Long-term effects are not fully established, with core data providing insight into outcomes for up to approximately one year.


2. Evidence for use in Stable Plaque Psoriasis

Clinical research for Tazarotene in stable plaque psoriasis involves short-term (around 12 weeks) randomized, controlled trials comparing its use against an inactive vehicle. The studies monitored outcomes by tracking changes in the key signs of psoriasis severity, including plaque thickness, scaling, and redness. These changes were often assessed using the Psoriasis Area and Severity Index (PASI), relevant in evidence describing how symptoms are measured.

Data show patterns related to changes in overall severity scores in the observed populations over the study duration. Studies monitored the evolution of symptoms in the observed populations. Tazarotene was also evaluated in studies involving combination therapies with other topical agents. The evidence base focuses primarily on short-term findings, and data for long-term use as monotherapy (alone) remain insufficient.


3. Evidence for use in Mild to Moderate Acne Vulgaris

Tazarotene was evaluated in multiple randomized, controlled Phase 3 trials involving adolescents and adults with mild to moderate facial acne. Researchers examined changes in lesion counts, distinguishing between inflammatory and non-inflammatory lesions. They also monitored the overall appearance of the skin using standardized global assessment scales.

Studies monitored measurements of change in lesion counts when Tazarotene was compared to a vehicle. Research also examined measurements of change when comparing different formulations (cream, gel, or foam). However, results apply only to the populations studied: mild to moderate acne. The evidence base is not structured to evaluate Tazarotene for severe forms of acne, such as cystic or nodular lesions.

Frequently Asked Questions (FAQ)

Common questions about Avage (FAQ)

Q: Are there any common foods or drinks that should be avoided when taking Avage?

Official product information focuses on specific interactions with other topical products or systemic medications that increase sun sensitivity. There are generally no specific restrictions on common foods or beverages mentioned in the regulatory documents for topical Avage. Regulatory information indicates that discussion of the use of alcohol or tobacco with a healthcare provider is a standard consideration for all medications.

Q: Does Avage affect or change the results of any common blood tests?

Because Avage is applied to the skin, official reports indicate it has low absorption into the bloodstream, which generally minimizes effects throughout the body. Unlike some oral medicines in the retinoid class, regulatory documents for topical Avage do not mandate routine blood tests, such as those for liver function or cholesterol, for all patients. Any decision regarding patient monitoring is made by a healthcare professional based on individual circumstances.

Q: Why do official materials emphasize not sharing Avage with others?

Avage is a prescription-only medication, and its use is highly restricted to specific individuals who meet strict eligibility criteria. Official materials emphasize not sharing the drug primarily due to the serious risk of Embryofetal Toxicity (harm to an unborn baby) if used during pregnancy. Additionally, the medicine has age restrictions and is only approved for certain populations, meaning it must only be used by the person for whom it was prescribed after a medical assessment.

Q: Are there any known interactions between Avage and herbal supplements?

The official drug label does not contain a specific list of known interactions with herbal supplements. However, regulatory guidance emphasizes informing the healthcare provider about all prescription and over-the-counter (OTC) medicines being taken. This includes all vitamins, mineral supplements, and herbal products, for the purpose of evaluating potential risks.

Q: Why do some people experience initial nausea when starting Avage?

Official regulatory documentation does not list nausea or vomiting as a common or expected initial side effect when Avage is used topically as directed. When these symptoms do occur, they are generally reported in the context of a serious allergic reaction or if the medication is accidentally ingested orally. Sudden or severe nausea is reported in the context of serious adverse events and typically warrants professional attention.

Q: Is Avage safe to use with alcohol, and what are the concerns?

The official product information does not specify an interaction with consumed alcohol. Regulatory guidance generally includes a provision to discuss the use of any medication with a healthcare professional, including the consumption of alcohol. Of note, other topical products that contain high concentrations of alcohol are advised to be avoided due to the potential for a combined, or cumulative, irritant effect on the skin.

Q: Is Avage known to interact with birth control pills?

Official regulatory documents strictly mandate the use of an effective method of contraception for all females who are capable of becoming pregnant and who are using Avage. The label, however, does not specifically state that topical Avage reduces the effectiveness of oral contraceptives (birth control pills) themselves. The purpose of the contraception requirement is to avoid the risk of Embryofetal Toxicity if pregnancy occurs while the medication is being used.

Q: Does Avage have a 'Black Box Warning' in its official documents?

While the specific term 'Black Box Warning' (or 'Boxed Warning') may not be used in all official documents, the product labeling does include prominent and critical statements under the Warnings and Precautions section. These warnings highlight the most serious safety constraints, specifically the risk of Embryofetal Toxicity (birth defects) and the potential for severe Photosensitivity (augmented susceptibility to sunburn).

Q: Are there restrictions on what vitamins can be taken with Avage?

Official regulatory documents do not list specific vitamins that must be restricted while using Avage. However, because Avage belongs to the retinoid class (related to Vitamin A), regulatory documents state that patients must inform their healthcare provider about all vitamins, minerals, and other supplements being taken. This step is a standard part of regulatory guidance to ensure complete medication transparency.

Q: If I have a mild reaction to Avage, should I continue using it?

Official regulatory guidance addresses situations where a patient experiences excessive skin irritation, such as severe itching, burning, or peeling. In such cases, the guidance states that the use of Avage should either be temporarily discontinued until the skin heals, or the frequency of application may be reduced. Any change to the treatment plan, including pausing or reducing use, is a decision that requires the involvement of the prescribing physician.

Q: Do people with asthma or other breathing issues need to be careful with Avage?

The official drug label does not list a specific caution for patients who have pre-existing conditions like asthma. However, in the safety information, breathing problems or wheezing are mentioned as potential symptoms that could indicate a severe allergic reaction to the medication. Regulatory information advises that such severe symptoms typically require immediate professional medical assistance, as with any serious drug reaction.

Q: What should be included in a doctor-patient discussion about Avage?

Regulatory guidance for patient counseling outlines several required discussion points before starting Avage. These topics include informing the doctor about all existing health conditions, confirming if the patient is pregnant or breastfeeding, and listing all other medicines or supplements currently being used. The discussion must also cover the mandatory need to use effective contraception and the consistent use of sunscreen and protective clothing throughout treatment.

Q: Is Avage a controlled substance?

The official classification for Avage (Tazarotene topical) confirms that it is not listed as a federally controlled substance by the U.S. Drug Enforcement Administration (DEA). The drug is considered a prescription-only medication, and this status is related to its safety profile and the required medical supervision for its use.

How should Avage be stored and disposed of?

How to Store and Dispose of Avage

The storage and disposal of Avage (tazarotene) Cream 0.1% must adhere strictly to regulatory requirements to ensure product stability and safety.

Storage Conditions

Detail Requirement
Temperature Store at controlled room temperature, 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F to 86°F). Do not freeze.
Handling Keep in the original container, tightly closed, and protect from excess heat and moisture. Do not store in the bathroom.
Child Safety Keep the medication out of the reach of children.

Disposal Instructions

Expired or unused Avage Cream must be discarded properly. Do not flush the product down the toilet or pour it into a drain unless instructed otherwise by a regulatory body. Consult a pharmacist or local waste disposal company for guidance on appropriate local disposal procedures.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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