Зодак

hypersensitivity to cetyrizin, hydroxysine or piperazine derivatives, as well as other components of the drug ;

terminal stage of renal failure (Cl creatinine <10 ml / min);

pregnancy;

children under 6 months of age (due to limited data on efficiency and safety).

With caution : chronic renal failure (Cl creatinine> 10 ml / min, metering regimen correction is required); elderly patients (with an age-related decrease in SCF); epilepsy and patients with increased convulsive readiness; patients with predisposing factors to urinary delay (infection of the spinal cord, prostate hyperplasia); period of breastfeeding.

The clinical picture observed during an overdose of cetyrizin was due to its influence on the central nervous system.

Symptoms : after a single intake of cetrizin at a dose of 50 mg, the following clinical picture was observed: confusion, diarrhea, dizziness, increased fatigue, headache, malaise, midriasis, skin itching, anxiety, sedative effect, drowsiness, stupor, tachycardia, tremor, urine delay.

Treatment: immediately after taking the drug, it is necessary to wash the stomach or induce vomiting. The appointment of activated carbon, symptomatic and supportive therapy are recommended. There is no specific antidote. Hemodialysis is ineffective.

Pregnancy. When analyzing prospective data, more than 700 cases of pregnancy outcomes did not reveal cases of formation of malformations, embryonic and neonatal toxicity with a clear causal relationship.

Experimental studies on animals did not reveal any direct or indirect adverse effects of cetrizin on a developing fetus (including.h. postnatal period), pregnancy and postnatal development. Adequate and strictly controlled clinical studies on the safety of the use of the drug during pregnancy were not conducted, so the drug Zodak^® should not be used during pregnancy.

Breastfeeding. Cetirisin stands out with breast milk at a concentration of 25 to 90% of the concentration of the drug in the blood plasma, depending on the time after appointment. During breastfeeding, they are used after consultation with the doctor if the intended benefit for the mother exceeds the potential risk for the child.

Fertility. Available data on the effect on human fertility are limited, but no negative impact on fertility has been identified.