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Эгилок

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Эгилок

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Эгилок

What is Эгилок? (Что такое Эгилок?)

Property Description
Active Ingredient Метопролола тартрат (Metoprolol tartrate)
Form Таблетки, покрытые пленочной оболочкой (Film-coated tablets)
Pharmacological Class beta1-Selective Adrenoceptor Blocker (Cardioselective Beta-Blocker)
Common Use Management of Cardiovascular Conditions
Origin Synthetic

Эгилок: Definition and Active Compound

Эгилок is a synthetic, single-ingredient (monopreparation) cardiovascular medicine that is administered orally as film-coated tablets. The core substance responsible for its effect is the compound Метопролола тартрат (Metoprolol tartrate), which is one of the two main salt forms of Metoprolol. This specific tartrate salt typically yields an immediate-release formulation, a characteristic that functionally distinguishes it from medications utilizing the metoprolol succinate salt, which are widely recognized for their extended-release properties. The formulation is clinically recognized for providing the rapid onset required when control of cardiac parameters is desired.

Classification as a Cardioselective Beta-Blocker

Эгилок belongs to the pharmacological class of cardioselective beta1-selective blockers, which are agents primarily designed to target beta1-adrenergic receptors found predominantly in the heart. This selectivity is supported by pharmacological studies demonstrating its high affinity for the cardiac receptors. The action of the medicine is specifically to interfere with the stimulating effects of catecholamines (stress hormones like adrenaline) on the heart. This targeted approach is a key pharmacological property that ensures a focused influence on cardiac function while aiming to minimize effects on other body systems, making it a well-established agent in cardiovascular medicine.

General Purpose and Hemodynamic Effect

By blocking stimulatory signals, the drug creates a negative chronotropic effect (lowering heart rate) and limits the force of contraction, thereby decreasing the heart's overall workload and oxygen demand. This mechanism is foundational to the general benefit of the medicine: helping to maintain a normalized heart rhythm and contributing significantly to the reduction of arterial blood pressure. This effect provides necessary systemic relief in situations of excessive cardiac demand.

Regulatory References

  1. Metoprolol Tartrate FDA Label (DailyMed)
  2. MedlinePlus: Metoprolol
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What side effects are possible with Эгилок?

Possible Side Effects and Safety Information

Эгилок (Metoprolol) is associated with adverse reactions primarily related to its beta-blocking activity, affecting the cardiovascular and nervous systems.

Adverse Reaction Categories

System-Organ Class Common Adverse Reactions Serious Adverse Reactions (Regulatory Focus)
Cardiac Disorders Bradycardia (slow heart rate), Palpitations, Hypotension Worsening of heart failure, Heart block (second or third degree), Severe bradycardia, Chest pain/Myocardial Infarction upon abrupt withdrawal
Nervous/Psychiatric Dizziness, Tiredness/Fatigue, Headache, Depression, Sleep disturbances (e.g., nightmares) Hallucinations, Confusion, Severe depression
Gastrointestinal Nausea, Diarrhea, Abdominal pain, Dry mouth Rare: Retroperitoneal fibrosis
Respiratory Shortness of breath on exertion Bronchospasm (especially in patients with asthma/COPD)

Safety Restrictions and Monitoring

Contraindications formally established in regulatory documents include severe bradycardia, second- or third-degree heart block, cardiogenic shock, and decompensated heart failure. The drug is also contraindicated in known hypersensitivity to the compound or other beta-blockers.

Safety-Related Limitations: Caution is required in patients with bronchospastic diseases (like asthma), diabetes mellitus (as the drug may mask the signs of hypoglycemia), and liver impairment (due to reduced clearance). The most critical safety warning is the risk of abrupt cessation, which can severely exacerbate angina or cause acute coronary events; therefore, the dosage must be gradually reduced over a period of one to two weeks under medical supervision. Monitoring of heart rate and blood pressure is noted in official documents.

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Overdose and Emergency Response

Эгилок Overdose and when to seek help

Overdose with Эгилок (Metoprolol tartrate) is primarily characterized by severe effects stemming from its action on the cardiovascular system. Documented manifestations in regulatory labeling include severe bradycardia (slowed heart rate), profound hypotension (low blood pressure), and atrioventricular (AV) block. Overdose may quickly escalate to life-threatening outcomes such as cardiogenic shock, acute cardiac failure, and in severe cases, death. Other documented symptoms include bronchospasm, as well as central nervous system effects such as impairment of consciousness, which may proceed to coma or seizure. Patients with a history of acute myocardial infarction or cardiac failure are noted to be particularly prone to significant hemodynamic instability during this scenario.


Emergency Action Required

Regulatory information mandates that if a suspected overdose occurs, immediate medical attention is required. Urgent action, such as calling emergency services, is specifically needed when symptoms involve collapse, trouble breathing, or when the patient cannot be awakened. Management of an overdose typically requires intensive care and focuses on symptomatic support, as no specific antidote is known for Metoprolol overdose. Procedures may include gastric lavage and the use of pharmacological agents such as glucagon, atropine, or vasopressors to counteract cardiovascular depression.

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Therapeutic Uses of Эгилок

Main Therapeutic Uses

Эгилок (metoprolol) is a selective beta-1 blocker primarily used to manage conditions affecting the cardiovascular system. By reducing the influence of stress hormones like adrenaline on the heart, it helps the organ beat more regularly and with less force.

Arterial Hypertension

The medication is frequently prescribed to manage high blood pressure. Lowering blood pressure helps reduce the workload on the heart and assists in the long-term maintenance of vascular health.

Angina Pectoris

For patients experiencing chest pain caused by reduced blood flow to the heart (angina), Эгилок is used as a preventive measure. It decreases the heart's oxygen demand, which helps reduce the frequency and severity of angina attacks and improves physical exercise tolerance.

Heart Rhythm Disorders

Эгилок is effective in treating various cardiac arrhythmias, particularly supraventricular tachycardia. It helps stabilize the heart rate in patients experiencing palpitations or irregular heartbeats.

Post-Myocardial Infarction

Following a heart attack, the medication is used as part of maintenance therapy. Its role is to support heart function during the recovery phase and reduce the risk of subsequent cardiovascular events.

Hyperkinetic Heart Syndrome

This condition involves an overactive heart response, often characterized by palpitations and high cardiac output. Эгилок helps normalize the heart's activity and relieves associated discomfort.

Migraine Prophylaxis

Beyond direct cardiac care, the medication is utilized to reduce the frequency and intensity of migraine headaches in patients who suffer from chronic episodes.


Benefits for the Patient

  • Cardiovascular Stability: Helps maintain a steady heart rhythm and controlled blood pressure throughout the day.
  • Improved Quality of Life: By reducing symptoms like chest pain and palpitations, patients may find it easier to engage in daily activities.
  • Organ Protection: Long-term management of hypertension and heart strain helps protect the heart muscle and blood vessels from progressive damage.
  • Versatility: The medication addresses both acute symptomatic issues, such as rapid heart rate, and long-term preventative needs, such as migraine or heart attack recurrence.

Regulatory References

  1. DailyMed NIH Label for Metoprolol Tartrate
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Eligibility and Restrictions for Use

Эгилок (Metoprolol tartrate) eligibility is defined by official regulatory documents based on existing patient conditions and demographics. The medicine is primarily approved for use in the adult population for its established indications. Use in older adults is generally permitted but may require conditional monitoring.

Absolute Contraindications (Must Not Use)

Official labeling strictly prohibits the use of Metoprolol tartrate in patients with certain severe cardiovascular conditions. These absolute contraindications include:

  • Second- or Third-Degree Atrioventricular (AV) Block.
  • Cardiogenic Shock.
  • Decompensated or Overt Cardiac Failure.
  • Sick Sinus Syndrome (unless a permanent pacemaker is in place).
  • Severe Bradycardia.
  • Known Hypersensitivity to Metoprolol or other beta-blockers.

Conditional Use and Restrictions

Use is restricted or requires caution in several population subsets:

  • Organ Function: Patients with severe hepatic impairment require conditional use and possible adjustment due to the drug's metabolism. Patients with renal impairment typically do not require routine restriction.
  • Comorbidities: Use requires careful consideration in patients with diabetes mellitus or bronchospastic disease (e.g., moderate COPD).
  • Age and Reproductive Status: Safety and efficacy are generally not established for use in the overall pediatric population. During pregnancy and lactation, use is conditional and only permitted if the potential benefit outweighs the documented risk.
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What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information describes clinically significant interactions based on two primary mechanisms: additive effects on heart function and metabolic changes via a specific enzyme.

Interacting Product Category Mechanism and Constraint
CYP2D6 Inhibitors (e.g., quinidine, fluoxetine, paroxetine) These drugs inhibit the enzyme responsible for metoprolol metabolism, significantly increasing its concentration in the blood. This can lead to a decrease in its selectivity and requires close patient monitoring when co-administration cannot be avoided.
Cardiovascular Agents (e.g., verapamil, diltiazem, digitalis glycosides, clonidine) Concomitant use with metoprolol may cause additive pharmacodynamic effects, increasing the risk of excessively slow heart rate or conduction delays. If clonidine is to be discontinued, metoprolol must be gradually withdrawn several days prior to clonidine cessation to avoid a rebound hypertensive crisis.
Catecholamine-Depleting Drugs (e.g., reserpine) May cause an additive effect with metoprolol, increasing the risk of low blood pressure or a very slow heart rate.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) May diminish the blood pressure-lowering effect of metoprolol.
Alcohol In some extended-release formulations, alcohol consumption can cause a rapid, potentially unsafe, release of the drug.

Additionally, patients with a history of severe allergic reactions may show unresponsiveness to the usual doses of epinephrine used to treat anaphylaxis.

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Mechanism of Action

Эгилок (metoprolol) is a selective beta1-adrenergic receptor antagonist that modulates the sympathetic nervous system's influence on key physiological pathways.

Cardioselective beta1-Receptor Blockade

This mechanism involves competitive antagonism at beta1-adrenergic receptors, which are predominantly located on heart muscle cells. By impeding the binding of endogenous catecholamines, the drug suppresses sympathetic signal transduction. This results in a reduction in adenylate cyclase activity and subsequent modulation of heart rate and contractile force.


Modulation of Conduction and Automaticity

This action affects cardiac electrical activity by engaging signaling pathways mediated by cyclic AMP. The beta1-receptor blockade modulates the rate of spontaneous depolarization in pacemaker cells and prolongs the effective refractory period within the cardiac conduction system.


Regulation of the Renin-Angiotensin System

This pathway involves beta1-receptors located on the juxtaglomerular apparatus of the kidneys. Blocking these receptors reduces the release of renin, which is the initial step in the renin-angiotensin-aldosterone cascade. This sequence modulates the systemic generation of angiotensin II and influences the balance of vasoconstriction and fluid retention.

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Dosage and Administration Information

How to Use Эгилок

Эгилок, which contains Metoprolol tartrate, is administered through defined routes and dosing schedules. The medicine is primarily used via the oral route for long-term chronic management, but an intravenous (IV) injection is utilized for acute, early intervention in settings such as a post-myocardial infarction protocol.


Official Dosing and Administration Patterns

The immediate-release nature of Metoprolol tartrate means that dosing is often divided throughout the day, particularly for certain conditions, to maintain a consistent therapeutic effect.

Usage Feature Official Guideline (Metoprolol Tartrate)
Route of Administration Oral (tablets) or Intravenous (IV) Injection
Oral Intake Condition Must be taken with food or immediately after a meal to enhance absorption.
Hypertension Dosing Starting dose is typically 100 mg daily; maintenance ranges from 100 mg to 450 mg daily.
Angina Dosing Starting dose is 50 mg twice daily; maintenance ranges up to 400 mg daily.

Procedural Administration Constraints

Therapy initiation involves titrating (adjusting) the dose at intervals of one week or more. If treatment needs to be stopped, it must not be done abruptly. The dose is required to be gradually reduced over a period of 1 to 2 weeks to prevent certain physiological responses. For population-specific guidance, no dosage adjustment is considered necessary for patients with renal impairment, but lower starting doses and cautious titration may be applied in cases of severe hepatic impairment. If a dose is missed, the general instruction is to skip the missed dose and take the next dose at the scheduled time, without doubling.

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Recent Clinical Evidence

Эгилок: Recent Clinical Evidence

The active substance in Egilok is metoprolol, a beta-adrenergic blocking agent primarily selective for beta-1 receptors. Its clinical application is supported by long-standing evidence from major cardiovascular trials focused on metoprolol formulations.

Key areas of research and established evidence include:

  • Chronic Heart Failure (CHF): Studies have demonstrated that extended-release metoprolol succinate, when used as part of standard heart failure therapy (alongside treatments like ACE inhibitors, diuretics, and digitalis), is associated with improved survival and a reduced rate of hospitalization in patients with stable, symptomatic mild to severe CHF. This is a critical evidence base for the drug class.

  • Post-Myocardial Infarction: Evidence supports the use of metoprolol in hemodynamically stable patients following a suspected or definite acute myocardial infarction (heart attack). Studies indicate its association with a reduced risk of cardiovascular mortality when initiated early and continued long-term. This effect is thought to be independent of the timing of initial therapy after symptom onset.

  • Hypertension and Angina Pectoris: Metoprolol is widely studied and used for managing high blood pressure and chronic stable angina. Clinical data show that treatment is linked to a reduction in blood pressure, which, over time, contributes to a lower risk of fatal and non-fatal cardiovascular events, including strokes and heart attacks. In angina, it is associated with a reduction in chest pain frequency.

Comparative and Formulations Research

Recent research often explores the comparative effects and different formulations of metoprolol. For example, some studies comparing long-acting metoprolol tartrate (like Egilok Retard) with long-acting metoprolol succinate have found comparable effects on lowering blood pressure and heart rate in patients with mild to moderate essential hypertension. Ongoing trials continue to assess the drug's role in combination therapies for various cardiac conditions.

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Frequently Asked Questions (FAQ)

Common questions about Эгилок (FAQ)


Q: How does Эгилок relate to Metoprolol?

Эгилок is a brand name for a medicine whose active ingredient is metoprolol tartrate. This means that Эгилок contains one of the specific salt forms of the common medicine metoprolol.


Q: Do you gain weight when taking Эгилок?

Regulatory reports on metoprolol tartrate list unusual weight gain or loss as a less common side effect. Concerns regarding weight changes are a topic that can be discussed with a healthcare provider.


Q: Can I take pain relievers like Ibuprofen with Эгилок?

Official information indicates that non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may potentially reduce the blood pressure-lowering effect of metoprolol. It is described that this interaction could lessen the overall benefit of the medicine.


Q: Is Эгилок safe for older adults (seniors)?

Use in the older adult population is generally permitted according to official guidance. However, due to potential changes in organ function, these documents describe that lower initial doses and careful adjustment over time (cautious titration) may be applied.


Q: Can women who are pregnant or breastfeeding use Эгилок?

Official regulatory documents describe use during pregnancy and lactation as conditional. Regulatory criteria describe that use during these periods is only considered when the potential benefit to the patient is determined to outweigh the documented risks to the fetus or infant.


Q: Is Эгилок appropriate for teenagers or children?

Regulatory documents state that the safety and effectiveness of metoprolol tartrate are generally not established for use in the overall pediatric patient population.


Q: How long does it typically take to feel the effects of Эгилок?

According to the official product information, the initial pharmacological effects (beta-blockade) of metoprolol tartrate typically begin to show within 1 hour after the oral dose is administered.


Q: What should I do if I notice a change in my heart rate after starting Эгилок?

The medicine is known to lower heart rate. Official safety information notes that if the heart rate becomes excessively slow (a condition called severe bradycardia) or if symptoms such as dizziness occur, these events are typically managed under the supervision of a healthcare provider.


Q: Where can I find official studies about the effectiveness of Эгилок?

Official documentation, such as the NIH DailyMed Label or the EMA Summary of Product Characteristics (SmPC), contains the clinical data and research evidence that support the approved uses of the medication.


Q: Is Эгилок approved in the US (FDA) or just in other countries?

The active ingredient in Эгилок, metoprolol tartrate, is an approved prescription medicine with official labeling and indications published by the U.S. Food and Drug Administration (FDA), in addition to regulatory bodies in other countries.


Q: What is the difference between Эгилок and other beta-blockers like Anaprilin?

Эгилок (metoprolol tartrate) is classified as a cardioselective beta1-blocker, meaning it is designed to primarily target receptors in the heart. Other beta-blockers, such as Propranolol (Anaprilin), are non-selective and affect both beta1 and beta2 receptors.


Q: Is it common to have nightmares or vivid dreams on Эгилок?

Official regulatory documentation lists nightmares as an uncommon or less frequent adverse reaction. This effect is categorized under nervous/psychiatric disturbances.


Q: Does Эгилок affect kidney function?

Metoprolol is primarily processed by the liver. Official information indicates that the drug's elimination in patients with renal impairment does not differ significantly from those with normal function, and a dose adjustment is typically not required for this condition.


Q: Is a metallic taste in the mouth a possible side effect of Эгилок?

Reports of adverse reactions have included the occurrence of unpleasant or unusual changes in taste. This sensation may include a metallic taste.


Q: Can taking Эгилок make symptoms of asthma worse?

Official warnings advise that patients with bronchospastic diseases, such as asthma, should generally not receive metoprolol. This is due to the risk of triggering or worsening respiratory symptoms like bronchospasm.


Q: Is there an extended-release version of Эгилок?

The active ingredient in Эгилок is metoprolol tartrate, which is usually an immediate-release formulation. A separate salt form of the medicine, metoprolol succinate, is widely recognized in official documents for its extended-release properties.


Q: Why is Эгилок prescribed for migraines?

Metoprolol tartrate is included in official prescribing information for the prophylactic treatment (prevention) of migraine headaches in some regulatory jurisdictions.


Q: Does the time of day matter when taking Эгилок?

Official administration guidelines specify that the oral tablets must be taken with food or immediately after a meal. This timing condition is necessary to enhance the absorption of the medicine.


Q: Can Эгилок cause a rash or skin irritation?

Official documentation lists skin rash and itchiness as common adverse reactions associated with the use of metoprolol.


Q: Does Эгилок affect cholesterol levels?

Post-marketing surveillance reports mention changes in blood lipids. These reports include a documented increase in blood triglycerides and a decrease in High Density Lipoprotein (HDL) cholesterol.


Q: Why is my doctor prescribing Эгилок when I don't have high blood pressure?

Official regulatory bodies have approved metoprolol tartrate for conditions beyond hypertension. These uses include the treatment of angina pectoris (chest pain) and for reducing the risk of cardiovascular mortality following a myocardial infarction (heart attack).


Q: Does Эгилок affect athletic performance or exercise tolerance?

The pharmacological action of the medicine reduces the heart rate and cardiac output both at rest and during physical activity. This effect can result in a reduction of the heart's typical response to physical exertion or stress.

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How should Эгилок be stored and disposed of?

Storage and Disposal of Эгилок (Metoprolol Tartrate)

The medicine Эгилок must be stored and handled according to specific regulatory requirements to maintain its stability.


Storage Requirements

Condition Requirement
Temperature Store at Controlled Room Temperature, which is 20 C to 25 C (68 F to 77 F).
Protection Keep in a tight, light-resistant container that is tightly closed, away from excess heat and moisture.
Child Safety Mandatory to keep out of the reach of children.

Disposal Instructions

Official instructions recommend disposing of unused or expired tablets through a drug take-back program. If a take-back option is unavailable, the product should be mixed with an unappealing substance (such as dirt or coffee grounds) and sealed in a container before being placed in the household trash. The medication must not be flushed down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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