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Клацид СР

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Клацид СР

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Клацид СР

Quick Facts

Property Description
Active ingredient Clarithromycin
Form Modified-Release tablet (СР/SR)
Pharmacological class Macrolide Antibiotic
General purpose Combats bacterial infections
Origin Semi-synthetic

The Core Identity: What Type of Medicine is Клацид СР?

Клацид СР is a prescription medicine containing the active ingredient Clarithromycin. It is formally classified as a macrolide antibiotic, placing it within the broader pharmacological class of antimicrobials. Its fundamental purpose is to address bacterial infections within the body. Clarithromycin is recognized as an enhanced, semi-synthetic derivative of the older antibiotic Erythromycin, having been engineered to improve chemical stability and ensure reliable absorption into the bloodstream.

SR Formulation: Composition and Distinctive Type

The active substance, Clarithromycin, is presented as a single-ingredient product in a Modified-Release tablet intended for oral use. The designation СР (or SR for Sustained Release) defines this product's most differentiating factor: its unique dosage form. This technology ensures the medication is delivered to the body in a controlled-release manner, differentiating it from immediate-release formulations. This consistent delivery is critical for maintaining steady therapeutic levels of the drug over a prolonged period, supporting the body's clearance of infectious-inflammatory diseases.

Regulatory References

  1. Macrolides (NIH Bookshelf/StatPearls)
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What side effects are possible with Клацид СР?

Possible Side Effects and Safety Information for Клацид СР

Adverse Reaction Scope

The most commonly documented adverse reactions from clinical trials (Common, ge 1% to <10%) primarily involve the Gastrointestinal System and Nervous System. These include diarrhea, nausea, vomiting, abdominal pain, and an altered sense of taste (dysgeusia). Headache and insomnia are also frequently reported.

Less common (Uncommon, ge 0.1% to <1%) effects include abnormal liver function tests, anxiety, and hypersensitivity reactions such as rash and urticaria.

Serious and Clinically Significant Reactions

Regulatory documents emphasize the potential for serious, low-frequency events (Not Known, cannot be estimated from available data), including:

  • Cardiovascular: Prolongation of the QT interval and ventricular arrhythmias, including Torsade de Pointes.
  • Hepatic: Severe liver dysfunction, including cholestatic/hepatocellular hepatitis, which can lead to fatal hepatic failure.
  • Dermatologic/Hypersensitivity: Severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and anaphylaxis.
  • Gastrointestinal: Clostridioides difficile-associated disease (CDAD), which can range from mild diarrhea to life-threatening colitis.

Safety Restrictions and Monitoring Notes

The use of Клацид СР (Clarithromycin) is contraindicated in patients with a history of QT prolongation, ventricular arrhythmia, hypokalemia, hypomagnesemia, or history of cholestatic jaundice/hepatic dysfunction associated with prior Clarithromycin use. The drug is also strictly contraindicated with numerous concomitant medications (e.g., specific statins like lovastatin/simvastatin, colchicine, cisapride, pimozide, ergot alkaloids) due to the risk of serious or fatal drug interactions, such as rhabdomyolysis or severe cardiac arrhythmias.

Population-Specific Risk: Regulatory warnings highlight a potential increased risk of all-cause death in patients with established coronary artery disease (CAD) following short-term use, lasting for years. Caution is advised in elderly patients and those with severe renal or hepatic impairment, often requiring dose adjustments and monitoring.

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Overdose and Emergency Response

️ Official Overdose Manifestations

The regulatory profile for Clarithromycin overdose primarily documents the expected acute clinical signs and the necessary emergency response. The core manifestations consistently listed in official labeling are severe gastrointestinal symptoms, which include significant abdominal pain, vomiting, nausea, and diarrhea. Additionally, high levels of exposure have been documented to potentially lead to transient hearing loss. While not primary acute symptoms, the risk of serious cardiac events (e.g., QT prolongation) associated with high concentrations is noted in the drug's overall safety profile and necessitates urgent action.

When to Seek Urgent Medical Help

Official regulatory guidance mandates that individuals must seek immediate medical attention or contact emergency services (e.g., a poison control center) for any confirmed or suspected overdose event. Immediate emergency assistance is required when a victim exhibits severe or life-threatening symptoms, such as collapse, a seizure, trouble breathing, or inability to be awakened, as stated in official prescribing information.

️ Regulatory Management and Limitations

The documented management strategy involves general supportive measures and the prompt elimination of unabsorbed drug from the system. A critical constraint noted in official labeling is that procedures like hemodialysis or peritoneal dialysis are explicitly stated as not expected to be effective at significantly reducing Clarithromycin concentrations in the body. The regulatory data focuses on these mandated actions and procedural limits, rather than prescribing specific therapeutic steps.

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Therapeutic Uses of Клацид СР

What Клацид СР treats: Main Uses and Benefits

This medication is generally used to provide therapeutic support against a wide array of bacterial infections. It is applied across therapeutic domains involving heightened local and systemic discomfort.

The medication is commonly used to help manage acute, symptomatic episodes such as Community-Acquired Pneumonia, sudden exacerbations of Chronic Bronchitis, and painful Acute Maxillary Sinusitis. It is also relevant for managing uncomplicated skin and soft tissue infections and is utilized as a vital component in multi-drug protocols for the eradication of Helicobacter pylori. The medication is applied in addressing the underlying bacterial cause, which supports symptomatic relief.

“The sustained therapeutic support assists in easing the impact of these acute manifestations on routine activities.”

It helps manage symptoms that create noticeable interference with daily stability, including fever, persistent cough, localized swelling, and abdominal discomfort associated with ulcers.


Quick Fact: Relief for Acute Infection Symptoms

Symptom Axis Therapeutic Benefit
Respiratory Compromise Supports improved comfort during periods of acute cough and difficulty breathing.
Inflammatory Pain Assists with managing localized pain, pressure, and swelling from skin and sinus infections.
Systemic Discomfort Is relevant for easing systemic discomfort associated with bacterial fever.

Regulatory References

  1. NIH MedlinePlus overview
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Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Клацид СР

Official regulatory documents define the eligible populations and strict exclusions for Клацид СР (Clarithromycin Extended-Release).

Classification Regulatory Status
Populations for whom use is allowed Adults and adolescents 12 years and older.
Populations for whom use is not recommended Children younger than 12 years; pregnant women (unless no suitable alternative therapy exists).
Populations for whom use is contraindicated Individuals with known hypersensitivity to Clarithromycin or any macrolide antibiotic; patients with a history of QT prolongation or ventricular arrhythmia (including Torsades de pointes).

Eligibility-Related Restrictions

Contraindications also apply to patients with uncorrected hypokalaemia/hypomagnesaemia, a history of cholestatic jaundice associated with prior Clarithromycin use, or severe hepatic failure combined with renal impairment.

Caution is specifically advised for use in patients with impaired hepatic function and those with severe renal impairment (creatinine clearance less than 30 mL/min), as the extended-release tablet cannot be dose-adjusted. Use requires caution for individuals with Myasthenia Gravis and existing cardiac conduction disturbances.

Pregnancy and Lactation: Use during pregnancy is generally not recommended. Use during lactation requires caution because the drug is distributed into breast milk.

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What should I know about interactions with other medicines?

Interactions with Other Medicines and Products

The interaction profile of Клацид СР (Clarithromycin Extended-Release) is primarily structured by its potent inhibitory effect on the Cytochrome P450 3A4 (CYP3A4) enzyme system and the P-glycoprotein (P-gp) transporter. This mechanism dictates specific regulatory constraints and prohibitions regarding co-administration.


Official Interaction Restrictions

Classification Interacting Medicines/Classes Practical Implication
Contraindicated HMG-CoA Reductase Inhibitors (Simvastatin, Lovastatin) Significantly increased risk of myopathy, including rhabdomyolysis.
Contraindicated Colchicine (in patients with renal/hepatic impairment) Highly increased systemic exposure to colchicine, risking severe toxicity.
Avoid/Requires Close Monitoring Class IA/III Antiarrhythmics (Quinidine, Disopyramide) Potential for QT prolongation and life-threatening cardiac arrhythmias.

Use with Caution and Monitoring

Co-administration with other medicines that are substrates of CYP3A4 requires caution and often necessitates dose reduction or careful monitoring of the co-administered drug's serum concentrations. This includes agents such as Oral Anticoagulants (Warfarin), requiring frequent International Normalized Ratio (INR) monitoring due to the risk of potentiated anticoagulant effects. Other examples include Digoxin, Midazolam, Alprazolam, Theophylline, Carbamazepine, Tacrolimus, and Sildenafil.

In all cases of co-administration with interacting agents, the risk of increased systemic exposure to the co-administered drug requires adherence to regulatory-specified monitoring or adjustment protocols.

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Mechanism of Action

Molecular Blockade of Bacterial Protein Synthesis

This mechanism targets the 50S ribosomal subunit within susceptible bacteria, specifically inhibiting the translocation step necessary for protein synthesis. The resulting molecular blockade of the ribosomal exit tunnel halts the bacterial cell's protein manufacturing process, resulting in a primary bacteriostatic effect (suppression of bacterial growth).

Time-Dependent Target Engagement

Clarithromycin's efficacy relates to maintaining its concentration above the minimum inhibitory threshold for a specific duration (T > MIC). The Sustained Release (СР) formulation facilitates a prolonged target exposure, supported by the synergistic activity of its active metabolite, 14-hydroxyclarithromycin. This sustained engagement supports the required duration of physiological suppression of bacterial growth.

Pleiotropic Immunomodulation and Mechanistic Constraints

Beyond its primary function, the drug modulates certain host inflammatory pathways, such as those involving cytokines, resulting in the modulation of host inflammatory signaling. This entire mechanism is subject to specific constraints, primarily bacterial resistance factors like efflux pumps or 23S rRNA methylation, which override the drug’s ability to bind to its molecular target.

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Dosage and Administration Information

The administration of Клацид СР (Clarithromycin Sustained-Release) is strictly governed by the product’s design to ensure a controlled release of the active ingredient over 24 hours. The medicine is intended for oral administration as a modified-release tablet.

Official Dosing and Frequency

The standard adult dosing regimen for approved indications is 1000 mg per day, typically achieved by taking two 500 mg tablets. Due to the nature of the formulation, the tablets are administered once daily (every 24 hours). The total treatment duration generally ranges from 7 to 14 days, depending on the specific application.


Administration Protocol and Restrictions

Proper use requires specific intake conditions. The tablets must be swallowed whole to preserve the integrity of the controlled-release mechanism; they must not be chewed, broken, or crushed. Furthermore, administration must occur with food to optimize the absorption of the medicine.


Special Usage Constraints

The use of this specific formulation is subject to population limits. The extended-release tablet is not recommended for use in children under 12 years of age. Additionally, the 1000 mg once-daily extended-release formulation should not be used in patients with severe renal impairment (CLcr < 30 mL/min), as the required 50% dose reduction cannot be achieved by splitting the tablet.

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Recent Clinical Evidence

Recent Clinical Evidence

Clinical research on Clarithromycin SR (extended-release) primarily focuses on its use in treating respiratory tract infections and comparing its performance to immediate-release formulations.

Efficacy and Comparative Trials

Clinical trials evaluated whether the extended-release formulation demonstrated a measurable effect in reducing symptoms associated with acute bacterial exacerbations of chronic bronchitis (ABECB), acute maxillary sinusitis, and community-acquired pneumonia (CAP).

  • Study Outcomes: A randomized, double-blind, parallel-group study comparing the extended-release and immediate-release formulations in patients with ABECB reported similar clinical cure rates in both treatment groups (approximately 83% and 82%, respectively, at the test-of-cure visit).
  • Formulation Comparison: Trials investigating the extended-release formulation focus on the potential for simplified dosing. One study found that the trial's results indicated a difference in the reported response rate in the active treatment group compared to the standard therapy group, specifically concerning morning stiffness.
  • Duration of Effect: Further research examined the duration of any observed symptom changes, with some studies in specific respiratory conditions reporting symptom relief within the first three days.

️ Safety Profile

Safety data collected across Phase III trials and post-marketing observational studies report that the drug is generally well-tolerated. The most commonly reported side effects were transient fatigue and mild gastrointestinal issues, such as diarrhea, taste alteration, and nausea.

  • Specific Populations: Available study data from the studied cohorts did not report significant safety concerns in people with specific liver conditions, though participant numbers were limited.
  • Ongoing Monitoring: Further research remains necessary to confirm safety profiles across broader patient demographics, particularly in long-term observational settings.

Overall, the findings across the studies demonstrate consistent measurement results in treating susceptible infections.

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Frequently Asked Questions (FAQ)

Common questions about Клацид СР (FAQ)

Q: What is the main reason doctors prescribe Клацид СР?

According to official product information, this medicine is indicated for treating specific bacterial infections. These typically include acute bacterial exacerbation of chronic bronchitis, acute maxillary sinusitis, and community-acquired pneumonia.

Q: How does Клацид СР differ from regular Клацид?

Клацид СР is a sustained-release (SR) tablet, which is a specialized design that controls the speed at which the active ingredient is released into the body. This unique formulation allows the medicine to be taken only once daily, offering a different dosing approach compared to immediate-release formulations.

Q: Is Клацид СР the same kind of medicine as penicillin?

No. Official documents classify Клацид СР (clarithromycin) as a macrolide antibiotic. While both macrolides and penicillin are used to treat bacterial infections, they belong to different drug classes and work against bacteria in different ways.

Q: What conditions does Клацид СР treat besides lung infections?

In addition to respiratory tract infections, the official indications for the active ingredient clarithromycin include certain infections of the skin and skin structures. It is also indicated for treating infections caused by Mycobacterium avium complex (MAC) in specific patient groups.

Q: Can Клацид СР be used for treating dental problems?

Regulatory documents indicate that this medicine is used to treat susceptible bacterial infections. However, specific dental indications are not consistently listed on the extended-release product label.

Q: How quickly does Клацид СР usually start working?

The onset of therapeutic effect varies by individual and the type of infection being treated. Clinical trial data for specific respiratory conditions has documented initial observations of symptom relief within the first few days of starting treatment.

Q: Does Клацид СР require taking the full course, even if I feel better quickly?

Official patient information for this type of antibiotic consistently recommends that the full course of treatment be taken as directed by a healthcare provider. This general guidance is important to help reduce the risk of developing bacterial resistance.

Q: Are there specific food types that interact with Клацид СР?

The official guidance specifies that the tablets should be taken with food to help optimize the absorption of the medicine into the body. No specific food types or ingredients are listed in regulatory sources as requiring avoidance.

Q: Are there any known long-term side effects associated with Клацид СР?

Regulatory documents have noted a specific observation regarding a potential increased risk of all-cause death in patients with established coronary artery disease (CAD). This potential risk was observed for years following short-term use of the medicine.

Q: What are the signs that a side effect from Клацид СР might be serious?

Official safety warnings list several signs of serious reactions that require immediate medical attention. These include developing a severe, spreading rash (such as Stevens-Johnson Syndrome), yellowing of the skin or eyes (signaling liver problems), or persistent, severe diarrhea (a sign of Clostridioides difficile-associated disease).

Q: Can someone with lactose intolerance use Клацид СР?

The official list of inactive ingredients for the tablet formulation often includes lactose (milk sugar). Individuals with known lactose intolerance should be aware of this excipient when considering the product.

Q: Are there warnings about sun exposure while using Клацид СР?

Official warnings for this specific formulation do not typically list photosensitivity as a common concern. However, it is noted that other antibiotics belonging to the macrolide class sometimes carry warnings about potential sun sensitivity.

Q: Is Клацид СР safe for use in older adults (seniors)?

Official warnings advise that caution should be used when prescribing this medicine to elderly patients. This is particularly true for seniors who have existing kidney or liver problems or other complex health conditions.

Q: Are there different brand names for the same medicine as Клацид СР?

Yes, the active substance is Clarithromycin. Regulatory cross-reference sources show that Clarithromycin is manufactured and sold by various companies under multiple brand names internationally, in addition to Клацид СР.

Q: What is the difference between a 'regular' antibiotic and a 'macrolide' like Клацид СР?

The difference is primarily in their mechanism of action. Official information states that macrolide antibiotics work by binding to the 50S ribosomal subunit of the bacteria. This action blocks the bacteria's ability to produce necessary proteins, thus stopping its growth.

Q: What happens if someone accidentally misses a dose of Клацид СР?

Official patient guidance typically recommends taking a missed dose as soon as it is remembered. However, if the timing is nearly that of the next scheduled dose, the guidance provided is generally to disregard the missed dose and resume the normal dosing schedule.

Q: How does the body eliminate Клацид СР after treatment is finished?

According to the drug's pharmacokinetics data, the body's metabolism first breaks down the active drug in the liver. The resulting active drug and its metabolites are then eliminated from the body primarily through two routes: the urine and the feces.

Q: What information should I provide to my healthcare provider before starting Клацид СР?

Official patient information highlights important factors that should be discussed with a healthcare provider before starting treatment. These include disclosing all current medications being taken, any history of heart or liver problems, any known allergies to macrolide antibiotics, and the patient's pregnancy status.

Q: Is the taste change associated with Клацид СР dangerous?

An altered sense of taste, or dysgeusia, is officially listed as a common side effect of the medicine. It is not, however, listed among the serious or life-threatening adverse reactions in regulatory safety warnings.

Q: Are there restrictions on driving or operating machinery while on Клацид СР?

Official product guidance states that patients should be aware of possible side effects that could affect motor skills. These side effects include dizziness, confusion, or vertigo, and caution is advised regarding driving or operating heavy machinery if these occur.

Q: Is it common for people to develop a resistance to Клацид СР over time?

Official microbiology information indicates that the drug's mechanism is subject to bacterial resistance factors. The use of any antibiotic, including this one, may lead to the selection and growth of bacteria that have become resistant to it.

Q: Is Клацид СР used for any chronic, long-term conditions?

For the majority of approved bacterial infections, the standard course of treatment is prescribed for a specific, short duration, typically ranging from 7 to 14 days. This indicates that it is primarily intended for short-term use.

Q: Why do official documents emphasize checking the expiration date of Клацид СР?

Regulatory guidance for all medications advises checking the expiration date printed on the packaging. This date represents the period during which the product is expected to remain stable and fully potent, assuming proper storage conditions.

Q: What types of bacteria is Клацид СР specifically designed to fight?

The drug is specifically designed to target and fight infections caused by certain susceptible bacterial strains. The official labeling lists the specific types of bacteria it is effective against, such as S. pneumoniae and H. influenzae.

Q: How does the use of Клацид СР relate to gut flora balance?

Regulatory documents warn of the serious risk of developing Clostridioides difficile-associated disease (CDAD). This condition occurs because the antibiotic can disrupt the natural balance of the normal bacteria, or flora, in the colon.

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How should Клацид СР be stored and disposed of?

Storage and Disposal of Клацид СР (Clarithromycin Extended-Release)

Clarithromycin extended-release tablets must be stored at controlled room temperature, specifically between 20 C to 25 C (68 F to 77 F). The medication must be protected from excessive heat and moisture.

Storage Requirements

The tablets should be kept in their original container and the container must remain tightly closed. For safety, keep this medication out of the sight and reach of children.

Disposal Requirements

Unused or expired product must be disposed of according to local regulations. It is recommended to use a drug take-back program where available. The unused medicine should not be flushed down a toilet or sink. If no take-back program is accessible, follow the procedure of mixing the product with an undesirable substance, sealing it in a bag, and discarding it in household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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