Celexa

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Celexa

Celexa is a prescription-only medication whose active ingredient is Citalopram hydrobromide, primarily classified as an antidepressant agent. It is a synthetic compound that operates on the central nervous system to help modulate mood and emotional balance.

Property Description
Active ingredient Citalopram hydrobromide
Form Oral tablet, oral solution
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
General purpose Supports mood stability and emotional balance
Origin Synthetic compound

What Type of Medicine is Celexa (Citalopram)?

Celexa belongs to the pharmacological class known as a Selective Serotonin Reuptake Inhibitor (SSRI). This classification identifies it as a highly specialized psychotropic drug designed to interact specifically with the brain's serotonin system. The chemical structure of Citalopram is defined as a bicyclic phthalane derivative, confirming its synthetic origin. The mechanism of Citalopram is highly selective for inhibiting the reuptake of serotonin compared to other neurotransmitters. This selective action is clinically recognized as a differentiating factor from older, less specific antidepressant medications.


Composition and Available Forms of Citalopram

The medication is a single-ingredient product where Citalopram hydrobromide is the sole active substance responsible for its therapeutic action. It is designed for oral administration and is available in two main dosage forms: the oral tablet (typically film-coated for easier ingestion) and an oral solution. Both formulations deliver the identical active compound, utilizing different excipients—solid binders for the tablet and an aqueous base for the liquid form—to provide flexibility for patients requiring alternative ways to take the medication. Citalopram is typically well-absorbed after oral administration. This means the active substance effectively enters the body to initiate its intended action.


General Purpose of SSRI Medication

The general purpose of this medication is to support mood stability and help balance emotional state by chemically modulating the nervous system. Citalopram achieves this function by acting as a reuptake inhibitor, which essentially blocks nerve cells from quickly reclaiming the neurotransmitter serotonin. This action increases the functional availability of serotonin in critical brain regions, which is necessary to foster a more stable emotional environment, such as in instances where emotional regulation becomes challenging.

What side effects are possible with Celexa?

Possible Side Effects and Safety Information

Celexa (Citalopram) is classified according to official regulatory documents based on the body systems affected and the frequency of the reactions. The most common adverse reactions, classified as Very Common (ge 1/10) in regulatory documents, include Nausea, Dry mouth, Insomnia, Somnolence, and Increased sweating. Other frequently documented reactions (Common, 1-10%) affect the nervous system (e.g., Tremor, Dizziness), the gastrointestinal system (Diarrhoea, Constipation), and the reproductive system (Impotence, Ejaculation disorder).


Serious Adverse Reactions and Safety Constraints

Official labeling emphasizes several serious adverse reactions. Citalopram is associated with a dose-dependent prolongation of the QT interval, a recognized electrical disturbance of the heart, which carries a risk of the life-threatening arrhythmia, Torsade de Pointes. This cardiac risk results in a maximum recommended daily dose restriction of 40 mg for most adults and 20 mg for specific populations, including those aged 60 and older or those with hepatic impairment.

The medication is strictly Contraindicated for use with or within 14 days of stopping Monoamine Oxidase Inhibitors (MAOIs). Additionally, a boxed warning in the FDA documentation highlights the increased risk of Suicidal thinking and behavior in children, adolescents, and young adults (up to age 24) during the initial months of therapy or following dose changes. Other serious documented risks include the potential for Serotonin Syndrome, activation of Mania or Hypomania, and severe Hyponatraemia (low sodium levels), particularly in older adults.

Overdose and Emergency Response

Overdose and When to Seek Help

Official government regulatory information emphasizes that a Celexa (Citalopram) overdose requires immediate medical attention due to the potential for severe and life-threatening physiological effects. The management of overdose is primarily symptomatic and supportive, as no specific antidote is officially documented.

Documented Manifestations and Severe Outcomes

System Documented Overdose Manifestations
Cardiovascular Tachycardia, QTc prolongation, ventricular arrhythmia (including Torsade de Pointes), and widening of the QRS complex
Neurological Seizures (convulsions), coma, agitation, dizziness, and Serotonin Syndrome
General Nausea, vomiting, sweating, and fever (pyrexia)

Overdose has been officially associated with a risk of sudden death resulting from severe cardiac toxicity.

When to Seek Immediate Medical Help

Immediate medical attention is mandatory for any signs of overdose. Regulatory guidance explicitly states that emergency services must be contacted immediately if the individual has collapsed, is experiencing an irregular heartbeat, has had a seizure, or cannot be awakened. Hospital management includes mandatory cardiac monitoring (ECG/EKG) and the correction of electrolyte imbalances. Population-specific regulatory notes indicate that patients over 60 years of age and those with hepatic impairment are at increased risk for the severe manifestation of QTc prolongation in overdose situations.

Therapeutic Uses of Celexa

The primary therapeutic role of Celexa (citalopram) is applied across domains where additional symptomatic support is needed in clinical situations marked by persistent disruptions in mood and emotional balance. Its primary application involves addressing certain distressing symptoms associated with affective disorders.

Celexa is commonly used across conditions characterized by periods of heightened symptoms, relevant in conditions such as Major Depressive Disorder, and is also considered relevant in contexts marked by increased discomfort, such as helping address generalized anxiety and panic attacks. It is used for managing core mood manifestations, including feelings of profound sadness and the significant loss of interest or pleasure in daily life. The key therapeutic benefit may help patients cope more steadily with difficult episodes, supporting general well-being during symptomatic phases.

Quick Fact: Relief for Low Mood and Anxiety Symptoms

The overall symptomatic support provided is considered relevant when symptoms become temporarily overwhelming, helping to ease the overall burden of persistent sadness and associated physical symptoms.

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

The eligibility for using Celexa (citalopram) is strictly defined by regulatory documents, which establish absolute contraindications and population-specific restrictions.

Contraindicated Populations

Celexa must not be used by patients with a known hypersensitivity to citalopram or its ingredients. Use is contraindicated if a patient is taking or has recently taken (within 14 days) a Monoamine Oxidase Inhibitor (MAOI), including agents like linezolid or intravenous methylene blue. It is also prohibited for use with the antipsychotic medication pimozide due to the risk of abnormal heart rhythms.

Age and Physiological Restrictions

Population Group Regulatory Status Restriction
Pediatric (Under 18) Not Approved Safety and effectiveness are not established.
Older Adults (Over 60) Restricted Use The maximum recommended dose is 20 mg daily.
Hepatic Impairment Restricted Use The maximum recommended dose is 20 mg daily.
Cardiac Conditions Not Recommended Patients with congenital long QT syndrome, bradycardia, or recent heart attack should avoid use.

Use is established only in adults who are mathbf18 years and older. Patients with severe renal impairment should be monitored closely, as data on use in this group is limited. Caution is advised for use during pregnancy and lactation, as the drug is known to be excreted into breast milk and late-stage pregnancy exposure may affect the neonate.

What should I know about interactions with other medicines?

Contraindicated Combinations

Co-administration of Citalopram is contraindicated with certain medicines due to documented risk of severe adverse events. These include Monoamine Oxidase Inhibitors (MAOIs), such as Linezolid or Phenelzine, because of the significant risk of Serotonin Syndrome (a pharmacodynamic interaction). Additionally, Citalopram is prohibited with medicinal products known to prolong the QT-interval, including Pimozide, due to the risk of additive effects on cardiac rhythm.

Pharmacokinetic and Exposure Interactions

Citalopram's metabolism is primarily dependent on the hepatic enzymes CYP2C19 and CYP3A4. Concomitant use with inhibitors of these enzymes, such as Cimetidine or Omeprazole, is expected to decrease Citalopram clearance, potentially increasing its plasma exposure. Conversely, Citalopram is documented as a weak inhibitor of CYP2D6 and may increase the exposure of substrates metabolized by that enzyme.

Interaction-Related Restrictions

  • Timing Rule: A mandatory 14-day washout period must elapse between discontinuing an MAOI (intended for psychiatric disorders) and initiating Citalopram, and vice versa.
  • Population Notes: Regulatory labeling restricts the maximum daily dose to 20 mg for patients with hepatic impairment and those identified as CYP2C19 Poor Metabolizers, owing to reduced clearance and heightened exposure risk.
  • Other Agents: Combining Citalopram with other serotonergic agents (e.g., Triptans, Tramadol, St. John's wort) or agents that interfere with hemostasis (e.g., NSAIDs, Warfarin) requires careful consideration due to documented additive pharmacodynamic effects.

Mechanism of Action

Selective Serotonin Reuptake Blockade

The mechanism of Citalopram initiates with the molecular targeting of the Serotonin Transporter (SERT) protein in the Central Nervous System. By acting as a selective inhibitor, Citalopram prevents the reabsorption of the neurotransmitter serotonin (5-HT) back into the presynaptic nerve terminal, thereby raising its concentration in the synaptic cleft. This potentiation of available serotonin immediately alters the signaling dynamics within relevant Central Nervous System circuitries.

Time-Dependent Neuroplastic Modulation

The subsequent phase relies on long-term neuroplasticity driven by the sustained increase in serotonin signaling. Over several weeks, this enhanced activity triggers intracellular cascades, leading to the upregulation of neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF). This biological process fosters the growth of new connections (synaptogenesis), providing a structural foundation that contributes to the long-term regulation of activity within limbic and cortical pathways.

Dosage and Administration Information

Celexa (citalopram) is administered orally and must be taken once daily, with or without food, as directed by a healthcare provider. The tablets or oral solution should be consumed around the same time each day.

Official Dosing Guidelines

Patient Group Initial Dose Maximum Daily Dose
Adults (18-60 years) 20 mg once daily 40 mg once daily
Patients >60 years 20 mg once daily 20 mg once daily
Hepatic Impairment 20 mg once daily 20 mg once daily

For most adult patients, the initial recommended dose is 20 mg once daily. The dosage may be increased to a maximum of 40 mg once daily after a minimum interval of one week. A maximum daily dose of 20 mg is mandated for patients over 60 years of age, those with hepatic impairment, and individuals taking certain concomitant medications (specifically CYP2C19 inhibitors). Dosages exceeding 40 mg per day are not recommended.

Missed Doses and Discontinuation

If a dose is missed, patients should skip the missed dose and take their next dose at the regularly scheduled time. Do not take two doses at once to make up for a missed dose. When discontinuing Celexa, the dosage should be reduced gradually over a period of at least one to two weeks, rather than stopping abruptly.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Celexa

Citalopram (Celexa) was studied for its use in conditions characterized by periods of heightened symptoms, such as Major Depressive Disorder (MDD) and Panic Disorder. The evidence comes primarily from randomized, controlled trials (RCTs), where researchers compare the medication against a placebo (an inactive substance) or another treatment, along with larger reviews of many studies called meta-analyses.


Evidence for Use in Major Depressive Disorder (MDD)

Citalopram was studied for its use in conditions characterized by periods of heightened symptoms, such as Major Depressive Disorder (MDD). These studies, often short-term (lasting 4 to 8 weeks), were used in research exploring how symptoms change over time. Researchers primarily monitored changes in symptom intensity or variability using standardized scales to track how symptoms evolved in the observed populations.

Findings describe patterns observed in the studies regarding symptom changes measured during the study period compared to placebo treatment. However, the outcomes related to achieving remission—the near-total disappearance of symptoms—have been mixed across different systematic reviews and meta-analyses. The consistency of achieving full remission remains uncertain, and findings were mixed across studies.


Evidence for Use in Panic Disorder

Citalopram was studied for its use in managing conditions characterized by fluctuating or episodic manifestations (such as Panic Disorder). These studies involved short-term (around 8 weeks) placebo-controlled trials. The research primarily examined the frequency of panic attacks as an outcome describing episodic or acute changes, along with measures of overall anxiety symptom intensity.

Findings indicate patterns of change in the frequency of panic attacks during the study period when compared to the placebo group. The evidence contributes to understanding symptom patterns, and was evaluated in high-quality research exploring short-term symptom changes.


Long-Term Research and Continuation Studies

Long-term maintenance studies, some lasting up to 6 to 12 months, were applied in research contexts involving fluctuating or unstable symptoms to assess outcomes after the initial acute treatment. While this research provides insight into short-term changes in relapse rates, long-term effects are not fully established. There is limited information for outcomes beyond one year.


Research in Specific Patient Populations and Gaps

Specific research was conducted to explore the use of Citalopram in populations of older adults and children/adolescents. In one study focused on the very elderly (age 75 and older), no measurable difference was observed in the overall sample of patients receiving Citalopram compared to those receiving placebo when assessing symptom scores. Data for groups like children and pregnant individuals remain insufficient.

Comparative evidence is lacking for many direct head-to-head trials against newer treatments. The research does not determine whether an individual will respond similarly to the group patterns observed in these studies.

Key Studies & References Citalopram therapy for depression: a review of 10 years of European experience and data from US clinical trials (Long-Term/Maintenance)

Frequently Asked Questions (FAQ)

Common questions about Celexa (FAQ)

Q: How long does it typically take to feel the effects of Celexa?

A: According to official product information, patients often start to show improvement one week after initiating therapy. However, the full change in symptoms may not become evident until the second week, or sometimes later. Review or adjustment of the dosage is noted in regulatory information as typically occurring after three to four weeks.


Q: Can Celexa cause changes in weight?

A: Clinical trial data included in regulatory documents indicate that changes in weight, both increases and decreases, are listed as possible adverse reactions. These effects are generally considered less common or infrequent.


Q: Is it common to feel more anxious when first starting Celexa?

A: Anxiety is listed as a possible adverse reaction in the official product labeling. In controlled studies, anxiety was reported by a small percentage of patients taking the drug. This effect occurs around the same rate as observed in the placebo group.


Q: Are there any foods or drinks I need to avoid while taking Celexa?

A: The official medication guide includes the explicit instruction: 'Do not drink alcohol while using citalopram tablets.' There are no general prohibitions regarding specific foods, as the medication can be taken with or without food.


Q: Does Celexa have a risk of withdrawal symptoms when stopping treatment?

A: Abrupt discontinuation should be avoided due to the risk of discontinuation symptoms (or 'withdrawal reactions'). Regulatory labeling specifies that the dose should be gradually reduced over a period, rather than stopping abruptly.


Q: Can Celexa affect my ability to drive or operate machinery?

A: Official information includes a caution about driving and operating hazardous machinery until the individual can be reasonably certain that the therapy does not adversely affect their abilities. This warning is due to potential side effects like drowsiness or dizziness.


Q: Can people with a history of heart issues use Celexa?

A: Regulatory warnings state that Celexa is generally not recommended for use in individuals with certain heart conditions. These conditions include congenital long QT syndrome, slow heart rate (bradycardia), recent acute heart attack, or uncompensated heart failure.


Q: Is it safe to take over-the-counter pain relievers while on Celexa?

A: Official drug interaction information cautions against the concurrent use of Celexa with certain pain relievers, specifically Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen. This is due to a potential increased risk of bleeding, particularly in the gastrointestinal tract.


Q: How long is a typical course of treatment with Celexa?

A: For Major Depressive Disorder, regulatory sources indicate that treatment should continue for a sufficient period of at least six months to help ensure a patient remains symptom-free. For conditions like Panic Disorder, the required course of therapy may last several months or potentially longer.


Q: Can Celexa cause sexual side effects, and are they permanent?

A: Sexual dysfunction, such as decreased libido or delayed ejaculation, is documented as a common side effect of the medicine. Official safety updates acknowledge that there have been reports of long-lasting sexual dysfunction where these symptoms continued even after the drug was discontinued.


Q: What are the known interactions between Celexa and herbal supplements, such as St. John's Wort?

A: Regulatory documents caution that taking Celexa at the same time as the herbal supplement St. John's Wort may increase the risk of Serotonin Syndrome. This potential interaction requires careful consideration from a healthcare provider.


Q: Is there a Black Box Warning associated with Celexa, and what does it concern?

A: Yes, the official labeling includes a prominent BOXED WARNING. This warning concerns the increased risk of suicidal thoughts and behavior observed in children, adolescents, and young adults (up to age 24) during short-term studies, particularly at the beginning of treatment or following dose adjustments.


Q: Can Celexa be used during pregnancy or while breastfeeding, according to regulatory information?

A: Official documents confirm that Citalopram is excreted into breast milk. Use during pregnancy, particularly during the late stages, may potentially affect the newborn baby. Official documents state that use during these periods should involve a careful assessment of potential benefits against risks.


Q: Why is Celexa sometimes described as a selective serotonin reuptake inhibitor (SSRI)?

A: Celexa is classified as an SSRI because of its primary mechanism of action. It is described as a potent and highly selective inhibitor of the neuronal reuptake of the neurotransmitter serotonin (5-HT). This action distinguishes it from older types of antidepressant medications.


Q: Does taking Celexa affect laboratory test results?

A: The official product label notes that clinical studies showed no clinically important changes in routine laboratory parameters associated with treatment. While some less common abnormalities have been reported, most common blood tests should not be significantly altered.


Q: Can I drink alcohol in moderation while taking Celexa?

A: The FDA-approved label explicitly states: 'Do not drink alcohol while using citalopram tablets.' This definitive instruction indicates that alcohol use is not recommended during therapy.


Q: What should I be aware of regarding Celexa and its effects on sleep?

A: Official adverse reaction tables list both insomnia (trouble sleeping) and somnolence (drowsiness) as very common side effects. This means that either effect on sleep is reported by a significant number of patients.


Q: Is the side effect profile of Celexa different at higher doses?

A: Yes, regulatory documents highlight that the risk of QT interval prolongation, which is an electrical disturbance of the heart, is dose-dependent. This cardiac risk is the reason for specific, stricter maximum daily dose restrictions in certain populations.


Q: Can Celexa interact with blood thinners or antiplatelet medicines?

A: Official drug interaction information states that Celexa can interact with blood thinners, such as Warfarin, and antiplatelet agents. The risk with these combinations is an increased potential for bleeding complications.


Q: Does Celexa cause problems with memory or concentration?

A: Official medication guides note that symptoms of a serious adverse reaction, specifically low sodium levels (hyponatremia), can include confusion. This serious effect can also manifest as problems with memory, concentration, or thinking.


Q: How does Celexa impact energy levels?

A: The side effect list documents common effects like fatigue and somnolence (drowsiness). Separately, an increase in energy is noted in regulatory warnings as a symptom associated with the serious risk of activating mania or hypomania.


Q: What is the risk of Serotonin Syndrome when taking Celexa with other serotonergic drugs?

A: Serotonin Syndrome, a serious reaction, has been reported with Celexa alone, but the risk is specifically heightened when taken with other serotonergic medicines. These include triptans, Tramadol, lithium, and the herbal supplement St. John's Wort.


Q: Does Celexa cause dry mouth, and is this a common side effect?

A: Yes, official adverse reaction data lists dry mouth as a very common side effect, meaning it is reported by a high percentage of patients (ge 1/10).


Q: How is Celexa eliminated from the body?

A: Official clinical pharmacology information explains that Celexa is primarily broken down (metabolized) by liver enzymes, specifically CYP2C19 and CYP3A4. A portion of the drug is then eliminated from the body via the kidneys (urine).


Q: What are the official warnings regarding Celexa and seizure disorders?

A: Regulatory warnings state that caution is advised for use in patients with a history of seizures or conditions that might predispose them to seizures. Furthermore, treatment should be discontinued if any patient develops seizures.


Q: Is it possible to take Celexa only when needed, or must it be taken every day?

A: The official Dosing and Administration section describes the medication as a single oral dose taken once daily. This continuous, once-daily regimen is characteristic of medications intended to treat chronic conditions.


Q: Does the time of day matter when taking Celexa?

A: The official administration instructions state that the tablets or oral solution should be consumed once daily and around the same time each day. However, the label does not specify a general preference for taking the medication in the morning or the evening.

How should Celexa be stored and disposed of?

Celexa (citalopram) must be stored and disposed of according to official regulatory requirements to ensure its stability and safety.

Storage Conditions

Celexa tablets and oral solution require controlled room temperature storage, defined as a range between 20 C to 25 C (68 F to 77 F). The medication must be kept in its original container and the container must remain tightly closed.

  • Oral Solution Stability: The Celexa oral solution must be discarded three months after the bottle is opened and requires protection from light.
  • Child Safety: All formulations must be stored out of the sight and reach of children.

Disposal Instructions

Unused or expired Celexa must be disposed of according to local requirements. The product must not be thrown away via wastewater. The FDA recommends using a drug take-back program. If a program is unavailable, mix the medication with an undesirable substance and seal it in a bag before placing it in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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