Стугерон

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Стугерон

Quick Facts

Property Description
Active ingredient Cinnarizine
Form Tablet (Oral administration)
Pharmacological class H1 Antihistamine and Calcium Channel Blocker
Common use Relief from dizziness and motion sickness symptoms
Origin Synthetic

What is Стугерон and What is its Active Ingredient?

Стугерон is the medicinal preparation containing the active ingredient Cinnarizine, a synthetic chemical compound first developed by Janssen Pharmaceutica in 1955. Supplied primarily in the form of a tablet for oral administration, Стугерон is a single-ingredient product designed for systemic absorption. Chemically, Cinnarizine is classified as a piperazine derivative, reflecting its origin as a synthetic compound rather than a natural extract. This identity establishes the drug as a foundational tool for addressing symptoms related to inner ear function and localized circulatory issues, a role supported by numerous pharmacological studies.


What Type of Medicine is Cinnarizine?

Cinnarizine belongs to a dual pharmacological class, functioning both as a first-generation H1 antihistamine and, crucially, as a calcium channel blocker. This dual functionality is clinically recognized for providing specialized therapeutic action in conditions affecting balance. The medicine achieves its effect by moderating the activity of the vestibular system—the body’s balance center—while simultaneously affecting the smooth muscles in blood vessels. Its action is distinct from pure antihistamines, as the calcium channel blocking property is essential for improving local microcirculation. The medicine is officially recognized under the Anatomical Therapeutic Chemical (ATC) classification as an Antivertigo preparation with the code N07CA02.


What is the General Purpose of Стугерон?

The general purpose of Стугерон is to reduce the symptoms associated with balance disruption, particularly vertigo, dizziness, and related nausea. By combining the stabilization of the inner ear signals with enhanced blood flow to these sensory organs, Cinnarizine provides relief from the spinning sensations and discomfort caused by compromised balance mechanisms. A review of Cinnarizine highlighted its primary action as an inhibitor of the inner ear's stimulation, confirming its role in stabilizing the patient's perception of motion. The high-level benefit centers on the physiological support of the inner ear and associated vascular structures, a therapeutic focus that has maintained its clinical relevance over decades.

Regulatory References

  1. Cinnarizine - MeSH

What side effects are possible with Стугерон?

Possible Side Effects and Safety Information

The safety profile of Cinnarizine is formally documented by regulatory agencies, detailing the nature and frequency of potential adverse reactions. The effects are classified according to regulatory standards and organized by the physiological system impacted.


Adverse Reaction Classification

Adverse reactions are grouped by their System-Organ Class (SOC) as listed in regulatory documents:

  • Nervous System Disorders: The most frequently reported adverse effects include Somnolence (drowsiness) and Fatigue. Serious reactions in this class, such as Extrapyramidal Disorder (including Parkinsonism and Tremor), are classified as 'Not Known' (cannot be estimated from available data).
  • Gastrointestinal Disorders: Common effects include Nausea and gastrointestinal discomfort such as Vomiting and Dyspepsia.
  • Metabolism and Nutrition Disorders: Weight Increased is officially classified as a Common adverse reaction.

Serious and Population-Specific Safety Notes

The risk of developing serious Extrapyramidal Symptoms is noted to be specifically associated with long-term use, particularly in older adults. For patients with pre-existing Parkinson's Disease, the medicine requires caution as regulatory information indicates a potential to aggravate the existing condition. Cholestatic Jaundice is documented within the safety profile as a serious reaction of unknown frequency affecting the Hepatobiliary system.

Safety notes also advise caution regarding concomitant use with alcohol and other Central Nervous System (CNS) depressants, as this combination may potentiate the primary sedative effect of Cinnarizine.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents define the Cinnarizine overdose profile by severe central nervous system (CNS) manifestations and the need for immediate supportive care. Treatment is strictly symptomatic, as no specific antidote is known.


Documented Overdose Manifestations

Classification Official Statements
CNS Presentation Alterations in consciousness are key manifestations, ranging from somnolence and stupor to coma. Other CNS effects include extrapyramidal symptoms and hypotonia (loss of muscle tone).
Severe Outcomes The most severe outcomes documented include the occurrence of seizures (convulsions), particularly observed in young children, and reported deaths following both single and polydrug exposures.

Required Emergency Actions

Seek immediate medical attention for any suspected overdose. The official protocol mandates the contact of a poison control centre for guidance on management. Since a specific antidote is unavailable, care focuses on symptomatic and supportive measures. Interventions such as activated charcoal (if presented within one hour) or gastric lavage may be considered. Hospital observation in a health care facility is specifically required, particularly for pediatric patients, due to the potential for serious neurological complications.

Therapeutic Uses of Стугерон

What Cinnarizine (Stugeron) Treats: Main Uses and Benefits

This medication is generally used across therapeutic domains where short-term symptom management is appropriate, contributing to easing the overall symptom load for the patient.

The core uses include supportive management for symptoms related to inner ear discomfort and balance issues, and are relevant for easing symptoms associated with motion sickness. This medication is commonly used to help address symptom clusters such as vertigo, dizziness, tinnitus, nausea, and vomiting that may arise during travel. When symptoms become more noticeable, this support helps patients cope more steadily.

Supportive Management of Inner Ear and Balance Symptoms

This domain is applied in addressing symptom clusters related to inner ear discomfort, such as vertigo and dizziness. This is commonly used across conditions presenting with episodic or fluctuating manifestations and supports the patient in maintaining a sense of stability when symptoms are more noticeable.


Supportive Management of Motion Sickness Discomfort

This medication is commonly used to help with the supportive management of symptoms related to motion sickness, including nausea and vomiting. This provides support that helps ease the overall symptom burden caused by travel and contributes to improved day-to-day comfort during symptomatic periods.


Quick Fact: Symptomatic Support for Travel-Related Nausea

Eligibility and Restrictions for Use

Population Eligibility and Contraindications

Cinnarizine (Stugeron) is typically allowed for use by adults and children aged 5 years and older. Its eligibility profile is defined by strict exclusions and requirements for special consideration based on a patient's health status and life stage.

Classification Population/Condition Restriction Basis
Contraindicated Known hypersensitivity to Cinnarizine or excipients Absolute exclusion
Contraindicated Porphyria (inherited blood disorder) Avoidance required
Not Recommended Children under 5 years old; Premature infants/neonates Age-based exclusion
Not Recommended Pregnancy and Lactation (Breastfeeding) Safety not established/No data on excretion in milk
Conditional Use Parkinson's disease Must only be given if benefits outweigh the risk of aggravation
Special Caution Hepatic or renal insufficiency Use with care; no specific studies documented

Official regulatory documents mandate that use is strictly contraindicated for patients with known hypersensitivity or the condition Porphyria. For patients with Parkinson's disease, the medicine may only be used after a physician's assessment determines the advantages exceed the possible risk of worsening the disease. Use is also not advisable during pregnancy and is not recommended for nursing mothers or children under five years of age due to established regulatory limitations on safety data.

What should I know about interactions with other medicines?

Стугерон Interactions with other medicines and products

Official regulatory information for Cinnarizine (the active ingredient in Стугерон) documents several important interactions, primarily related to its properties as a Central Nervous System (CNS) depressant and H1 antihistamine.

Interaction Type Documented Interacting Substances
Potentiated Sedation Alcohol, CNS Depressants, Tricyclic Antidepressants
Diagnostic Interference Dermal Reactivity Indicators (Skin Testing)
Pharmacodynamic Effects Antihypertensives (potential enhancement), Betahistine (potential opposition)

Interaction Constraints and Restrictions

Regulatory documents highlight that co-administration with Alcohol and other CNS Depressants may potentiate the sedative effects. Patients are advised to avoid alcoholic drinks. For diagnostic procedures, Cinnarizine should be discontinued for 4 days prior to skin testing to prevent the masking of a positive reaction due to its antihistamine effect.

Population-Specific and Condition-Based Cautions

Use of Cinnarizine should be avoided in the hereditary metabolic condition Porphyria. In patients with Parkinson's disease, the official label advises that Cinnarizine should only be used if the expected benefits outweigh the possible risk of aggravating the disease. Additionally, caution is noted for use in patients with Hepatic or Renal insufficiency.

Food Administration Note

As noted in prescribing information, taking the tablets after meals may help diminish the gastric irritation that may occur with Cinnarizine administration.

Mechanism of Action

How Стугерон Works

The action of Cinnarizine involves a dual pharmacological mechanism that simultaneously acts on central vestibular signaling pathways and local vascular structures.


Stabilizing Inner Ear Sensory Input

Cinnarizine acts on the vestibular sensory hair cells by blocking L-Type Ca^2+ Channels. This mechanism involves the reduction of excitability in these cells, which modulates the output of afferent vestibular signals to the brain. This action alters the signaling dynamics within the peripheral vestibular pathway.


Calming Central Balance Signals

The drug exerts competitive antagonism on Histamine H1 receptors and, to a secondary extent, Dopamine D2 receptors in the central nervous system (CNS). This mechanism involves the modulation of neurotransmission within the brainstem's vestibular nuclei and the Chemoreceptor Trigger Zone (CTZ), altering the central integration of vestibular signals.


Modulating Local Microcirculation

Cinnarizine utilizes its Ca^2+ channel blockade on vascular smooth muscle cells, leading to vasodilation in the cerebral and vestibular arteries. This action results in vasodilation that increases local microcirculation to the inner ear structures. The mechanism modifies pathway activity that regulates local vascular tone, thereby altering the supply dynamics.

Dosage and Administration Information

How to Use Стугерон: Official Administration Guidelines

Стугерон (Cinnarizine) is intended exclusively for oral administration in the form of a tablet. The administration protocol is determined by the intended use, and all patients must adhere to the maximum daily dose of 225 mg, which must not be exceeded.

Administration Details and Timing

The tablets should preferably be taken after meals to help reduce the possibility of gastric irritation. The method of intake is flexible; tablets may be swallowed whole, chewed, or sucked.

Usage Scenario Standard Adult Dosing (Typical Range) Frequency/Schedule
Disorders of Balance 25 mg to 75 mg Usually divided and taken three times daily.
Motion Sickness Prophylaxis 25 mg initial dose Taken at least 30 minutes before the start of the journey, followed by doses during travel if required.

Population-Specific Usage

The labeled instructions include specific considerations for certain age groups. For children aged 5 to 12 years, the recommended dose is typically half of the adult dose. Use in children younger than 5 years is generally not recommended. For older adults, while the dose is typically the same as the adult dose, the long-term use of Cinnarizine requires careful assessment.

Handling Missed Doses

If a dose is missed, a minimum interval of 8 hours must be maintained before the next dose is taken. A double dose must never be taken to compensate for a missed dose.

Recent Clinical Evidence

Research evidence for Cinnarizine (Стугерон) has primarily focused on data that was evaluated in research exploring conditions involving balance disruption and acute motion-related symptoms. Findings describe group patterns, not personal outcomes, and research provides context but not individual predictions.


Evidence for Use in Vestibular Vertigo and Balance Symptoms

Research scenarios involving periods of increased symptom activity were examined through short-term Randomized Controlled Trials (RCTs) against placebo or other agents. These trials included primarily adult populations and monitored changes using patient-reported outcomes like the Mean Vertigo Score (MVS) and functional scales. Findings describe patterns observed in the studies related to specific changes measured in vertigo scores. However, certainty remains low regarding monotherapy findings, as comparative evidence is often limited by a research focus on Cinnarizine's fixed-dose combination counterpart. Evidence is predominantly short-term.


Evidence for Use in Motion Sickness Discomfort

Research examined Cinnarizine's use in the context of acute, disruptive episodes, such as those caused by travel and motion. Studies monitored outcomes describing episodic or acute changes, examining rates of nausea and vomiting, predominantly in prophylactic study designs (before symptom onset). Data show patterns related to the study of symptoms during motion exposure. Comparative evidence is lacking for the use of Cinnarizine as an acute treatment after severe symptoms have already begun, meaning study results reflect specific, pre-exposure conditions.


⏱️ Follow-up Duration and Long-Term Research

Follow-up durations were limited in most controlled trials for vertigo, typically lasting approximately four weeks. Consequently, long-term effects are not fully established, and research does not provide insight into the potential for sustained patterns of change or chronic symptom management beyond the study periods.


Research in Special Populations

Cinnarizine was evaluated in studies involving the pediatric population (children aged five years and older) for motion sickness. Research also included some analyses of the older adult population (age 65 and above) for balance disorders. However, data for certain groups remain insufficient, and specific findings about long-term use in these subgroups are uncertain across the evidence base.


What is Still Uncertain About the Research for Стугерон

A key gap remains in the comparative evidence for Cinnarizine as a single agent versus its fixed-dose combination. Furthermore, evidence quality varies across studies, and research remains ongoing regarding long-duration use and comparison with a broader range of current alternative therapies.

Key Studies & References

  1. Betahistine or cinnarizine with or without dimenhydrinate for Ménière's disease/syndrome and symptoms of vestibular vertigo and/or tinnitus (HTA Report)
  2. Cinnarizine 15mg Tablets - Summary of Product Characteristics (SmPC)

Frequently Asked Questions (FAQ)

Common questions about Стугерон (FAQ)

Q: What is the primary purpose of Cinnarizine (Стугерон)?

A: Cinnarizine is a medication that has been studied for its historical use in addressing symptoms associated with vestibular disorders, such as vertigo and nausea. It is also sometimes used in the management of motion sickness. The drug's documented effects relate to its influence on circulation and the vestibular system.


Q: How quickly does Cinnarizine begin to work?

A: Available evidence does not specify a consistent or definitive timeline for when individuals may observe effects. As with any medication, the time it takes to observe any change can vary widely among individuals. Individuals should follow their healthcare provider’s instructions regarding administration.


Q: Can Cinnarizine be taken with other medications?

A: It is essential to discuss all current medications with a qualified healthcare provider or pharmacist before taking Cinnarizine. This includes over-the-counter drugs, vitamins, and herbal supplements. A medical professional is best positioned to evaluate potential interactions and provide guidance tailored to your specific health profile.


Q: What are some common observations reported in clinical studies of Cinnarizine?

A: The most frequently reported observation in studies involving Cinnarizine is drowsiness. Other reported observations have included gastrointestinal discomfort or mild fatigue. Patients should consult the full prescribing information for a comprehensive list of reported events and discuss any concerns with a healthcare professional.

How should Стугерон be stored and disposed of?

How to Store and Dispose of Stugeron (Cinnarizine)

Official regulatory information requires Stugeron tablets to be stored below 30 C and protected from light. The medicine must be kept in its original blister packaging to maintain stability until the expiry date. Do not use the tablets after the date printed on the pack.

Handling and Safety

It is a mandatory requirement to keep this medicine out of the sight and reach of children. No special handling, mixing, or dilution is required for this tablet formulation.

Disposal Rules

Disposal instructions strictly prohibit discarding Stugeron through household waste or wastewater, as these measures help protect the environment. Any unused or expired product must be disposed of in accordance with local regulations; typically by returning it to a pharmacist or designated collection point.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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