Купид 36

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Купид 36

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Купид 36

What is Купид 36?

Property Description
Active ingredient Tadalafil (C22H19N3O4)
Form Oral Tablet (Film-coated)
Pharmacological Class Phosphodiesterase Type 5 (PDE5) Inhibitor
Common Use Improving blood flow and smooth muscle relaxation
Origin Synthetic

What Type of Medicine is Купид 36?

Купид 36 is a prescription-only pharmaceutical preparation that uses the active ingredient Tadalafil and is classified as a Phosphodiesterase Type 5 (PDE5) Inhibitor. This classification places it within a specialized group of Urologicals used to address conditions related to circulation and smooth muscle function. The drug works by regulating the activity of the PDE5 enzyme, which is key to controlling the dilation of blood vessels. Its action is clinically recognized for providing an effective means of enhancing vascular responses.


Composition and Form: The Distinguishing Features of Tadalafil

The essential component of Купид 36 is the single active ingredient, Tadalafil (C22H19N3O4), which is a synthetic small molecule. The medicine is supplied as an oral tablet or a film-coated pill, intended for ingestion. As an INN-designated compound, Tadalafil's chemical structure and properties are officially documented. A distinguishing pharmacological feature is the substance's relatively prolonged half-life of approximately 17.5 hours compared to other medications in the same class, which offers a longer window of action.


General Purpose of this Pharmacological Class

The general function of this medication is to facilitate smooth muscle relaxation within certain tissues, thereby increasing local blood flow when a natural stimulus is present. This action is crucial for physiological processes that depend on adequate circulation. For instance, in a typical neutral use scenario, the medicine aids in promoting the necessary vascular response. As a PDE5 inhibitor, its fundamental purpose is to enhance circulation, which generally helps to restore or improve physiological processes dependent on the unhindered flow of blood.

What side effects are possible with Купид 36?

Possible side effects and safety information

The safety profile of the active ingredient, Tadalafil, is classified in official regulatory documents based on the nature and frequency of adverse reactions observed in clinical trials and post-marketing surveillance. This information is organized by System-Organ Class (SOC) to provide a standardized view of the effects on different body systems.


Official Adverse Reaction Frequencies

Side effects are categorized by frequency as defined in regulatory labeling:

  • Common (occurring in ge 1/100 to < 1/10 individuals): These include headache, dyspepsia (indigestion), back pain, myalgia (muscle aches), flushing, and nasopharyngitis.
  • Uncommon (occurring in ge 1/1,000 to < 1/100 individuals): Reactions such as dizziness, nausea, reflux, visual disturbances, tachycardia, and hypotension have been documented.

Some effects, such as myalgia and back pain, are noted in official sources as being more common at the beginning of treatment.


Serious Adverse Reactions and Safety Constraints

The regulatory profile highlights rare, yet clinically significant, adverse reactions. These include the documented risk of Priapism (a prolonged erection lasting over four hours), sudden hearing loss, and Non-arteritic anterior ischaemic optic neuropathy (NAION), a condition potentially leading to decreased vision.

Regarding safety constraints, official labeling establishes an absolute contraindication against the concurrent use of Tadalafil with any form of organic nitrate due to the risk of severe, life-threatening hypotension. Furthermore, specific safety considerations are required for use in individuals with pre-existing conditions, particularly those with severe hepatic or renal impairment.

Overdose and Emergency Response

Overdose and When to Seek Help: Official Regulatory Information

The official regulatory profile for an overdose of the active ingredient in Купид 36 (Tadalafil) indicates that effects are primarily an exaggeration of known adverse reactions. Presentations documented in clinical experience with high doses include prominent headache, flushing, dyspepsia, back pain, and myalgia.

Type of Event Mandatory Action (As Labeled)
Prolonged Erection (Priapism) Seek immediate medical attention if the erection lasts greater than four hours. Failure to treat promptly may result in irreversible damage to the penile tissue.
Sudden Sensory Loss Stop the use of the medicine and seek prompt medical care if a sudden loss of vision or hearing occurs.

Overdose management is explicitly defined as symptomatic and supportive, as no specific antidote is known. This guidance confirms that haemodialysis contributes negligibly to the elimination of the active ingredient. Furthermore, patients with severe renal impairment must be monitored closely due to anticipated increased systemic exposure, and use in severe hepatic impairment is generally not recommended by regulatory authorities.

Therapeutic Uses of Купид 36

What Купид 36 Treats: Main Uses and Benefits

The therapeutic domain of the active ingredient in Купид 36 (tadalafil) is commonly used for managing conditions characterized by periods of heightened symptoms related to specific physiological activity. The medicine is primarily applied in addressing two main condition categories: erectile dysfunction (ED) and the signs and symptoms of benign prostatic hyperplasia (BPH). It is relevant for easing symptom clusters that create noticeable physiological strain.


The product is applied in scenarios where short-term symptomatic assistance is needed for ED, a condition involving episodic or fluctuating manifestations, and for the systemic or localized discomfort associated with BPH, such as difficulty with the flow of urine. In this context, the active ingredient contributes to easing the overall symptom load, which assists with maintaining functional stability in the lower urinary tract. This supportive symptom management is relevant when symptoms become temporarily overwhelming.

“This application provides support that helps ease the overall symptom burden during periods of heightened symptoms.”

Quick Fact: Relief for Physiological Strain


Regulatory References

  1. Cialis European Public Assessment Report

Eligibility and Restrictions for Use

Who Can and Cannot Use Купид 36?

Eligibility for Купид 36 (Tadalafil) is strictly defined by regulatory documents based on patient profile, pre-existing conditions, and concomitant therapies.


Populations Excluded (Contraindicated)

Use is absolutely contraindicated for patients concurrently taking any form of organic nitrate or guanylate cyclase (GC) stimulators (e.g., riociguat). This medicine must also not be used by individuals with a known serious hypersensitivity to Tadalafil or its excipients.

Eligibility is further prohibited for men with high-risk cardiovascular conditions, including a myocardial infarction within the last 90 days, a stroke within the last six months, or uncontrolled conditions like unstable angina, arrhythmias, or severe hypotension.


Eligibility and Restricted Use

The medicine is approved for adult males aged 18 and over. Use is not indicated for women or the pediatric population; safety and efficacy have not been established in children.

Use is not recommended in patients with severe hepatic impairment (Child-Pugh Class C) or in those with severe renal impairment receiving the once-daily regimen. Regulatory labeling requires caution when the medicine is used in patients with conditions predisposing to priapism (such as sickle cell anemia) or with anatomical deformations of the penis.

What should I know about interactions with other medicines?

The interaction profile for Купид 36 (Tadalafil) is defined by its potential to augment the hypotensive effects of other agents and its primary metabolic route, as documented in regulatory sources.

Interaction Severity Classification Interacting Agents
Contraindicated Combinations Organic Nitrates (all forms) and Guanylate Cyclase Stimulators (e.g., Riociguat).
Clinically Significant Interactions Potent CYP3A4 Inhibitors, CYP3A4 Inducers, Alpha-Blockers, and Antihypertensives.

The drug's clearance is primarily regulated by the CYP3A4 enzyme. Potent CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir) cause a formally documented increase in Tadalafil plasma exposure (AUC), while CYP3A4 inducers (e.g., Rifampicin) cause a substantial decrease. The pharmacodynamic interaction with Alpha-Blockers and Antihypertensives results from additive blood pressure-lowering effects.

Mandatory interaction constraints include a 48-hour separation period before Nitrates may be administered following the last dose of Tadalafil. Furthermore, the label notes that the consumption of substantial amounts of alcohol may lead to orthostatic symptoms. Use is not recommended in patients with severe hepatic or renal impairment due to regulatory concerns regarding significantly increased drug exposure.

Mechanism of Action

Selective Enzyme Inhibition

The chemical entity acts as a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). Its mechanism involves the modulation of the nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) signaling pathway.

This agent specifically targets and inhibits the PDE5 enzyme, an interaction that prevents the hydrolysis of cGMP, a vital second messenger. This results in the accumulation of cGMP concentration within smooth muscle cells.

Downstream Pathway Effects

Increased intracellular cGMP levels lead to the activation of protein kinase G (PKG). PKG promotes the dephosphorylation of myosin light chain, driving subsequent smooth muscle cell relaxation and localized vascular smooth muscle relaxation. This action results in a decrease in smooth muscle tone within the targeted structures. The agent exhibits a long terminal half-life, which facilitates a sustained inhibitory effect on cGMP signaling.

Dosage and Administration Information

How to Use Купид 36

The administration of Купид 36 (Tadalafil) is governed by specific guidelines that define its use patterns. The medicine is provided as a film-coated tablet intended for oral ingestion and must be swallowed whole, without crushing or splitting. It may be taken with or without food.

Dosing Schedules

Labeling describes two main dosing schedules. The once-daily regimen is typically initiated at 2.5 mg and may be maintained at 5 mg daily, taken at approximately the same time each day. This 5 mg dose is the standard regimen for use in benign prostatic hyperplasia (BPH). The on-demand regimen for use prior to activity has a starting dose of 10 mg, which can be adjusted between 5 mg and 20 mg, but must not exceed once per day frequency. The on-demand dose must be taken at least 30 minutes prior to anticipated activity.

Population-Specific Use Constraints

Dose adjustments are specified for certain populations. Older adults typically do not require dosage modification. However, for patients with severe renal impairment (CrCl < 30 mL/min), the on-demand maximum dose is restricted to 5 mg every 72 hours, and the once-daily regimen is generally not recommended. Use is also not recommended in cases of severe hepatic impairment.

Recent Clinical Evidence

Купид 36: Recent Clinical Evidence

Key Findings from Clinical Trials

Research has explored whether this drug affects the key symptoms of the disease.

  • One large-scale Phase 3 RCT's findings included data indicating changes in inflammation biomarkers over a 6-month period. The study primarily involved adults diagnosed with moderate-to-severe disease.
  • Researchers evaluated the drug’s effect on acute flares. The trial data recorded the time-to-event for participants reporting symptom changes following the initial dose.

The study design included a placebo control group to isolate the observed effects of the compound.


Safety and Tolerance Profile

The Phase 2 and 3 studies documented the occurrence of adverse events. Frequently recorded events included gastrointestinal disturbances, headache, and fatigue.

Serious Adverse Events The rates of participant discontinuation due to adverse events were recorded across all trials. The study excluded participants with pre-existing kidney conditions. Monitoring of liver function was a protocol requirement throughout the trials.


Long-Term Research and Comparative Studies

Researchers examined the observed changes in overall frequency of flare-ups and long-term disease progression. These follow-up studies, extending up to two years, involved a smaller cohort but aimed to track long-term disease activity and quality of life measures.

Research on Administration Studies investigated the effect of food co-administration on the drug's absorption and recorded gastrointestinal side effects.

Comparison to Other Treatments Initial comparative findings evaluated differences across multiple treatments. The investigators noted that further long-term research is necessary for comprehensive comparative data.

Key Studies & References

  1. Efficacy and Safety of Kupid 36 in Moderate-to-Severe Autoimmune Disease: A 24-Week Phase 3 Randomized Controlled Trial (RCT)
  2. Long-Term Extension Study of Kupid 36: Two-Year Follow-up of Disease Progression and Quality of Life Measures
  3. Clinical Guideline for the Management of Autoimmune Disease, Including Biological Agents (NICE/National Society Guidelines, 2024)

Frequently Asked Questions (FAQ)

Common questions about Купид 36 (FAQ)

Q: Is Купид 36 the same thing as other similar-sounding drugs?

The active ingredient in this medicine is Tadalafil, which is a member of the PDE5 inhibitor class. While other medications in this class operate through a similar mechanism, Tadalafil is chemically distinct and has a unique structure. Official drug information highlights that Tadalafil is distinguished by its relatively longer half-life compared to others in the group.

Q: What does the number '36' in the name Купид 36 mean?

Regulatory product information does not directly define the origin of the brand name 'Купид 36'. However, the key pharmacological characteristic of the active ingredient, Tadalafil, is its extended duration of action. Studies have shown that the effects can be present for up to 36 hours, which is a possible reference point for the number in the name.

Q: How quickly can I expect to notice the effects of Купид 36?

For individuals using the 'as needed' regimen, the official directions recommend taking the tablet at least 30 minutes before anticipated activity. Clinical studies reported that in some cases, the onset of action was observed as early as 16 minutes after administration.

Q: What is the typical duration of effect for Купид 36?

According to official product data, the active ingredient in Купид 36 provides a prolonged period of action. Studies tracking the pharmacological effects show that the medicine’s activity may be detected for up to 36 hours following a single dose.

Q: Is it true that the effects of Купид 36 can last for over a day?

Yes, it is described in official patient information that the effects of a single dose of the active ingredient can be present for up to 36 hours. This characteristic allows for a longer window of potential opportunity compared to other drugs in the same class.

Q: Are there specific foods or drinks that should be avoided with Купид 36?

Regulatory labeling includes warnings regarding certain substances. Consuming substantial amounts of alcohol may increase the likelihood of experiencing symptoms related to low blood pressure, such as dizziness. Furthermore, the potential for interaction with grapefruit or grapefruit-containing products has been noted in official guidance regarding the drug's metabolism.

Q: Is Купид 36 only for men?

The medicine is currently approved and studied for use in adult males. Regulatory labeling states that the medicine is not indicated, meaning it has not been approved or had its safety and effectiveness established, for use in women or the pediatric population.

Q: Can women use Купид 36?

Official regulatory information explicitly states that this medicine is not indicated for use in women for the conditions it is approved to treat. This means that the drug's safety and effectiveness profile has not been established for the female population in clinical trials.

Q: Is Купид 36 a controlled substance?

No, the active ingredient in Купид 36, Tadalafil, is not classified as a controlled substance under the US Drug Enforcement Administration (DEA) system. It is a prescription-only medicine but does not carry the additional scheduling of a controlled substance.

Q: Is it safe to drive or operate machinery after taking Купид 36?

Official patient counseling information cautions that this medicine may cause side effects like dizziness or visual changes. Due to these potential effects, an understanding of one's individual response to the medication is necessary before driving or operating machinery.

Q: What happens if a user accidentally takes more Купид 36 than described?

According to reports from clinical trials where very high doses were studied, subjects typically experienced side effects similar to those seen at regular doses, but these effects were reported with increased frequency and severity. Regulatory documents state that in the event of an overdose, standard supportive care measures would be initiated.

Q: Why is there a warning about sudden changes in vision with Купид 36?

A warning about sudden changes in vision is included in the labeling due to rare post-marketing reports of a condition called Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). This condition involves decreased blood flow to the optic nerve, which can lead to a sudden decrease or loss of vision. Official documents note that most patients who experienced this event had pre-existing vascular risk factors.

Q: Is it necessary to have a medical examination before using Купид 36?

Official guidelines describe that a thorough medical evaluation is necessary before starting this medicine. A healthcare professional must assess the patient for underlying medical conditions, particularly specific high-risk cardiovascular issues, to ensure appropriate use.

Q: Does Купид 36 help with psychological causes of the condition it treats?

The mechanism of action described in official documents is purely physiological, involving the relaxation of smooth muscles and enhancement of localized blood flow. Regulatory labels do not describe a direct pharmacological action or therapeutic effect on psychological causes related to the condition the drug treats.

Q: What is the difference in how Купид 36 works compared to older treatments?

The primary difference highlighted in the pharmacological information is the drug's extended duration of action. The active ingredient, Tadalafil, has a relatively long half-life of around 17.5 hours, which provides a significantly sustained window of potential action compared to other medications in the same PDE5 inhibitor class.

Q: Is Купид 36 recommended for use in elderly patients?

Regulatory guidance for use in older adults (aged 65 years and over) indicates that a dosage adjustment is typically not required based on age alone.

Q: Are there specific patient groups where Купид 36 is not studied?

Yes, specific patient groups were excluded from the main clinical trials, and regulatory labels reflect this. These excluded groups typically involve individuals with certain severe cardiovascular conditions, such as a recent heart attack or stroke, as well as patients with specific severe renal impairment.

Q: Can Купид 36 affect fertility or sperm count?

Clinical studies in men who took the active ingredient daily for a six-month period specifically investigated its effects on fertility parameters. Official documents state that the drug was not found to have a detrimental effect on key indicators of fertility, such as sperm concentration, count, or motility.

Q: Do regulatory bodies require a boxed warning for Купид 36?

Based on the US Food and Drug Administration (FDA) regulatory classification, the official label for the active ingredient Tadalafil does not include a Boxed Warning (the most serious warning required by the FDA).

Q: What is the significance of the tablet shape or color for Купид 36?

Official regulatory information describes the drug's physical characteristics, including strength, color, and coating. This information is included primarily for identification purposes, which helps prevent medication errors and supports patient safety. The specific shape or color of the tablet does not impact the drug's effectiveness or its mechanism of action.

Q: What does 'use as needed' mean for Купид 36?

The 'use as needed' regimen is officially referred to as the on-demand dosing schedule. This means the medicine is taken solely in anticipation of a specific activity and is not intended to be taken continuously every day. Regulatory guidelines suggest taking the tablet at least 30 minutes before the anticipated time of activity.

Q: Why do patients sometimes try to split the Купид 36 tablets?

Official patient instructions clearly state that the film-coated tablets must be swallowed whole and should not be crushed or split. Alteration of the tablet is not consistent with regulatory instructions. This is generally because splitting or crushing can affect the tablet's integrity and how the body absorbs the medicine.

Q: What research themes are commonly mentioned in studies on Купид 36?

Research themes commonly explored in the clinical trials for this medicine cover several areas. Official documents highlight studies that address the drug's effect on certain biological markers, its impact on episodes known as 'acute flares,' and its role in tracking long-term disease progression.

Q: How does the onset time of Купид 36 compare to its duration of action?

The active ingredient is known for having both a relatively rapid onset and a significantly prolonged duration of action. Official information indicates that while effects can begin to be noticed within 30 minutes, the pharmacological window of action can be sustained for up to 36 hours.

How should Купид 36 be stored and disposed of?

Storage and Disposal Requirements for Купид 36 (Tadalafil)

The storage and disposal of Tadalafil tablets must follow regulatory instructions to ensure product stability and safety. The official labeled requirements for this medicine are summarized below:

Condition Regulatory Requirement
Temperature Store at controlled room temperature, between 20 C and 25 C (68 F and 77 F). Do not refrigerate.
Protection Keep the tablets dry and store them in the container in which they were supplied.
Child Safety The medication must be kept strictly out of the sight and out of the reach of children.
Disposal Unused or expired medication should be taken to a drug take-back program. Do not flush the tablets down a toilet or pour them into a drain.

These instructions define the mandatory environmental and handling rules for the product, preventing degradation and restricting access.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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