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Бурана

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Бурана

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Бурана

Property Description
Active Ingredient Ibuprofen
Pharmacological Class Nonsteroidal Anti-Inflammatory Drug (NSAID)
General Purpose Relief from pain, fever, and inflammation
Origin Synthetic compound

Burana: Definition, Identity, and Pharmacological Class

Burana is a widely recognized pharmaceutical preparation defined by its single, core active ingredient, which is the chemical substance Ibuprofen. The World Health Organization classifies Ibuprofen as a Nonsteroidal Anti-Inflammatory Drug (NSAID), reflecting its precise function and generalized therapeutic capability. As a product of chemical synthesis, Burana is a synthetic compound. Originating in Finland and developed by Orion Pharma, the brand offers a specific range of strengths; lower concentrations are frequently available as a self-care product (OTC), while higher doses are restricted as a prescription drug. This distinction based on concentration is a key feature of the brand’s market positioning.

Composition and Available Pharmaceutical Forms

The composition of Burana centers on the single active agent, Ibuprofen, combined with standard inert pharmaceutical excipients that provide structure to its diverse dosage form(s). The product is supplied in several forms, including conventional oral tablets, liquid-filled softgel capsules (marketed as Burana Caps), liquid oral suspension, and rectal suppositories. This varied portfolio ensures alternative routes of administration—oral, rectal, and sometimes topical—making the medication accessible to different target audience groups, including children and adults, when swallowing is difficult.

General Therapeutic Purpose of Burana

The overall general purpose of Burana is to provide systemic relief from widespread discomfort, fever, and swelling by leveraging its characteristic triple pharmacological action. Its efficacy as both an analgesic and antipyretic is broadly recognized in clinical settings. This means the medication is verified to help the body effectively bring down fever and manage generalized pain, for example, during mild febrility. Furthermore, its classification confirms its crucial anti-inflammatory effect that works to minimize tissue swelling and tenderness. This combined efficacy aims to resolve multiple key symptoms associated with the body’s inflammatory or febrile responses, providing foundational, comprehensive relief.

Regulatory References

  1. WHO Essential Medicines List
  2. Ibuprofen MedlinePlus Drug Information
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What side effects are possible with Бурана?

Possible Side Effects and Safety Information

The safety profile of Burana, whose active ingredient is Ibuprofen (a Nonsteroidal Anti-Inflammatory Drug or NSAID), is formally documented by regulatory authorities. Adverse reactions are classified by the affected physiological system and frequency of occurrence, ensuring a neutral descriptive framework.

Adverse Reaction Categories

Side effects are grouped by incidence, with Common reactions often including dyspepsia, nausea, abdominal pain, flatulence, diarrhoea, headache, and dizziness. Reactions are also categorized by the affected body system, such as Gastrointestinal Disorders, Nervous System Disorders, and Cardiac and Vascular Disorders.

Serious Adverse Reactions and Safety Patterns

Official labeling highlights the potential for serious adverse reactions. These include gastrointestinal bleeding, ulceration, and perforation, which can be fatal. The regulatory data also notes an increased risk of arterial thrombotic events, such as myocardial infarction (heart attack) or stroke, which is particularly associated with higher doses (e.g., 2400 mg/day) and longer duration of use.

Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson Syndrome (SJS), are documented, with the highest risk reported to be early in the course of therapy.

Population and Contraindication Notes

The elderly population is officially noted to have an increased frequency of adverse reactions, especially fatal gastrointestinal events. Safety constraints include contraindications for individuals with severe hepatic failure, severe renal failure, or severe heart failure (NYHA Class IV), as explicitly defined in regulatory documents. Furthermore, Ibuprofen can mask symptoms of underlying infection, a factor noted in official safety documentation.

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Overdose and Emergency Response

Overdose and when to seek help

Suspected overdose of Burana (Ibuprofen) requires immediate and urgent action as documented by regulatory authorities. The official overdose profile is characterized by specific symptom clusters and the potential for severe systemic outcomes.


Documented Manifestations and Severe Outcomes

Overdose presentations frequently involve gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea. Central nervous system effects are also documented, including headache, somnolence (drowsiness), and tinnitus. In cases of massive ingestion, more serious manifestations may occur, including convulsions, decreased consciousness, metabolic acidosis, and respiratory depression. Regulatory information warns that severe outcomes may be potentially fatal, such as gastrointestinal bleeding and perforation, as well as acute renal failure and hypotension or shock. Elderly patients and children are noted in official labeling as having specific considerations or increased risk following overdose.


Required Emergency Actions and Management

Regulatory guidance is explicit that individuals must seek immediate medical attention or contact a Poison Control Center right away following any suspected overdose. Emergency medical care is required immediately if the patient exhibits any signs of a serious cardiovascular event, such as chest pain or trouble breathing. Since no specific antidote is known, management is strictly symptomatic and supportive treatment. This often includes monitoring vital signs and laboratory findings. Officially described procedural steps include the administration of activated charcoal within one hour of ingestion, and hospital observation for a period of time is generally required.

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Therapeutic Uses of Бурана

What Burana Treats: Main Uses and Benefits

Burana is primarily utilized for its ability to provide symptomatic relief across three major therapeutic domains involving symptoms related to physical discomfort, inflammatory states, and systemic imbalance (fever). The medication is used to relieve pain, tenderness, swelling, and stiffness in various contexts, from acute aches to conditions characterized by periods of heightened symptoms. It is applied in clinical settings where temporary assistance in symptom stabilization is appropriate, helping to maintain a sense of stability when symptoms become more noticeable.

Burana is commonly used to help with a wide range of conditions presenting with acute or recurrent episodes, including pain from tension headaches, dental pain, and the cyclical discomfort of primary dysmenorrhea (menstrual cramps), as well as general aches associated with seasonal illnesses (common cold, flu). It is commonly used to help with pain and swelling associated with conditions involving inflammatory or irritative processes, such as sprains, strains, and chronic conditions like osteoarthritis and rheumatoid arthritis.

“This application generally helps address symptom clusters that appear suddenly, providing support that helps ease the overall burden of symptoms.”

Key Use: Symptomatic support for Joint Pain, Fever, and Acute Aches

Burana is considered relevant for its fever-reducing action and is often applied during phases where the patient experiences sudden, heightened discomfort, contributing to improved day-to-day comfort during symptomatic periods.

Regulatory References

  1. NIH MedlinePlus overview
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Eligibility and Restrictions for Use

Who Can and Cannot Use Burana?

Eligibility for using Burana (Ibuprofen) is strictly governed by regulatory classifications based on patient status, age, and pre-existing health conditions, as mandated by official drug authorities.


Populations for Whom Use is Contraindicated

Use is absolutely prohibited for certain populations, including:

  • Individuals with a history of allergic reactions (hypersensitivity, asthma) to aspirin or any other Nonsteroidal Anti-Inflammatory Drug (NSAID).
  • Patients with active gastrointestinal bleeding or peptic ulceration, and those with severe organ failure (hepatic, renal, or NYHA Class IV heart failure).
  • Patients receiving treatment for peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery.
  • Women who are in the third trimester of pregnancy (after 30 weeks of gestation).

Age and Condition-Based Restrictions

Eligibility Status Population or Condition
Use is Approved Adults, adolescents (12 years and older), and pediatric patients 6 months and older (via age/weight-appropriate formulation).
Use is Restricted Individuals with moderate organ impairment or uncontrolled hypertension, requiring careful consideration and the lowest effective dose.
Not Recommended Infants under 6 months and patients with advanced renal disease or those attempting to conceive.

Older adults are classified as a high-risk population for serious gastrointestinal and cardiovascular adverse events, requiring use to be limited to the shortest duration possible.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

This profile outlines interaction patterns documented in authoritative government regulatory sources.

Contraindicated Combinations and Restrictions The use of Ibuprofen is strictly contraindicated for treating peri-operative pain following Coronary Artery Bypass Graft (CABG) surgery. Co-administration must be avoided with other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), including COX-2 selective inhibitors, due to the high risk of serious gastrointestinal adverse events.

Pharmacodynamic Interactions (Additive Risk) Ibuprofen carries an additive risk of bleeding when co-administered with Anticoagulants (e.g., Warfarin), Anti-platelet Agents, Oral Corticosteroids, and Selective Serotonin Re-uptake Inhibitors (SSRIs). Furthermore, Ibuprofen may reduce the therapeutic effect of Antihypertensives (ACE Inhibitors, ARBs, Diuretics) and may exacerbate renal risk when combined with these medicines, or with Ciclosporin. To minimize interference with low-dose Aspirin's antiplatelet action, immediate-release Aspirin should be taken at least 2 hours before Ibuprofen.

Pharmacokinetic and Population Notes Ibuprofen can increase the plasma concentrations of certain co-administered drugs, including Lithium, Methotrexate, and Digoxin, requiring plasma level monitoring. Excessive alcohol consumption increases the documented risk of gastrointestinal bleeding. Interaction-related risks are pronounced in elderly patients (GI complications) and dehydrated children and adolescents (renal impairment).

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Mechanism of Action

Mechanism of Action: Prostanoid Synthesis Inhibition

Бурана (Ibuprofen) exerts its pharmacodynamic effect as a non-selective, reversible inhibitor of the Cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This molecular interaction immediately interrupts the arachidonic acid cascade, preventing the conversion of arachidonic acid into signaling molecules known as prostanoids, including prostaglandins, particularly PGE2, and thromboxanes.

The resulting mechanistic cascade leads to a dual physiological effect: a peripheral modulation of inflammatory and nociceptive signaling (by preventing sensitization of nociceptive fibers) and a central modulation of thermoregulation (by adjusting the hypothalamic set point). The inhibition of PGE2 synthesis directly results in reduced local tissue edema, the desensitization of nociceptive fibers, and the reduction of an elevated core body temperature through heat-dissipation mechanisms. The non-selective action also produces the transient inhibition of platelet aggregation via COX-1.

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Dosage and Administration Information

Official Guidelines for Administering Бурана

The administration of Ibuprofen (Бурана) is governed by established guidelines that define the approved routes, dosage limits, and timing. The medication is approved for use via the oral, rectal (suppositories), and intravenous (IV) routes. The oral route, which includes tablets, capsules, and liquid suspensions, is the most common method of administration for symptomatic use.

Dosing and Frequency Adult dosing is highly dependent on the condition and product concentration. For acute symptom relief, doses typically range from 200 mg to 800 mg per administration, taken every four to six hours as required. A minimum interval of four to six hours between doses must be maintained. The maximum non-prescription daily dose is generally limited to 1,200 mg, while prescription use for inflammatory conditions may extend to a maximum of 3,200 mg per day in divided doses.

Specialized Use and Duration

For pediatric patients aged six months and older, dosing is determined by body weight, generally between 5 mg/kg and 10 mg/kg per dose. The maximum daily dose for children is capped at 40 mg/kg. Oral forms may be taken with food or milk to minimize potential gastrointestinal discomfort. The fundamental principle guiding administration is to utilize the lowest effective dose for the shortest duration necessary to manage symptoms. Non-prescription use is restricted to a maximum of ten days for pain and three days for fever. Intravenous formulations must be administered as a slow infusion by a qualified professional in a controlled clinical setting.

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Recent Clinical Evidence

Research evidence / Overview of Studies for Бурана (Ibuprofen)


Evidence for Use in Acute, Short-Term Pain Relief

Research has extensively used short-term Randomized Controlled Trials (RCTs) to evaluate Бурана's active ingredient in situations involving outcomes related to physical discomfort, such as headaches, dental pain, and discomfort associated with short-term injuries like sprains. These studies primarily monitored outcomes linked to inflammatory or irritative states by measuring changes in pain intensity over short timeframes, and recording the time until patients noted an initial change in their pain level.

Studies describe patterns observed in the studies related to changes in perceived discomfort. For instance, research highlights changes measured during the study period concerning the need for additional pain relievers. These results apply only to the populations studied, and a key limitation is that follow-up durations were limited in many of these efficacy studies. While there is a substantial body of evidence describing short-term effects, there is limited information for long-term outcomes.


Evidence for Antipyresis (Fever Management)

Бурана's active ingredient was studied in managing elevated body temperature in both children and adults. The core research primarily relies on controlled trials that monitored physiological strain or stress by focusing on outcomes related to systemic or functional imbalance (fever). Studies explored the speed at which body temperature was observed to change from its baseline and the duration over which the change was maintained.

Findings indicate that studies report how symptoms evolved in the observed populations, specifically detailing measurements of temperature decrease within the first day of treatment. Comparative evidence was observed in research contexts involving fluctuating or unstable symptoms. Research has not fully established long-term effects concerning repeated use over extended periods of time. Data for certain groups remain insufficient, particularly for critically ill patients or those with severe underlying health issues.


Evidence for Chronic Inflammatory Conditions

The use of Бурана in conditions characterized by functional limitations, such as Osteoarthritis and Rheumatoid Arthritis, was evaluated in studies lasting several weeks or months. Research monitored patient-reported outcomes describing perceived discomfort and outcomes related to systemic or functional imbalance, such as joint stiffness and ability to perform daily activities.

Studies report how symptoms evolved in the observed populations over these defined time intervals. The evidence quality varies across studies, and the follow-up durations were limited when considering the lifetime span of chronic conditions. The available data for very long-term functional efficacy remains limited.

Key Studies & References

  1. Ibuprofen - StatPearls (General evidence and use context)
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Frequently Asked Questions (FAQ)

Common questions about Бурана (FAQ)


Q: How quickly can a person typically expect Бурана to start working?

According to official pharmacological data, some fast-acting forms of the medication may begin to work within 30 minutes. However, the time required to achieve the greatest observed change in pain or fever levels is described as taking up to two hours after administration.


Q: What is the usual duration of the pain-relieving effects of Бурана?

Official product information indicates that the pain-relieving and fever-reducing effects of the medication typically wear off after approximately four to six hours. Regulatory guidelines specify that a new dose is not to be administered until this time interval has passed.


Q: Does taking Бурана with food influence its absorption or action time?

Taking this medication with food or milk is recommended in official guidelines to minimize potential gastrointestinal discomfort. However, official pharmacokinetic data indicates this may delay the time it takes for the active ingredient to be absorbed and for the effects to begin.


Q: Are there official warnings about the use of Бурана in patients with high blood pressure?

Official labeling contains warnings that NSAIDs, including this medication, can potentially cause new onset or worsening of pre-existing high blood pressure (hypertension). Regulatory documents describe that use is required to be undertaken with caution in patients who have this condition.


Q: What are the signs of an allergic reaction to the medication found in Бурана?

Symptoms of a severe allergic reaction, according to regulatory documents, may include hives, swelling of the face, throat, or tongue, and difficulty breathing (asthma or wheezing). The appearance of these signs requires prompt contact with a medical professional.


Q: Is a person who has asthma strictly forbidden from using Бурана?

Use is strictly contraindicated for individuals who have a history of hypersensitivity or allergic reactions, such as aspirin-sensitive asthma, to aspirin or any other NSAID. This is because NSAIDs can potentially trigger severe breathing difficulties (bronchospasm) in these susceptible patients.


Q: What advice do official documents give about using Бурана alongside aspirin for heart health?

Regulatory guidance notes that taking this medication for pain relief may interfere with the antiplatelet benefits of low-dose aspirin taken for heart protection. To help minimize this potential interference, regulatory guidance specifies that immediate-release aspirin should be administered at least two hours before this medication.


Q: What information do regulatory documents provide about using Бурана during pregnancy?

The use of the medication is strictly prohibited during the third trimester of pregnancy (after 30 weeks of gestation). For the first and second trimesters, the regulatory status indicates that use should be avoided unless deemed necessary based on individual patient needs.


Q: What is the difference between prescription-strength and over-the-counter Бурана?

The difference is defined by dosage limits. The maximum recommended daily dosage for over-the-counter (OTC) use is typically 1,200 mg, while prescription-strength use for certain inflammatory conditions may extend to a maximum of 3,200 mg per day under medical supervision.


Q: What should be done if a patient accidentally takes a dose too close to the previous one?

If a dose is taken too soon, the regulatory principle is to wait a suitable period and ensure that the maximum daily dosage is not exceeded. Contact with a medical professional is generally recommended if a person feels unwell or has concerns about an overdose.


Q: Does Бурана only treat symptoms or does it address the underlying cause of inflammation?

The medication works by blocking the production of chemical messengers, called prostaglandins, that cause pain, fever, and swelling. It is described as providing symptomatic relief by treating these symptoms and the resulting inflammation, but it does not address the underlying cause of the original condition.


Q: What research has been done regarding the long-term safety of the active ingredient in Бурана?

Regulatory warnings note that risks, particularly gastrointestinal bleeding and cardiovascular events, are associated with longer duration of use, especially when taking higher doses. Research on very long-term safety outcomes of the medication is officially noted as limited.


Q: How is the safety profile of Бурана monitored by regulatory bodies?

The safety profile is continuously monitored by regulatory bodies through official post-marketing surveillance. This involves the ongoing collection and review of reported adverse events from patients and healthcare professionals.


Q: What is meant when official sources describe Бурана as having an "analgesic effect"?

An analgesic effect is a term used in official documentation to describe the medication's ability to alleviate or relieve pain. Essentially, it means the medication is designed to function as a painkiller without causing a loss of consciousness.


Q: Can a person with a history of heart attack or stroke use Бурана?

Official drug labels carry a boxed warning about an increased risk of heart attack and stroke associated with NSAID use. Official documentation indicates that individuals with a history of these events are considered high-risk and that use is limited to the lowest effective dose for the shortest time, typically under medical supervision.


Q: Does Бурана contain any opioid or addictive substances?

No. According to the World Health Organization and official product information, the medication is a Nonsteroidal Anti-Inflammatory Drug (NSAID). It does not contain any opioid or narcotic substances and is not classified as an addictive or controlled substance.


Q: Can Бурана interact with prescription medications for depression or anxiety?

Official documentation notes that Ibuprofen can interact with certain types of antidepressants known as Selective Serotonin Reuptake Inhibitors (SSRIs). This combination may potentially increase the risk of bleeding.


Q: Does Бурана have an interaction with common dietary supplements?

Regulatory documents specify that caution is described when combining the active ingredient with certain herbal or dietary supplements. Those that have blood-thinning effects may carry an increased risk of bleeding when taken together with this medication.


Q: Is Бурана use linked to fertility concerns in men or women?

Official documentation notes that the active ingredient may temporarily affect female fertility. Use of this medication is not typically described for women who are trying to conceive.


Q: Is Бурана generally considered suitable for use while breastfeeding?

Studies show that only very small amounts of the active ingredient pass into breast milk. The active ingredient is generally described in official sources as compatible with short-term use during breastfeeding when administered at low doses.


Q: Is there a difference in how quickly the various formulations of Бурана work?

Yes, formulations that are absorbed more rapidly, such as liquid-filled capsules or certain salt forms, may show a faster onset of pain relief compared to standard tablet formulations.


Q: What should be done if a patient forgets a dose of Бурана? (Seeking non-directive, official information)

In the case of a forgotten dose, general regulatory guidance describes the usual recommendation as taking the dose when remembered or skipping it, and taking the next dose at the regularly scheduled time. It is essential to ensure that the recommended minimum time interval between doses is maintained.


Q: Have studies examined the effectiveness of Бурана for period pain (dysmenorrhea)?

Yes, the active ingredient in this medication is an officially indicated use for the relief of pain associated with menstrual cramps, known as dysmenorrhea.


Q: What type of evidence is available regarding the effectiveness of Бурана for menstrual pain?

Yes, the active ingredient in this medication is an officially indicated use for the relief of pain associated with menstrual cramps, known as dysmenorrhea.


Q: Where can patients find the official patient information leaflet (PIL) for Бурана?

The official Patient Information Leaflet (PIL) or Medication Guide can typically be obtained from the dispensing pharmacy. It is often also available on the official websites of national regulatory bodies, such as the FDA, EMA, or MHRA.


Q: What is the general guidance on stopping the use of Бурана after short-term relief?

The primary regulatory guidance for this medication is to use the lowest effective dose for the shortest duration necessary to treat symptoms. This guidance emphasizes the expectation that the medication will be discontinued once the symptoms are resolved.


Q: What official information is there about whether Бурана affects a person's ability to drive?

Official drug labeling often states that side effects such as dizziness, headache, or visual disturbances (which are common side effects) may temporarily impair a person's ability to drive or operate machinery.


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How should Бурана be stored and disposed of?

The storage and disposal of Burana (Ibuprofen) must comply with official regulatory labeling to ensure product stability and environmental safety.

Storage Requirements

Item Official Regulatory Requirement
Temperature: Store at a controlled room temperature, typically 20 C to 25 C (68 F to 77 F).
Protection: Must be stored to protect from excessive heat, moisture, and light.
Container/Safety: Keep in the original container and store out of the sight and reach of children.

Disposal Requirements

Official instructions mandate that expired or unused Burana must not be disposed of via wastewater (e.g., down the sink or toilet) or with general household waste.

All disposal must follow local requirements, which usually involve returning the product to a pharmacy or using an official drug take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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