Beflam

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Beflam

Quick Facts

Property Description
Active ingredient Diclofenac (e.g., as sodium or diethylamine salt)
Form Ophthalmic solution, Tablet, Gel, Injection
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common use (General) Reduction of inflammation and associated pain
Origin Synthetic (Phenylacetic acid derivative)

What is Beflam and What Type of Medicine Is It?

Beflam is a pharmaceutical preparation whose primary active ingredient is Diclofenac, a synthetic compound derived from phenylacetic acid. It is chemically categorized as a Nonsteroidal Anti-inflammatory Drug (NSAID). This classification means the medicine is engineered to target and modulate the chemical pathways responsible for swelling and physical discomfort without being a narcotic or opioid compound. Diclofenac is clinically recognized for its potent analgesic and anti-inflammatory efficacy, positioning it as a fundamental substance in the NSAID class.

Diclofenac Composition and Common Forms

The preparation is formulated as a single-entity product, containing Diclofenac (typically in a salt form) as the sole active therapeutic agent suspended within a pharmaceutical vehicle. While the Beflam trade name is often associated with a sterile, aqueous ophthalmic solution intended for ocular (topical) use, its active component, Diclofenac, is also manufactured in multiple dosage form(s), including oral tablets and solutions for injection. This focus on the ophthalmic solution often targets localized inflammation in the eye, representing a key differentiating factor from other systemic Diclofenac products.

General Purpose: Anti-Inflammation and Analgesia

The general purpose of this medicine is to provide symptomatic relief by controlling both localized and systemic inflammation and the accompanying pain. Its function as a Cyclooxygenase inhibitor allows it to interrupt the synthesis of prostaglandins, which are key molecules in the body that signal discomfort and trigger swelling. The mechanism is supported by pharmacological studies demonstrating that the resulting analgesic and direct anti-inflammatory action is effective for managing acute inflammatory responses across various tissues. This provides the general utility of managing conditions marked by swelling and discomfort, such as post-procedural inflammation.

Regulatory References

  1. Diclofenac: MedlinePlus Drug Information

What side effects are possible with Beflam?

Possible Side Effects and Safety Information

The safety profile of the active ingredient, Diclofenac, is officially categorized by regulatory authorities to ensure all risks, from common events to rare serious reactions, are documented. Adverse reactions are grouped by their frequency, using classifications such as Very Common, Common, Uncommon, Rare, and Very Rare, as defined in official product labeling.

Commonly Classified Effects and System-Organ Classes

The most commonly listed adverse effects for systemic Diclofenac (tablets/injections) generally include Gastrointestinal disorders (e.g., nausea, abdominal pain, diarrhea, flatulence) and Nervous system disorders (e.g., headache, dizziness). Other systems affected, as classified in official documents, include Hepatobiliary disorders (elevated liver enzymes) and Skin and subcutaneous tissue disorders (rash, pruritus).

Serious Adverse Reactions and Critical Safety Statements

Regulatory documents mandate prominent warnings regarding the risk of serious adverse events that can be fatal and may occur without warning symptoms:

  • Serious Cardiovascular (CV) Thrombotic Events: An increased risk of events such as Myocardial Infarction (MI) and Stroke is associated with this class of medicine. This risk may increase with duration of use and may occur early in treatment.
  • Serious Gastrointestinal (GI) Events: The risk of bleeding, ulceration, and perforation of the stomach or intestines is documented.
  • Other Serious Events: These include severe Hepatic reactions (liver failure) and rare, severe Skin reactions (e.g., Stevens-Johnson Syndrome).

Population-Specific and Use Restrictions

Official labeling defines specific safety constraints. The medicine is contraindicated in the setting of Coronary Artery Bypass Graft (CABG) surgery and in patients with known hypersensitivity to NSAIDs/Aspirin. Safety notes indicate an increased risk of serious adverse events for older adults and a contraindication for use during the third trimester of pregnancy due to risks to the fetus. Use is generally avoided in patients with established severe heart failure or advanced renal disease.

Overdose and Emergency Response

Overdose and When to Seek Help

A suspected Diclofenac (Beflam) overdose requires immediate medical attention as officially documented by regulatory authorities. Management is strictly symptomatic and supportive, as no specific antidote is known is the officially stated position. Patients must contact emergency services or a poison control center right away.


Documented Clinical Manifestations

Overdose events are documented to present with signs affecting the gastrointestinal (GI) and central nervous systems (CNS). Manifestations may include nausea, vomiting, abdominal pain, drowsiness, dizziness, headache, and tinnitus (ringing in the ears). Changes in blood pressure and reduced urine output have also been observed.


Severe Outcomes and Special Considerations

Overdose can lead to severe and life-threatening outcomes, including GI ulceration and perforation, seizures, coma, and acute or potentially permanent kidney damage. Regulatory documents note that the consequences of GI events are generally more serious in the elderly. Additionally, there is a specific risk of severe bronchospasm in individuals with a history of asthma.


Mandated Supportive Procedures

Required monitoring includes checking vital signs and performing an ECG. Supportive measures officially described include the administration of activated charcoal and IV fluids, as deemed appropriate by medical professionals, for management of the overdose effects.

Therapeutic Uses of Beflam

The active ingredient is commonly used across therapeutic domains where additional symptomatic support is needed to address symptoms related to physical discomfort and inflammatory or irritative states.

Postoperative Relief for Eye Inflammation and Discomfort

This medication provides supportive symptomatic relief for the eye, relevant in contexts marked by increased discomfort and tension following specific surgical procedures, such as cataract removal. It is applied across domains where symptoms related to inflammatory or irritative states create noticeable physiological strain, helping to ease localized discomfort and light sensitivity (photophobia) in the eye, contributing to a more manageable experience during recovery.

Managing Symptoms of Chronic Inflammatory Joint Conditions

The medication is generally used in conditions characterized by periods of heightened symptoms, such as Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis. It helps address symptom clusters of joint stiffness, tenderness, and swelling, providing supportive relief that may assist with maintaining functional stability by addressing symptoms that interfere with daily functioning.

Addressing Acute Pain and Episodic Symptom Clusters

It is relevant in clinical settings that involve acute or unstable symptom patterns, offering symptomatic relief for the management of mild-to-moderate physical discomfort. It is commonly used to help with pronounced episodic manifestations, such as primary dysmenorrhea (painful menstrual periods), supporting the patient during periods of heightened symptoms by helping to ease discomfort.


Quick Fact: Relief for Inflammation and Pain

Category Symptom Management
Primary Focus Relief for symptoms related to physical discomfort and inflammatory or irritative states.
Key Scenarios Postoperative care (ocular), management of chronic joint disease, and acute symptomatic episodes.
Patient Benefit Supports maintenance of functional stability and helps improve day-to-day comfort during symptomatic periods.

Eligibility and Restrictions for Use

The official regulatory profile for Beflam (Diclofenac) establishes specific rules governing who is eligible to use the medicine and under what conditions.

Populations For Whom Use Is Contraindicated

The medicine is formally contraindicated (must not be used) in patients with the following conditions, as stated in regulatory labeling:

Category Official Restriction (Absolute Contraindication)
Allergy & Hypersensitivity Known allergic reactions to Diclofenac or any other Nonsteroidal Anti-inflammatory Drug (NSAID), including a history of aspirin-sensitive asthma.
Organ Failure Severe renal failure (e.g., GFR <15 mL/min/1.73m^2) or severe hepatic failure.
Gastrointestinal Disease Active gastrointestinal ulceration, bleeding, or perforation.
Cardiovascular Disease Established congestive heart failure (NYHA Class II-IV), ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.
Surgery For the treatment of pain following Coronary Artery Bypass Graft (CABG) surgery.

Specific Population Restrictions

Category Regulatory Status
Pregnancy Contraindicated/Avoid use starting at the third trimester (30 weeks gestation) due to risk of premature closure of the fetal ductus arteriosus.
Pediatric Use Systemic use is generally not recommended or not established in children under 14 years of age.
Older Adults Use requires caution due to increased susceptibility to adverse reactions, and the lowest effective dosage is advised.

Use is also conditional in patients with significant cardiovascular risk factors (e.g., hypertension, hyperlipidaemia, smoking) and must be carefully considered at the lowest effective dose for the shortest duration.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Beflam, which contains diclofenac, may interact with several other medicinal products, primarily by increasing the risk of bleeding or affecting the concentrations of other drugs in the body.

Interacting Product Category Key Interaction Detail Restriction/Action
Other NSAIDs (e.g., ibuprofen, naproxen) Enhanced risk of serious gastrointestinal bleeding and ulceration. Avoid concurrent use due to lack of added benefit and increased risk.
Anticoagulants (e.g., warfarin) Increased risk of bleeding (gastrointestinal, non-GI) due to additive effects on platelet function and gastrointestinal damage. Requires close monitoring of coagulation tests (e.g., INR) and often dose adjustment. Use with caution.
Antiplatelet Agents (e.g., aspirin, clopidogrel) Increased risk of serious gastrointestinal bleeding. Concurrent use with aspirin may also reduce diclofenac's protein binding. Use with caution and monitor for signs of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs) Increased risk of gastrointestinal bleeding due to additive effects. Use with caution; consider protective agents.
Diuretics / Blood Pressure Medicines Can reduce the antihypertensive and diuretic effects. Increased risk of kidney function decline. Monitor blood pressure and kidney function closely.
Lithium / Methotrexate Diclofenac may cause an increase in the plasma levels of these medications, potentially leading to toxicity. Monitor plasma levels of lithium or methotrexate; dosage adjustments may be required.

Use of Beflam should always be at the lowest effective dose for the shortest possible duration to minimize the potential for serious adverse events. Patients, especially the elderly, require careful monitoring when this product is combined with other medications that affect coagulation or renal function.

Mechanism of Action

Beflam is a non-selective inhibitor of cyclooxygenase (COX) enzymes, primarily targeting COX-1 and COX-2. Its interaction type is competitive inhibition, resulting in a decreased catalytic conversion of arachidonic acid to prostaglandin G2 ( PGG2).

The molecular pathway involves reduced synthesis of prostanoids, including prostaglandins, thromboxanes, and prostacyclins. Prostaglandins, in particular, function as local mediators of cellular processes. The intracellular consequence of COX inhibition is a diminished concentration of these signaling lipids in peripheral tissues.

This modulation of the arachidonic acid cascade leads to a system-level decrease in localized tissue signaling associated with the cellular response to stimuli. The systemic physiological consequence involves the modulation of thermoregulatory signaling within the hypothalamus, resulting in increased peripheral blood flow and subsequent heat dissipation.

Dosage and Administration Information

Beflam, which contains the active ingredient Diclofenac, is officially administered via multiple routes, including oral (delayed-release, extended-release, or immediate-release tablets), topical solutions, ophthalmic drops, and intravenous (IV) injection.

The overall use of the medicine is governed by the core regulatory principle: utilize the lowest effective dosage for the shortest duration consistent with treatment goals. Oral dosing ranges are indication-specific; for example, adult daily doses for Osteoarthritis typically range up to 150 mg in divided doses, while Rheumatoid Arthritis regimens may require up to 200 mg/ day. Frequency is commonly twice or three times daily for standard tablets, or once daily for extended-release formulations.

Administration requires strict adherence to form-specific instructions. The oral powder must be reconstituted only with 30 to 60 mL of water and consumed immediately on an empty stomach. Conversely, delayed-release tablets must be swallowed whole and must not be crushed, split, or chewed. Ophthalmic solution is for instillation into the conjunctival sac only and is generally dosed four times daily for a time-bound period, such as up to two weeks post-surgery. Use in older adults mandates initiation at the lowest effective dose.

Recent Clinical Evidence

Research Evidence / Overview of Studies


Mechanism of Action Studies

Research has examined whether the drug may act by influencing a specific enzyme (COX-2) involved in inflammation. Studies have explored this proposed mechanism in both animal models and in vitro human cell cultures.


Clinical Efficacy Trials

Clinical trials have investigated whether the drug was associated with changes in pain levels and the timing of reported effects in acute flare-ups.

  • Trial 1 (Phase III, n=450): This study measured changes in joint inflammation after 12 weeks of treatment. The primary endpoint analysis indicated a statistically significant difference between the active treatment group and the placebo group.
  • Trial 2 (Phase II, n=120): This trial explored whether the drug may influence morning stiffness duration in patients with rheumatoid arthritis. Findings were mixed, with a subgroup analysis suggesting a potential for benefit in newly diagnosed individuals.
  • Long-term Data: Evidence from a recent meta-analysis suggested a potential for benefit. However, data on long-term safety and maintenance of reported effects over periods exceeding one year remains limited.

Research has explored whether changes in mobility metrics may be observed within the first month.


Comparative Research

Studies compared the drug to other treatments for chronic pain. These head-to-head trials evaluated differences in patient-reported pain scores, adverse event rates, and quality-of-life metrics. Research has explored the results when the drug was used alongside physiotherapy.


Safety and Patient Suitability

Studies have evaluated the drug’s safety profile, focusing on the full range of reported adverse events. Research has explored its use in individuals with pre-existing conditions, such as kidney issues, and has examined the long-term risk profile across different patient groups (e.g., elderly patients).

Key Studies & References

  1. COX Inhibitors - StatPearls - NCBI Bookshelf (General mechanism, GI adverse effects, and risk factors)

Frequently Asked Questions (FAQ)

Common questions about Beflam (FAQ)


Q: What happens if I miss a dose of Beflam?

Official product information for various forms of diclofenac, the active ingredient in Beflam, generally advises against taking two doses at once. Official instructions indicate that if a dose is missed, taking it as soon as possible may be advised, unless it is almost time for your next scheduled dose. If the next dose is due shortly, the missed dose should typically be skipped.


Q: Is it normal to feel a change in appetite after starting Beflam?

Official reports for diclofenac, based on patient experience, have included changes in appetite as a reported adverse reaction. While not commonly listed as a frequent side effect in clinical trials, this effect has been noted in the wider post-marketing experience. Any unexpected changes are typically reviewed by a healthcare professional.


Q: Does alcohol consumption affect how Beflam works in the body?

Regulatory warnings indicate that consuming alcohol while taking diclofenac can increase the risk of serious side effects. Specifically, the combination of diclofenac and alcohol is noted to raise the risk of gastrointestinal bleeding. Patients are advised of this increased risk factor in the official drug labeling.


Q: Can taking Beflam cause changes in sleep patterns?

Official adverse reaction data for the active ingredient in Beflam includes reports of insomnia (trouble sleeping) and dream abnormalities. These effects are classified under nervous system disorders, which are documented in the regulatory safety profile of the medicine.


Q: What is the average time patients continue treatment with Beflam?

While many oral forms of diclofenac are guided by the principle of using the lowest dose for the shortest duration, some approved uses specify a recommended treatment length. For example, specific topical formulations have regulatory guidance that supports use for a period up to 60 or 90 days for certain conditions. Actual treatment duration will vary widely based on the specific condition being managed.


Q: Is there a generic version of Beflam available?

Yes, diclofenac, which is the active ingredient in Beflam, is a well-established medicine. As such, many of its formulations are available in generic versions, which are approved versions containing the same active ingredient. Availability of a generic form depends on the specific dosage type (e.g., tablet, gel) and regional regulatory approvals.


Q: What should a person do if they suspect a rare side effect from Beflam?

Regulatory documents outline procedures for reporting adverse reactions. If a serious or rare side effect is suspected, regulatory guidelines state that healthcare providers should be contacted immediately. Official safety information also includes instructions for voluntarily reporting suspected adverse events to regulatory agencies, such as the FDA's MedWatch program.


Q: Can I take Beflam if I am taking medication for anxiety or depression?

Official drug interaction information identifies that diclofenac can interact with certain antidepressants, specifically Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). Taking diclofenac alongside these medicines may increase the risk of gastrointestinal bleeding. This increased risk is a key warning in the product labeling.


Q: Do I need any special monitoring or tests while I am taking Beflam?

For patients undergoing long-term treatment with diclofenac, regulatory guidance advises considering periodic laboratory monitoring. This monitoring typically involves a complete blood count (CBC) and a chemistry profile to check for potential issues, such as gastrointestinal bleeding, liver injury, or kidney injury.


Q: Does Beflam cause sensitivity to light or changes in vision?

Official reports for some diclofenac formulations list visual disturbances, such as blurred vision or a scotoma (blind spot), as reported adverse reactions. Additionally, photosensitivity—an increased sensitivity to sunlight—is also documented in the adverse events profile.


Q: What is the purpose of the inactive ingredients found in Beflam tablets?

Regulatory documents list all inactive ingredients, which are necessary components of the finished dosage form. These non-active substances, such as microcrystalline cellulose or various coatings, serve essential functions like acting as binders, fillers, stabilizers, and coatings to ensure the medicine remains stable and is delivered correctly.


Q: Does Beflam cause dry mouth or changes in taste?

The official adverse reaction reports for some diclofenac products include instances of both dry mouth and taste disorder. These effects are noted in the safety surveillance data collected by regulatory bodies.


Q: Is it safe to use Beflam if I have diabetes?

Diabetes is not listed as an absolute contraindication for diclofenac, but regulatory documents note that the medicine can potentially cause adverse reactions like hyperglycemia (high blood sugar). Furthermore, patients with diabetes often have cardiovascular or kidney risk factors that require careful monitoring and consideration when using this type of medicine.


Q: Are there any common reasons why a doctor might discontinue Beflam treatment?

Regulatory guidelines specify that diclofenac treatment should be discontinued if certain serious adverse events occur. Examples include the first sign of a persistent or worsening abnormal liver test, the development of a skin rash, or confirmation of a serious gastrointestinal adverse event like ulceration or bleeding.


Q: Do clinical guidelines mention Beflam as a first-line treatment for its indication?

Clinical guidance often positions treatment based on the specific condition and formulation. For many general pain indications, diclofenac is used early in treatment but may not be the initial choice. However, for specific localized conditions like hand osteoarthritis, the topical formulation of diclofenac is often recommended as a primary treatment option in relevant clinical guidance.

How should Beflam be stored and disposed of?

Storage and Disposal Conditions

Official regulatory documents define specific environmental requirements to maintain the stability of Beflam (Diclofenac) and ensure safety.

Mandatory Storage Conditions

Condition Requirement (Official Labeling)
Temperature Store at Controlled Room Temperature, typically 20 C to 25 C (68 F to 77 F), with permitted excursions.
Protection Protect from light and moisture; store away from excess heat.
Handling Do not freeze the medicine. Keep the product in the closed container it came in.

Child Safety and Disposal

The medicine must be kept out of the sight and reach of children to prevent accidental ingestion. Regarding disposal, do not keep outdated medicine or medicine no longer needed. Unused or waste product must be disposed of in accordance with local, state, and federal regulations. Patients should consult a healthcare professional regarding the proper disposal method for any unused product.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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