Yaz

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Yaz

Property Description
Active Ingredients Drospirenone (DRSP) and Ethinyl Estradiol (EE)
Form Film-coated tablets
Pharmacological Class Hormonal Contraceptive; Estrogen-Progestin Combination
Common Use Contraception (prevention of pregnancy)
Origin Synthetic steroid hormones

What Is Yaz and Its Pharmacological Classification?

Yaz is a combination oral contraceptive (COC) that belongs to the pharmacological class of Hormonal Contraceptives and Estrogen-Progestin Combinations. This medication is a synthetic entity, supplied as film-coated tablets for oral administration. This combination is a highly effective hormonal method used primarily to prevent pregnancy. The combination of synthetic hormones is designed to regulate the reproductive cycle through systemic action, which is why the drug is clinically recognized for delivering a consistent approach to reproductive planning.

Yaz Composition: Drospirenone and Ethinyl Estradiol

The active ingredients in Yaz are the synthetic steroid compounds Drospirenone (DRSP) and Ethinyl Estradiol (EE). Drospirenone is a unique synthetic progestin recognized as a fourth-generation compound with distinguishing antiandrogen properties. Ethinyl Estradiol serves as the synthetic estrogen component. As a monophasic combination product, Yaz integrates these two components into a single preparation, ensuring a consistent dose of active ingredients during the tablet-taking phase, differentiating it from phased formulations.

What Is the General Purpose of Taking Yaz?

The general and overarching purpose of Yaz is contraception, effectively preventing pregnancy in women of reproductive potential. The drug achieves its primary function by introducing stable, regulated levels of synthetic hormones into the body to disrupt the natural processes required for conception. This systemic approach is primarily mediated through the suppression of ovulation and the alteration of the cervical environment. This combination product is a reliable hormonal contraceptive. This medication is typically considered when a patient requires a daily, non-barrier form of birth control.

Regulatory References

  1. The U.S. National Library of Medicine
  2. The European Medicines Agency (EMA)

What side effects are possible with Yaz?

Possible Side Effects and Safety Information

This section describes the officially documented adverse reactions and high-level safety constraints of this combination hormonal contraceptive, as categorized by regulatory authorities.

Frequency-Classified Adverse Reactions

Adverse reactions are classified based on the frequency of observation in clinical data. Regulatory documents classify several effects as Very Common (occurring in ge 1/10 women), including headache, nausea, breast pain, abdominal pain, intermenstrual bleeding/spotting, and weight increase. Effects classified as Common (occurring in ge 1/100 to <1/10 women) include migraine, depression, affect lability, decreased libido, vomiting, diarrhea, acne, and fluid retention.

Serious Adverse Reactions and Systemic Risk

Official labeling emphasizes the risk of Serious Adverse Reactions, which primarily involve vascular events. These include Venous Thromboembolism (VTE), such as deep vein thrombosis and pulmonary embolism, and Arterial Thromboembolism (ATE), which encompasses events like myocardial infarction and stroke. The drospirenone component specifically introduces the potential for Hyperkalemia (elevated serum potassium levels) in susceptible individuals, alongside risks of Hypertension and Liver Tumors.

Safety Constraints and Special Populations

The regulatory safety profile defines limitations for use based on specific conditions and demographics. The medication is contraindicated in women over 35 who smoke, due to a significantly increased risk of serious cardiovascular events. Furthermore, it is not for use in individuals with pre-existing conditions such as severe hepatic impairment, severe renal insufficiency, or adrenal insufficiency. Regulatory documentation also requires that the medication be discontinued at least four weeks before and through two weeks after major surgery or during prolonged immobilization, due to the established risk pattern of VTE. The risk of VTE is officially stated to be highest during the first year of use.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents define the manifestations and required actions for a suspected overdose of Yaz (drospirenone and ethinyl estradiol). Acute ingestion of the product is generally not considered life-threatening; however, seeking immediate professional assessment is a mandatory regulatory requirement.

Documented Manifestations

The clinical signs of overdose reported in regulatory labeling primarily involve certain non-severe presentations. These manifestations include nausea and vomiting. Additionally, the occurrence of vaginal bleeding, or withdrawal bleeding, is documented as an expected effect in adult females. This manifestation is also noted as an expected observation in prepubertal females following accidental ingestion.

Required Emergency Actions and Management

Due to the seriousness of any suspected overdose event, regulatory authorities mandate prompt intervention. In the event of a known or suspected overdose, individuals are required to seek emergency medical attention or contact the Poison Help line. Management is constrained by the fact that no specific antidote is known for the active components of Yaz. Therefore, the officially described intervention is strictly limited to symptomatic and supportive treatment to manage the manifestations. Healthcare providers may also institute monitoring measures, including observation for elevated serum potassium (hyperkalemia) in high-risk patients.

Therapeutic Uses of Yaz

The core therapeutic purpose of this combination pill is commonly used to help with symptoms related to systemic imbalance. Yaz is utilized to help with symptoms that interfere with daily functioning. It is indicated for contraception, the treatment of Premenstrual Dysphoric Disorder (PMDD), and the treatment of moderate acne vulgaris.

Primary Use and Symptom Relief

The primary purpose is to offer contraception for women of reproductive potential who choose a hormonal method. Furthermore, it is applied in addressing symptoms associated with acute or episodic changes. This includes supporting the management of distressing symptoms related to physical discomfort in the context of PMDD, such as intense irritability, depressed mood, and bloating. This medication also assists with managing symptoms related to inflammatory or irritative states (moderate acne). This supportive relief helps maintain a sense of stability when symptoms are more noticeable.

“This medication is relevant when supportive symptom management is appropriate alongside the need for contraception.”

Quick Fact: Relief for Cyclical Mood and Skin Symptoms This medication is applied in managing conditions characterized by periods of heightened symptoms, and supports the patient during difficult episodes by easing distress.

Eligibility and Restrictions for Use

Official Eligibility for Yaz (Drospirenone/Ethinyl Estradiol)

Yaz is officially authorized for use only in females of reproductive potential who have attained menarche. Regulatory bodies strictly define specific populations and conditions where the medication is contraindicated.

Who Must Not Use Yaz (Contraindications)

The medicine is strictly contraindicated in women with a current or history of thromboembolism (VTE or ATE) or conditions conferring high risk, such as smoking over age 35 or uncontrolled hypertension. It is also prohibited for those with severe renal impairment or adrenal insufficiency due to the risk of hyperkalemia, as well as those with severe liver disease or known or suspected hormone-sensitive tumors (e.g., breast cancer).

Age and Physiological Status

The medicine is not indicated for use in females prior to menarche or in postmenopausal women. It is contraindicated during pregnancy and not recommended while breastfeeding.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This medication’s interaction profile is categorized by regulatory documents based on metabolism and pharmacodynamic effects.

Contraindicated Combinations

Co-administration is contraindicated with specific Hepatitis C combination regimens, including those containing Ombitasvir, Paritaprevir/Ritonavir, and Dasabuvir, or Glecaprevir, Pibrentasvir, and Sofosbuvir, due to the potential for elevated liver enzymes. Oral Tranexamic Acid and Fezolinetant are also contraindicated.

Pharmacokinetic Interactions

  • CYP3A4 Inducers (e.g., Rifampin, Phenytoin, St. John’s Wort) increase the clearance of the contraceptive steroids, resulting in reduced systemic exposure and diminished effectiveness.
  • Strong CYP3A4 Inhibitors (e.g., Ketoconazole, Clarithromycin) decrease the clearance, leading to a significant increase in the plasma concentrations (AUC/Cmax) of Drospirenone and Ethinyl Estradiol.
  • Ethinyl Estradiol reduces the concentration of certain drugs metabolized by UGT-glucuronidation, such as Lamotrigine.

Pharmacodynamic Interactions

  • Hyperkalemia Risk: Drospirenone's anti-mineralocorticoid activity creates a risk of hyperkalemia when co-administered with other potassium-increasing medications, including Potassium-Sparing Diuretics (e.g., Spironolactone), ACE Inhibitors, and ARBs. Monitoring is advised during the first month for high-risk patients concomitantly taking strong CYP3A4 inhibitors.

Population-Specific Notes

Regulatory warnings state that the risk of hyperkalemia is heightened in populations with predisposing conditions, specifically renal impairment, hepatic impairment, and adrenal insufficiency.

Mechanism of Action

Primary Ovarian Axis Modulation

Yaz combines the progestin drospirenone (DRSP) with the estrogen ethinyl estradiol (EE). The EE component acts centrally to suppress the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. This central action influences the hypothalamic-pituitary-ovarian (HPO) axis, which is the main mechanism for inhibiting ovulation.


Drospirenone's Receptor Binding and Secondary Mechanisms

DRSP functions as a progestin with distinct anti-androgenic and anti-mineralocorticoid activity. Its anti-androgenic effect is mediated by competitive binding to the androgen receptor, which modulates receptor activity. DRSP also exhibits high binding affinity for the mineralocorticoid receptor. The combined hormonal action contributes to a thickening of cervical mucus and results in alterations to the endometrium.

Dosage and Administration Information

How to Use Yaz: Administration Guidelines

Yaz (drospirenone/ethinyl estradiol) is an oral medication administered on a continuous, daily schedule using a 28-day blister pack. The tablets must be taken at the same time every day, and may be taken with or without food.

Administration Procedure

The 28-day regimen consists of 24 light pink active tablets followed by 4 white inert/reminder tablets. Tablets must be swallowed whole and taken in the order directed on the blister pack.

Starting Method First Day of Tablet-Taking
Day 1 Start Take the first light pink tablet on the first day of menstrual bleeding.
Sunday Start Take the first light pink tablet on the first Sunday after menstrual bleeding begins.

Regardless of the starting method, a new pack must be started the day after the last tablet of the previous pack, without a break in tablet-taking.

Missed Dose Instructions

  • One light pink active tablet missed: Take the missed tablet as soon as possible, even if this means taking two tablets in one day. Continue taking the rest of the pack at the regular time. No back-up method is required.
  • Two or more light pink active tablets missed: Follow the specific instructions provided on the packaging for the week the tablets were missed. A non-hormonal back-up method (e.g., condoms) is generally required for the next 7 days.
  • Any white inert/reminder tablet missed: Throw away the missed tablet(s) and continue taking one tablet daily until the pack is finished. No back-up method is required.

Recent Clinical Evidence

Research Evidence: Overview of Studies for Yaz

Evidence for Contraception: Trial Design and Measured Outcomes

The prevention of pregnancy was studied for this combination drug primarily through large-scale clinical trials and observational research involving women of reproductive potential. These studies included randomized designs, where the drug was compared against other hormonal birth control methods, and single-group trials across various global populations. The research examined measures of ovarian activity and patterns of cycle regulation.

Outcomes related to pregnancy prevention were measured in the studies using the Pearl Index, which reflects the number of pregnancies that occur per 100 women over one year of use. Findings describe patterns observed in studies evaluating use under controlled conditions and patterns observed in typical-use settings. The overall evidence contributes to the understanding of patterns observed when this drug is used as a form of contraception.

What remains uncertain in this research area primarily relates to the difference between the closely monitored environment of a clinical trial and the daily life of a person. Comparative evidence research suggests is lacking to definitively show the subtle differences in outcomes when compared to all other hormonal contraceptive options available today.

Evidence for Premenstrual Dysphoric Disorder (PMDD) Evaluation

Research for the PMDD indication has focused on clinical trials that are double-blinded and placebo-controlled, meaning the drug was compared against an inactive substance (placebo). This approach was used in research exploring how symptoms change over time in women with a formal clinical diagnosis of PMDD who also use a hormonal birth control method.

Research exploring short-term symptom changes for PMDD was conducted during periods of increased symptom activity and typically covered only three menstrual cycles. Because of this short follow-up duration, long-term effects are not fully established regarding the maintenance of symptom patterns beyond those three cycles. Additionally, research is limited to women diagnosed with PMDD and does not include data for the broader, less severe Premenstrual Syndrome (PMS).

Frequently Asked Questions (FAQ)

Common questions about Yaz (FAQ)


Q: What are the main FDA-approved uses for Yaz besides preventing pregnancy?

A: According to official regulatory documents, Yaz is approved for more than just preventing pregnancy. It is also indicated for the treatment of moderate acne in women at least 14 years old who choose an oral contraceptive for birth control. Additionally, it is approved for the treatment of symptoms associated with Premenstrual Dysphoric Disorder (PMDD).

Q: Does Yaz have a lower dose of estrogen compared to other combination birth control pills?

A: Yaz is described as containing a low dose of the synthetic estrogen component, ethinyl estradiol. Official product information states it contains 0.02 mg of this component. In comparison, its related formulation, Yasmin, is described as containing 0.03 mg.

Q: Can Yaz cause or worsen mood changes or anxiety?

A: Official safety documents list depression and affect lability (changes in mood) as common side effects observed in clinical data. Regulatory warnings also note that women with a pre-existing history of emotional disturbances may be more prone to experience a recurrence while taking hormonal contraceptives.

Q: Does Yaz affect a person's libido or sex drive?

A: Official safety documents indicate that a decrease in libido (sex drive) is listed as a common adverse reaction for this medication, based on clinical trial data collected for regulatory purposes.

Q: Is weight gain or water retention a common side effect reported by users of Yaz?

A: Yes, regulatory documents list both weight increase as a very common side effect and fluid retention as a common side effect. The drospirenone component of Yaz has antimineralocorticoid activity, which is described as affecting fluid balance in the body.

Q: What is the recommended protocol if I experience severe headaches or migraines after starting Yaz?

A: Regulatory warnings state that a significant change in the pattern of headaches should be medically evaluated. If a serious change is indicated, the medication may be discontinued. Furthermore, the medication is contraindicated (should not be used) for women who experience migraines with aura.

Q: Is it normal to have a lighter or shorter period while taking Yaz due to the 24/4 schedule?

A: The 24/4 dosing regimen, which involves a shorter hormone-free interval, is associated with alterations in bleeding patterns. Official product information notes that spotting or intermenstrual bleeding (bleeding outside the expected withdrawal bleeding days) is listed as a very common adverse reaction.

Q: Is it possible to take Yaz continuously to skip periods, and what does official information say about this?

A: Official instructions require taking one pill every day for 28 days, including the four inactive pills, and starting a new pack without a break. The medication is only approved and labeled for this specific 24/4 regimen.

Q: Does Yaz contain the same hormones and doses as Yasmin?

A: Yaz and Yasmin both contain the progestin drospirenone in a 3 mg dose. However, they differ in the amount of estrogen: Yaz contains 0.02 mg of ethinyl estradiol, while Yasmin is described as containing 0.03 mg.

Q: Can Yaz be less effective if I experience severe vomiting or diarrhea?

A: Severe gastrointestinal issues like vomiting or diarrhea can prevent the body from properly absorbing the active hormones. If a tablet is not properly absorbed, regulatory instructions for two or more missed doses apply. This may include using a non-hormonal back-up method as described in the official product information.

Q: How soon after stopping Yaz can a person expect to become pregnant?

A: Regulatory information indicates that temporary infertility following discontinuation of treatment is a potential effect documented in research. However, official information does not provide a guaranteed or expected timeline for the return of fertility.

Q: Is Yaz associated with an increased risk of developing gallbladder problems?

A: Official product information states that the use of hormonal contraceptives may be associated with an increased risk of gallbladder disease. This is listed as a potential serious safety concern in regulatory documents.

Q: Are there certain vitamins or supplements that are known to interfere with Yaz?

A: Regulatory documents explicitly identify the herbal supplement St. John’s Wort as a substance that may interfere with Yaz. It may increase the clearance of the contraceptive steroids, which could potentially reduce the effectiveness of the medication.

Q: How effective is Yaz at preventing pregnancy with typical use compared to perfect use?

A: The effectiveness of the medication is reported with two measures: perfect use (ideal, consistent use) is estimated to be approximately 99%, and typical use (accounting for human error) is estimated to be approximately 91%. Pregnancy prevention effectiveness is often measured using the Pearl Index in studies.

Q: Does the risk of side effects change after the first few months of taking Yaz?

A: Official safety information for serious adverse reactions indicates that the risk of Venous Thromboembolism (VTE), or blood clots, is highest during the first year of use. However, information regarding the overall frequency of common side effects over a longer duration is not specified in the same way.

Q: What does research say about the use of Yaz specifically for treating the symptoms of PMDD?

A: Clinical studies conducted for regulatory approval found that the medication can alleviate the emotional and physical symptoms associated with Premenstrual Dysphoric Disorder (PMDD). This indication is for women who desire an oral contraceptive for birth control.

Q: Are there any known drug-food interactions for Yaz?

A: The official drug label indicates a potential interaction with grapefruit or grapefruit juice due to their effects on how the body processes the medication. While the pill may be taken with or without food, specific warnings apply to grapefruit.

Q: Does taking Yaz affect the results of any common laboratory tests?

A: Hormonal contraceptives, including Yaz, may affect the results of certain laboratory tests. For this reason, official patient information advises individuals to inform their healthcare professional before any scheduled testing.

Q: Can Yaz cause breast tenderness or changes in breast size?

A: Official safety documents list breast pain as a very common adverse reaction and breast tenderness as a common adverse reaction observed in clinical trials. Changes in breast size are not explicitly listed in the documented side effect profile.

Q: Is it true that the drospirenone in Yaz has a diuretic-like effect?

A: Yes, the drospirenone component in Yaz possesses antimineralocorticoid activity. This action is often described as having a diuretic-like effect because it can impact the balance of salt and water in the body, similar to the action of some diuretic medications.

Q: Can Yaz cause vision changes or discomfort with contact lenses?

A: Regulatory documents state that patients using oral contraceptives may experience corneal edema, which can cause visual disturbances. This may also lead to a change in tolerance for wearing contact lenses.

Q: Are there any long-term health risks associated with taking Yaz for several years?

A: The documented serious long-term adverse reactions primarily involve vascular events, such as venous and arterial thromboembolism (VTE and ATE), and the potential for Liver Tumors. Regulatory warnings focus on these specific risks observed in official data.

Q: Are there any clinical studies that have examined the effectiveness of Yaz in specific ethnic populations?

A: Regulatory information notes that studies have been conducted across various global populations. Post-authorization research has specifically examined the effectiveness and safety in populations such as Chinese women.

Q: How does the risk of blood clots with Yaz compare to the risk from pregnancy?

A: Regulatory documents state that the risk of developing blood clots when using Yaz is described as being lower than the risk associated with pregnancy and the postpartum period.

Q: What are the serious cardiovascular risks associated with taking Yaz while smoking?

A: The medication carries a boxed warning stating it is contraindicated for women over 35 who smoke. This is due to a significantly increased risk of serious cardiovascular events, including stroke and myocardial infarction (heart attack).

Q: Why are people with kidney, liver, or adrenal disease advised not to take Yaz?

A: The medication is contraindicated for those with renal (kidney) impairment or adrenal insufficiency because the drospirenone component can lead to an unsafe rise in potassium levels (hyperkalemia). It is also contraindicated in severe liver disease because the body's exposure to the drug is significantly higher.

Q: What is the difference between Yaz and Beyaz?

A: Beyaz is a related formulation containing the same active ingredients as Yaz (drospirenone and ethinyl estradiol) plus an added component, levomefolate calcium (a form of folate).

Q: What does regulatory information state regarding the safety of Yaz use during breastfeeding?

A: Regulatory information indicates the medication is not recommended while breastfeeding. This is due to the possibility of diminution (reduction) in lactation and the fact that the steroid components of the drug are excreted in breast milk.

Q: What should I do if I forget to take a white (inactive) pill in the last week of the cycle?

A: The four white tablets are inert (inactive) and do not contain any hormones. Missing a white tablet is described in official instructions as not impacting the contraceptive effectiveness of the drug.

How should Yaz be stored and disposed of?

How to Store and Dispose of Yaz (Drospirenone/Ethinyl Estradiol)

Yaz tablets must be stored at Controlled Room Temperature, which is maintained at 25 C (77 F). The official label permits temporary temperature excursions between 15 C and 30 C (59 F and 86 F).

Protection and Handling

The medication must be stored in its original, closed container, protected from excess heat, light, and moisture. For safety, Yaz must always be kept out of the reach and sight of children and pets.

Disposal Requirements

Disposal must be conducted according to official local regulations. The product should not be flushed down the toilet or thrown into the drain. Unused or expired medication should be disposed of via a medicine take-back program to mitigate environmental risk.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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