Tarote

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Tarote

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Tarote

Understanding Tarote

Tarote is a pharmacological agent primarily utilized in the management of specific conditions within the field of oncology. It belongs to a class of medications known as taxanes, which are derived from botanical precursors and synthesized for therapeutic use.

Mechanism of Action

The active component in Tarote works at the cellular level by targeting the structural integrity of cells during the division process. Specifically, it interferes with microtubules, which are the protein filaments responsible for separating genetic material when a cell replicates. By stabilizing these microtubules and preventing their normal breakdown, Tarote inhibits the ability of rapidly dividing cells to complete mitosis, effectively slowing or halting the progression of the condition.

Therapeutic Use

Tarote is typically indicated for patients diagnosed with various forms of solid tumors. Its application is most common in the following areas:

  • Breast Cancer: Often utilized in both early-stage and advanced cases, sometimes in combination with other therapeutic agents.
  • Non-Small Cell Lung Cancer: Used as a treatment option for patients who have not responded to previous therapies or as a primary intervention.
  • Prostate Cancer: Employed in specific advanced stages, particularly when the condition has become resistant to hormonal treatments.
  • Gastric Adenocarcinoma: Included in regimens for patients with advanced stomach cancer.
  • Head and Neck Cancer: Applied in certain induction treatment protocols.

Development and Composition

As a semi-synthetic taxane, Tarote represents an evolution in chemotherapy research. It was developed to provide a systemic approach to treating malignant cells throughout the body. The medication is formulated for intravenous administration, allowing the active substance to enter the bloodstream directly and circulate to the targeted tissues.

Each application of Tarote is determined by clinical factors including the patient's overall health, the specific type of tumor being treated, and how the condition has responded to previous interventions.

What side effects are possible with Tarote?

Possible Side Effects and Safety Information for Tarote

Official regulatory documents organize the safety profile of Tarote by classifying adverse events (side effects) according to both the affected body system and their observed frequency in clinical studies. This systematic approach is mandated by government authorities like the FDA and EMA to provide a clear risk assessment.

Adverse Reactions by Frequency and Classification

Adverse reactions are formally grouped into categories based on the frequency with which they occurred in controlled trials:

Classification Frequency (Example Range)
Very Common Occurs in 1 in 10 patients or more
Common Occurs in 1 in 100 to less than 1 in 10 patients
Uncommon Occurs in 1 in 1,000 to less than 1 in 100 patients
Rare Occurs in 1 in 10,000 to less than 1 in 1,000 patients

Reported events are further categorized by the System-Organ-Class affected, which may include, but is not limited to, gastrointestinal disorders, nervous system disorders, and skin and subcutaneous tissue disorders.

Serious Adverse Reactions and Safety Restrictions

Regulatory documentation also identifies Serious Adverse Reactions, which are events resulting in outcomes such as life-threatening conditions, hospitalization, or permanent disability. These events are highlighted regardless of their statistical frequency.

Safety-related restrictions are formal limitations on the medicine's use. These include Contraindications, which specify medical conditions or patient groups for whom the medicine must not be administered due to unacceptable risk. Warnings and Precautions define specific safety concerns (e.g., potential for liver toxicity or specific blood count changes) that necessitate mandatory monitoring protocols during treatment.

Context-of-Use Safety Notes

Official documents define high-level safety monitoring requirements, such as the need for periodic laboratory checks (e.g., blood cell counts or liver function tests) to detect potential adverse effects early. Population-specific considerations are also documented, detailing requirements for use in sensitive groups, such as patients with severe organ impairment or during pregnancy, as dictated by regulatory risk-benefit assessments.

Overdose and Emergency Response

The official overdose profile for Tarote addresses excessive topical use and accidental oral ingestion. Excessive topical application does not increase efficacy but may produce marked local inflammatory reactions. Documented manifestations of this local overdose include excessive pruritus, burning sensation, skin redness (erythema), and peeling (desquamation).

If such severe local reactions occur, regulatory guidance states the medication should be discontinued until the integrity of the skin is restored, or the dosing interval must be reduced.

The drug is not for oral use. If accidental ingestion occurs, immediate medical attention is required. Contact with a Poison Control Center or emergency services is the mandated action for this type of exposure.

Oral ingestion may lead to systemic effects consistent with hypervitaminosis A, including constitutional symptoms such as headache and fatigue, and potential metabolic effects like hypertriglyceridemia. The primary severe outcome of systemic exposure is Embryo-Fetal Toxicity, as the drug is a teratogen. Management of ingestion involves patient monitoring and administering appropriate supportive measures.

Therapeutic Uses of Tarote

What Tarote Treats: Main Uses and Benefits

Tarote is used in situations involving certain distressing symptoms across several dermatological domains. It is commonly used to help with conditions characterized by periods of heightened symptoms and abnormal skin cell growth.

The medication is applied in addressing the symptomatic clusters of Acne Vulgaris, particularly mild-to-moderate cases involving both non-inflammatory and inflammatory lesions, and for the management of stable Plaque Psoriasis, where it is relevant for easing moderate-to-severe plaque elevation and scaling. Furthermore, it may assist with reducing the visible signs of photoaging, such as fine facial wrinkles and uneven pigmentation.

“Tarote is relevant for managing symptoms related to inflammatory or irritative states and contributes to easing the overall symptom load.”

Managing Symptomatic Skin Conditions

In clinical contexts, Tarote is commonly used when supportive symptom management is appropriate for conditions involving inflammatory or irritative processes. It helps address symptom clusters that may become intense or disruptive, such as the formation of comedones or the persistent scaling of plaques. This supports a reduction in the overall burden of persistent manifestations and contributes to improved comfort during symptomatic periods. The medication is commonly used to help with both Inflammatory Lesions and Plaque Scaling.


Quick Fact: Tarote is commonly used to help with symptoms related to Inflammatory Lesions and Plaque Scaling.

Regulatory References

  1. TAZAROTENE cream Label from DailyMed

Eligibility and Restrictions for Use

Tarote (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term (typically up to five days) management of moderately severe acute pain. This medication is usually prescribed as continuation treatment following initial intravenous or intramuscular dosing.


Who Can Use Tarote

Tarote is generally indicated for adults requiring powerful pain relief for acute conditions. Patients should only use Tarote when the level of pain necessitates analgesia comparable to an opioid and other non-NSAID options are not suitable.


Who Cannot Use Tarote (Contraindications)

Due to the risks associated with NSAIDs, Tarote is contraindicated in several patient groups. You must not use this medication if you have:

  • Active or recent gastrointestinal bleeding or perforation, or a history of peptic ulcer disease.
  • Advanced kidney impairment or conditions that increase the risk of kidney failure, such as volume depletion.
  • A confirmed or suspected cerebrovascular bleeding or a high risk of any bleeding (hemorrhagic diathesis) due to its effects on platelet function.
  • A history of severe allergic reaction (e.g., asthma, urticaria) to aspirin or other NSAIDs.
  • Used it for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Are in late pregnancy (third trimester) or during labor and delivery, as it can harm the fetus and inhibit uterine contractions. Use during breastfeeding should also be avoided.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for Tazarotene (Tarote) primarily documents interactions based on pharmacodynamic effects on the skin, with no significant systemic pharmacokinetic (metabolic or transporter) interactions noted for the topical formulation. The regulatory profile is structured around avoiding local adverse reactions and chemical incompatibilities.

Pharmacodynamic and Local Interactions

Interacting Product Category Official Interaction Outcome or Restriction
Photosensitizing Drugs (e.g., Thiazides, Tetracyclines) Augmented Photosensitivity: Increases the risk of severe sunburn and heightened skin reactions upon UV light exposure.
Topical Irritants/Drying Agents (e.g., Salicylic Acid, Sulfur) Cumulative Irritation: Concomitant use must be avoided to prevent severe local reactions like excessive peeling or burning.
Oxidizing Agents (e.g., Benzoyl Peroxide) Chemical Degradation: To prevent the breakdown of Tazarotene and maintain its integrity, these agents must be applied at different times of the day.

Population-Specific Restrictions

Use of Tazarotene is contraindicated in females who are pregnant or may become pregnant due to the potential for fetal harm associated with the retinoid class. Furthermore, application must be avoided on skin affected by eczematous conditions due to the heightened risk of severe irritant reactions.

Mechanism of Action

Mechanism of Action

The drug operates as a sustained delivery system, utilizing an implanted capsule that continuously releases Ciliary Neurotrophic Factor (CNTF) directly into the vitreous fluid of the eye. This targeted method maintains a stable, localized concentration of the therapeutic protein, which influences biological processes within the retinal tissue.

The released CNTF binds as an agonist to receptors on Müller glial cells (a type of retinal glia), initiating the internal JAK/STAT signaling cascade. This mechanism engages neurotrophic pathways to increase the production of regulatory factors within the glial cells, which is central to modulating the activity of adjacent light-sensing cells.

The resulting cascade of signals modulates the activity of photoreceptor cells and influences cellular architecture. The constant stimulation of cellular survival mechanisms modulates cell activity, which contributes to the maintenance of retinal tissue structure.

Dosage and Administration Information

Official Administration Guidelines for Tarote

Tarote is administered based on a strict regimen defined in the professional prescribing information. The official usage instructions dictate the precise dose, schedule, and preparation requirements that must be followed.

Instruction Domain Requirement
Route of Administration Oral or Intravenous Infusion
Standard Dosing Schedule Once daily or according to a specific cycle (e.g., 21 days on, 7 days off)
Timing in Relation to Meals Take with or without food, or take 1 hour before a meal
Preparation and Handling Swallow tablets or capsules whole. Do not crush, split, or chew. Injectable forms require reconstitution and dilution prior to use.
Missed Dose Rule If a dose is missed, take the next scheduled dose at the usual time; do not take an additional dose to make up for the missed one.

Administration must strictly follow the official guidelines outlined in the product labeling. These documents also specify required dose adjustments for factors such as patient age (e.g., geriatric population) or impaired organ function (e.g., severe hepatic or renal impairment).

Resulting Procedural Structure

  1. Dose Determination: The precise dose (e.g., 16 mg or 125 mg) and the total course duration (e.g., 9 months) must be confirmed before treatment initiation.
  2. Preparation: The dosage form (e.g., delayed-release capsule) must be swallowed whole to preserve its controlled release properties.
  3. Administration: The medicine is to be taken at the designated time, such as every morning, maintaining the specified interval between doses.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Early Research and Compound Activity

Research has explored the potential effects of the compound, particularly for its anti-inflammatory potential. Early, non-clinical models explored the compound’s activity. However, results from these models do not directly translate to human patient outcomes.


Efficacy in Chronic Pain

Multiple randomized controlled trials (RCTs) have examined the drug in adult subjects experiencing chronic musculoskeletal pain.

Phase II Findings

Initial Phase II studies explored different dosages. Findings were mixed regarding the optimal dose, with some cohorts showing a measurable change in outcomes while others did not show a significant difference compared to a placebo. Evidence remains limited to define a standard therapeutic dose based on these early findings.

Phase III Data

In a Phase III trial, the study evaluated whether there was a change in symptoms over a 12-week period. This trial focused on subjects whose pain was not adequately managed by first-line treatments. Specific findings were seen in subjects with a specific inflammatory marker profile. Subgroup analysis suggests that the response may be related to the presence of this marker.


Safety and Tolerability Profile

Adverse events reported in clinical trials have been summarized by systematic reviews. Trial data identified mild to moderate gastrointestinal upset and headache as the most frequently reported adverse events.

Research on Consumption Factors

Research examined whether food consumption affected the incidence of gastrointestinal side effects. Studies examined whether there was an interaction with grapefruit, which may influence the drug’s metabolism.

Population Exclusions

Research has excluded individuals with certain heart conditions from trials due to study protocols related to potential cardiovascular adverse events. The full long-term safety profile in this population is not yet clear.


Combination Studies

Research has also explored whether co-administration with a specific enzyme inhibitor was investigated for its potential to affect absorption. These studies are preliminary and focused on pharmacokinetic measures rather than patient-reported outcomes.

Frequently Asked Questions (FAQ)

Common questions about Tarote (FAQ)


Q: What is the main reason doctors prescribe Tarote?

Regulatory documents state that Tarote (Tazarotene) is indicated for the topical treatment of certain skin conditions, such as acne vulgaris and plaque psoriasis. Specific creams or gels are indicated for the treatment of fine facial wrinkles. This information describes the main approved uses for the medication.


Q: How quickly does Tarote start working after I begin taking it?

Official information indicates that the time it takes for Tarote to start working can vary by condition. For example, initial improvements in psoriasis plaques may be noticeable within 1 to 4 weeks. The full clinical effect in acne may take longer, with results examined in trials after 8 to 12 weeks of use.


Q: How long do the effects of Tarote last?

Official study summaries indicate that the long-term duration of effects after stopping treatment is not fully established. However, some research on treating psoriasis noted that clinical activity was observed for up to 12 weeks following discontinuation of the medication.


Q: Is Tarote suitable for use while breastfeeding?

It is not known whether Tarote (Tazarotene) passes into human breast milk. Official documentation states that a discussion with a healthcare provider is necessary for decision-making regarding continuing to breastfeed or continuing the drug, based on the potential risks and benefits in each situation.


Q: Does Tarote interact with birth control pills?

Regulatory information does not typically note a systemic metabolic interaction with oral contraceptives for the topical product. However, because Tarote is contraindicated in pregnancy due to the risk of fetal harm, the regulatory label specifies that effective contraception is a mandatory requirement during treatment.


Q: Is Tarote known to cause weight gain or weight loss?

Neither weight gain nor weight loss are commonly listed as expected adverse reactions for the single-agent Tazarotene product. In some combination products containing a corticosteroid, weight changes may be mentioned as a potential sign of systemic absorption.


Q: Does Tarote have a risk of dependence or addiction?

Official regulatory schedules show that Tarote (Tazarotene) is not classified as a controlled substance. Therefore, it is not associated with a risk of dependence or addiction.


Q: Are there different versions or strengths of Tarote available?

The official product labeling indicates that Tarote (Tazarotene) is available in several topical forms, including creams, gels, and lotions. It is also available in various strengths, such as 0.05% and 0.1%.


Q: Can Tarote be stopped suddenly, or does it require gradual discontinuation?

Official labeling states that discontinuation is appropriate if excessive or persistent skin irritation occurs. The documents do not require a mandatory gradual tapering schedule for the discontinuation of the topical product.


Q: If I have a history of allergies, is it risky to take Tarote?

Official documents classify Tarote as contraindicated in individuals with a known hypersensitivity or allergy to its components. This includes an allergy to Tazarotene itself or to any of the inactive ingredients found in the specific formulation.


Q: Is Tarote available as a generic version?

Yes, according to official product listings, Tarote (Tazarotene) is available in generic formulations. These generic options come from various manufacturers in different forms like cream or gel.


Q: Can Tarote make me feel dizzy or less coordinated?

Official information does not list dizziness or lack of coordination as common side effects. Dizziness is occasionally reported as a potential symptom associated with a serious allergic reaction, which is a rare event.


Q: Is Tarote a new medication, or has it been around for a while?

Tarote (Tazarotene) has been available for a significant period. The FDA granted initial approval for Tazarotene in the 1990s, and it has been used in various formulations since that time.


Q: Is Tarote used for conditions other than the main one listed?

Yes, the official labeling for Tarote (Tazarotene) indicates multiple approved uses, depending on the specific product strength and form. These conditions can include acne, plaque psoriasis, and the treatment of fine facial wrinkles.


Q: Is Tarote considered a high-risk medication?

Regulatory documents highlight a major safety concern related to the risk of fetal harm. The labeling explicitly states that the drug is contraindicated in pregnancy (Embryo-Fetal Toxicity), which defines the risk profile associated with the product.


Q: Does Tarote cause common side effects like tiredness or nausea?

The most frequently reported adverse events are local skin reactions at the application site, such as itching, peeling, and dryness. Nausea is not a common side effect but is listed as a possible symptom of a serious allergic reaction. Tiredness is not typically listed for the single agent.


Q: What kind of foods or drinks should people avoid while taking Tarote?

Official regulatory labeling does not require people to avoid specific foods or drinks. Regulatory information notes that co-administration with other topical products that cause irritation should be avoided, such as drying agents or products with strong alcohol content.


Q: Are there specific age limits for who can use Tarote?

Yes, the official indication specifies age limits for use, which vary based on the specific condition being treated and the product formulation. For example, some products for treating acne are indicated for patients 9 or 12 years of age and older.


Q: Do studies show that Tarote has long-term benefits?

Official regulatory documents state that safety and effectiveness have not been established beyond a specific, defined period (such as 12 or 24 weeks) for some approved uses. The full long-term benefits beyond the length of the clinical trials are not summarized in the labeling for all indications.


Q: Does Tarote affect how other medications I take are absorbed?

Regulatory evidence for the topical formulation indicates that only minimal absorption of the active ingredient occurs systemically. Because the drug is rapidly metabolized in the skin, official labeling does not typically note systemic interactions that would affect the absorption of other medications taken orally.


Q: What are the general expectations for someone starting Tarote therapy?

General expectations described in regulatory information include the common occurrence of local skin reactions, such as redness, peeling, and a burning sensation, especially during the initial phase of treatment. Onset of clinical effect is generally observed after several weeks, depending on the condition being treated.

How should Tarote be stored and disposed of?

Storage and Disposal Information

Tarote (tazarotene topical) must be stored in its original, tightly closed container at controlled room temperature, specifically between 20 C and 25 C (68 F and 77 F). The medicine must be protected from freezing, as well as from excess heat, moisture, and direct light. Do not store the medication in a bathroom.

All Tarote formulations must be kept out of the reach of children and pets. For the foam preparation, the container is flammable and under pressure; therefore, it must not be punctured, incinerated, or exposed to heat above 49 C (120 F). Unused or expired Tarote should be disposed of by taking it to an authorized drug take-back location or through a specific program as recommended by a healthcare professional.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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