Voydol

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Voydol

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Voydol

Voydol: Definition and Pharmacological Class

Property Description
Active Ingredient Ketorolac tromethamine
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common Use Short-term management of acute pain
Origin Synthetic organic compound
Key Forms Tablet, Injectable solution, Nasal spray, Ophthalmic solution

Voydol is a non-narcotic, prescription-only medication whose active component is ketorolac tromethamine, classified as a powerful Nonsteroidal Anti-inflammatory Drug (NSAID). This distinction clarifies that, unlike opioid medications, it is not a controlled substance and does not carry the associated risks of dependency. Its structural classification places it in the unique pyrrolo-pyrrole group of NSAIDs, chemically differentiating it from common over-the-counter pain relievers.

This drug is clinically recognized for its high-level analgesic activity and is specifically intended for the short-term relief of moderate-to-severe acute pain. This agent is frequently employed to manage pain severity comparable to that treated by opioid alternatives, offering a non-controlled therapeutic option. The primary mechanism involves functioning as a non-selective cyclooxygenase (COX) inhibitor, blocking the enzymatic pathway that produces prostaglandins, which are the chemical mediators responsible for signaling pain and inducing inflammation.

Composition, Origin, and Available Pharmaceutical Preparations

The active component, ketorolac tromethamine, is a synthetic organic compound and a single-entity product. It is supplied as a racemic mixture, where the biologically active S-enantiomer is responsible for the medicinal effect.

This medicinal entity is supplied in various pharmaceutical preparations to enable different routes of administration, including the oral tablet, a sterile injectable solution for intramuscular or intravenous routes, a nasal spray, and the ophthalmic solution (eye drops). The availability of an injectable form, for instance, distinguishes it from many common NSAIDs, underscoring its role in clinical settings where rapid, systemic pain control is required.

Regulatory References

  1. MedlinePlus Drug Information
  2. NIH StatPearls

What side effects are possible with Voydol?

Possible Side Effects and Safety Information

Voydol (Ketorolac) is an Nonsteroidal Anti-inflammatory Drug (NSAID) with a safety profile requiring careful consideration, which is strictly limited to short-term use. Prolonged use or higher doses increase the risk of serious adverse events.


Serious and Clinically Significant Risks

Official regulatory documents contain a Boxed Warning highlighting two primary, potentially fatal risks:

  • Cardiovascular Thrombotic Events: Voydol may increase the risk of serious heart attack, stroke, and related cardiovascular events, which can occur without warning. This risk may increase with duration of use.
  • Gastrointestinal (GI) Risk: The drug carries a significant risk of causing GI bleeding, ulceration, and perforation of the stomach or intestines. These serious GI events can also occur at any time without prior symptoms.

Additionally, serious events involving the liver (hepatotoxicity), kidneys (acute renal failure), and hypersensitivity (anaphylaxis and severe skin reactions like Stevens-Johnson Syndrome) are documented.

Adverse Reaction Categories

Commonly reported adverse effects (occurring in 1% to 10% of patients in clinical trials) include headache, dizziness, drowsiness, diarrhea, nausea, dyspepsia, and abdominal pain.

Contraindications and Limitations

Voydol is contraindicated in patients with a history of GI bleeding or peptic ulcer disease, advanced renal impairment, cerebrovascular bleeding, and concurrently with other NSAIDs or anticoagulants. The combined total duration of use for all forms of Voydol is not to exceed five days.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory profile for Voydol (ketorolac tromethamine) overdose focuses on documenting clinical manifestations, severe potential outcomes, and mandated emergency actions.

Aspect Officially Documented Information
Documented Manifestations Symptoms of an acute oral overdose may include gastrointestinal signs such as nausea, vomiting, abdominal pain, or epigastric pain. Central nervous system effects such as lethargy, drowsiness, and hyperventilation have also been reported in regulatory records.
Severe Outcomes The label documents the potential for serious complications, including gastrointestinal bleeding, acute renal failure, hypertension, and, in rare instances, coma or respiratory depression.
Emergency Action Immediate medical help must be sought if an overdose is suspected. Regulatory guidance requires individuals to get medical help right away, contact a Poison Control center, or call emergency services if severe symptoms are present.
Management Note No specific antidote is known for this medication. Overdose management is limited to providing symptomatic and supportive care. Specific procedural measures, such as the administration of activated charcoal, may be indicated in a regulated context for certain large oral ingestions, typically when seen within four hours.

The information confirms that while most acute presentations are reversible with supportive care, the potential for life-threatening renal and gastrointestinal complications necessitates an urgent response as defined by regulatory authorities.

Therapeutic Uses of Voydol

What Voydol Treats: Main Uses and Benefits

Voydol (ketorolac tromethamine) is a prescription medication applied across domains where additional symptomatic support is needed for the short-term management of physical distress. This medication is commonly used to help with symptoms related to physical discomfort. Its therapeutic benefit may be applied in conditions associated with acute or disruptive episodes and is relevant in **clinical settings that involve acute or unstable symptom patterns.

Symptomatic Support for Acute Discomfort

This medication is relevant for easing symptom clusters that may become intense or disruptive and relate to inflammatory or irritative states following trauma or surgical procedures. Common applications may assist with symptoms of physical discomfort, such as acute pain following procedures, discomfort associated with severe injuries, and relief for acute ocular inflammation.

Patient Benefit and Stability

The primary therapeutic benefit contributes to easing the overall symptom load and supports patients during episodes of heightened discomfort. This supportive relief may assist with maintaining functional stability when symptoms interfere with routine activities.


Quick Fact: Symptomatic Support for Acute Pain Voydol is relevant in contexts requiring short-term support for symptoms related to physical discomfort that interfere with daily functioning.

Regulatory References

  1. NIH MedlinePlus overview of Ketorac

Eligibility and Restrictions for Use

Official Eligibility Rules for Voydol Use

Official regulatory documentation defines the eligible population for Voydol (ketorolac tromethamine) primarily as adult patients for short-term management. The total duration of combined systemic therapy (oral and injectable forms) is strictly limited to five days.

Populations for Whom Use is Contraindicated

Contraindication Category Official Regulatory Statement
Gastrointestinal Risk Active peptic ulcer disease, recent GI bleeding or perforation, or a history of these conditions.
Renal Risk Advanced renal impairment or risk of renal failure due to volume depletion.
Bleeding Risk Suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, or high risk of bleeding.
Hypersensitivity Known allergy to ketorolac tromethamine or allergic reactions to aspirin or other NSAIDs.
Concomitant Use Patients currently receiving aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs), probenecid, or pentoxifylline.
Surgical Setting Treatment of pain during the peri-operative setting of Coronary Artery Bypass Graft (CABG) surgery; use as a prophylactic analgesic before any major surgery.

Age-Related and Condition-Specific Restrictions

Pediatric Patients: The medicine is not indicated for use in pediatric patients, as safety and efficacy for systemic use are generally not established in those under 17 years of age.

Geriatric Patients (Age ge 65): Use requires conditional restriction, including the need for a reduced total daily dose.

Pregnancy and Lactation Status: Use is contraindicated in the third trimester of pregnancy, during labor and delivery, and is contraindicated in nursing mothers (lactation).

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section outlines interactions for Voydol (ketorolac tromethamine) as documented in official government regulatory sources, detailing specific substance prohibitions and pharmacokinetic effects.

Formal Interaction Restrictions

Category Prohibited Combinations / Restrictions
Drug–Drug Prohibitions Co-administration is formally contraindicated with Aspirin, other NSAIDs, Probenecid, Oxpentifylline (Pentoxifylline), and Anticoagulants (such as Warfarin and prophylactic low-dose Heparin) due to increased exposure risk or additive adverse effects.
Administration Restriction The total combined duration of treatment (oral and parenteral) must not exceed five days. The injectable solution must not be mixed with certain other solutions, like Morphine Sulfate, due to documented physical precipitation.

Pharmacokinetic and Pharmacodynamic Effects

Co-administration with Lithium results in the elevation of plasma lithium levels and a reduction in renal lithium clearance. The interaction with Methotrexate is defined by Voydol inhibiting its renal accumulation, which may enhance toxicity.

Regarding pharmacodynamic effects, Voydol can reduce the intended natriuretic effect of Diuretics and increases the risk of renal impairment when combined with ACE Inhibitors or ARBs. Official documents also note that a high-fat meal reduces the peak plasma concentration and delays the time to reach maximum concentration of the oral formulation.

Mechanism of Action

The mechanism of action is rooted in its function as a non-selective, competitive inhibitor of the Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) enzymes. This binding activity prevents the conversion of arachidonic acid into prostanoids, initiating the drug’s pharmacological cascade. This enzymatic blockade is critical because it intercepts the primary synthetic step for key physiological mediators.

By sharply reducing the synthesis of Prostaglandin E2 (PGE2), the drug alters the transmission of nociceptive signals. PGE2 typically sensitizes peripheral sensory nerve endings; therefore, its decreased concentration results in a decreased sensitization of these fibers to nociceptive stimuli. This action modulates the activity of peripheral and central signaling pathways, influencing the physiological response patterns linked to mediator release. The effect profile stems directly from the drug’s specificity to the prostanoid pathway. This mechanism is physiologically constrained, meaning it only modulates processes dependent on COX-derived mediators and does not modulate non-prostanoid signaling systems.

Dosage and Administration Information

Voydol (ketorolac tromethamine) is administered via multiple official routes, including Intravenous (IV) and Intramuscular (IM) injection, Oral tablet, and Nasal spray. The usage protocol mandates a sequential approach for systemic treatment that must not exceed 5 total days across all formulations combined.

The medication is intended to begin with the injectable forms, typically administered as 30 mg every 6 hours for adults under 65 years, up to a maximum of 120 mg per day. For parenteral administration, the IV bolus must be delivered over no less than 15 seconds, while IM injections require a slow and deep technique.

The Oral tablet is strictly indicated only for continuation therapy following initial parenteral treatment; it is not approved to initiate the course. The standard oral regimen is 10 mg every four to six hours, with the total daily oral dose not to exceed 40 mg. The nasal spray provides an alternative non-injectable systemic route, typically dosed at 31.5 mg every six to eight hours.

Specific population rules govern the systemic dosing. A reduced maximum daily dose is required for patients 65 years and over, individuals with low body weight, and those with renal impairment. For these groups, the maximum IV/IM dose is limited to 60 mg per day. The instructions note that exceeding the regulatory maximums does not increase efficacy.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Phase III Clinical Trials

Research focused on patients aged 18 to 75 with severe, uncontrolled asthma. These participants were already receiving high-dose maintenance therapy with inhaled corticosteroids (ICS) and at least one other controller medication at the time of study enrollment.

The primary research question was whether the study drug could influence lung function (measured by forced expiratory volume) in this severe asthma patient population. Secondary endpoints included the measured rate of severe asthma exacerbations and health-related quality of life measures.


Findings Related to Asthma Exacerbations

The reviewed clinical data indicated that studies examined the frequency of severe asthma exacerbations in relation to the drug's use. The studies defined a severe exacerbation as an event requiring the use of systemic corticosteroids for at least three days, or a hospitalization.

Research explored the potential for this specific type of therapy to influence health-related quality of life measures in individuals with asthma. These measures covered aspects like physical functioning, emotional state, and limitations due to asthma symptoms.

One key study reported on the timeframe until a measured clinical change was observed in some participants (e.g., within 12 weeks).


Evaluation of Concomitant Therapy

Studies evaluated whether the use of the drug was related to a change in oral corticosteroid (OCS) dosage in patients dependent on OCS for asthma control. The analysis evaluated the proportion of participants who were able to reduce their OCS dose while maintaining a pre-defined level of asthma control.

Research evaluated the drug’s potential influence on various biomarkers measured during the studies.

Combination Therapy Studies

Research has also explored the use of the drug in combination with established therapies, such as a long-acting beta-agonist (LABA) and an inhaled corticosteroid (ICS). The studies reviewed examined drug levels and exposure (pharmacokinetics) in these combination settings.

The study design specified that participants received the study drug concomitantly with their existing standard maintenance therapies.

Frequently Asked Questions (FAQ)

Common questions about Voydol (FAQ)

Q: Is Voydol the same kind of medicine as [similar generic name]?

A: Official information classifies Voydol (ketorolac tromethamine) as a Nonsteroidal Anti-inflammatory Drug (NSAID) that belongs to a specific chemical group called pyrrolo-pyrrole. This classification means it is chemically distinct from other common NSAIDs. The medication is recognized for its analgesic activity.


Q: How quickly should someone notice the effects of Voydol?

A: According to the official product information, the drug's peak pain-relieving effect is typically reached within approximately 2 to 3 hours after administration. This timeframe reflects when the concentration of the drug in the body is at its highest, corresponding to the maximum measured analgesic effect.


Q: Does Voydol cause weight changes, like gain or loss?

A: Regulatory documents do not list general weight changes as a common or frequent adverse reaction. However, edema, which is swelling caused by fluid retention, is documented as a less common adverse effect of this medication. Fluid retention can sometimes be associated with a change in weight.


Q: Is there a generic version of Voydol available yet?

A: Yes, the active ingredient in Voydol is ketorolac tromethamine. Because the active ingredient's patent has expired, generic versions of this medication are available through various manufacturers.


Q: Can Voydol be taken alongside common pain relievers like ibuprofen?

A: Official guidance strictly contraindicates taking Voydol with aspirin or any other Nonsteroidal Anti-inflammatory Drug (NSAID), which includes medications like ibuprofen. This restriction is in place because combining them significantly increases the cumulative risk of severe, NSAID-related side effects, such as gastrointestinal bleeding.


Q: Why is Voydol sometimes prescribed off-label (for informational clarification only)?

A: Voydol is officially approved for the short-term management of acute pain in adults. However, authoritative medical sources note that its use is sometimes explored in other populations, such as in pediatric pain management, or for pain control in specific contexts, though these uses are not included in the official label indications.


Q: Does Voydol require special handling or storage conditions?

A: Specific forms of Voydol, such as the nasal spray, have special handling requirements. The label requires storage of the unopened nasal spray in the refrigerator and protection from light. The label also stipulates that the opened spray should be discarded 24 hours after the first use.


Q: Can you just stop taking Voydol, or do you have to lower the dose slowly?

A: Voydol is strictly approved for the short-term management of acute pain, and the total course of therapy for all forms combined must not exceed five days. Due to this mandated short-term limit, official regulatory information does not indicate that a slow reduction of the dose, often called tapering, is required when discontinuing the medication.


Q: Is it normal to feel slightly dizzy when you first start Voydol?

A: Dizziness and drowsiness are both listed in regulatory documents as commonly reported adverse effects of the drug. These are effects that are known to occur in a percentage of patients using the medication.


Q: What happens if you miss a dose of Voydol?

A: Regulatory patient information includes guidance stating that if a dose is missed, the medication should be taken as soon as possible, or skipped if it is almost time for the next scheduled dose. The guidance also advises against taking a double dose to compensate for a missed one.


Q: Are there any food restrictions while taking Voydol?

A: Official documents note that consuming a high-fat meal may affect the pharmacokinetics (how the drug is absorbed), potentially reducing the medication's peak concentration in the body. Additionally, official guidance sometimes suggests taking tablets with food or an antacid to help reduce the risk of stomach upset.


Q: How long does Voydol stay in your system after the last use?

A: The elimination half-life of the drug, which is a measure of how long it takes for the amount in the body to decrease by half, generally ranges from 5 to 6 hours. The majority of the drug and its metabolites are eliminated from the body through the urine.


Q: What is the list of inactive ingredients in Voydol tablets?

A: The inactive ingredients in the tablet form, as listed in the FDA label, are intended to help stabilize the pill and aid absorption. They include lactose, magnesium stearate, microcrystalline cellulose, hydroxypropyl methylcellulose, polyethylene glycol, titanium dioxide, and FD&C Red #40 Aluminum Lake.


Q: Are there common reasons why people might stop taking Voydol?

A: The primary reason for stopping the drug is the mandatory regulatory limit of five days of use for all patients. Beyond this, common reasons for discontinuation in clinical trials include adverse effects such as headache, nausea, and gastrointestinal pain. The drug also carries a risk of serious events like GI bleeding or acute renal failure.


Q: Are there common non-drug interactions with Voydol (like sunlight or heat)?

A: Official labeling includes a report of photosensitivity (an increased skin sensitivity to sunlight) as a potential adverse reaction. This effect may result in a need for protective measures when exposed to direct sun.


Q: Is Voydol supposed to be taken indefinitely or just for a short time?

A: Voydol is approved for the short-term management of moderately severe acute pain. Official warnings clearly state that the total combined duration of treatment, including all forms, must not exceed five days. It is not intended for chronic or indefinite use.


Q: What is the difference between Voydol and a supplement?

A: Voydol is a prescription-only medication officially classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). Unlike a supplement, which is regulated as food, this drug is regulated and approved by governmental health agencies as a pharmacological drug used to treat a medical condition.


Q: Are the side effects of Voydol worse in the first week?

A: Official regulatory information indicates that the risk of serious adverse events, such as cardiovascular and gastrointestinal complications, may increase with the total duration of use. The overall rate of adverse reactions is generally linked to increasing doses, rather than a specific time frame like the first week.


Q: Can Voydol change the results of blood tests?

A: Yes, official regulatory documents note that the use of the drug may lead to changes in certain lab values. These reported changes include elevated liver enzymes, increased bleeding time due to the drug's effect on platelets, and abnormal renal (kidney) function test results.


Q: Does Voydol cause dry mouth?

A: Dry mouth (xerostomia) is listed in official regulatory documents as a reported adverse reaction. This is generally listed under the gastrointestinal system category of side effects.


Q: Is it normal if my urine looks slightly different when taking Voydol?

A: Official documents note that the drug can potentially affect the urinary system. Reported adverse reactions in this area include changes such as painful urination, increased or decreased urinary frequency, and hematuria (blood in the urine).

How should Voydol be stored and disposed of?

Storage and Disposal of Voydol

The official labeling defines specific requirements for storing and discarding Voydol (ketorolac tromethamine) to ensure its quality.

Storage Requirements

Voydol must be stored at room temperature and away from excess heat and moisture; storage in humid environments like a bathroom is prohibited. The tablets must be kept in the original container and the container must remain tightly closed when not in use. For child safety, the medication must be stored out of the sight and reach of children.

Stability and Disposal

The product is only stable for a limited period after its first use. After the first opening of the bottle, the tablets must be used or discarded within 48 days. Disposal of any unused or expired Voydol must be conducted in accordance with local requirements for pharmaceutical waste, such as authorized drug take-back programs, rather than flushing down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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