Sultan

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Sultan

Property Description
Active ingredient Diphenhydramine Hydrochloride
Pharmacological class First-generation Antihistamine
Origin Synthetic compound
Primary Forms Oral solids (e.g., tablets), Oral liquids, and Topical preparations
General Purpose Relieves allergic discomfort and promotes sleep

What Type of Medicine is Sultan (Diphenhydramine)?

Sultan is the name given to a medication whose core ingredient is the synthetic compound Diphenhydramine Hydrochloride, which is scientifically classified as a first-generation antihistamine. This chemical agent is typically offered as a single-ingredient product, which simplifies its action profile. Diphenhydramine’s classification as a first-generation compound is clinically recognized for its capacity to easily cross the blood-brain barrier. This inherent CNS-penetrating ability is a key differentiating factor from newer antihistamine generations and is the foundation of its unique properties.

How Does Sultan’s Classification Relate to its General Use?

The antihistamine classification means the drug's core action involves competitively blocking histamine from binding to H1 receptors throughout the body, thereby preventing the chemical cascade that triggers allergic discomfort. Due to its specific first-generation chemical structure, the compound is pharmacologically noted for its significant side effect of sedation. Diphenhydramine is recognized for its capacity to induce sleep and manage allergic conditions. Consequently, the medication’s primary benefit is its dual capacity: effective relief from symptoms like itching or a runny nose, and the provision of a restful effect useful for temporary sleeplessness.

In What Physical Forms Is Sultan Available?

The active compound is manufactured for both systemic and topical use, offering a range of dosage forms to match different user needs. Systemic preparations include oral solids (tablets, capsules) and oral liquids (syrups), primarily absorbed through the gastrointestinal tract. Conversely, topical forms, such as creams and gels, are designed for external application to the skin. This versatility, offering both internal and external routes, defines the product’s broad scope, allowing for focused relief of localized conditions like hives or generalized relief for systemic allergic responses.

What side effects are possible with Sultan?

The safety profile of Sultan (Diphenhydramine) is characterized by effects primarily related to its action as a first-generation antihistamine, focusing on the central nervous system (CNS) and anticholinergic activity, as documented in official regulatory labeling.

Adverse Reaction Classifications

The most frequent adverse reactions noted in regulatory documents are sedation and sleepiness. Other common effects include dry mouth, dry nose, dry throat, dizziness, and disturbed coordination. Adverse reactions are categorized by the physiological system affected, including the Nervous System, Gastrointestinal System, and Cardiovascular System.

Rare but serious adverse reactions documented in official sources include anaphylactic shock and specific blood disorders such as hemolytic anemia, thrombocytopenia, and agranulocytosis.

Population-Specific Safety Considerations

Specific safety warnings exist for certain populations:

  • Pediatric Patients: Use is contraindicated in neonates or premature infants. The label notes that the medication may cause paradoxical excitation in young children, and overdosage carries risks of convulsions or death.
  • Older Adults: Individuals aged 60 and older are more likely to experience effects such as dizziness, sedation, and hypotension, along with increased risk of confusion and anticholinergic effects.
  • Lactation: The medication is contraindicated in nursing mothers due to the risk to the infant.

Safety Restrictions and Limitations

Official labeling mandates caution in individuals with specific pre-existing conditions, including narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, and bladder-neck obstruction.

Overdose and Emergency Response

A Sultan overdose results in a spectrum of toxicity affecting the central nervous system (CNS) and the cardiovascular system. Documented overdose presentations range from CNS stimulation, including agitation, hallucinations, seizures, and delirium, to severe CNS depression leading to drowsiness, coma, and respiratory depression. Clinical signs of anticholinergic syndrome, such as mydriasis (dilated pupils), dry mouth, and urinary retention, are also officially recognized.

The most serious outcomes warned by regulatory authorities include ventricular dysrhythmias, QRS widening, and cardiovascular collapse, which can lead to death.

Official regulatory documents mandate that medical help must be sought immediately when critical signs are observed. Seek immediate medical attention or contact poison control if the person is hallucinating, cannot be awakened, has a seizure, has trouble breathing, or has collapsed.

Management of overdose is defined as symptomatic and supportive, and no specific antidote is available. Interventions may include activated charcoal and mandatory Electrocardiogram (ECG) monitoring to assess for cardiac risk. Overdose in pediatric patients is particularly associated with excitation and an increased risk of convulsions, while elderly patients are more susceptible to hypotension and sedation.

Therapeutic Uses of Sultan

Quick Facts: Therapeutic Domain

  • Acute Treatment: Migraine headache, with or without aura.
  • Acute Treatment: Cluster headache episodes.

Sultan is designated for the relief of symptoms associated with specific headache manifestations. Its approved indication is focused on the treatment of acute episodes of migraine headache, which may present with or without a preceding aura. It is important to note that Sultan is intended for acute disorder management and should not be used for preventative care of these conditions. The benefit of this medication is observed through its action during a migraine event, providing symptomatic relief.

The medication is also utilized in the acute treatment of cluster headache episodes, another severe form of headache manifestation. Its therapeutic application requires that it be taken as directed after the onset of the episode but not as a regular daily preventative measure for the condition. This focus on acute disorder management defines its primary clinical utility.

Eligibility and Restrictions for Use

Sultan (Diphenhydramine HCl) has distinct population eligibility rules defined by official regulatory bodies, primarily related to age, physiological status, and pre-existing health conditions.

Absolute Contraindications (Do Not Use)

Sultan must not be used by the following populations or those with these conditions, as documented in regulatory labels:

  • Infants and Mothers: Premature infants, neonates, and nursing mothers (lactation).
  • Hypersensitivity: Patients with known allergy to diphenhydramine HCl or antihistamines of a similar chemical structure.
  • Gastrointestinal: Patients with stenosing peptic ulcer or pyloroduodenal obstruction.

Age and Conditional Use Restrictions

  • Pediatric Use: Use in children under 6 years is often restricted or requires the direction of a doctor. Use as a nighttime sleep-aid is not established for those under 12 years.
  • Older Adults: The medicine is generally not recommended for use in older adults (aged approx 60 or older) due to increased risk of adverse effects, though it is used for managing severe allergic reactions.
  • Pregnancy: Use during pregnancy is not recommended unless clearly needed. Use during the third trimester may result in adverse reactions in the newborn.

Restrictions for Existing Conditions

Sultan must be used with considerable caution or under medical guidance in patients with specific conditions, including:

  • Ocular/Urinary: Narrow-angle glaucoma, symptomatic prostatic hypertrophy, or bladder-neck obstruction.
  • Respiratory: Bronchial asthma, emphysema, or chronic obstructive pulmonary disease ( COPD).
  • Organ Function: Patients with moderate to severe hepatic impairment or renal impairment are identified as requiring caution.

What should I know about interactions with other medicines?

The interaction profile for Sultan (Diphenhydramine) is structured by formal restrictions against specific drug classes and warnings about additive pharmacological effects. All documented interaction information is based strictly on regulatory labeling.

Interaction Category Official Regulatory Statement
Contraindicated Combination Co-administration with Monoamine Oxidase Inhibitors (MAOIs) is prohibited. This combination prolongs and intensifies the drug’s anticholinergic effects, and the restriction applies for at least two weeks after MAOI therapy is discontinued.
Pharmacodynamic Additive Effects The medication has additive effects with Central Nervous System (CNS) Depressants, including opioids, sedatives, hypnotics, and tranquilizers, resulting in amplified drowsiness. Similar potentiation occurs with other anticholinergic drugs.
Pharmacokinetic Effects The drug is documented as an inhibitor of the CYP2D6 enzyme. This interaction may reduce the clearance of other medicinal products metabolized by CYP2D6, potentially leading to increased systemic exposure of co-administered drugs, such as Metoprolol.
Substance Interaction The drug has an additive CNS depressant effect with alcohol (ethanol), requiring regulatory-aligned constraints on concurrent use. No known interaction is documented in the official regulatory prescribing information for food.

Population-Specific Caution

Interaction-related effects, specifically excessive sedation and hypotension, are noted to be more significant in elderly patients when co-administered with other interacting substances.

Mechanism of Action

Central Arousal Pathway Suppression

The mechanism requires the drug to cross the blood-brain barrier and act as an inverse agonist at the brain's Histamine H1 receptors . This engagement suppresses the activity of histaminergic neurons, which are key components of the sleep-wake cycle and arousal system, resulting in a modulated signaling state within the arousal system.


️ Peripheral H1 Blockade and Vascular Modulation

A concurrent mechanism involves the binding and antagonism of H1 receptors located in peripheral tissues, such as those lining blood vessels and sensory nerves. This action alters local physiological responsiveness by limiting histamine-mediated effects on capillary permeability and sensory nerve depolarization.


️ Cholinergic System and Autonomic Modulation

The drug also engages a distinct molecular target by acting as a competitive antagonist at Muscarinic Acetylcholine Receptors in both central and peripheral pathways. This secondary mechanism modulates the cholinergic system, which alters signaling related to involuntary smooth muscle contraction and modulates input from the vestibular system's afferent pathways.

Dosage and Administration Information

Administration Overview

Sultan is typically administered as an oral tablet. The medication should be taken consistently to maintain stable levels within the bloodstream. It is generally recommended to take the tablet with a full glass of water.

Food Interactions

The absorption of the medication may be influenced by food intake. Depending on the specific formulation, it may be advised to take the dose either on an empty stomach or with a meal. Following a consistent routine regarding food can help ensure the medication performs predictably.

Handling and Storage

  • Storage: Keep the medication in its original packaging to protect it from moisture and light.
  • Temperature: Store at room temperature, away from excessive heat or direct sunlight.
  • Consistency: Taking the medication at the same time each day helps in maintaining a regular schedule.

Missed Routine

If a scheduled application is missed, the routine should typically resume with the next planned event. Maintaining the regular cycle is the primary focus for long-term management. Users should be aware of their daily schedule to minimize disruptions in the regimen.

Recent Clinical Evidence

Evidence for use in Rheumatoid Arthritis (RA)

Research exploring Sultan's application in Rheumatoid Arthritis has involved various studies, primarily focusing on conditions characterized by functional limitations and periods of heightened symptom activity. The most comprehensive information comes from short-term and intermediate-term randomized controlled trials (RCTs). These studies compared Sultan to an inactive substance (placebo) or an active control.

Researchers examined a variety of outcomes related to physical discomfort and outcomes reflecting daily functioning or activity level. Studies report patterns of change in these disease activity scores measured during the study period. However, the exact extent of these reported changes may vary across different patient populations and across different studies.


Evidence for use in Ulcerative Colitis (UC)

Sultan was studied for Ulcerative Colitis, a condition characterized by fluctuating or episodic manifestations and symptoms linked to inflammatory or irritative states. Research included two main types of controlled trials: short-term induction studies and longer-term maintenance studies.

Studies primarily measured two distinct sets of outcomes. The first set focused on monitored clinical endpoints, meaning that the patient's symptoms returned to a level that researchers classified as inactive. The second set involved endoscopic outcomes. Data describe patterns related to the monitored clinical endpoints in the short-term induction phase.


What is Still Uncertain About Sultan Research

Despite the existing body of research, several aspects of Sultan remain uncertain. Evidence is limited for comprehensive, long-term follow-up that is crucial for chronic conditions. Comparative evidence is lacking for direct, head-to-head trials against all available treatments, making it difficult to contextualize its observed patterns versus every available option. Furthermore, subgroup findings are uncertain due to modest sample sizes within certain defined populations. Research is ongoing to fill these identified gaps.

Frequently Asked Questions (FAQ)

Common questions about Sultan (FAQ)


Q: How long does it usually take to feel the initial effects of Sultan?

A: According to the official prescribing information, a single oral dose of Sultan is absorbed quickly, with the initial onset of activity occurring in approximately 30 minutes. The maximum effects typically occur within one to two hours after administration.


Q: What is the typical age range for people who use Sultan?

A: According to the official product information, dosing guidelines are provided for use in adults and in pediatric patients typically starting at approximately two years of age. However, the medication is contraindicated for use in neonates and premature infants due to specific safety concerns.


Q: Can Sultan be taken with common over-the-counter pain relievers?

A: Official information indicates that Sultan can generally be taken with common non-opioid pain relievers such as acetaminophen or ibuprofen. However, concurrent use with prescription painkillers that contain opioids may amplify the sedative effects (drowsiness) due to the additive effects on the central nervous system.


Q: What happens if a person misses a dose of Sultan?

A: General patient instructions advise that if a dose is missed, individuals may take it as soon as it is remembered. However, to avoid taking extra medication, if it is near the time of the next scheduled dose, skipping the missed dose is generally advised.


Q: Is Sultan intended for long-term or short-term treatment?

A: Official uses, such as treatment for temporary sleeplessness or acute allergic events, suggest that Sultan is generally intended for temporary or short-term relief. Furthermore, regulatory research notes that evidence is limited for long-term follow-up when the drug is used for chronic conditions.


Q: Are there any specific foods or drinks that should be avoided while taking Sultan?

A: Official product information states there is no known interaction documented with food. However, regulatory warnings emphasize that alcohol (ethanol) has an additive depressant effect on the central nervous system, and its concurrent use requires constraint due to amplified drowsiness.


Q: Does Sultan interact with herbal supplements like St. John's Wort?

A: Regulatory-aligned information indicates that combining Sultan with certain herbal supplements like St. John's Wort may increase certain side effects. This includes feelings of amplified drowsiness, dizziness, and confusion.


Q: Is Sultan considered to have a risk of dependence or withdrawal?

A: Studies and case reports examining chronic use have associated the regular, long-term use of Sultan with the development of physical tolerance and dependence. In these cases, acute withdrawal symptoms have been reported upon abrupt cessation of the drug.


Q: What are the key differences between Sultan and other similar medications?

A: Sultan is classified as a first-generation antihistamine, a category noted for its ability to easily cross the blood-brain barrier. This characteristic is a key difference from newer antihistamine generations, and it is the reason Sultan is associated with a greater risk of sedation and drowsiness.


Q: Does Sultan need to be taken at a specific time of day?

A: Official dosing instructions direct that when Sultan is used specifically as a sleep aid, administration is typically recommended approximately 30 minutes before bedtime.


Q: Is it true that Sultan is available in a generic version?

A: Yes, the active ingredient in Sultan, Diphenhydramine Hydrochloride, is widely available as a generic medication.


Q: How does the official prescribing information describe Sultan's effectiveness?

A: The official prescribing information describes Sultan’s effectiveness for several indications, including the amelioration of allergic reactions, the management of motion sickness, and its use as a sleep aid for temporary sleeplessness.


Q: Is Sultan used to prevent a condition, or only to manage existing symptoms?

A: Regulatory documentation explicitly notes the drug's use for the prophylactic treatment of motion sickness, meaning it is used for prevention. Therefore, Sultan is used for both prevention and the management of existing symptoms.


Q: What is the expected duration for the effects of a single dose of Sultan?

A: According to the official product information, the duration of activity for an average dose of Diphenhydramine is generally described as lasting from four to six hours.


Q: Can Sultan affect a person's ability to drive or operate machinery?

A: Official warnings advise that Sultan may cause drowsiness and dizziness. Therefore, caution is advised, and individuals are generally advised to avoid driving or operating machinery until they are certain how the medication affects them.


Q: Why is Sultan only available with a prescription?

A: Sultan is classified as a first-generation antihistamine known for its significant central nervous system (CNS) effects. Its sedative and anticholinergic properties are factors that regulatory bodies in certain jurisdictions may use to impose prescription-only control.


Q: Is Sultan generally considered well-tolerated by most patients?

A: Regulatory documentation avoids subjective assessments like 'well-tolerated.' Instead, it reports that the most frequent adverse reactions are sedation, sleepiness, dry mouth, and dizziness. These effects are common and are important considerations when assessing tolerability.


Q: What should be done if a person experiences a rare side effect listed for Sultan?

A: General patient instructions recommend seeking emergency medical attention or contacting a healthcare provider immediately if an individual experiences any signs of the rare or serious side effects listed in the product information.


Q: Is Sultan only effective for a certain amount of time?

A: Studies and case reports indicate that regular, chronic use of Sultan may be associated with the development of physical tolerance. This means that its therapeutic effect may diminish over a period of time.


Q: Do studies show that Sultan is less effective over time (tolerance)?

A: Research examining chronic use has associated Sultan with the development of physical tolerance, where the body adjusts to the drug, leading to a reduced therapeutic effect over time. This is particularly noted concerning its sedative properties.


Q: Is feeling a slight headache a common initial reaction to Sultan?

A: Authoritative sources include headache as a potential side effect associated with first-generation antihistamines like Sultan.


Q: How do the different forms of Sultan (if applicable) compare in terms of effect?

A: While the underlying therapeutic effects (antihistaminic and sedative) are shared across systemic forms (oral and injectable), the official information notes that the injectable formulation has a faster onset of action compared to the oral form.


Q: Are there any reported long-term effects of using Sultan consistently?

A: Studies on the consistent, long-term use of anticholinergic medicines like Sultan have associated it with an increased risk of cognitive decline, particularly in older adults. Official research notes that comprehensive, long-term safety follow-up for chronic conditions remains limited.

How should Sultan be stored and disposed of?

How to Store and Dispose of Sultan (Diphenhydramine)

Storage Requirements

Sultan must be stored at Controlled Room Temperature, specifically between 20 C and 25 C (68 F to 77 F). The product should be kept in its original container and the container must remain tightly closed to protect it from moisture. Liquid formulations of Sultan must not be frozen to maintain stability. All medicine must be kept out of the reach and sight of children.

Disposal Instructions

Do not flush unused or expired Sultan down the sink or toilet. Proper disposal involves utilizing local drug take-back programs. Alternatively, the medicine should be mixed with an undesirable substance, such as kitty litter or coffee grounds, sealed in a plastic bag, and then placed in the household trash, following FDA guidelines.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Sultan found in:

A-Z Index: