Serecor

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Serecor

Quick Facts: Serecor (Fluticasone Propionate/Salmeterol)

Property Description
Active ingredient Fluticasone Propionate (ICS) and Salmeterol (LABA)
Form Inhalation Powder, Inhalation Aerosol
Pharmacological class Combination Inhaled Corticosteroid and Long-Acting beta2-Adrenergic Agonist
General purpose Long-term maintenance of respiratory function
Origin Synthetic Combination Product

What Type of Combination Medicine is Serecor?

Serecor is a fixed-dose combination drug utilized for the maintenance therapy of chronic respiratory conditions, formally classified as a Bronchodilator Combination medicine. The preparation uses two distinct, fully synthetic active components: Fluticasone Propionate and Salmeterol, ensuring both anti-inflammatory action and prolonged muscle relaxation are delivered simultaneously. Fluticasone Propionate belongs to the class of Inhaled Corticosteroids (ICS), while Salmeterol is defined as a Long-Acting Beta-Adrenergic Agonist (LABA), recognized clinically for its 12-hour duration of action. This synchronized approach is utilized for maintaining respiratory stability and reducing the reliance on separate single-agent treatments for control.

Delivery Forms, Differentiation, and General Therapeutic Purpose

This combination is supplied for the inhalation route, commonly existing as either an Inhalation Powder (e.g., in a Diskus-type device) or an Inhalation Aerosol (e.g., in a Metered Dose Inhaler), designed for local pulmonary delivery. Regarding its function, the general therapeutic purpose is to provide continuous, dual-action control over two pathological processes: the underlying inflammation and the physical constriction of the airways, thereby sustaining improved breathing function. The combination of Salmeterol with an inhaled corticosteroid is characterized by its ability to offer control compared to monotherapies. While the generic name refers to this respiratory product, the brand name Serecor is also regionally used for Hydroquinidine Hydrochloride, an entirely separate antiarrhythmic medication, a key differentiation point based on geographical regulation.

Regulatory References

  1. Salmeterol - StatPearls - NCBI Bookshelf

What side effects are possible with Serecor?

Possible Side Effects and Safety Information

The safety profile for Serecor, which contains Fluticasone Propionate (an inhaled corticosteroid) and Salmeterol (a long-acting beta-agonist), is defined by officially recognized frequency classifications and system-organ effects documented in regulatory labeling.

Adverse Reaction Scope

Classification Common Adverse Reactions (Official Listing)
Very Common Headache, Nasopharyngitis (in COPD patients)
Common Oral candidiasis (thrush), Pharyngitis, Dysphonia (hoarseness), Bronchitis, Musculoskeletal pain

Serious Adverse Reactions: Regulatory documents highlight a class effect associated with the LABA component, including the risk of asthma-related death or hospitalization. Other serious, documented risks include paradoxical bronchospasm (immediate worsening of breathing), systemic corticosteroid effects such as adrenal suppression or hypercorticism, and cardiovascular effects like fast heartbeat or hypertension.

Safety Constraints and Special Populations

  • Duration-Related Patterns: Long-term exposure to the inhaled corticosteroid component is associated in official labeling with risks of glaucoma, cataracts, and decreased bone mineral density.
  • Pediatric Patients: The official label advises monitoring the growth of pediatric patients.
  • Restrictions: The medicine is contraindicated for use with an additional medicine containing a Long-Acting Beta-Agonist (LABA) and in cases of known hypersensitivity to any component.
  • Coexisting Conditions: Caution is necessary for patients with pre-existing cardiovascular disorders, seizures, thyrotoxicosis, and diabetes mellitus due to the beta-adrenergic component.

Connection to the overall safety profile: The official safety data structures the medicine's risk profile by formally defining the frequency and nature of expected adverse reactions via regulatory classification. This framework also isolates the critical risks, such as systemic corticosteroid effects and LABA-associated warnings, which establish explicit limitations and safety monitoring requirements defined in governmental documents.

Overdose and Emergency Response

Overdose and When to Seek Help

The most critical and potentially fatal consequence of an acute overdose is Metformin-associated Lactic Acidosis (MALA). This life-threatening condition is characterized by elevated blood lactate levels, anion gap acidosis, and high plasma Metformin concentrations, which can result in death.

Documented Overdose Manifestations

Initial signs of overdose are often nonspecific and may include gastrointestinal distress, such as nausea, vomiting, abdominal pain, and malaise. These symptoms can rapidly progress to severe systemic compromise, including:

  • Metabolic: Severe lactic acidosis, hypothermia, and hypoglycemia (less common).
  • Cardiovascular: Hypotension (low blood pressure) and bradyarrhythmias (slow heart rate).
  • Neurological: Somnolence, seizures, and coma.

Emergency Action Required

Immediate emergency medical help must be sought for any known or suspected overdose. Because MALA can have a subtle onset followed by rapid deterioration, urgent attention is required even if initial symptoms appear mild or nonspecific.

If Metformin-associated Lactic Acidosis is suspected, general supportive measures must be initiated in a hospital setting. The official and most effective method for drug removal and correction of severe acidosis in overdose cases is prompt hemodialysis.

Therapeutic Uses of Serecor

What Serecor Treats: Main Uses and Benefits

Long-Term Control for Persistent Asthma Symptoms

Serecor is a commonly used component of maintenance therapy for patients, including adults and children 4 years and older, whose persistent asthma is not adequately controlled on long-term controller medication alone. It is used to manage the daily burden of chronic symptoms such as wheezing, coughing, and chest tightness. The medication is used for managing conditions characterized by chronic symptoms, such as asthma and Chronic Obstructive Pulmonary Disease (COPD).


Managing Flare-ups and Sustaining Stability

The medication is considered relevant in the long-term maintenance treatment of COPD, which includes chronic bronchitis and emphysema, in adults with moderate-to-severe disease. Its purpose is to support sustained management of airflow limitation and chronic symptoms, which is commonly used to help with stabilizing the condition. The primary therapeutic benefit may assist with reducing the frequency and severity of exacerbations (flare-ups), which may assist with maintaining functional stability during difficult episodes.

“The therapy is commonly used to help with maintaining functional stability and managing the risk of acute respiratory events.”


Quick Fact: Relief for Chronic Respiratory Symptoms
Primary Therapeutic Goal Supports sustained management of airflow limitation and chronic symptoms.
Symptom Domains Addressed Wheezing, coughing, chest tightness, and shortness of breath.
Role in Treatment Component of long-term maintenance therapy (not acute relief).

Regulatory References

  1. DailyMed - NIH Label

Eligibility and Restrictions for Use

Serecor (Fluticasone Propionate/Salmeterol) eligibility is strictly defined by regulatory documents, distinguishing between approved user groups and populations for whom use is contraindicated or restricted.

Approved Age Groups

The medicine is officially approved for adults and adolescents (12 years and older) with asthma, and for children aged four years and older with asthma. It is also authorized for use in adult patients with COPD. For children younger than four years, safety and efficacy have not been established. No dose adjustment is required for the geriatric population or those with renal impairment.

Absolute Exclusions (Contraindications)

Use is contraindicated for the primary treatment of status asthmaticus or other acute episodes of asthma or COPD, as the medicine is strictly for maintenance treatment. It is also prohibited for patients with a known hypersensitivity to any component, including excipients (e.g., severe milk protein allergy). Concurrent use with another Long-Acting Beta-Adrenergic Agonist (LABA) is forbidden.

Conditional Restrictions

Regulatory labeling requires caution and close monitoring for patients with hepatic impairment (liver disease), cardiovascular disorders, diabetes mellitus, or specific untreated infections (such as tuberculosis). During pregnancy and lactation, administration should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus or child, reflecting limited human data.

These eligibility criteria define who can and cannot use the drug according to official government documentation, preventing its use in acute conditions or populations with specific health risks.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile for Serecor is defined by pharmacokinetic and pharmacodynamic constraints documented in regulatory labeling.

The co-administration of Serecor with any other medicinal product containing a Long-Acting beta2-Adrenergic Agonist (LABA) is strictly prohibited, as this combination carries a high risk of beta2-agonist overdose.

Strong Cytochrome P450 3A4 (CYP3A4) Inhibitors

Co-administration with potent CYP3A4 inhibitors, such as ritonavir or ketoconazole, is officially not recommended. These substances interfere with the metabolism of Fluticasone Propionate, increasing its systemic plasma concentration (exposure), which may result in increased systemic corticosteroid effects.

Pharmacodynamic Interactions and Caution

Regulatory labeling requires extreme caution when co-administering with Monoamine Oxidase Inhibitors (MAOIs) or Tricyclic Antidepressants (TCAs), which can potentiate the effects of the Salmeterol component on the vascular system. Similarly, beta-adrenergic receptor blocking agents should be used with caution, as they may antagonize Salmeterol’s bronchodilatory action and potentially precipitate severe bronchospasm. Non-potassium-sparing diuretics also require caution due to the risk of worsening hypokalemia associated with beta2-agonists. Additionally, Grapefruit Juice is noted as a potential interacting agent. The documented clearance of both active ingredients may be reduced in patients with hepatic impairment, necessitating cautious use in this population.

Mechanism of Action

Modulation of Receptor-Mediated Signaling

Serecor acts within domains involving receptor- or enzyme-mediated signaling by selectively binding to specific high-affinity receptors. This interaction either initiates or suppresses signaling sequences that produce downstream pathway effects. The resulting mechanism involves the adjustment of sensitivity at these key regulatory points.

Targeting Systems with Dysregulated Mediators

The compound affects systems where specific transmitters or mediators dominate, particularly those associated with sustained pathway activation. Serecor engages mechanisms that regulate processes, often by modifying early molecular steps that shape systemic pathway outcomes. This directly influences the impact of mediator activity within the targeted biological system.

Influence on Feedback Regulation within Pathways

Serecor influences feedback regulation within cascades where multiple layers of pathway activation occur, supporting the modulation of processes driven by distinct signaling patterns. The resulting effect involves influencing the signaling state within targeted pathways, thereby shaping the drug’s overall pharmacological profile.

Dosage and Administration Information

Serecor (Fluticasone Propionate/Salmeterol) is utilized as a fixed-schedule, long-term controller medication. The protocol for its use focuses on consistent, scheduled intake. The medication is administered exclusively via oral inhalation and is not intended for the relief of acute bronchospasm. All usage follows the administration guidelines summarized below.

Official Administration Guidelines

Feature Official Labeled Instruction
Administration Route Oral inhalation only; the medication is designed for local pulmonary delivery.
Dosing Frequency Fixed-schedule, Twice Daily (BID). Administrations should occur approximately 12 hours apart and must not exceed two times every 24 hours.
Adult Asthma Dosing One inhalation of the 100/50, 250/50, or 500/50 mcg strength twice daily. The maximum recommended strength for asthma is 500/50 mcg twice daily.
COPD Dosing One inhalation of the 250 mcg/50 mcg strength twice daily. This is the dose utilized for maintenance treatment in adults with COPD.
Pediatric Dosing Children 4 to 11 years: 100 mcg/50 mcg strength twice daily as the initial starting dose for pediatric patients with asthma.

Required Procedural Steps

Adherence to specific procedural rules ensures proper administration:

  • Oral Hygiene: Following each administration, the user must rinse the mouth with water and spit it out (do not swallow).
  • Missed Dose: If a dose is missed, an extra inhalation should not be taken. The next scheduled dose should be taken at the usual time.
  • Device Priming: Inhalation Aerosol devices require a specific priming sequence before initial use or if unused for four weeks or longer.

These standardized instructions define the protocol for using Serecor, structuring the administration around a precise twice-daily schedule and specific procedural hygiene to maintain consistent therapy.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Serecor

Evidence for Use in Persistent Asthma

The research for Serecor in the context of asthma maintenance was studied in patients with persistent asthma who were using an inhaled corticosteroid (ICS). Studies conducted include numerous Randomized Controlled Trials (RCTs) and larger Systematic Reviews that evaluate its use in adults, adolescents, and children aged four years and older. Research examined outcomes related to physical discomfort and outcomes linked to inflammatory or irritative states.

These trials described patterns observed in the studies related to symptom variability and the need for rescue inhalers. The outcomes studied included objective changes in lung function (like FEV1) and the frequency of asthma exacerbations (flare-ups). These findings describe how patients reported their experience, and contribute to the research base for conditions where symptoms may vary in intensity.

Evidence for Use in Chronic Obstructive Pulmonary Disease (COPD)

Serecor research examined how symptoms and airflow limitations changed over time in adults with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), including those with chronic bronchitis and emphysema. Research scenarios primarily involved large-scale Randomized Controlled Trials (RCTs).

Studies monitored outcomes reflecting daily functioning, with a key focus on the annualized rate of COPD exacerbations. Findings show patterns related to how the observed populations reported changes in health status metrics. Data are limited for comparisons against all other available non-corticosteroid long-acting bronchodilator therapies for certain long-term outcomes, such as the risk of all-cause mortality, where certainty remains low.

Key Areas of Scientific Uncertainty

While research provides context, certain areas remain where evidence quality varies across studies or where data are still emerging. Data are insufficient for the use of Serecor in the pediatric population younger than four years of age. Also, there is limited information for long-term outcomes, particularly for very long durations (e.g., several years) for certain patient subgroups. Research provides insight into short-term changes, but the findings describe group patterns, not personal outcomes.

Key Studies & References

  1. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease (GOLD) Report 2024
  2. Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events (Cochrane Review/NCBI)

Frequently Asked Questions (FAQ)

Common questions about Serecor (FAQ)


Q: What is Serecor used for, simply put?

A: Serecor is officially used as a long-term, fixed-schedule maintenance treatment for chronic respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD). The medicine is for daily control and is not intended for the relief of sudden, acute breathing problems.


Q: How long does the effect of Serecor last?

A: The bronchodilator component (Salmeterol) of the medicine is considered long-acting, with effects lasting over 12 hours. This long duration of action supports its use as a fixed-schedule medication.


Q: Are there any common foods or drinks that interact with Serecor?

A: Official information notes that Grapefruit Juice is a potential interacting agent. It may interfere with the body's breakdown of the Fluticasone Propionate component, which could lead to increased systemic effects. Discussing the use of grapefruit products with the prescriber is recommended.


Q: Does Serecor interact with blood pressure medicine?

A: Yes, the official label notes that caution is necessary with beta-adrenergic receptor blocking agents (beta-blockers), which are often used for blood pressure and heart conditions. Using beta-blockers may block the bronchodilatory action of Serecor and risks a sudden, severe worsening of breathing.


Q: Can Serecor be used long-term?

A: Serecor is prescribed specifically as a long-term controller medication for maintenance treatment. According to official documents, long-term use of the inhaled corticosteroid component may necessitate periodic monitoring for effects on bone mineral density and for the growth rate of children.


Q: Are there any known interactions between Serecor and herbal supplements?

A: While the regulatory label specifically notes Grapefruit Juice as an interacting agent, there is no comprehensive list covering all herbal supplements. Because supplements can affect how the body processes medicine, it is recommended to disclose all herbal products and non-prescription medicines to the healthcare provider.


Q: What are the major reasons someone might stop using Serecor?

A: Regulatory information states that the drug should be discontinued if severe side effects occur. These include a sudden, worsening of breathing called paradoxical bronchospasm, or if the patient develops signs of systemic corticosteroid effects like hypercorticism or adrenal suppression.


Q: Is there a maximum time Serecor can be used according to regulatory sources?

A: Serecor is generally intended for long-term maintenance therapy. Regulatory sources do not specify a fixed maximum duration of use. Once asthma control is achieved, regular assessment by a physician is referenced in the label to determine if a reduction in therapy is warranted.


Q: Does Serecor help prevent a condition or only manage symptoms?

A: The official indication describes it as maintenance treatment, which focuses on control of underlying symptoms and airflow obstruction. Studies and official information indicate findings related to a reduction in the rate of exacerbations (flare-ups or attacks) in both COPD and asthma populations.


Q: What does the term 'contraindication' mean for Serecor?

A: A contraindication describes a condition or situation in which the medicine should not be used, as the documented risks are judged to be greater than the potential benefit. For Serecor, contraindications include known severe allergy to any component and the primary treatment of acute, life-threatening breathing emergencies.


Q: How quickly can someone expect Serecor to start working?

A: Studies and official information indicate that improvement in asthma control can begin relatively quickly, often within 30 minutes after the first inhalation. However, the maximum therapeutic benefit may take a week or longer to fully achieve.


Q: Does Serecor have a black box warning?

A: Yes. The long-acting beta2-agonist (LABA) component of Serecor carries an FDA-required Boxed Warning. This warning addresses the increased risk of asthma-related death and asthma-related hospitalization noted in certain studies, primarily involving pediatric and adolescent patients.


Q: Is Serecor habit-forming or addictive?

A: Regulatory documentation does not list this medicine under any controlled substance schedule. Regulatory documentation does not contain information regarding addiction or habit formation risks.


Q: Can Serecor affect my ability to drive?

A: The official label notes that caution is necessary for patients with central nervous system disorders due to the stimulating effects of the beta-adrenergic component. Uncommon side effects like dizziness or tremor have been noted, which could potentially affect the ability to drive or operate machinery.


Q: What should I know about taking Serecor with alcohol?

A: Official information does not note a direct interaction between alcohol and the medicine. However, alcohol consumption may worsen uncommon side effects such as dizziness or headache. Discussing alcohol use with the prescriber is recommended, especially if side effects occur.


Q: Can Serecor interact with over-the-counter pain relievers?

A: Official labeling requires caution with certain prescription medicines, but not all over-the-counter pain relievers are explicitly listed as interacting agents. Caution has been suggested with common relievers like acetaminophen (Paracetamol) in specific patient populations. Discussing the use of all OTC pain relievers with the prescriber is recommended.


Q: Does Serecor affect lab test results?

A: Yes, Serecor can affect certain laboratory test results. The Salmeterol component may affect plasma potassium and glucose levels. Separately, the Fluticasone Propionate component may affect urine cortisol levels, which are sometimes monitored by physicians.


Q: Is Serecor related to medications for anxiety?

A: Anxiety is listed as an uncommon side effect of Serecor (in 0.1% to 1% of patients). Furthermore, the official interaction section notes that caution is necessary if taking Monoamine Oxidase Inhibitors (MAOIs) or Tricyclic Antidepressants (TCAs), which are medication classes sometimes used to treat anxiety or mood disorders.


Q: Does Serecor cause weight gain or weight loss?

A: Official post-marketing reports indicate that weight gain is listed as a common side effect, occurring in between 1% and 10% of patients. If weight changes are a concern, speaking to a healthcare provider is recommended.


Q: Can Serecor cause problems with sleep?

A: Yes. Sleep disorders are listed in official safety information as an uncommon side effect, occurring in 0.1% to 1% of patients. This may include difficulty falling asleep or staying asleep.


Q: What happens if Serecor is taken close to bedtime?

A: The medicine is prescribed for a twice-daily schedule with doses approximately 12 hours apart. Since sleep disorders are a known, albeit uncommon, side effect, the timing of the evening dose should be discussed with the prescriber if sleep is affected.


Q: Is it common for Serecor to cause fatigue?

A: Fatigue or unusual tiredness is not listed as a common side effect in the official safety profile. However, unusual weakness is noted as a potential symptom of a more serious risk involving the adrenal glands associated with long-term use.


Q: Can I use Serecor if I am scheduled for surgery?

A: The use of the medicine during periods of severe stress, such as surgery, may require temporary adjustments. Official guidance notes that due to potential adrenal effects, temporary medication may be necessary during periods of severe stress or surgery.


Q: Can Serecor affect mood or cause emotional changes?

A: Yes. Official reports list anxiety and general mental/mood changes as uncommon side effects. In postmarketing reports, adverse effects such as depression and aggression have also been noted, predominantly in pediatric patients.


Q: Is it possible to have an overdose on Serecor?

A: Yes. The official label notes that using Serecor in combination with other long-acting beta2-agonists carries a serious risk of overdose. Symptoms of an overdose may include chest pain, tremors, and seizures.


Q: Can Serecor be crushed or split?

A: The medicine is administered exclusively via inhalation and is not designed for modification, such as crushing, splitting, or chewing. Attempting to modify the device or formulation would compromise the proper delivery of the medicine.

How should Serecor be stored and disposed of?

Serecor (fluticasone propionate/salmeterol) must be stored according to official regulatory labeling to maintain product stability and safety.

Storage Conditions and Handling

The medication must be stored at controlled room temperature, maintaining 20^circmathrmC to 25^circmathrmC (68^circmathrmF to 77^circmathrmF), with excursions permitted between 15^circmathrmC and 30^circmathrmC. It is required to keep the product in its original container and to protect it from freezing, direct heat, moisture, and light. The pressurized aerosol canister must not be punctured or exposed to temperatures above 49^circmathrmC (120^circmathrmF). The product must be kept out of the reach and sight of children.

Stability and Disposal

The Inhalation Powder device must be discarded 1 month after opening the foil pouch or when the dose counter reads zero. Unused or expired product should be disposed of in accordance with local regulations; the canister must not be incinerated or thrown into fire.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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