Psoriderm

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Psoriderm

Psoriderm is a synthetic, single-ingredient topical medicinal preparation whose active component is the highly effective substance known as Clobetasol propionate. It is classified within the corticosteroid pharmacological group and is characterized as a very potent agent, intended exclusively for direct application to the skin or scalp.

Quick Facts Description
Active Ingredient Clobetasol propionate
Form Solution (Topical)
Pharmacological Class Glucocorticoid (Corticosteroid)
General Purpose Managing severe skin inflammation and irritation
Origin Synthetic derivative

What Type of Medicine is Psoriderm?

Psoriderm belongs to the class of Glucocorticoids, which are synthetic agents that emulate the action of certain natural anti-inflammatory hormones produced by the body. This classification defines the core mechanism of the medicine: reducing localized inflammation and immune activity in the area of application. Clobetasol propionate is a high-potency topical steroid primarily used for its anti-inflammatory properties. The high efficacy of Clobetasol propionate is clinically recognized for managing inflammatory conditions where rapid suppression is required. Clobetasol propionate is categorized in the most potent class of topical corticosteroids, Group IV (Very Potent).


Composition and Formulation: The Clobetasol Propionate Solution

The medicinal entity Psoriderm is formulated as a liquid solution, a specific dosage form designed for efficient topical administration to the scalp and other hair-bearing areas. The solution vehicle ensures the Clobetasol propionate can penetrate the skin beneath the hair shafts for uniform coverage. This specific formulation differentiates Psoriderm from other generic Clobetasol preparations, which may be available as creams or ointments. This liquid presentation is strategically preferred when treating conditions in areas with dense hair, as it minimizes residue while ensuring effective delivery of the active substance.


What is the General Purpose of This Potent Agent?

The general purpose of this potent agent is to provide rapid and significant relief from symptoms associated with severe inflammatory skin conditions. This is achieved through Clobetasol propionate’s powerful anti-inflammatory effect, which calms the redness, swelling, and heat of the affected skin, and its concurrent anti-proliferative effect, which suppresses abnormal skin cell growth. These medicinal preparations are highly effective for conditions requiring swift reduction in skin cell turnover and inflammation. This demonstrates the medicine's role in normalizing the skin's growth cycle and mitigating severe, debilitating irritation.

What side effects are possible with Psoriderm?

Possible Side Effects and Safety Information

The safety profile of Psoriderm is primarily associated with local skin reactions and specific precautions related to the product’s composition and flammability.

Adverse Reactions

Classification Adverse Reaction
Rare Skin irritation, acne-like eruptions, skin photosensitivity (increased sensitivity to sunlight).
Rarely Staining of the skin, hair, or fabric.
Other Skin irritation may occur in people intolerant to the excipient propylene glycol.

Contraindications and Warnings

Psoriderm is contraindicated for use in the following conditions:

  • Known hypersensitivity or allergy to distilled coal tar or any of the product's excipients.
  • On acute, sore, or pustular psoriasis.
  • In the presence of infection on the skin.

Special Safety Warnings

  • Fire Hazard: Fabric (such as clothing, bedding, and dressings) that has been in contact with the product burns more easily, posing a serious fire hazard. Patients are warned not to smoke or go near naked flames during and after application.
  • Avoid Contact: The product should be kept away from the eyes, mouth, inside of the nose, genital or rectal areas, and broken skin (cuts and grazes) due to potential irritation.

Use in Specific Populations

The product is generally considered suitable for use in adults, children, and the elderly. Regarding pregnancy and breastfeeding, the product can be used. Although the ingredients have a history of widespread use without reported issues in this population, formal safety trials have not been conducted. The product is not known to affect the ability to drive or use machinery, nor is it known to interact with other medicines.

Overdose and Emergency Response

Overdose and when to seek help

Psoriderm is a topical treatment containing coal tar solution 5%. The primary safety consideration related to the use of coal tar topical products involves excessive or prolonged application, or accidental ingestion.

Acute Exposure and Systemic Symptoms

Overdose from accidental ingestion of topical coal tar preparations may lead to systemic effects. While official regulatory documents for Psoriderm do not define specific overdose symptoms, general information on coal tar suggests that systemic toxicity following accidental swallowing may manifest as vomiting, headache, and drowsiness. Over-application to large areas of skin, especially over long periods, may theoretically increase the potential for systemic absorption, although this is not considered a common event.

When to Seek Urgent Medical Help

Urgent medical attention is required in the event of accidental swallowing of Psoriderm or if any severe reaction or systemic symptoms occur after use. Specifically, call emergency services immediately if the individual:

  • Has collapsed,
  • Experiences trouble breathing,
  • Has a seizure, or
  • Cannot be awakened.

For advice on overdose management or less severe symptoms following ingestion, contact a Poison Control Center right away. If severe skin irritation, a generalized rash, or signs of an allergic reaction (e.g., swelling of the face, tongue, or throat; severe dizziness) develop, discontinue use and seek medical assessment.

Therapeutic Uses of Psoriderm

Psoriderm is indicated for the topical management of sub-acute and chronic psoriasis, a condition characterized by raised, red patches of skin often covered with silvery scales. It is available in formulations for both the skin and the scalp.

Quick Facts

  • Target Condition: Sub-acute and chronic psoriasis.
  • Primary Benefits: May help manage common symptoms such as redness, irritation, and scaling.
  • Therapeutic Goal: Intended to support the restoration of normal skin development and ease localized itching associated with the condition.
  • Suitability: This treatment is considered appropriate for adults, children, and the elderly for its approved uses.

Use of Psoriderm is part of a recommended care plan to address the visual and physical manifestations of long-term psoriasis. The cream or shampoo may contribute to reducing the excessive proliferation of skin cells that occurs in affected areas, providing symptom relief.

Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Psoriderm — Official Regulatory Information

The eligibility for Psoriderm (Distilled Coal Tar) is defined strictly by official regulatory labeling, outlining specific populations who are permitted or prohibited from using the medicine.

Eligibility Scope

Scope Regulatory Statement
Populations Allowed Adults, Children, and the Elderly are approved for use.
Populations Contraindicated Patients with known hypersensitivity to Distilled Coal Tar or any other ingredient.
Age-related Eligibility Use is approved across all major age groups (Adults, Children, and the Elderly).
Pregnancy and Lactation Status Regulatory documents state "No special precautions" are necessary for use during pregnancy or while breastfeeding.
Eligibility-Related Restrictions Contraindicated for use on infected skin or for cases of acute, sore, or pustular psoriasis.

Connection to the Overall Eligibility Profile

Regulatory documentation confirms Psoriderm is approved for use in all age groups, but its use is absolutely prohibited in patients with a confirmed allergy to its ingredients. Furthermore, the medicine must not be used when the affected skin is infected or the psoriasis is classified as acute, sore, or pustular. The official labeling confirms that use is established during pregnancy and lactation.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents for Psoriderm products, including the cream and scalp lotion shampoo, consistently state that no clinically significant interactions with other medicinal products are known. This classification indicates that regulatory authorities have concluded that there are no identified, clinically significant pharmacokinetic or pharmacodynamic interactions that require specific constraints, monitoring, or dose adjustments when Psoriderm is used concurrently with other systemic or topical medicines. The established interaction profile is based on the authoritative product labeling from government regulatory agencies, such as the Medicines and Healthcare products Regulatory Agency (MHRA).

Interaction Status Summary

Interaction Domain Official Regulatory Statement
Specific Interacting Medicines None explicitly listed
Interacting Product Categories None identified
Mechanistic Basis Not applicable; no known interactions
Interaction-Related Constraints None documented in relation to other medicines

This lack of documented interactions means the product is not known to affect, or to be affected by, any other medicines. Therefore, no special precautions related to co-administration with other medicines are required according to the official regulatory information. This profile is consistent across the various formulations, including Psoriderm Cream and Psoriderm Scalp Lotion Shampoo.

Mechanism of Action

How Psoriderm Works — Mechanism of Action

Psoriderm's action is defined by a multi-domain local effect primarily involving Distilled Coal Tar, often combined with Salicylic Acid.


Biological Inhibition of Keratinocyte Cell Cycle

The Coal Tar components function as inhibitors of DNA synthesis and mitosis (cell division) within epidermal keratinocytes. This antiproliferative mechanism directly regulates the high rate of epidermal cell turnover, resulting in the modulation of epidermal architecture and thickness.


Local Modulation of Inflammation and Sensory Signaling

Coal tar components influence the local cutaneous environment, potentially via the Aryl Hydrocarbon Receptor (AhR) pathway, exerting a mild anti-inflammatory effect by modulating local immune responses. This domain also involves the dampening of cutaneous sensory signals, influencing the pathways governing local vasodilation and nerve signaling.


Desmolytic Breakdown of Hyperkeratotic Layers

This mechanistic domain, driven by Salicylic Acid, involves desmolysis—the physical breakdown of the intracellular connections (cement) between corneocytes in the stratum corneum. This desmolytic action promotes the exfoliation of hyperkeratotic layers, allowing increased access for other components to the deeper, proliferating epidermal layers below.

Dosage and Administration Information

How Psoriderm is Used: Official Administration Guidelines

Psoriderm (Clobetasol Propionate 0.05% Solution) is a very potent topical corticosteroid for which administration guidelines are established to ensure appropriate use and limit systemic exposure. The official instructions focus on precise application, short treatment duration, and limiting the total quantity used.


Official Dosing and Use

Administration Detail Official Regimen (Based on Clobetasol Propionate 0.05% Solution)
Route of Administration Strictly Topical (dermatologic use only). Not for ophthalmic, oral, or intravaginal use.
Application Area Exclusively for the scalp and other affected hair-bearing areas.
Dosing Frequency Apply twice daily (BID) to the affected area(s).
Maximum Dose The total dosage used must not exceed 50 mL/grams per week.

Duration and Special Instructions

Due to its high potency, Psoriderm is intended for short-term, controlled use.

  • Treatment Duration Limit: Therapy must be limited to no more than 2 consecutive weeks. The product should be discontinued immediately when control is achieved.
  • Method of Application: Apply the solution sparingly and gently rub it into the affected area(s). Only use the minimum quantity required to cover the area.
  • Occlusion Restriction: The treated area must not be covered with occlusive dressings, bandages, or wraps unless specifically instructed by a physician. This is an important procedural constraint.
  • Population Restriction: The use of this solution is not recommended for children under 12 years of age due to an increased risk of systemic side effects.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Psoriderm (Clobetasol Propionate)

This section provides an overview of the types of official research that have explored the use of the medicine, outlining what researchers studied and what findings they reported, according to the available evidence base.


Evidence for Use in Plaque Psoriasis (Body)

Research exploring this medicine for psoriasis on the body has primarily been conducted through short-term, randomized controlled trials (RCTs), often comparing the active ingredient against an inactive substance (a vehicle or placebo) or against another study agent in trials. The research examined how symptoms change over defined time intervals, with outcomes related to physical discomfort and outcomes linked to inflammatory or irritative states. Researchers monitored measured changes in objective severity scales like the Psoriasis Area and Severity Index (PASI), alongside assessments of individual signs such as scaling, redness, and plaque elevation.

Studies conducted during periods of increased symptom activity reported patterns observed in the measured changes to these severity scores during the short-term treatment period of typically two to four weeks. Findings described patterns in how symptoms evolved in the observed populations with moderate to severe plaque psoriasis. Long-term outcomes following treatment cessation or sustained intermittent use are not fully established, and there is limited information for long-term outcomes.


Evidence for Use in Scalp Psoriasis

Specific research has explored the use of the medicine in formulations designed for hair-bearing areas, particularly for moderate to severe psoriasis of the scalp. The evidence base includes randomized, vehicle-controlled trials focusing on conditions characterized by fluctuating or episodic manifestations. These studies monitored changes in a global severity score specific to the scalp, along with individual physical outcomes such as scaling, plaque thickening, and erythema.

Research also explored outcomes related to inflammatory or irritative states over defined time intervals. Findings describe patterns observed in how scalp symptoms evolved following an initial period of daily application. Additionally, some research has explored longer-term maintenance strategies, with studies observing responses over extended periods up to six months when the application frequency was reduced. Data for prolonged, extended maintenance beyond the initial six-month period are still emerging.


Evidence in Special Populations and Subgroups

Research primarily focused on adults with psoriasis, meaning data for certain groups remain limited. The data show patterns related to how the drug was evaluated in specific age ranges. Studies have explored the medicine in adolescents (ages 12 to 17) to assess systemic exposure patterns and monitored changes in symptoms.

Key Studies & References

  1. Label: CLOBETASOL PROPIONATE aerosol, foam - DailyMed (FDA Monograph summarizing clinical trials)
  2. Clobetasol Propionate Lotion in the Treatment of Moderate to Severe Plaque-Type Psoriasis (Key RCT demonstrating efficacy and equivalence to cream)
  3. Recommendations | Psoriasis: assessment and management | Guidance - NICE (Clinical guidelines on topical steroid use, duration, and patient groups)

Frequently Asked Questions (FAQ)

Common questions about Psoriderm (FAQ)

Q: What is Psoriderm cream/ointment actually used for?

A: According to official product information, Psoriderm products that contain distilled coal tar (such as the cream, ointment, and bath additive) are indicated for the topical treatment of sub-acute and chronic plaque psoriasis. These various forms are specifically designed to be applied to affected skin and the scalp.


Q: How quickly does Psoriderm start to make a difference on skin patches?

A: Regulatory documents do not specify an exact onset of action. However, official guidance for the coal tar formulations advises that if a lack of improvement is seen after four weeks of use, this is generally considered a reason for discontinuation.


Q: Can Psoriderm be used for types of eczema, or is it only for psoriasis?

A: The officially approved use (the regulatory indication) for Psoriderm is the treatment of psoriasis. While the active ingredients target inflammation, the official indications for Psoriderm products do not explicitly list the treatment of other conditions like eczema.


Q: Does Psoriderm make skin more sensitive to sunlight?

A: Yes, official safety information states that skin photosensitivity (meaning increased sensitivity to sunlight) can occur rarely as a side effect. Official safety documents indicate that if photosensitivity occurs, treatment should generally be stopped, and further guidance should be sought.


Q: What is the maximum amount of Psoriderm Clobetasol Propionate solution that can be applied per week?

A: For the Psoriderm Clobetasol Propionate solution, official guidelines strictly limit the total amount used to no more than 50 mL/grams per week. Regulatory documents do not typically translate this maximum dosage into a specific percentage of the total body surface area that can be treated.


Q: Can using Psoriderm for a long time thin the skin?

A: For the highly potent Psoriderm Clobetasol Propionate solution, official constraints limit therapy to no more than two consecutive weeks. This short treatment duration is officially constrained due to the drug’s high potency, which helps to mitigate potential adverse effects.


Q: Why is Psoriderm sometimes recommended for scalp psoriasis?

A: Psoriderm is suitable for the scalp because certain formulations, such as the Scalp Lotion Shampoo, are specifically indicated for hair-bearing areas. The liquid vehicle is designed to allow the active ingredient to reach the skin through the hair, aiming for uniform coverage.


Q: Why does Psoriderm have a distinct smell?

A: The distinct and characteristic odour of certain Psoriderm products is associated with the active ingredient, distilled coal tar. This smell is inherent to coal tar, which is the key therapeutic component in the cream, ointment, and bath additive formulations.


Q: What's the main ingredient in Psoriderm that helps with skin flare-ups?

A: The main active ingredient depends on the product. The very potent Psoriderm Clobetasol Propionate solution contains the corticosteroid Clobetasol propionate. Other Psoriderm products, such as the cream and shampoo, rely on distilled coal tar as their primary active ingredient.


Q: What is the difference between Psoriderm and coal tar shampoos?

A: Psoriderm coal tar products are regulated medicinal products with a specific strength of distilled coal tar. Other key features are the unique excipients (inactive ingredients) used in the formulation. These details are outlined in the official product information.


Q: Is it normal for the skin to feel slightly warm or stingy right after applying Psoriderm?

A: Official regulatory documents state that skin irritation is a possible adverse reaction. If this feeling is persistent or severe, official safety guidance suggests discontinuing use and seeking further professional guidance.


Q: Can Psoriderm be used on the face or sensitive skin areas?

A: The regulatory warnings advise that the product should be kept away from highly sensitive areas such as the eyes, mouth, nose, genital, and rectal areas. This is due to the potential for irritation in these areas.


Q: What is the purpose of the bath oil version of Psoriderm?

A: The Psoriderm Emulsion Bath Additive is an oil formulation designed to be added to bath water. Its purpose is to assist in the treatment of sub-acute and chronic plaque psoriasis affecting large areas of the body.


Q: Do you need to wash off Psoriderm after a certain amount of time?

A: Yes, depending on the formulation. The Scalp Lotion Shampoo and Bath Additive require rinsing or a soak time, respectively. The shampoo must be left on for a few minutes then rinsed out; the bath additive requires soaking for about five minutes, followed by patting the skin dry.


Q: Can Psoriderm help with the itchiness of psoriasis?

A: Official information for the coal tar products notes that the active ingredient, distilled coal tar, is generally included in treatments for its ability to help soothe irritated skin and relieve itching associated with psoriasis.


Q: What is the shelf life of Psoriderm after opening the tube?

A: Official storage instructions state the medicine must be used before the expiry date printed on the packaging. While a dedicated 'in-use' shelf life after opening is not always specified, directions mandate that the cap must always be replaced tightly after use to maintain product integrity.


Q: Why do people sometimes find Psoriderm messy to use?

A: Psoriderm products may be perceived as messy because staining of the skin, hair, or fabrics can occur in rare cases. This staining is a known effect of coal tar preparations.


Q: Does Psoriderm contain parabens or other preservatives?

A: Official regulatory documents list all of the product’s excipients (non-active ingredients). These lists confirm that the formulations may contain other substances, such as the preservative phenoxyethanol.


Q: Is it true that Psoriderm can sometimes cause acne or folliculitis?

A: Official safety information states that acne-like eruptions can occur rarely as an adverse reaction. Folliculitis (inflammation of hair follicles) is not specifically listed as a common reported side effect in the official documents.


Q: How does Psoriderm help reduce inflammation?

A: The Clobetasol Propionate solution is a very potent corticosteroid used to reduce localized inflammation. The coal tar products are also noted to have mild anti-inflammatory properties and influence the body's local immune response in the skin.


Q: Are there any long-term health concerns associated with Psoriderm use?

A: Regulatory documents include constraints on use to manage potential risks, such as limiting the Clobetasol solution treatment to two consecutive weeks. There is also a Special Safety Warning regarding the fire hazard associated with product residue on fabrics, and users are advised of the necessary precautions related to fire safety.


Q: Do I need to avoid showering or bathing immediately after applying Psoriderm?

A: The instructions for creams and ointments generally state to apply the medicine and then wash your hands. The product is generally expected to remain on the skin to be effective, which is why immediate washing of the treated area is typically avoided, although an explicit waiting period is not always specified in the directions.


Q: Can applying too much Psoriderm cause side effects?

A: Official instructions for the Clobetasol solution advise using only the minimum quantity needed to cover the area. For the coal tar cream, regulatory documents state that if excess is applied, it should simply be removed with a tissue.


Q: Is it normal for the skin to get worse after starting Psoriderm?

A: If a user's skin condition appears to look or feel worse, official patient information advises discontinuing use and seeking further guidance. If there is no improvement after four weeks of using the coal tar products, treatment should also be stopped.


Q: Why is it important to wash hands thoroughly after applying Psoriderm?

A: The directions for use state to always wash your hands after application. This is a standard safety measure intended to prevent accidentally transferring the active ingredients to sensitive areas like the eyes, mouth, or other untreated skin.


Q: What percentage of the active ingredient is in Psoriderm?

A: The active ingredient strength varies by product. The Psoriderm Clobetasol Propionate solution is 0.05%. The Psoriderm Cream contains 6.0% w/w distilled coal tar, and the Scalp Lotion Shampoo contains 2.5% w/v distilled coal tar.


Q: Can Psoriderm be used under occlusion (bandages or wraps)?

A: For the Psoriderm Clobetasol Propionate solution, official instructions state that the treated area must not be covered with occlusive dressings, bandages, or wraps unless specifically instructed by a physician. Occlusion (covering the area) is specifically constrained for the Clobetasol solution as it may affect the way the medicine works.


Q: Are there any ingredients in Psoriderm that people commonly have allergic reactions to?

A: Psoriderm is contraindicated (should not be used) if a patient has a known allergy or hypersensitivity to its active ingredients (clobetasol propionate or distilled coal tar) or any of the inactive ingredients (excipients). The excipient propylene glycol is also specifically mentioned in official documents as potentially causing skin irritation.

How should Psoriderm be stored and disposed of?

How to Store and Dispose of Psoriderm?

The storage and disposal of this medicine are governed by specific regulatory guidelines to maintain product stability and ensure public safety.

Official Storage Requirements

Condition Requirement Restriction
Temperature Do not store above 25 C (77 F). Do not refrigerate or freeze.
Protection Store in the original container. Keep away from light, excess heat, and open flames (for solutions containing alcohol).
Child Safety Keep out of the sight and reach of children. Mandatory regulatory requirement.

Disposal Instructions

To protect the environment, unused or expired Psoriderm must not be disposed of via wastewater or household waste. Official instructions direct users to consult a pharmacist for guidance on discarding medicines no longer required, ensuring disposal complies with local regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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