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Losartan Stada

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Losartan Stada

What is Losartan Stada?

Property Description
Active ingredient Losartan Potassium
Form Oral film-coated tablet
Pharmacological class Angiotensin II Receptor Blocker (ARB)
General Purpose To lower high blood pressure (Antihypertensive)
Origin Synthetic (Chemically synthesized)

What Type of Medicine is Losartan Stada?

Losartan Stada is a prescription-only, synthetic cardiovascular agent classified as an Angiotensin II Receptor Blocker (ARB). It is primarily supplied as a single-ingredient product in the form of an oral tablet intended for oral administration. Losartan belongs to a class of medications designed to manage chronic conditions such as high blood pressure, or hypertension. Losartan is used for its role in treating high blood pressure and in helping protect the kidneys in certain patient groups with diabetes.

Active Ingredient and Its Role

The active ingredient in this medicine is Losartan, typically compounded as the potassium salt, Losartan Potassium. The overarching goal of the compound is to reduce the workload on the heart by promoting lower blood pressure. Losartan achieves this general purpose by selectively blocking the action of Angiotensin II on its main receptor, the AT1 receptor, in various tissues. This selective targeting action is key to managing hypertension and reducing the risk of cardiovascular complications. The ARB class provides consistent action in achieving sustained antihypertensive effects.

How Losartan Differs from Other Blood Pressure Drugs

Losartan and other ARBs are distinct from Angiotensin-Converting Enzyme (ACE) inhibitors because they block the final effect of Angiotensin II, rather than blocking its production. While ACE inhibitors stop the enzyme that creates the pressure-raising hormone, Losartan works by acting as an antagonist to block the hormone's ability to bind to the AT1 receptor. This specific receptor blockade prevents the hormone from triggering vasoconstriction (blood vessel tightening), which ultimately leads to vasodilation (vessel widening) and a stable reduction in blood pressure.

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What side effects are possible with Losartan Stada?

Possible side effects and safety information

The official safety profile for Losartan Potassium classifies adverse reactions by the frequency of occurrence and the specific System-Organ Class affected, according to regulatory standards (e.g., EMA/FDA).


Common adverse reactions, which may affect up to 1 in 10 people, include dizziness, headache, fatigue or asthenia, upper respiratory infection, and back pain. Other documented common effects involve the gastrointestinal system, such as diarrhea. Blood chemistry changes, including a risk of elevated potassium levels (hyperkalemia), are also noted.

Serious Adverse Reactions and Safety Constraints

Losartan's regulatory documentation highlights specific serious, low-frequency reactions. These include angioedema (severe swelling of the face, lips, throat, or tongue) and rare anaphylactic reactions. Severe hypotension (low blood pressure) may occur, particularly in volume-depleted patients, often at the start of treatment or following a dose increase.

Specific safety constraints are formally defined for certain populations. The medicine carries a Boxed Warning because it is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal toxicity. Use is also generally not recommended in patients with severe hepatic (liver) impairment. Due to the nature of the medication, the official labels require the monitoring of both renal function and serum potassium levels in susceptible individuals.

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Overdose and Emergency Response

Overdose Scope and Clinical Manifestations

The official regulatory documents state that an overdose of Losartan Stada presents primarily as an exaggeration of its intended effects, potentially leading to hypotension (excessively low blood pressure). Other documented clinical signs include changes to the heart rate, such as tachycardia (rapid heart rate) or, less commonly, bradycardia (slow heart rate due to vagal stimulation). These manifestations affect the cardiovascular system.


Emergency Action and Regulatory Management

Any suspicion of overdose, particularly if symptoms of severe symptomatic hypotension manifest, is classified as a condition capable of resulting in life-threatening symptoms. Due to this risk, the regulatory instruction is to seek immediate medical attention, contact emergency services (e.g., 911), or call a Poison Control Center immediately.

The mandated clinical action is the institution of symptomatic and supportive treatment. The regulatory basis for treatment is constrained because no specific antidote is known, and the medicine and its active metabolite are not removable by hemodialysis due to high protein binding.


Connection to the Overall Overdose Profile

Government regulatory documents define the overdose profile by its core pharmacological risk, which is a significant, rapid reduction in blood pressure. This severe cardiovascular manifestation establishes the condition under which immediate medical help must be sought. Emergency care is explicitly directed toward comprehensive supportive treatment of these manifestations, given the limitations on specific reversal agents.

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Therapeutic Uses of Losartan Stada

What Losartan Stada treats: main uses and benefits

Losartan is commonly used to help manage symptoms that create noticeable physiological strain, particularly those related to chronic high blood pressure. Its therapeutic scope extends across areas involving systemic and localized discomfort.


This medication is applied in managing conditions characterized by periods of heightened symptoms and associated long-term risk. Its primary indications are commonly used across conditions presenting with acute episodes, such as high blood pressure (Hypertension), and applied in situations with significant discomfort, like those associated with Diabetic Nephropathy (kidney disease in Type 2 diabetes patients) and Left Ventricular Hypertrophy (LVH).

Losartan is applied in clinical settings that involve unstable symptom patterns, such as those related to chronic high blood pressure. It contributes to easing the overall symptom load by achieving and maintaining control over the arterial pressure. This management helps address symptoms that create noticeable physiological strain and may assist with maintaining functional stability, which is relevant for easing the impact of cardiovascular risks.

In patients with Type 2 diabetes, the medicine is considered relevant in conditions presenting with systemic or localized discomfort, assisting in managing symptom clusters like the presence of excessive protein in the urine (proteinuria).

"This medicine may assist with maintaining functional stability and supports the patient during difficult episodes by easing distress related to the ongoing symptomatic burden."

Quick Fact: Relief for Sustained Strain
Losartan supports the patient during symptomatic periods of high blood pressure and associated discomfort, helping to manage symptoms that interfere with daily comfort.

Regulatory References

  1. DailyMed (NIH) Label for Losartan Potassium Tablet
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Eligibility and Restrictions for Use

Losartan is an angiotensin II receptor blocker (ARB) whose use is governed by specific regulatory eligibility requirements detailed in official drug labeling.

Contraindications and Restrictions

Classification Population or Condition Status
Absolute Contraindication Hypersensitivity to losartan/excipients Must not use
Pregnancy (2^nd and 3^rd trimesters) Must not use
Severe Hepatic Impairment Must not use
Drug-Drug Contraindication Patients with Diabetes taking Aliskiren Must not use
Restricted/Conditional Use Pregnancy (1^st trimester) Not recommended; discontinue immediately
Breastfeeding Not recommended
Volume- or Salt-Depleted patients Correct condition or use lower starting dose
Mild-to-Moderate Hepatic Impairment Consider lower starting dose

Age-Related Eligibility

Losartan is approved for use in adults and pediatric patients (6 to 18 years) for hypertension. It is not recommended for children under the age of six (6) due to a lack of established safety and efficacy data, nor for pediatric patients with a Glomerular Filtration Rate (GFR) less than 30 mL/min/1.73 m^2.

The eligibility profile strictly defines groups that are entirely excluded from use (e.g., severe liver impairment, late-stage pregnancy) and those requiring a cautious, low-dose approach (e.g., mild liver impairment) based solely on authoritative government documents.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile for Losartan Stada is primarily defined by the potential for pharmacodynamic reinforcement (additive physiological effects) and pharmacokinetic interference (altered drug levels).


Official Interaction Statements

Interaction Type Interacting Substance(s) Official Outcome Restriction/Context
Contraindicated Aliskiren Increased risk of hypotension, hyperkalemia, and renal impairment (dual RAS blockade). Restricted use in patients with diabetes or renal impairment (GFR < 60 ml/min/1.73m²).
Pharmacodynamic Potassium-Sparing Diuretics and Potassium Supplements/Salts Increased risk of severe hyperkalemia. Co-administration may require specific regulatory precautions.
Pharmacodynamic Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Reduced antihypertensive effect and increased risk of worsening renal function. Clinically significant interaction noted in official labels.
Pharmacokinetic Fluconazole (CYP2C9 Inhibitor) Reduced plasma concentrations of the active metabolite. Alters drug exposure of the active compound.
Clearance Effect Lithium Reduced renal clearance of Lithium. Increased risk of lithium toxicity is documented.

Population and Substance Notes

Severe Hepatic Impairment is an officially noted restriction due to pharmacokinetic data showing significantly increased plasma concentrations of Losartan. Alcohol (ethanol) co-administration may also lead to additive hypotensive effects, such as dizziness, as stated in regulatory documents.

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Mechanism of Action

Losartan is a pharmaceutical agent that works exclusively by targeting the Renin-Angiotensin-Aldosterone System (RAAS), a key hormonal pathway involved in systemic vascular tone and volume control. Its primary mode of action is to interrupt this system at the point where it delivers its strongest signal.


The Core Mechanism: Selective AT1 Receptor Blockade

Losartan and its active metabolite, EXP-3174, act as selective antagonists that block the Angiotensin II Type 1 ( AT1) receptor. This mechanism prevents the hormone Angiotensin II from binding to the receptor, thereby suppressing the initiation of its physiological effects. This targeted receptor interference avoids altering the creation of Angiotensin II itself, focusing instead on interrupting the receptor binding step that initiates downstream effects.


Systemic Modulation of Vascular Tone

By blocking AT1 receptors on the smooth muscle of blood vessels, Losartan suppresses the Angiotensin II-driven signal for vasoconstriction (arterial tightening). This molecular intervention leads to the physiological effects of arterial relaxation and widening (vasodilation), which reduces Total Peripheral Resistance (TPR). This key action reduces the mechanical load experienced by the vascular walls.


Influence on Fluid and Tissue Remodeling Signals

The mechanism also extends to secondary hormonal and cellular functions. AT1 blockade on the adrenal glands diminishes the release of Aldosterone, which results in the modulation of fluid balance through the modest promotion of sodium and water excretion. Furthermore, this action suppresses the AT1-mediated signals that promote the pathological growth and thickening of heart and vessel walls.

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Dosage and Administration Information

How Losartan Stada is Used

Losartan Stada is intended for oral administration as a film-coated tablet that must be swallowed whole with water. The fundamental principle of its usage is a once-daily schedule across all approved indications, establishing a pattern for long-term, sustained management. The full therapeutic effect typically requires consistent daily intake over three to six weeks.


Standard Adult Dosing Principles

The most common initial dose for adult patients with hypertension is 50 mg of Losartan Potassium once per day. The dose may be adjusted based on necessity, up to a maximum recommended daily dose of 100 mg.

Indication Initial Dose Maintenance Range (Max)
Hypertension 50 mg once daily Up to 100 mg once daily
Diabetic Nephropathy 50 mg once daily Up to 100 mg once daily

Losartan tablets are formulated to be administered with or without food. If a dose is missed, the next dose is taken at the regularly scheduled time, rather than taking a double dose to compensate.

Usage in Specific Populations

Specific considerations apply to certain patient groups. A lower initial dose of 25 mg once daily is generally recommended for individuals with hepatic impairment or those who are intravascularly volume-depleted. For pediatric patients aged 6 to 16 years, the regimen is weight-based, starting at approximately 0.7 mg per kilogram once daily, not to exceed 50 mg. No mandatory initial adjustment is typically required for patients with renal impairment.

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Recent Clinical Evidence

Research evidence / Overview of Studies for Losartan Stada

The research evidence for Losartan Stada is primarily based on large, controlled clinical trials that focus on chronic cardiovascular and kidney conditions. These studies help show what has been observed so far in specific patient groups over defined time intervals. Findings describe group patterns, not personal outcomes, and research provides context but not individual predictions.


Evidence for High Blood Pressure (Hypertension) Management

Research has explored patterns observed with Losartan in adults with essential hypertension across a variety of study designs. These include short-term Randomized Controlled Trials (RCTs) that typically last about 8 to 12 weeks. Studies reported measurements showing changes in blood pressure, with researchers primarily focused on the reduction in systolic and diastolic blood pressure and the proportion of participants who reached predefined blood pressure goals. What remains uncertain is the long-term impact on major cardiovascular events specifically within the low-risk, general hypertensive population, as this group was not the main focus of the most extensive, multi-year studies.


Evidence for Use in Patients with Left Ventricular Hypertrophy (LVH)

Research exploring the use of Losartan in contexts involving high blood pressure and Left Ventricular Hypertrophy (LVH) comes from large-scale RCTs with an average follow-up duration of approximately 5 years. These studies was observed in older adults with established hypertension and LVH. Researchers examined patterns by measuring a composite endpoint which included the occurrence of cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction. A key limitation is that the observed pattern concerning stroke incidence was not evident in the Black patient subgroup evaluated in the main trial; generalizability may be restricted to certain high-risk hypertensive patients with LVH.


Evidence for Kidney Disease in Type 2 Diabetes Patients (Diabetic Nephropathy)

The research for Losartan in patients with Type 2 diabetes and kidney disease was conducted using large RCTs over an intermediate-term period, with an average follow-up of about 3.4 years. The trials explored a composite endpoint related to the progression of kidney failure, which included the need for dialysis and death. Research also examined changes in the amount of protein in the urine (proteinuria) over time. Some analyses indicated that the treatment did not influence the measurements related to overall mortality during the study's observation period.

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Frequently Asked Questions (FAQ)

Common questions about Losartan Stada (FAQ)


Q: Why is Losartan sometimes prescribed when other similar drugs, like Lisinopril, are available?

Official information indicates Losartan belongs to the ARB drug class, which works differently from ACE inhibitors (like Lisinopril).

Studies show that Losartan is often used as an alternative treatment for patients who develop a persistent cough, which can be a common adverse event associated with ACE inhibitors.

Losartan’s incidence of cough is reported to be similar to that of a placebo.


Q: Is Losartan Stada the same drug as the brand name Cozaar?

The active ingredient in Losartan Stada is Losartan potassium, which is the same active ingredient found in Cozaar.

Cozaar is the reference drug used by regulatory agencies for approving generic or alternative brand versions of Losartan products.

The different brand names distinguish the manufacturers and specific formulations.


Q: Are there any over-the-counter pain relievers that interact with Losartan Stada?

Official drug information notes an interaction between Losartan and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), which include some over-the-counter pain relievers.

This interaction may cause a reduction in Losartan’s blood pressure-lowering effect and regulatory sources indicate it can increase the risk of worsening kidney function.


Q: Can people with certain types of kidney problems still use Losartan Stada?

Official labeling indicates that a mandatory initial dose adjustment is typically not required for patients with general renal impairment, including those on dialysis.

However, Losartan is contraindicated for patients with kidney disease who are also taking the drug aliskiren.

This contraindication is due to the potential for increased risk of adverse reactions, such as low blood pressure and high potassium.


Q: What does official information say about the safety of long-term use of Losartan Stada?

Losartan is intended for the long-term management of chronic conditions such as high blood pressure.

Official regulatory documents do not provide a singular statement on overall long-term safety, but they highlight known risks and monitoring requirements.

Some past product recalls were issued for Losartan products from specific manufacturers due to impurities that posed a potential theoretical risk with long-term use.


Q: How often does a person typically need to have blood tests while on Losartan Stada?

Regulatory guidance advises that blood tests for electrolytes (such as potassium) and kidney function should be assessed before starting Losartan.

Monitoring is typically suggested to be repeated again within two to four weeks after Losartan is initiated.

These tests help ensure that the body is responding appropriately to the medication.


Q: Can Losartan Stada be crushed or split?

Official information states that the film-coated tablets should be swallowed whole.

If difficulty swallowing occurs, official information suggests consulting a healthcare provider regarding the possible use of a prepared oral suspension.


Q: Is a drop in blood pressure after starting Losartan Stada considered normal?

The primary function of Losartan is to achieve a therapeutic reduction in high blood pressure.

However, regulatory information cautions that severe or symptomatic low blood pressure (hypotension) can occur.

This risk is noted especially when treatment is first started.


Q: What conditions besides high blood pressure is Losartan Stada approved to treat?

In addition to treating high blood pressure (hypertension), Losartan is approved for two other conditions.

It is used to reduce the risk of stroke in patients who have hypertension along with left ventricular hypertrophy (enlarged heart muscle).

Losartan is also indicated for treating kidney problems (nephropathy) in patients with type 2 diabetes.


Q: Can Losartan Stada be used in the treatment of heart failure?

Official product information contains a specific dosing regimen for the treatment of heart failure.


Q: Is hair loss a reported side effect of Losartan Stada?

Alopecia, the medical term for hair loss, has been reported as an adverse reaction associated with Losartan use.

However, regulatory documents state that the frequency of this side effect is not known based on controlled studies.


Q: Does Losartan Stada commonly cause ankle or leg swelling?

Official product information lists edema (swelling, often of the ankles or legs) as a common adverse event.

Common side effects are those that may affect between 1% and 10% of people who use the medication.


Q: Are changes in body weight reported with Losartan Stada use?

Official labeling does not list weight gain as a common or rare side effect.

However, fluid retention (edema) is reported as a common side effect, which can temporarily increase body weight.


Q: Is a persistent dry cough usually linked to Losartan Stada use?

Cough is reported as a common side effect in some adverse event listings for Losartan.

However, clinical data indicates that the incidence of cough in patients who switch from ACE inhibitors to Losartan is similar to that observed with a placebo.


Q: Can Losartan Stada affect sleep patterns or cause insomnia?

Official adverse event listings include insomnia, or trouble sleeping, as a common side effect.

Common side effects are those that may affect up to 1 in 10 people.


Q: Does Losartan Stada interact with grapefruit or grapefruit juice?

Official information notes that consuming grapefruit or grapefruit juice may potentially increase the absorption and concentration of Losartan in the body.

Official information advises consulting a healthcare professional regarding the consumption of grapefruit products while taking this medication.


Q: How quickly does Losartan Stada usually begin to lower blood pressure?

Regulatory monographs indicate that the initial blood pressure-lowering effect of Losartan is substantially present within one week of starting treatment.

Maximum therapeutic effect is generally observed after consistent use over three to six weeks.


Q: What happens in the body if a person stops taking Losartan Stada suddenly?

Official guidance states that the medicine should not be stopped abruptly.

Regulatory notes indicate that the immediate risk to health may be higher if chronic treatment is discontinued without an alternative plan in place for managing the underlying condition.


Q: Does Losartan Stada have specific limitations or warnings for elderly patients?

Official documentation states that no initial dosage adjustment is typically required for elderly patients.

However, the regulatory notes do caution that greater sensitivity to the medication in some older individuals cannot be ruled out.


Q: Has Losartan Stada been subject to any recent drug recalls?

Losartan potassium products from certain manufacturers have been subject to recalls in the past.

These regulatory actions were taken due to the detection of specific impurities, such as NMBA and Azido, in the drug ingredients.


Q: Does Losartan Stada contain any sulfa ingredients that may cause allergic reactions?

Losartan tablets contain Losartan potassium as the active ingredient.

Official formulation documents show that while the active ingredient is Losartan potassium, some specific formulations may include inactive ingredients (excipients) that contain sulfa compounds, such as sodium polystyrene sulphonate.


Q: Does official information mention any effect of Losartan Stada on sexual function or libido?

Official adverse event reports indicate that a decrease in libido (sexual desire) and issues related to sexual ability, drive, or performance have been reported.

The frequency of these specific side effects is not known based on controlled studies.

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How should Losartan Stada be stored and disposed of?

How to Store and Dispose of Losartan Stada?

Losartan Stada tablets must be stored according to regulatory requirements to ensure stability. The medicine must be kept at Controlled Room Temperature (CRT), which is 20 C to 25 C, with excursions permitted up to 30 C.


Storage Requirements

The tablets must be stored in the original package, protected from both light and moisture (a dry place). A mandatory child-safety rule requires keeping the medicine out of the sight and reach of children.


Disposal Instructions

Unused or expired Losartan Stada must not be disposed of via household waste or flushed down wastewater. Patients are required to consult a pharmacist or local waste authority for instructions on approved methods for discarding unused medicines.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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