Goldar

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Goldar

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Goldar

What is Goldar? Defining the Gold Preparation

Property Description
Active ingredient Auranofin
Form Oral Capsule
Pharmacological Class Disease-Modifying Antirheumatic Drug (DMARD) / Chrysotherapeutic Agent
General Purpose Long-term disease control; immunomodulation
Origin Synthetic Organogold Compound

Goldar is the brand name for a prescription medication containing the active ingredient Auranofin. It is formally classified as a Disease-Modifying Antirheumatic Drug (DMARD), belonging to the established category of chrysotherapeutic agents (gold preparations). A DMARD's defining purpose is to alter the underlying activity of the disease rather than merely provide symptomatic relief, a therapeutic approach clinically recognized for managing chronic inflammatory conditions.

The chemical structure of Auranofin defines it as a lipophilic organogold compound because it incorporates a gold(I) cation within its complex framework. Goldar is provided as a single-ingredient oral capsule for easy ingestion, distinguishing it as an orally administered medication within a class historically dominated by injectables. This form offers a distinct patient-friendly approach compared to intramuscular gold salts.

The general purpose of this medicine is to act as an immunomodulator, helping to influence the activity of specific immune cells responsible for causing chronic inflammation and joint damage. Auranofin's mechanism is directed toward controlling the immune system's activity in inflammatory diseases. This compound helps to influence the cellular environment to suppress the progression of the disease. By working at this foundational level, the medication is intended for long-term disease control and aims to prevent the progressive erosion of bone and cartilage, which is the critical goal of DMARD therapy in adults diagnosed with active rheumatoid arthritis.

Regulatory References

  1. Auranofin (MedlinePlus)

What side effects are possible with Goldar?

Possible Side Effects and Safety Information for Goldar

Official government regulatory bodies classify a medicine's risks to ensure patients receive clear, structured information. The safety profile of Goldar is organized by the severity and frequency of adverse reactions observed in clinical study populations.

Adverse Reactions and Safety Categories

Side effects documented in regulatory labeling are grouped primarily by the System-Organ Class (SOC), which categorizes reactions according to the body system affected (e.g., Gastrointestinal Disorders, Nervous System Disorders). They are also classified by Frequency using standard definitions derived from clinical trial occurrence rates:

  • Very Common: Occurring in 1 out of 10 people or more.
  • Common: Occurring in less than 1 out of 10 people but at least 1 out of 100 people.
  • Uncommon or Rare: Less frequent events that are still officially documented.

Serious Adverse Reactions and Risk Mitigation

Serious Adverse Reactions (SARs) represent medically significant events, such as those that are life-threatening or result in hospitalization. These events are specifically highlighted in official documents to define the critical risks associated with the medicine.

Safety-Related Restrictions formally establish the conditions under which the medicine must not be used (Contraindications) or situations that require extreme caution or specific monitoring (Precautions). These restrictions are mandated by regulatory authorities to manage inherent risks.

Population-Specific Safety Considerations apply to certain patient groups, such as those with pre-existing kidney or liver impairment, or during pregnancy and lactation. These statements define necessary risk adjustments or monitoring protocols for those specific groups, according to the official documentation. The frequency of certain adverse events may also be explicitly documented as Dose- or Exposure-Related, meaning the risk is tied directly to the amount or duration of use.

This structured regulatory summary ensures all documented safety information is communicated in a standardized manner, structuring the overall understanding of the medicine’s risk profile.

Overdose and Emergency Response

Goldar Overdose and when to seek help

Overdosage of Goldar (Auranofin) is officially documented in regulatory sources as potentially leading to manifestations of severe gold toxicity. These effects can impact multiple physiological systems. Documented clinical signs include specific neurological findings, such as encephalopathy and peripheral neuropathy, and severe gastrointestinal effects like persistent, severe diarrhea or stomatitis.

The official profile notes potential laboratory evidence of severe toxicity, including hematologic changes such as a fall in hemoglobin and leukopenia, as well as renal complications like proteinuria and hematuria.

Required Emergency Actions

In an overdose situation, regulatory authorities mandate that emergency medical attention must be sought immediately. It is required to call 911 if the individual has collapsed, had a seizure, is experiencing trouble breathing, or is unable to be awakened. Contacting a poison control center right away is also specified.

Official regulatory texts recommend immediate procedures such as the induction of emesis or gastric lavage, followed by appropriate supportive therapy. The prescribing information states there is no specific experience with treating Auranofin overdosage with chelating agents, although their potential use is referenced based on data for injectable gold. No population-specific overdose manifestations are detailed in the official overdosage section.

Therapeutic Uses of Goldar

What Goldar Treats: Main Uses and Benefits

The primary purpose of Goldar (Auranofin) is to serve as a Disease-Modifying Antirheumatic Drug (DMARD) for the long-term control of symptoms associated with specific chronic inflammatory conditions, and is primarily used to address symptoms related to Active Rheumatoid Arthritis (RA).


Supporting the Management of Active Joint Inflammation and Swelling

Goldar is commonly applied in the symptomatic management of adults with active classical or definite rheumatoid arthritis. The medication is used to help address symptoms related to systemic imbalance, such as swollen, tender joints and pronounced morning stiffness. Its role is to help ease the overall symptom burden caused by ongoing inflammatory or irritative states.


Structural Support in Long-Term Disease Management

A key long-term benefit of Goldar is its role in structural support. The drug is applied in the context of long-term disease management and may assist with managing symptoms related to the progressive joint damage that can be associated with active RA. This supports maintaining functional stability, which contributes to improved comfort during periods of heightened symptoms and helps improve day-to-day comfort during symptomatic periods. Goldar is considered relevant as a second-line option when other symptomatic therapies, such as Nonsteroidal Anti-inflammatory Drugs (NSAIDs), have not provided sufficient support.


“It plays a role in managing chronic symptoms that interfere with daily functioning.”


Quick Fact: Support for Joint Tenderness Goldar helps address symptom clusters that may become intense or disruptive, assists with easing symptoms related to physical discomfort (pain, swelling, and sensitivity) in the joints.

Regulatory References

  1. DailyMed drug label

Eligibility and Restrictions for Use

Official Eligibility Rules for Goldar (Auranofin)

Goldar is officially indicated for the management of adults diagnosed with active classical or definite rheumatoid arthritis, typically when initial non-steroidal anti-inflammatory drug (NSAID) therapy has failed or was not tolerated. The eligibility for using this medication is strictly defined by regulatory authorities.


Absolute Non-Use (Contraindications)

Population Group Restriction
History of Gold Toxicity Contraindicated in patients with any prior severe gold-induced reactions, including exfoliative dermatitis, pulmonary fibrosis, or necrotizing enterocolitis.
Severe Disorders Contraindicated in patients with severe pre-existing hematologic disorders (e.g., bone marrow aplasia) or severe organ disease.

Conditional and Restricted Use

Population Group Regulatory Status
Pediatric Patients Safety and efficacy have not been established for the labeled indication in children and adolescents.
Pregnancy Category C; use is allowed only if the potential benefit outweighs the potential risk.
Lactation Not recommended due to the documented excretion of gold into breast milk.
Organ Impairment Use requires caution and monitoring in patients with progressive renal disease or significant hepatocellular disease.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory documents define the interaction profile of Goldar (Auranofin) primarily through specific restrictions and documented outcomes with other medicinal products.

Interaction-Related Restrictions

The formal regulatory restriction on co-administration applies to the substance Dimercaprol, which is strictly prohibited. The safety of concurrent use with several other agents is not established, necessitating caution. This includes Injectable Gold Preparations due to the recognized risk of additive gold toxicity. Similar unestablished safety profiles exist for co-administration with other antirheumatic agents, such as Penicillamine, which carries a documented potential for blood cell or kidney toxicity. The same caution applies to other Immunosuppressive Agents (e.g., Methotrexate, Cyclophosphamide) and High-Dose Steroid Medication.

Exposure Modification and Substance Status

A clinically relevant interaction is the exposure-altering effect on Phenytoin. Official documents state that co-administration may result in Goldar increasing the plasma concentrations of Phenytoin. No specific enzyme or transporter mechanism is cited in the label for this effect. Regarding common consumables, the regulatory label explicitly states that the interaction status between Goldar and alcohol is unknown, and there are no known interaction rules pertaining to food.

Mechanism of Action

Targeting Intracellular Redox Balance

The mechanism begins with the gold(I) ion component of Auranofin binding to and irreversibly inhibiting the enzyme Thioredoxin Reductase (TrxR). This highly specific molecular action alters the cell's redox homeostasis, generating intracellular oxidative stress within inflammatory cells.


️ Suppressing Chronic Inflammatory Signaling

The resulting oxidative stress acts as a biochemical signal to modulate key immune pathways, specifically inhibiting the NF-kappaB pathway. This results in the attenuation of pro-inflammatory cytokine (like IL-6) synthesis and release by immune cells (macrophages and lymphocytes). This action contributes to the modulation of the chronic inflammatory signaling cascade.


⏳ Mechanism-Dependent Delayed Onset

The overall effect relies on the cumulative suppression and functional alteration of these overactive immune cell populations, rather than an immediate receptor interaction. This means the pharmacological action requires weeks to months to achieve the necessary physiological change. The mechanism is consequently physiologically constrained in contexts demanding a rapid-onset effect.

Dosage and Administration Information

How to Use Goldar

Goldar, which contains the active ingredient Auranofin, is a prescription medication used according to standardized regimens. As a chrysotherapeutic agent, its administration pattern is defined by a specific oral route, fixed low-dose ranges, and required long-term monitoring.


Official Administration Protocol

The medication is administered exclusively via the oral route using the approved 3 mg capsule strength. The therapy requires a fixed starting dose and an extended observation period before any adjustments can be considered.

Usage Parameter Instruction
Starting Dose Typically 6 mg daily (two 3 mg capsules).
Dosing Frequency Administered either once daily or in two divided doses (e.g., 3 mg twice daily).
Maximum Dose May be increased to a maximum of 9 mg daily, administered in three divided doses, if the response is inadequate.
Meal Relationship When using a divided dose, instructions may recommend taking the capsules with meals.

Duration and Adjustment Principles

Goldar is designed for long-term therapy; a satisfactory clinical response is typically not observed until 3 to 6 months after treatment initiation. The initial 6 mg daily dose must be trialed for this full period before any dose increase is considered. Therapy should generally be discontinued if no sufficient response is achieved after a 3-month trial at the maximum 9 mg daily dose.

Special Use Contexts

When transferring a patient from injectable gold salts, oral Goldar therapy is initiated at the standard 6 mg daily dose. The safety and effectiveness of Goldar have not been established for use in children under 16 years of age.

Recent Clinical Evidence

Research evidence / Overview of studies for Goldar

Evidence for Use in Active Rheumatoid Arthritis (RA)

The core research for Goldar (Auranofin) has centered on its use for Active Classical or Definite Rheumatoid Arthritis (RA) in adults. The evidence base primarily consists of Randomized Controlled Trials (RCTs), where researchers explored how symptoms change over defined time intervals. The research has explored outcomes relevant to long-term disease management.

Studies monitored outcomes related to physical discomfort, specifically measuring the number of tender joints and the number of swollen joints. They also monitored patient-reported outcomes describing perceived discomfort. Findings describe patterns observed in the studies where researchers measured changes in these short-term symptom outcomes compared to placebo. However, the observed changes in some pooled data have often been characterized as modest when compared with patterns seen with some other treatments.

Types of Studies and Outcomes Measured

The majority of the evidence comes from RCTs where Goldar was evaluated in patients with established RA over periods ranging from six months to two years. The research examined how the medication was associated with changes in outcomes reflecting daily functioning or activity level. The research also included assessments of structural outcomes, which monitored radiological progression to assess changes in joint damage. However, the findings related to this structural impact were observed in some studies but have been mixed or inconsistent across the full evidence landscape.

Long-Term Evidence and Follow-up Durations

For assessing longer-term outcomes, such as functional status evaluations, studies were observed in settings extended to 12 months and sometimes up to 2 years. The extent of long-term evidence is limited regarding changes in the progression of joint damage over many years. Outcomes reflecting systemic or functional measures over the patient’s full disease course are not fully characterized in the current research, and data for long-term outcomes remains insufficient compared to the evidence for short-term symptomatic relief.

Key Evidence Gaps and Areas of Uncertainty

Scientific reviews point to a few areas where the evidence remains insufficient or unclear. The most prominent gap is the inconsistency of findings regarding the long-term impact on changes in radiological progression of joint damage. Furthermore, sample sizes were modest in some original trials, and evidence quality varies across studies. Research provides context by describing group patterns, and further research is ongoing to clarify these patterns and outcomes.

Key Studies & References

  1. Auranofin (Goldar) Label Information
  2. ACR Guidelines for the Management of Rheumatoid Arthritis

Frequently Asked Questions (FAQ)

Common questions about Goldar (FAQ)

Q: Is Goldar the same type of medicine as [similar common drug name]?

A: Goldar is the brand name for the medicine containing the active ingredient Auranofin. Official product information classifies it as a Disease-Modifying Antirheumatic Drug (DMARD), specifically falling under a historical category known as chrysotherapeutic agents (gold preparations).

Its classification is based on its specific mechanism, which is intended to modify the underlying disease activity, distinguishing it from general pain relievers.

Q: Can taking Goldar affect my ability to drive or operate machinery?

A: Official safety information for Auranofin indicates that reported side effects can include dizziness and changes in vision.

If these effects occur, they could potentially affect a person's ability to drive or safely operate machinery.

Q: Is it true that Goldar can cause weight gain or weight loss?

A: According to reports from clinical study populations, weight loss or a decrease in appetite is an effect noted during Auranofin treatment.

This information is included in the medicine's official safety profile regarding metabolism and nutrition effects.

Q: Does Goldar interact with common over-the-counter pain relievers?

A: Official drug interaction data for Auranofin indicates the potential for interactions with other common medicines, including some nonsteroidal anti-inflammatory drugs (NSAIDs).

The concurrent use of these agents may require caution, as outlined in the regulatory documents.

Q: Can Goldar be taken by older adults (e.g., those over 65)?

A: Clinical studies evaluating Auranofin did not include a large enough group of patients aged 65 and older to determine if they experience unique responses compared to younger individuals.

Regulatory documents generally note this lack of specific comparative data in the geriatric population.

Q: Is a metallic taste in the mouth or dry mouth common with Goldar?

A: According to official prescribing information, a metallic taste in the mouth is a possible effect of Auranofin.

This symptom can sometimes serve as a signal for potential issues like stomatitis (oral inflammation), which is an observation that should be noted.

Q: What are the most commonly reported side effects of Goldar?

A: The most frequently reported side effects observed in clinical studies for Auranofin include gastrointestinal issues such as loose stools or diarrhea, abdominal pain, and nausea.

Skin inflammation, such as dermatitis or rash, is also among the commonly reported reactions in official safety documents.

Q: Does Goldar make you feel tired or sleepy during the day?

A: Unusual tiredness is listed in regulatory documents as a potential indicator of hematologic issues, which are serious adverse reactions associated with Auranofin.

This specific type of unusual tiredness is noted in the safety profile as a symptom that warrants medical monitoring.

Q: How long does Goldar stay in your system after you stop taking it?

A: Official pharmacokinetic data indicates that the active components of Auranofin have a prolonged half-life.

Because of this, gold levels can remain detectable in the body for several months after a person discontinues the medication.

Q: Are there any documented interactions between Goldar and birth control pills?

A: Official regulatory documents do not provide specific interaction data regarding Auranofin and oral contraceptives.

However, due to the drug’s Pregnancy Category C classification, the use of adequate contraception methods is a topic often discussed in the context of Auranofin treatment.

Q: Is it normal to feel a bit dizzy in the first few days of Goldar treatment?

A: Dizziness is noted as a reported side effect in the official safety profile for Auranofin.

As with any new medication, the body may adjust to the treatment over time. Dizziness is noted in the official safety profile.

Q: What type of medical professional typically prescribes Goldar?

A: Regulatory safety measures state that Auranofin therapy should be initiated and carefully monitored by a physician who is experienced with this specific class of medicine, known as chrysotherapy.

This is intended to ensure that the risks and benefits of the treatment are properly managed by a specialist familiar with the therapy.

Q: Is there a possibility of an allergic reaction to Goldar?

A: As with other gold compounds, the possibility of serious allergic reactions exists, including events like anaphylaxis and angioedema.

Official warnings highlight these risks, and they are recognized as medically significant adverse reactions in the safety documentation.

Q: Why is Goldar sometimes called by a different name in other countries?

A: Goldar is a specific brand name for the medicine containing the active ingredient Auranofin.

This medication may be sold under its generic name (Auranofin) or other trade names, such as Ridaura, depending on the country of sale and regulation.

Q: Are there any specific lifestyle changes recommended when taking Goldar?

A: Official regulatory guidance notes the potential for increased skin sensitivity to sunlight (photosensitivity).

Because of this, the practice of limiting sun exposure and using sun protection is described in the product information.

Q: Can Goldar be used by people with a history of heart conditions?

A: Regulatory warnings indicate that certain pre-existing conditions, such as congestive heart failure and hypertension, are typically managed prior to the initiation of gold therapy.

This is to ensure patient safety according to official warnings and precautions.

Q: Do the official patient information leaflets mention anything about hair loss or changes?

A: Official prescribing information notes that partial or complete hair loss, known as alopecia, has been reported as an effect associated with this class of gold compounds.

This is listed among the documented adverse reactions.

Q: What is the main purpose of the black box warning on Goldar's label?

A: The US regulatory label includes a Boxed Warning—often referred to as a black box warning—to alert prescribers and patients to the potential for serious toxicity.

This toxicity includes gold-induced effects like persistent diarrhea, skin rash, mouth inflammation (stomatitis), and blood cell suppression (hematologic depression).

Q: What does 'contraindication' mean in the context of Goldar's use?

A: In official drug information, a 'contraindication' describes a specific situation or pre-existing medical condition where the medicine must not be used.

For Auranofin, this means the potential health risks in those situations are considered to outweigh any possible benefits of the treatment.

Q: Can Goldar be used by people who are lactose intolerant?

A: Official regulatory labeling contains a warning that patients with certain rare hereditary conditions, including Lapp lactase deficiency or glucose-galactose malabsorption, should not take this medicine.

This is because of the inactive ingredients included in the product.

Q: Does Goldar interact with medications used for high blood pressure?

A: Official warnings state that blood pressure management is typically addressed prior to the initiation of gold therapy like Auranofin.

This is a specific precaution noted in the official product information to guide prescribers.

Q: Is a headache a common side effect when starting Goldar?

A: Headache is reported as a possible side effect that may occur while taking Auranofin.

This information is included in the medicine's official safety profile.

Q: What should I do if I notice a change in the color of my urine while on Goldar?

A: Regulatory safety documents indicate that changes in the amount or color of urine can be a sign of potential kidney problems, which is known as renal toxicity.

Such observations are noted as part of the overall safety monitoring requirements for Auranofin.

How should Goldar be stored and disposed of?

How to Store and Dispose of Goldar

The storage of Goldar (Auranofin) oral capsules must adhere to specific regulatory requirements to maintain product stability and safety. The medication must be kept in its original container, which must be tightly closed, and stored at controlled room temperature, specifically between 59 F and 86 F. It is required to store the capsules away from excess heat, moisture, and light; freezing should also be avoided.

All medicines, including Goldar, must be kept out of the sight and reach of children and pets.

For disposal, unused or expired capsules should not be flushed down the toilet or poured down a drain. The official procedure recommends using a drug take-back program or mixing the capsules with an undesirable substance (such as dirt) and placing them in a sealed container before discarding in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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Equivalent of Goldar found in:

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