Flugesic

do not chew the capsule and drink enough liquid (preferably water). If possible, the drug is taken while in an upright position.

Apply 100 mg (1 capsule) 3-4 times a day with equal intervals between doses. For severe pain — 200 mg (2 caps.) 3 times a day. The maximum daily dose is 600 mg/day (6 capsules).

The doses are selected depending on the intensity of the pain and the individual tolerability of the drug. The minimum effective dose should be used for the shortest possible period of time. The duration of treatment should not exceed 2 weeks.

patients with concomitant liver disease or alcoholism,

children under 18 years of age.

renal failure, hypoalbuminemia, elderly over 65 years of age.

often-dyspepsia, nausea, vomiting, pain in the stomach, constipation, abdominal pain, dryness of the oral mucosa, flatulence, diarrhea.

often-sweating.

very often — fatigue/weakness (in 15% of patients), especially at the beginning of treatment.

it persists until depolarization of the cell membrane occurs (indirect antagonistic effect on NMDA receptors).

₁- (5-hydroxytryptophan)-, 5NT- serotonin, opioid, central m-and n-cholinergic receptors.

This central action of flupirtin leads to the realization of three main effects.

. Consequently, when the neuron is excited, the transmission of ascending nociceptive impulses is inhibited.

₁

Another metabolite — M - it is not biologically active, it is formed as a result of the oxidation reaction (phase 1) of p-fluorobenzyl followed by conjugation (phase 2) of p-fluorobenzoic acid with glycine. Studies on which isoenzyme is predominantly involved in the oxidative degradation pathway have not been conducted. It should be expected that flupirtin will have only a minor ability to interact.

T

In elderly patients (over 65 years of age), compared with young patients, there is an increase in T

Most of it is excreted by the kidneys (69%): 27% - in unchanged form, 28% - in the form of the metabolite M (acetyl-metabolite), 12% - as a metabolite of M

Increases the effect of alcohol, sedatives and muscle relaxants.

Due to the fact that flupirtin has a high degree of binding to proteins, it can change the degree of binding to proteins of other drugs used simultaneously. As a result of the study

With the simultaneous use of flupirtin and indirect anticoagulants-coumarin derivatives-it is recommended to regularly monitor the PV in order to adjust the dose of indirect anticoagulants in a timely manner. There are no data on interaction with other anticoagulant or antiplatelet agents (including acetylsalicylic acid).