Neo Borocillina Gola Dolore

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Neo Borocillina Gola Dolore

Quick Overview: What is Neo Borocillina Gola Dolore?

Property Description
Active ingredient Flurbiprofen
Form Lozenge (Pastiglia), Oral Mucosal Spray, Mouthwash (Collutorio)
Pharmacological class Nonsteroidal Anti-Inflammatory Drug (NSAID)
Common use Symptomatic relief of sore throat and oral inflammation
Origin Synthetic, derived from propionic acid

Classification and Nature of the Medicine

Neo Borocillina Gola Dolore is a branded medicinal product primarily classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID). Its core purpose is the symptomatic relief of local irritation and pain within the oropharyngeal cavity. As an NSAID, the product is clinically recognized for providing combined analgesic (pain-relieving) and anti-inflammatory effects, addressing both the discomfort and the underlying inflammation that causes it.

This medicine is designed exclusively for local use, meaning its action is concentrated directly on the affected throat mucosa, which is a key distinguishing factor from NSAIDs taken systemically (by mouth).

Flurbiprofen: The Active Ingredient and Topical Action

the product is a single-ingredient (monocomponent) preparation containing Flurbiprofen as the sole active ingredient. Flurbiprofen is a synthetic compound derived from propionic acid. Its mechanism is supported by pharmacological studies confirming that it works by inhibiting the synthesis of prostaglandins, the chemical mediators responsible for driving inflammation and pain.

Neo Borocillina Gola Dolore is available in multiple dosage forms optimized for the topical oropharyngeal route, including the lozenge and oral mucosal spray. The availability of these forms ensures flexible and targeted delivery of the active substance exactly where the inflammation is located, providing effective, localized relief.

Regulatory References

  1. Flurbiprofen LiverTox Entry

What side effects are possible with Neo Borocillina Gola Dolore?

Possible Side Effects and Safety Information

The safety profile of Neo Borocillina Gola Dolore, which contains low-dose Flurbiprofen for local use, primarily reflects documented adverse reactions and class warnings associated with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) as documented in regulatory sources.


Adverse Reaction Classification

Side effects are officially classified by frequency. The Common reactions (affecting 1 to 10 users in 100) are typically localized, including oral discomfort (soreness, burning, irritation, dry mouth) and taste disturbance. Less frequent, Uncommon reactions may involve the gastrointestinal system (nausea, abdominal pain, mouth ulceration) or skin (rash, pruritus). Rarely, serious adverse reactions may occur.


Serious Adverse Reactions and NSAID Class Warnings

As an NSAID, Flurbiprofen carries regulatory warnings concerning rare, serious systemic events associated with the drug class, although the risk is noted to be lower with short-term local administration. These include the possibility of Gastrointestinal bleeding, ulceration, or perforation and, in rare instances, Cardiovascular thrombotic events (such as stroke or myocardial infarction). Severe hypersensitivity reactions (e.g., anaphylaxis, angioedema) and rare severe skin reactions are also officially documented.


Population-Specific Safety Constraints

Official labeling defines specific restrictions based on safety profiles:

  • Contraindications: The medicine is contraindicated in the last trimester of pregnancy due to risk of fetal toxicity. It is also restricted for use in individuals with a history of hypersensitivity to aspirin/NSAIDs (e.g., prior asthma, angioedema) or active peptic ulceration/haemorrhage.
  • Elderly: Regulatory documents note the increased frequency and risk of serious adverse reactions, especially GI effects, in older individuals.
  • Duration: The risk of some adverse effects, such as analgesic-induced headache or cardiovascular events (class warning), may increase with prolonged use.

Overdose and Emergency Response

Overdose and When to Seek Help

The following information details the officially documented signs of overdose and the required emergency actions for the active ingredient, Flurbiprofen, as stated in government regulatory sources.

Domain Official Regulatory Statement
Documented Overdose Presentations Symptoms may include nausea, vomiting, epigastric pain, headache, dizziness, drowsiness, and tinnitus (ringing in the ears). Less common symptoms like metabolic acidosis have also been documented.
Physiological Systems Affected Primary systems affected include the Gastrointestinal (GI) system, Central Nervous System (CNS), and potentially renal and hepatic function in severe cases.
Severe and Life-Threatening Outcomes Regulatory sources document the potential for severe outcomes, including gastrointestinal haemorrhage (bloody or tarry stools), acute renal failure, and profound CNS depression (such as coma).
Antidote Status & Management No specific antidote is known for Flurbiprofen overdose. Management is officially described as symptomatic and supportive treatment. Procedures such as gastric lavage and administration of activated charcoal may be considered.
Population-specific Notes Patients with pre-existing renal or hepatic impairment are at a potentially greater risk of NSAID-induced toxicity following an overdose.
When Immediate Medical Help is Required Official instructions mandate to seek immediate medical attention. Urgent help is required if a potentially life-threatening dose is suspected, or if the victim has collapsed, had a seizure, has trouble breathing, or cannot be awakened.

Therapeutic Uses of Neo Borocillina Gola Dolore

What Neo Borocillina Gola Dolore Treats: Main Uses and Benefits

The medicine is commonly used to provide symptomatic relief across key domains of acute oropharyngeal discomfort, which may support patients in coping more steadily with difficult episodes. The medicine is generally indicated for the short-term symptomatic relief of acute sore throat in adults and adolescents over 12 years of age.


Easing Pain and Inflammation in Symptomatic Episodes

This medicine is generally used in situations involving the irritative-inflammatory conditions of the mouth and throat, such as pharyngitis (sore throat), gingivitis, and stomatitis. It helps address symptom clusters defined by localized pain, burning, and the sensation of swelling. The therapeutic benefit is supportive symptomatic relief that helps moderate pronounced symptoms and supports general well-being during symptomatic periods.

“The primary goal is to address the acute, localized discomfort, offering supportive relief that assists with maintaining functional stability.”

The medicine is also relevant in contexts where symptoms interfere with daily functioning, such as addressing discomfort and inflammation following minor dental procedures. This supportive benefit offers relief that helps patients cope more steadily, and may assist with managing the pain associated with swallowing (dysphagia) when symptoms cluster into patterns requiring short-term symptomatic assistance.


Quick Fact: Relief for Acute Discomfort
Symptom Focus: Localized pain, throat soreness, and inflammatory swelling.
Context of Use: Acute episodes of pharyngitis and post-procedural oral inflammation.
Patient Benefit: Provides support that helps ease the overall symptom burden and assists with maintaining comfort during symptomatic phases.

Eligibility and Restrictions for Use

Official Population Eligibility Status

Neo Borocillina Gola Dolore is generally approved for use in Adults and Adolescents aged 12 years and over for short-term symptomatic relief. Eligibility is strictly defined by regulatory documents, primarily restricting use based on the known risks of its active ingredient, the NSAID Flurbiprofen.


Populations Who Must Not Use This Medicine (Contraindications)

Contraindicated Group Condition Regulatory Status
Hypersensitivity Known allergy to Flurbiprofen, other NSAIDs, or aspirin Contraindicated
Organ Failure Severe heart failure, severe renal failure, or severe hepatic failure Contraindicated
GI/Bleeding Active or recurrent peptic ulceration/haemorrhage history Contraindicated
Pregnancy Women in the third trimester of pregnancy Contraindicated

Restricted and Non-Recommended Use

Population Group Eligibility Rule
Children Not recommended for those under 12 years of age (use not established)
Pregnancy (1st/2nd) Not recommended (unless clearly necessary)
Lactation Not recommended for breastfeeding women
Older Adults Use with caution due to increased risk of adverse reactions

Use is also restricted to short-term relief only. Caution is required for patients with non-severe organ impairment, bronchial asthma history, or chronic inflammatory bowel diseases.

What should I know about interactions with other medicines?

The interaction profile for Neo Borocillina Gola Dolore is defined by the official restrictions and warnings associated with its active ingredient, Flurbiprofen, a Nonsteroidal Anti-Inflammatory Drug (NSAID).

Documented Interaction Restrictions

Regulatory documents mandate that co-administration with other NSAIDs, including cyclooxygenase-2 selective inhibitors, be strictly avoided. This restriction also applies to Acetylsalicylic Acid (Aspirin) at doses greater than 75 mg daily, due to a documented increased risk of adverse reactions.

Pharmacodynamic and Exposure Effects

Several substances are noted for increasing pharmacodynamic risk. Co-administration with Anticoagulants (e.g., Warfarin), Anti-platelet agents, Oral Corticosteroids, and SSRIs may enhance the potential for gastrointestinal ulceration or bleeding. Additionally, Flurbiprofen may reduce the therapeutic effect of antihypertensive drugs (e.g., Diuretics, ACE inhibitors).

Interactions that modify drug exposure are also documented: Flurbiprofen may increase the serum levels of medicines such as Lithium and Cardiac Glycosides. Agents like Probenecid may delay the excretion of Flurbiprofen.

Timing and Substance Constraints

Timing constraints are specified for certain interactions. Flurbiprofen must not be used for 8 to 12 days after administration of Mifepristone, and a 24-hour separation is required when administered with Methotrexate to manage the risk of elevated concentrations. Furthermore, Alcohol consumption is officially restricted as it increases the risk of adverse reactions.

Mechanism of Action

How Neo Borocillina Gola Dolore Works

The mechanism of Flurbiprofen involves the functional modulation of the inflammatory process through its localized action as a non-steroidal anti-inflammatory drug (NSAID).


Inhibiting the Prostaglandin Synthesis Pathway

Flurbiprofen operates by acting as a non-selective inhibitor of the Cyclooxygenase (COX) enzymes (COX-1 and COX-2). This molecular interaction inhibits the arachidonic acid cascade, reducing the synthesis of inflammatory mediators known as prostaglandins within the oropharyngeal tissue.


Attenuating Local Nociceptive Signaling

The reduction of prostaglandins, particularly PGE2, alters the chemical environment of the local sensory nerves. This action functionally desensitizes the peripheral nociceptors (pain receptors), raising the threshold for the transmission of nociceptive signals from the site of inflammation.


Modulating Vascular Inflammatory Response

The reduced prostaglandin concentration limits the signals that promote vasodilation (widening of blood vessels) and increase vascular permeability. This mechanistic step interrupts the vascular cascade, constraining the accumulation of plasma fluid and inflammatory cells and decreasing the localized incidence of edema.

Dosage and Administration Information

How Neo Borocillina Gola Dolore Is Used

The administration of this medicine is defined by its localized action, utilizing the oromucosal route to deliver the active ingredient, flurbiprofen 8.75 mg, directly to the throat and mouth mucosa. The overarching principle for its use, consistent with Non-Steroidal Anti-Inflammatory Drug (NSAID) guidelines, is to administer the lowest effective dose for the shortest duration necessary for symptomatic relief.


Dosing Regimens and Frequency

Standard dosing is applicable to adults and adolescents aged 12 years and older. The medication is used on an intermittent, as-needed (PRN) basis, rather than a fixed regimen.

Formulation Unit Dose Frequency and Limit
Lozenge One lozenge (8.75 mg) Repeat every 3 to 6 hours as required. Maximum of five lozenges per 24 hours.
Oral Mucosal Spray One dose (three actuations, 8.75 mg) Repeat every 3 to 6 hours as required. Maximum of five doses per 24 hours.

Administration Technique and Duration

For the lozenge form, the dose must be sucked slowly and continuously moved around the mouth during dissolution. This technique is a crucial procedural condition for proper use. The oral spray requires priming before first use, and users must not inhale during actuation.

Usage is strictly restricted to short-term symptomatic relief. The duration of administration must not exceed three days. If symptoms persist or worsen after this period, further professional evaluation is indicated.

Recent Clinical Evidence

Research evidence / Overview of studies for Neo Borocillina Gola Dolore

The research base for Neo Borocillina Gola Dolore, which contains the active ingredient Flurbiprofen, is founded on clinical trials and scientific literature that have been applied to settings involving symptom patterns within the oropharyngeal cavity. The evidence focuses on a low-dose, localized formulation, and regulatory assessments indicate the data contributes to the broader evidence landscape for this specific application.

Evidence for Symptomatic Relief of Acute Sore Throat and Pharyngitis

The primary evidence base consists of short-term Randomized, Double-Blind, Placebo-Controlled Trials (RCTs), a study type used in research exploring how symptoms change over time. This research was largely applied in studies examining patient-reported experiences related to acute sore throat, a condition associated with acute or disruptive episodes.

In these trials, researchers monitored outcomes related to physical discomfort in the throat. The outcomes monitored reflecting daily functioning included measurements of changes in sore throat pain intensity, the degree of difficulty swallowing (dysphagia), and the subjective sensation of a swollen throat. Studies were typically conducted during periods of increased symptom activity and were designed to assess effects over both single-dose periods and short, multiple-dose treatment courses.


The Landscape of Study Designs and Evidence Quality

The consistency and breadth of the methodology and data for short-term use of this topical NSAID is typically labeled as High. This label reflects the methodological consistency and volume of controlled research available, but it is not a judgment on the medicine’s performance. The research has focused on outcomes linked to heightened symptom activity in the oropharyngeal area. The data contributes to understanding how patients reported their experience of pain and discomfort over the short treatment period.


Areas of Ongoing Research and Uncertainty

Research efforts primarily explored short-term symptom changes. The follow-up durations for the main efficacy studies were limited to the acute treatment period, up to a maximum of 7 days of multiple-dose use. The available research base provides limited information for long-term outcomes or the durability of reported changes beyond this short-term framework.

Data for certain groups remain insufficient. The populations most extensively evaluated in the primary research were adults and adolescents over 12 years of age, and the results apply only to the populations studied. Research exploring short-term symptom changes does not determine whether an individual will respond similarly to the group patterns observed in the studies.

Key Studies & References

  1. Public Assessment Report Scientific discussion Strepfen Orange Sugar free 8.75 mg, lozenges (flurbiprofen) NL/H/4697

Frequently Asked Questions (FAQ)

Common questions about Neo Borocillina Gola Dolore (FAQ)

Q: What are the different forms of Neo Borocillina Gola Dolore (lozenges, spray, etc.)?

A: According to the official product information, Neo Borocillina Gola Dolore is generally available in various forms optimized for local use in the mouth and throat. These dosage forms typically include lozenges, an oral mucosal spray, and in some markets, a mouthwash (collutorio). All forms are designed to deliver the active ingredient directly to the affected area.

Q: Do all the different versions of Neo Borocillina Gola Dolore contain the same active ingredient?

A: Official regulatory documents indicate that the primary forms of the product (lozenges, oral spray, and mouthwash) contain flurbiprofen as the single active pharmaceutical ingredient. Flurbiprofen is classified as a non-steroidal anti-inflammatory drug (NSAID).

Q: Can Neo Borocillina Gola Dolore be used for pain after dental procedures?

A: The product's official indications in certain markets describe the symptomatic treatment of irritative-inflammatory conditions of the oropharyngeal cavity, including pain associated with conservative or extractive dental therapy. This means the product is indicated for localized pain or irritation following routine dental work.

Q: Does Neo Borocillina Gola Dolore cause drowsiness or affect alertness?

A: Official warnings note that the medicine can affect the ability to drive or operate machinery, as side effects such as dizziness or drowsiness may occur. Regulatory documents recommend waiting until the user knows how the medicine affects them before driving or operating machinery.

Q: Is there a risk of stomach upset or stomach irritation from using this product?

A: As an NSAID, the product has documented adverse effects. Nausea, abdominal discomfort, and indigestion (upset stomach) are listed as known systemic reactions. Additionally, oral discomfort, including mouth irritation, is officially classified as a common local side effect.

Q: Can people with a history of stomach ulcers use Neo Borocillina Gola Dolore lozenges or spray?

A: Official documents clearly state that the medicine is contraindicated (is not allowed for use) in patients with active or a history of recurrent peptic ulceration, gastrointestinal bleeding, or perforation related to prior NSAID treatment. This is a critical safety restriction based on the active ingredient, flurbiprofen.

Q: Can people with kidney problems use Neo Borocillina Gola Dolore?

A: The medicine is contraindicated (not allowed for use) in patients with severe renal failure. Official documents state that use in patients with non-severe renal impairment (kidney problems) is advised with caution, as NSAIDs may impact kidney function.

Q: Can the lozenges be taken with food or only on an empty stomach?

A: While official administration instructions do not specify whether to take the lozenges with food, official safety information notes that gastrointestinal discomfort or nausea may occur. Patients who experience such effects often find relief by taking oral medication after a small snack or milky drink.

Q: How quickly does Neo Borocillina Gola Dolore typically start to provide symptom relief?

A: Clinical studies examining the use of the lozenge form have provided data on the timeline for relief. Evidence indicates that the median time to first perceived pain relief in patients with acute sore throat was reported to be approximately 11 minutes.

Q: Is the drug designed for short-term use only, or can it be used for prolonged periods?

A: The product is indicated for short-term symptomatic relief only. Official product information states that the maximum duration of administration is three days. Continuing the use of NSAIDs for prolonged periods may be associated with an increased risk of certain adverse effects.

Q: Is the small amount of ethanol (alcohol) in the spray form considered a safety concern?

A: The oromucosal spray contains a small amount of ethyl alcohol (ethanol) as an excipient. Regulatory documents note that at recommended dosages, the amount of ethanol is considered much lower than the quantity that would cause systemic effects. The amount of alcohol in the spray is not generally expected to cause harm.

Q: Do the sugar-free lozenges contain any ingredients that can affect blood sugar levels?

A: The sugar-free lozenges and the spray contain excipients such as liquid sorbitol. Sorbitol is officially recognized as a source of fructose, which is a concern. For safety reasons, the product is contraindicated (not allowed for use) in patients diagnosed with rare hereditary problems of fructose intolerance.

Q: Does Neo Borocillina Gola Dolore contain lactose or gluten?

A: Official documents mandate that all excipients, including potential allergens like lactose or gluten, be detailed on the product label and in the Patient Information Leaflet (SmPC). If a user has a specific intolerance, it is recommended that the complete list of excipients be verified on the package leaflet or SmPC, as formulation specifics can vary.

Q: Are there any specific warnings for people with heart conditions?

A: The medicine is contraindicated (not allowed for use) in patients with severe heart failure. Official NSAID class warnings state that use in patients with non-severe cardiac conditions, history of heart attack, or unmanaged high blood pressure is advised with caution.

Q: Is it possible to become sensitive to the product if used for too long?

A: Yes, official warnings specifically note that the use of the oral mucosal spray and other forms, especially if prolonged, may give rise to phenomena of sensitization or local irritation in the mouth and throat. If signs of sensitization or local irritation occur, the regulatory guidance is to discontinue use of the product.

Q: Can using the lozenges or spray cause an allergic reaction?

A: Yes, Flurbiprofen is known to potentially cause both localized and systemic allergic reactions. Symptoms can include swelling, rash, or hives. If a user experiences any signs of an allergic reaction, use of the product should be immediately discontinued.

Q: Are there any common local side effects like mouth or tongue irritation?

A: Yes, official safety information classifies oral discomfort as a common side effect. This discomfort can include symptoms such as soreness, a burning sensation, or general irritation in the mouth or throat area.

Q: Does the medicine contain sorbitol, and why might that be a concern for some people?

A: Certain formulations contain sorbitol, which is officially a source of fructose. Its presence is noted as a specific concern for patients diagnosed with rare hereditary fructose intolerance, for whom the product is contraindicated.

Q: Why are the lozenges designed to be dissolved slowly in the mouth?

A: The official instructions require the lozenge to be sucked slowly and moved continuously around the mouth. This specific administration technique is provided to help prevent local irritation in the mouth and throat, ensuring the active ingredient is properly distributed for its localized effect.

Q: Is accidental swallowing of the spray or lozenge harmless, according to official information?

A: The regulatory guidance states that at the recommended doses, swallowing the oral mucosal spray does not cause any harm. This is due to the low quantity of the active ingredient delivered in one localized dose.

Q: Can the spray be used for mouth ulcers (stomatitis) not related to a sore throat?

A: Yes, the official indications for the product often go beyond just pharyngitis (sore throat). In some regulatory contexts, the product is indicated for the symptomatic treatment of irritative-inflammatory conditions such as stomatitis (mouth inflammation/ulcers) and gingivitis, in addition to pharyngitis.

Q: Do the mouthwash and spray versions have different contraindications?

A: The main contraindications (e.g., allergy to NSAIDs, severe organ failure, third trimester of pregnancy) are based on the active ingredient (flurbiprofen) and are generally the same for the mouthwash and spray dosage forms. Minor differences, if any, would be limited to specific warnings related to non-active excipients present in one form but not the other.

How should Neo Borocillina Gola Dolore be stored and disposed of?

Official Storage and Disposal Requirements

The storage and disposal instructions for Neo Borocillina Gola Dolore are defined by regulatory labeling to maintain quality and ensure environmental safety.

Storage Conditions

Condition Requirement
Temperature Must be stored at a temperature not exceeding 25 C (77 F).
Stability The oral spray is valid for 1 year after the first opening of the container.
Child Safety Must be kept out of the reach and sight of children.

Disposal Instructions

Expired or unused medicine must not be disposed of via wastewater or household waste. The official guidance instructs users to ask the pharmacist for information on how to properly discard medicines that are no longer needed, which is required to protect the environment. The medicine must not be used past the expiry date indicated on the package.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Neo Borocillina Gola Dolore found in:

A-Z Index: