Дерматоп

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Дерматоп

Treatment option: Neurodermatitis, Psoriasis, Eczema

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Дерматоп

What is Дерматоп? (Prednicarbate)

The following table provides essential, verifiable facts about Дерматоп (Prednicarbate), defining its identity and class.

Property Description
Active ingredient Prednicarbate
Form Cream, Ointment
Pharmacological class Topical Corticosteroid (Glucocorticoid)
Common use Symptom relief for inflammatory skin conditions
Origin Synthetic, Non-halogenated Derivative

Identity and Pharmacological Class

Дерматоп is a prescription medicine for dermal use, primarily characterized by the active substance Prednicarbate. It is classified as a synthetic, single-agent topical corticosteroid and belongs to the glucocorticoid class of medicines. This classification means its effectiveness is clinically recognized for controlling local immune responses in the skin. Prednicarbate itself is chemically distinct as a non-halogenated derivative, a feature that sets it apart from older, halogenated corticosteroids, placing it within the medium-potency category for topical application.

Active Ingredient, Composition, and Available Forms

The medicine contains Prednicarbate as the sole active pharmaceutical ingredient, typically at a 0.1% concentration. It is available for topical administration in two principal dosage forms: a cream and an ointment. This presentation ensures flexible application depending on the condition of the skin; the occlusive nature of the ointment base is suitable for dry, thickened lesions, while the cream base is generally preferred for less severe or weeping areas. This flexibility in base formulation is a specific advantage designed to maximize drug delivery across different clinical presentations.

General Purpose and Function of the Medicine

The fundamental purpose of Дерматоп is the rapid suppression of symptoms associated with inflammatory skin conditions that are corticosteroid-responsive. The core anti-inflammatory and antipruritic actions of the active substance mean the medicine is intended to alleviate disruptive symptoms. Its action translates into the general benefit of effectively reducing tissue swelling, controlling excessive redness (erythema), and providing meaningful relief from the intense itching (pruritus) that accompanies the underlying skin inflammation, such as in cases of contact dermatitis or eczema.

What side effects are possible with Дерматоп?

Possible side effects and safety information

The safety profile of Дерматоп (Prednicarbate) is officially classified by regulatory authorities based on adverse events documented in clinical use, which fall into categories of local reactions and potential systemic effects.


Local Dermatological Reactions and Frequency

The most frequently documented adverse effects are local to the application site. Regulatory classification indicates that reactions such as a burning sensation and pruritus (itching) are categorized as Infrequent (approximately le 2% incidence) in controlled studies. Other less common local effects documented in official labeling include irritation, erythema (redness), and folliculitis.

Adverse effects whose frequency is Not Known include skin changes associated with long-term topical corticosteroid use, such as skin atrophy (thinning), striae (stretch marks), telangiectasia (spider veins), and hypopigmentation (skin lightening).


Serious Systemic Safety Considerations

As with all topical corticosteroids, the medicine carries a documented risk for rare but serious Systemic Safety Effects following extensive or prolonged use, especially when applied under occlusive dressings or to large body surface areas. These effects relate to the suppression of the Hypothalamic-Pituitary-Adrenal (HPA) axis, which may lead to manifestations of Cushing's syndrome or adrenal insufficiency upon discontinuation. Metabolic changes such as hyperglycemia (high blood sugar) have also been officially documented.


Population-Specific Safety Notes

Pediatric patients are identified in official labeling as being at a greater risk for systemic side effects, including HPA-axis suppression, due to their higher ratio of skin surface area to body weight. Furthermore, the risk of developing systemic effects is increased when the medicine is applied near the eyes due to the possibility of ocular effects.

Overdose and Emergency Response

Topical corticosteroids, including Дерматоп (Prednicarbate), can be absorbed through the skin in sufficient amounts to produce systemic effects, which constitutes the primary overdose concern documented in regulatory labeling. This risk is particularly relevant with prolonged application to a large surface area or under occlusive dressings.

Documented Manifestations and Serious Outcomes

The major physiological manifestation of overdose is Hypothalamic-Pituitary-Adrenal (HPA) axis suppression. Clinical signs officially documented include manifestations of Cushing's syndrome, hyperglycemia (high blood sugar), and glucosuria (sugar in the urine). Severe outcomes listed in official sources include the potential for glucocorticosteroid insufficiency following withdrawal, and in pediatric patients, intracranial hypertension and linear growth retardation.

Emergency Actions and Monitoring

Regulatory documents mandate that immediate medical attention must be sought if the medicine is accidentally swallowed or if overdose is suspected due to prolonged overuse. Management involves symptomatic and supportive treatment. Medical evaluation requires periodic monitoring for HPA suppression using specific diagnostic tests, such as the ACTH stimulation test.

Pediatric patients are noted to have a greater susceptibility to these systemic effects due to their larger skin surface area to body weight ratio.

Therapeutic Uses of Дерматоп

What Дерматоп Treats: Main Uses and Benefits

The medicine is relevant in contexts involving heightened systemic burden for symptomatic management. Дерматоп is commonly used in situations involving certain distressing symptoms associated with corticosteroid-responsive dermatoses, such as Atopic Dermatitis (Eczema), Psoriasis, and Seborrheic Dermatitis. It supports comfort during episodes of heightened discomfort and helps ease symptoms related to inflammatory or irritative states, which may include pronounced redness (erythema) and tissue swelling.


Quick Fact: Relief for Intense Pruritus The medicine is considered relevant for easing symptom clusters that may become intense or disruptive, and is applied in addressing the symptoms of pruritus (intense itching).


The medicine is relevant for easing irritation and symptoms of scaling associated with lesions. This provides support that helps ease the overall symptom burden, assisting with maintaining functional stability during symptomatic periods. The medicine is commonly used across conditions presenting with acute episodes and unstable symptom patterns, relevant in situations where symptoms may intensify temporarily.

“The medicine is relevant when supportive symptom management is appropriate.”

Eligibility and Restrictions for Use

Eligibility for Дерматоп (Prednicarbate)

Official regulatory documents define strict population rules governing the use of this medicine, establishing who is eligible for treatment and who is absolutely prohibited from using it.

Populations for Whom Use is Contraindicated

Use is contraindicated (must not be used) in individuals with known hypersensitivity to the active ingredient or any excipients. Absolute contraindications include applying the medicine to specific skin conditions such as rosacea, perioral dermatitis, acne, skin ulcers, or areas of skin atrophy. The medicine is also prohibited for use on untreated primary cutaneous infections (e.g., viral, bacterial, fungal, or parasitic) and is strictly not for ophthalmic use.

Age-Related and Special Population Restrictions

Population Regulatory Status
Infants (< 1 year) Use is not recommended or is contraindicated; safety and efficacy are not established.
Children (≥ 1 year) Use must be limited to the minimum effective amount and shortest possible duration.
Pregnancy Conditional use (Category C); use is restricted to situations where the benefit justifies the risk. Large-scale or prolonged use is not recommended.

Use on sensitive areas like the face, underarms, or groin should be restricted. Caution is advised for breastfeeding women due to unknown systemic absorption into milk.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile for Dermatop (Prednicarbate), a topical corticosteroid, is primarily defined by the potential for systemic absorption and specific substance interactions documented in regulatory materials.

Pharmacodynamic and Exposure Interactions

Co-administration with other systemic corticosteroids may result in an additive pharmacodynamic effect, increasing the risk of adrenal system suppression and manifestations related to Cushing’s syndrome. Due to the potential for systemic absorption to induce hyperglycemia and glucosuria, this medicine may also antagonize the therapeutic action of anti-diabetic agents.

An exposure-modifying interaction occurs when the treated area is covered with occlusive dressings or plastic pants (such as in the diaper area of infants), as this significantly increases percutaneous absorption and systemic exposure. Consequently, regulatory guidance restricts the use of occlusive materials. Furthermore, the drug can interfere with diagnostic tests assessing adrenal function, such as the Metyrapone test, requiring discontinuation prior to testing.

Product-Substance Restrictions

The formulation contains paraffin, which interacts with certain latex-containing products, including condoms and diaphragms. This interaction causes material degradation and reduces the effectiveness of the latex product. Regulatory agencies strictly advise avoiding contact between the medicine and these products.

Mechanism of Action

How Дерматоп works: Mechanism of Action

Дерматоп (prednicarbate) initiates its effect by acting as an agonist for the cytoplasmic Glucocorticoid Receptor (GR) in target cells. The activated drug-receptor complex translocates into the nucleus, where it modulates gene expression, upregulating anti-inflammatory proteins and downregulating pro-inflammatory factors, which leads to a downstream consequence involving reduced immune cell activity.

A key subsequent action is the induction of lipocortin (Annexin A1). This protein inhibits the enzyme phospholipase A2 ( PLA2), a crucial step that blocks the release of arachidonic acid. By disrupting this precursor molecule, the mechanism effectively reduces the synthesis of key inflammatory mediators, including prostaglandins and leukotrienes.

At the tissue level, the mechanism restricts the movement and accumulation of immune cells, such as lymphocytes and macrophages, into the affected area. This is combined with a direct vasoconstrictive effect on local blood vessels, resulting in decreased fluid accumulation in tissue and local reduced vasodilation.

Dosage and Administration Information

How to Use Дерматоп (Prednicarbate) — Official Administration Guidelines

This section describes the official administration principles for Дерматоп (Prednicarbate), defining the prescribed method, schedule, and limitations for its use.


Administration Scope

The medicine is administered via the topical route, using either the 0.1% cream or ointment formulation. The standard regimen specifies that a thin film should be applied to the affected skin areas and rubbed in gently. This application is typically carried out twice daily.

Instruction Detail
Route of administration Topical (For external application to the skin only).
Dosing schedule Apply a thin film of the 0.1% product.
Frequency pattern Twice daily (q12hr).

Use Protocol and Restrictions

Therapy is governed by the principle of discontinuation when control is achieved. If no improvement is observed within two weeks, a professional reassessment is required.

Age-Group Administration Rules:

The product has specific age restrictions. Use is generally not recommended in infants below 1 year of age. For pediatric patients, the cream is permitted for those 1 year of age or older, and the ointment for those 10 years or older. Safety has not been established for use longer than three weeks in the pediatric population.

Special Procedural Conditions:

Administration should be for external use only, avoiding contact with the eyes. The treated area should not be covered (occluded) with bandages or plastic unless specifically directed by a prescriber, and the product must not be applied in the diaper area of infants, as this constitutes occlusion.

Recent Clinical Evidence

Research evidence / Overview of studies for Дерматоп

Evidence for Use in Atopic Dermatitis (Eczema)

Research exploring how symptoms change over time in atopic dermatitis has included short-term randomized controlled trials (RCTs) and vehicle-controlled studies designed to examine patterns related to the medicine. These studies were conducted during periods of increased symptom activity and often involved measuring outcomes related to physical discomfort. Trials focused on populations including adults and pediatric patients who had moderate to severe skin involvement. Research also examined systemic absorption, which was monitored using physiological tests to examine temporary physiological imbalance.

Evidence for Other Inflammatory Skin Conditions

Research examined corticosteroid-responsive dermatoses, including conditions like psoriasis and certain contact dermatitis manifestations. This body of evidence includes controlled trials and comparative studies, often comparing the medicine to other topical corticosteroids to examine patterns related to potency. Data show patterns related to how inflammation and the severity of symptoms were measured in the studies, such as those related to scaling and pruritus. The medicine's classification as a medium-potency topical corticosteroid research describes in established pharmacological research.

Long-Term Evidence and Follow-Up Duration

The primary clinical research programs for Дерматоп typically involved follow-up durations that were limited, with most core efficacy studies observing patient responses over short time intervals of a few weeks. While evidence contributes to the broader understanding of short-term changes, the data are still emerging regarding the potential effects of using the medicine over extended periods of time. Long-term consequences of repeated, intermittent use over many months are not well characterized by the existing core trials.

Limitations and Research Gaps

Research examined the cream formulation in pediatric patients one year of age and older, with research exploring its use for periods up to three weeks. However, the research record shows that the safety and effectiveness of the ointment form has not been established in studies involving children and infants. Data for certain groups, specifically those under one year old, remain insufficient, limiting the available insight into use.

Key Studies & References

  1. Prednicarbate Emollient Cream 0.1% in Pediatric Patients With Atopic Dermatitis (Uncontrolled 3-week HPA axis study)
  2. Prednicarbate Ointment 0.1% (Canadian Product Monograph on Pediatric and Long-Term Use Limitations)

Frequently Asked Questions (FAQ)

Common questions about Дерматоп (FAQ)

Q: How quickly does Dermatope start working?

Official product information does not specify an exact time frame for when the medication begins to act. However, official guidance states that if lack of improvement is observed within two weeks, a reassessment of the diagnosis by a healthcare professional is indicated.


Q: What should I do if I miss an application of Dermatope?

According to the official patient information, if a scheduled dose is missed, applying it as soon as it is remembered is described. If it is almost time for the next scheduled dose, the missed dose is skipped to resume the regular schedule. Double doses are not used to make up for a missed application.


Q: Can I use Dermatope with other creams simultaneously?

Official guidance advises caution regarding the application of any other products to the treated area. The use of other topical skin products, including non-medicated creams or moisturizers, is generally advised against without first consulting a healthcare professional.


Q: How do I know if Dermatope has started helping?

The primary measure of effectiveness is the achievement of control over the skin condition being treated, which typically means a reduction in symptoms like inflammation and itching. If the condition does not improve or appears to worsen after a two-week period, reassessment of the diagnosis by a health professional is indicated.


Q: Should I stop using Dermatope gradually?

Official product information indicates that once control of the condition is achieved, the frequency of application or the concentration of the product may be reduced to the minimum necessary to maintain control. Discontinuation of the product occurs when the condition is maintained without the use of the medicine.


Q: Does Dermatope affect the ability to drive a car?

The official labeling for this topical medicine does not contain a specific warning or prohibition regarding the ability to drive or operate machinery. However, due to the potential for rare systemic absorption, some systemic side effects like blurred vision or dizziness have been documented.


Q: Why doesn't Dermatope work for some people?

Dermatope is indicated for conditions classified as corticosteroid-responsive. If lack of improvement is observed within two weeks, reassessment by a health professional is indicated to determine if the diagnosis is appropriate or if an untreated infection, which is a contraindication, is present.


Q: What do studies say about the safety of Dermatope in the elderly?

According to official product information and safety guides, no specific information is available regarding the relationship of age to the effects of topical prednicarbate in the geriatric patient population.


Q: What interactions exist between Dermatope and food or drinks?

Official guidance indicates that individuals consult a health professional regarding the use of this medicine in relation to consuming food, alcohol, or tobacco. This is a general caution provided in official drug information.


Q: What is considered an overdose when using Dermatope?

Acute overdose with this topical medicine is considered unlikely by official sources. However, prolonged use, or application over extensive body surface areas, may lead to systemic absorption. This can result in potential serious systemic effects, such as the suppression of the body's natural hormone production (HPA axis suppression).


Q: How does Dermatope affect wound healing?

Regulatory documents advise against applying the medication to broken or infected skin. Use in open wounds is specifically listed as a contraindication for the product.


Q: What percentage of patients experience side effects?

Official reports from clinical trials indicate that the adverse effects of burning sensation of the skin, pruritus (itching), skin pain, and dry skin (xeroderma) were reported in leq 2% of the patients involved in the clinical trials.


Q: Can Dermatope interact with supplements or vitamins?

The active ingredient has documented interactions with various systemic drugs and supplements. Official guidance indicates that a health professional should be consulted regarding the use of all prescription medicines, non-prescription drugs, herbs, and dietary supplements being used.


Q: Is it true that symptoms can return after stopping Dermatope?

Official product information describes that a gradual reduction in application frequency or concentration is implemented once the condition is under control. This process is used to maintain the control of the condition and avoid a potential return or relapse of symptoms.


Q: Can Dermatope be used to prevent flare-ups?

The product is officially indicated for the treatment of corticosteroid-responsive dermatoses. After symptoms are controlled, the application frequency may be reduced to the minimum required to maintain control, which is sometimes described as a twice-weekly approach for maintenance.


Q: What components of Dermatope cause the most concern for patients?

Regulatory documents highlight a specific caution regarding contact between the medicine and latex-containing products, such as condoms and diaphragms. Components within the cream or ointment base may cause damage to the latex material, which could reduce its effectiveness.


Q: Can long-term use of Dermatope cause dependence?

Using this product too frequently or for extended periods of time has been associated with the risk of reduced effectiveness, technically known as tolerance or tachyphylaxis. Official information stresses that the product should be used for the shortest duration required to control the condition.

How should Дерматоп be stored and disposed of?

How to Store and Dispose of Дерматоп (Prednicarbate)

Storage Requirements

Дерматоп (Prednicarbate) must be stored at controlled room temperature, specifically between 15 C and 30 C (59 F and 86 F). The medication must be kept from freezing and protected from excessive heat, moisture, and direct light. Always store the medicine in its closed container and ensure it is kept out of the reach of children.

Disposal Instructions

Do not keep outdated or no longer needed medicine. To dispose of unused or expired Дерматоп, consult a healthcare professional or pharmacist for specific local guidance. If an authorized take-back program is unavailable, follow regulatory instructions for household disposal: mix the medicine with an undesirable substance (such as dirt), place it in a sealed container, and discard it in the trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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