Chamomile

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Chamomile

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Chamomile

What is Chamomile? Overview and Quick Facts

Property Description
Active ingredients Volatile oil (Chamazulene, alpha-Bisabolol) and Flavonoids (Apigenin)
Form Dried flower heads, Infusion (Tea), Liquid Extract, Tincture, Ointment
Pharmacological class Phytomedicine, Antispasmodic, Anti-inflammatory agent
Common use Relieving digestive discomfort and soothing mild irritation
Origin Natural (Botanical), Matricaria recutita (German Chamomile)

Defining Chamomile: A Primary Herbal Medicine Identity

Chamomile is a widely utilized phytomedicine, or herbal drug, derived from the dried flower heads (flos) of the Matricaria recutita plant, specifically known as German Chamomile. This differentiation from Roman Chamomile is significant, as the German variety is the primary source recognized in major pharmacopoeias for its specific chemical profile. It is categorized as a traditional single-entity product and is officially described in various forms, including infusions (tea), liquid extracts, and topical ointments, allowing for various routes of administration such as oral intake and application to the skin and mucous membranes. It is recognized for use in mild gastrointestinal spasms and inflammation.


Active Components and General Purpose

The activity of Chamomile is attributed to a complex mixture of natural substances, primarily its Volatile oil and Flavonoids. The essential oil contains key sesquiterpenes, notably Chamazulene and alpha-Bisabolol, which are crucial for quality control and possess distinct anti-inflammatory properties. Based on the effects of these constituents, Chamomile is broadly classified as an antispasmodic and anti-inflammatory agent. Its general utility is defined by its ability to provide smooth muscle calming to help relieve common digestive discomforts like gas and minor cramping, while simultaneously addressing mild skin irritation through its anti-inflammatory properties. Chamomile is utilized for mild anxiety and stomach upset, among other uses.

Regulatory References

  1. Chamomile: Usefulness and Safety | NCCIH - NIH

What side effects are possible with Chamomile?

Possible Side Effects and Safety Information

The regulatory safety profile for Chamomile (Matricaria recutita) is defined primarily by the risk of hypersensitivity reactions and documented safety constraints in specific populations, based on official government documents and monographs.


Adverse Reaction Scope

The most commonly cited safety concern is the potential for allergic reactions (Immune System Disorders). These effects may manifest as dermatological reactions, such as contact dermatitis with topical use, or systemic responses like urticaria.

Classification Adverse Reactions System-Organ Class
Uncommon Nausea, Dizziness Gastrointestinal, Nervous
Not Known Allergic Reactions, Anaphylaxis Immune System, Skin

Serious Adverse Reactions officially documented as a potential, though rare, risk include Anaphylaxis (a severe, systemic hypersensitivity reaction).


Safety Constraints and Special Populations

Chamomile is contraindicated in individuals with known allergies to plants in the Asteraceae/Compositae family (e.g., ragweed, marigolds, chrysanthemums) due to the recognized potential for cross-reactivity and severe allergic response.

For Special Populations, use is generally avoided during pregnancy and lactation due to the absence of sufficient, reliable clinical data confirming safety in these groups. Furthermore, regulatory safety notes include the potential for sedation or drowsiness, which is a high-level safety consideration when used with other Central Nervous System depressants.

Overdose and Emergency Response

Chamomile Overdose and When to Seek Help

The officially documented profile for chamomile overdose focuses heavily on severe allergic reactions rather than a toxic dose resulting in classic poisoning.

Overdose Presentations

The most serious documented manifestation is anaphylaxis, a severe, potentially life-threatening allergic reaction. Other serious reported reactions are severe hypersensitivity reactions (e.g., hives, throat swelling, difficulty breathing) and severe contact dermatitis (rash, redness, swelling) following skin application.

Less severe presentations from taking large doses may include drowsiness and vomiting.

Required Emergency Actions

Immediate emergency medical attention is required if you experience any signs of a serious allergic reaction, such as hives, difficult breathing, or swelling of your face, lips, tongue, or throat. If you suspect an overdose has occurred, or if you experience any severe or unexpected adverse reaction, you must immediately seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Regulatory documents caution that using multiple forms of chamomile (such as tablets, liquids, and teas) concurrently may increase the risk of an overdose. The primary systems affected in serious reactions are the respiratory system and the integumentary system (skin).

Therapeutic Uses of Chamomile

Chamomile: Main Uses and Benefits

Chamomile has a long history of traditional use for various conditions. It is commonly used as a folk or traditional remedy for sleeplessness and to manage anxiety. Some preliminary research suggests that a chamomile dietary supplement may be helpful for generalized anxiety disorder.


Other Traditional and Supportive Uses

In traditional practice, chamomile is often applied to help manage gastrointestinal conditions such as upset stomach, gas, and diarrhea. It is also used topically for certain skin conditions and as a rinse for mouth ulcers that may result from cancer therapy. Some evidence indicates that chamomile may have modest anxiolytic activity (a process to relieve anxiety). However, for specific conditions like insomnia, studies on the effectiveness of chamomile alone have not produced sufficient reliable evidence to rate its clinical usefulness.


Quick Facts: Chamomile's Therapeutic Domain

  • Relieves: Anxiety, upset stomach, gas, diarrhea (traditional/folk uses)
  • Supports: Management of sleeplessness, certain skin conditions, and mouth ulcers

Regulatory References

  1. NIH MedlinePlus guidance

Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Chamomile

Chamomile's eligibility profile is formally defined by regulatory bodies through specific contraindications and restrictions related to allergy, age, and reproductive status due to insufficient data.

Eligibility Scope

Category Official Regulatory Statement
Populations for whom use is allowed Adults and Adolescents (typically over 12 years of age) are included in the standard use population.
Populations for whom use is not recommended Pregnant women and Lactating (breastfeeding) women are listed as not recommended.
Populations for whom use is contraindicated Patients with known hypersensitivity or allergy to Chamomile or other plants of the Asteraceae (Compositae) family (e.g., ragweed, chrysanthemums).
Age-related eligibility rules Children under a specified age (which varies by preparation) are frequently not recommended for use due to insufficient data to establish safety.
Condition-specific eligibility rules Allergic conditions: Contraindicated in people allergic to the Asteraceae family.

Eligibility Classifications (High-Level)

Category Regulatory Status as Defined in Official Documents
Eligibility severity classification Contraindicated (for hypersensitivity/allergy); Not Recommended (for lack of established data).
Eligibility-context constraints Constraints are primarily focused on immunological status and physiological maturity/status.

Connection to the overall eligibility profile

Regulatory documents define who can and cannot use Chamomile by applying two primary exclusions: an absolute contraindication for individuals with known allergies to the product or its botanical relatives, and a non-recommendation for populations where safety data are officially not established. These populations include pregnant women, breastfeeding women, and specific pediatric age groups, thereby restricting use to the general Adult and Adolescent population unless otherwise specified in the product's official labeling.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The following interaction information for Chamomile (Matricaria recutita) is based on established scientific documentation and regulatory warnings.

Chamomile has the potential to interact with certain medicinal products primarily through pharmacodynamic and pharmacokinetic mechanisms.


Documented Interaction Categories

Category Description and Practical Implication
Central Nervous System (CNS) Depressants Concurrent use with sedatives, anxiolytics, and hypnotics may lead to additive sedative effects (increased drowsiness). This also applies to the co-administration of alcohol.
Anticoagulants and Antiplatelets Due to the presence of coumarins, Chamomile may augment the effects of blood-thinning medicines (e.g., Warfarin), potentially increasing the risk of bleeding or bruising.
Cytochrome P450 Metabolism Chamomile is documented as a weak inhibitor of certain CYP enzymes (e.g., CYP1A2). This pharmacokinetic effect may theoretically alter the concentration of some co-administered drugs metabolized by these pathways, such as Tamoxifen or estrogen-containing oral contraceptives.

Interaction-Related Constraints

It is generally advised that individuals discontinue the use of Chamomile at least two weeks prior to scheduled surgery. This constraint is necessary to minimize the potential for interactions with anesthetic agents and to mitigate the risk of excessive bleeding during the procedure.

Mechanism of Action

How Chamomile Works

Chamomile's pharmacodynamic mechanism is mediated primarily by its active compounds, including apigenin, alpha-bisabolol, and chamazulene, which act across multiple biological systems.

  1. Central Nervous System (CNS) Pathway: Apigenin interacts with the CNS by acting as a positive allosteric modulator of mathbfGABAA receptors. This molecular interaction facilitates the inhibitory action of gamma-aminobutyric acid (GABA) and modulates downstream neurotransmitter signaling pathways.
  2. Inflammatory and Smooth Muscle Modulation: alpha-Bisabolol and matricin (a precursor to chamazulene) modulate inflammatory responses by decreasing cyclooxygenase (COX-2) enzymatic activity and inhibiting histamine release from mast cells. The extract's influence on smooth muscle contraction is attributed to components that antagonize muscarinic acetylcholine receptors.
  3. Gastrointestinal (GI) Integrity: Specific flavonoids in the extract further influence epithelial function by enhancing tight junction protein expression in intestinal epithelial cells.

Dosage and Administration Information

How to use Chamomile: Administration Guidelines

Chamomile flower preparations are administered through various routes, reflecting the traditional use of different forms. The recognized application methods include oral intake (as tea or liquid extract), oromucosal rinsing (for the mouth and throat), inhalation (steam), and cutaneous application (washings or compresses).

Administration Scope Detail
Route of Administration Oral, Oromucosal, Inhalation, Cutaneous, Bath Additive.
Standard Adult Dosing Oral Infusion: 1.5 to 4 g of the comminuted substance per single dose. Topical Washings: 3 to 10 g of substance per 100 ml water.
Frequency Pattern Oral preparations are typically taken in a divided schedule of 3 to 4 times daily. Topical and mucosal applications are generally used several times daily as needed.
Preparation Requirements Infusion requires pouring boiling water over the herbal substance, covering it, and steeping for 5 to 10 minutes. Liquid extracts must be diluted in water before intake or application.
Age-Group Rules Children (6 months to 12 years): Specific, reduced oral infusion doses are defined based on age ranges and are lower than the standard adult dose.
Use-Context Constraint Oral infusions for digestive use are often specified to be taken between meals. For self-treatment, a doctor should be consulted if symptoms persist for more than one week.

Established parameters provide a standardized approach to using Chamomile by defining precise dosages and preparation methods for each route of administration. These instructions ensure the consistency of the administered form, whether for internal use or external application, by requiring the correct dilution and steeping procedures.

Recent Clinical Evidence

Chamomile: Recent Clinical Evidence

Clinical research has explored the role of chamomile (Matricaria chamomilla L.) extracts and tea across various health domains. The traditional uses of chamomile, particularly for calming and digestive support, are the primary focus of modern investigation.

Clinical Findings Summary

Studies, largely randomized controlled trials (RCTs) and systematic reviews, have focused on specific areas of potential benefit:

  • Generalized Anxiety Disorder (GAD): Some long-term and short-term trials involving standardized chamomile extract (capsules) have investigated a reduction in GAD symptoms compared to placebo. One meta-analysis suggested significant improvement in GAD symptoms after 2 and 4 weeks of treatment.
  • Sleep Quality: Research has evaluated the effect of chamomile extract and tea on sleep disturbances. While some trials in older adults reported significantly improved sleep quality scores compared to control groups, evidence regarding its effect on chronic insomnia severity is inconsistent.
  • Anti-inflammatory Effects: Clinical studies have investigated chamomile's potential to soothe inflammation, particularly when applied topically or used as a rinse. A meta-analysis demonstrated that chamomile was associated with statistically significant reductions in mucositis severity (inflammation of the mucous membranes) and related pain levels.
  • Premenstrual Syndrome (PMS): An RCT exploring chamomile extract's use during menstrual cycles suggested a measurable reduction in the overall severity of PMS symptoms, particularly the psychological components, when compared to a non-steroidal anti-inflammatory drug.

Limitations and Safety Profile

Overall, chamomile is generally considered safe when consumed in amounts typical of teas and extracts. Reported side effects in clinical trials are infrequent and typically mild. However, studies often combine chamomile with other botanicals, making it difficult to isolate the precise effects and safety profile of chamomile alone. Furthermore, due to the botanical nature of the product, the chemical composition can vary widely across different commercially available preparations.

Frequently Asked Questions (FAQ)

Common questions about Chamomile (FAQ)

Q: What is the difference between German Chamomile and Roman Chamomile?

Official regulatory monographs and scientific studies primarily focus on German Chamomile (Matricaria recutita). While both belong to the same plant family, the German variety is the primary species recognized as a traditional phytomedicine. Roman Chamomile (Chamaemelum nobile) is a different genus but shares the common name.


Q: Are there any general food or beverage types that should be avoided when using Chamomile?

Official labeling and regulatory documents do not generally note specific interactions between Chamomile and common food or non-alcoholic beverages. Warnings are focused on potential drug interactions, such as an additive effect with alcohol. Chamomile may also interact with certain drugs because it can affect how the liver processes them.


Q: Is Chamomile generally safe for use by children?

Official product information from bodies like the European Medicines Agency (EMA) acknowledges the traditional use of certain preparations in children as young as six months. For medicinal purposes, the National Institutes of Health (NIH) considers Chamomile to be possibly safe for children orally over the short term. Specific age groups are often noted as 'not recommended' due to a lack of complete safety data.


Q: What pre-existing medical conditions might make someone ineligible to use Chamomile?

Chamomile is contraindicated in individuals with known allergies to the Asteraceae/Compositae family, which includes ragweed and daisies. Additionally, preliminary studies have examined the potential for use in people with conditions that are sensitive to estrogen exposure, such as breast or uterine cancer.


Q: Why do some people report feeling dizzy or drowsy after consuming Chamomile?

Chamomile contains a compound called apigenin, which may contribute to a mild sedative effect by interacting with specific receptors in the brain. Regulatory safety profiles include dizziness and nausea as uncommon side effects. Official warnings highlight the potential for drowsiness, especially when used with other Central Nervous System depressants.


Q: Does Chamomile interact with common pain relievers?

Regulatory documents report potential interactions with medications classified as blood-thinners, or anticoagulants, which may include some common pain relievers. This interaction is noted due to the presence of coumarins in Chamomile. Official safety information documents the potential for these combinations to augment the blood-thinning effects.


Q: Are there any specific warnings for people with liver or kidney conditions?

The NIH LiverTox database has reviewed available data and has not convincingly linked Chamomile to cases of clinically apparent liver injury. It is classified as an unlikely cause of such issues. Official product labeling does not typically include general warnings against use in people with pre-existing kidney conditions.


Q: Are there variations in how different Chamomile product forms (tea, oil, extract) work?

Official regulatory monographs acknowledge different forms, such as teas, extracts, and oils, and approve them for specific routes of administration. For instance, oral intake is often cited for digestive discomfort, while inhalation is cited for common cold symptoms. This distinction confirms that the product form and application route are authorized for different uses based on traditional application.


Q: Is Chamomile use usually restricted for older adults?

The European Medicines Agency (EMA) monograph generally includes the elderly population within the standard adult dosing and indication groups for traditional use. Official information does not impose blanket age-related restrictions for older adults beyond the general safety precautions.


Q: Are there any reports of Chamomile causing dependence or withdrawal symptoms?

Regulatory safety documents and monographs focus on known adverse effects, such as allergic reactions and drowsiness. Official sources do not list dependence or withdrawal symptoms among the documented safety concerns for Chamomile.


Q: Does Chamomile contain any caffeine?

Chamomile, derived from the plant species Matricaria recutita, does not naturally contain caffeine. Regulatory-cited chemical analyses of the plant's active components confirm the absence of compounds like xanthines, which are the source of caffeine.


Q: Can Chamomile be used by people who have diabetes?

Some scientific research suggests that Chamomile may have effects on blood sugar levels. Official regulatory warnings state that specific guidance from a healthcare provider is necessary when considering use alongside blood sugar-lowering medication, as some herbal teas may interact with these drugs.


Q: Is there any evidence that Chamomile affects blood pressure levels?

Regulatory-cited articles on the pharmacological activity of Chamomile indicate that it may have a hypotensive effect, meaning it may contribute to lowering blood pressure. This potential effect is a subject of ongoing research, which also examines the herb's role in blood pressure regulation.


Q: Is it possible to develop a sensitivity to Chamomile over time?

The NIH guidance indicates that avoidance is necessary for individuals who have had even a mild allergic reaction to Chamomile. This is because allergic reactions to botanical products may potentially become worse over time with repeated exposure.


Q: Is there a risk of overdose or toxicity from consuming too much Chamomile?

Chamomile is widely considered likely safe by the NIH when consumed orally in amounts typically found in teas and foods. Regulatory documents list side effects as uncommon and generally mild, focusing on rare but serious allergic reactions as the primary safety concern.


Q: Does Chamomile have antioxidant properties?

Official documents and regulatory-cited scientific articles confirm that Chamomile contains compounds with antioxidant properties. The activity is attributed to a complex mixture of natural substances, including its flavonoids.

How should Chamomile be stored and disposed of?

How to Store and Dispose of Chamomile

Official regulatory guidelines for Chamomile preparations mandate specific conditions to preserve product quality, particularly the volatile oil content.

Storage Requirement Official Guidance
Temperature Store in a cool, dry place, typically below 25 C or 30 C, away from heat and ignition sources.
Container Protection Keep the product in its original, tightly closed container and protected from light and moisture.
Child Safety Store all products out of the sight and reach of children.
Disposal Follow local regulations. Unused or expired product should be returned to a drug take-back program or, if unavailable, mixed with an unappealing substance and sealed before discarding in household trash; do not dispose of it in wastewater systems.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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