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Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 26.06.2023
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- H1antihistamines
When studying the drug interaction of cetyrizin with pseudoephedrine, cimetidine, ketokonazole, redytromycin, azithromycin, diazepam, glypidine and antipyrin, clinically significant unwanted interactions were not detected.
With simultaneous use with theophylline (400 mg / day), the total clearance of cetyrizin is reduced by 16% (theophylline kinetics does not change).
With simultaneous use with AUC ritonavir, cetyrizin increased by 40%, while the same indicator of the ritonavir slightly changed (−11%).
With simultaneous use with macrolides (azitromycin, red bloodmicin) and ketoconazole, changes to the ECG were not noted.
When using the drug in therapeutic doses, data on the interaction with alcohol were not obtained (at a blood alcohol concentration of 0.5 g / l). Nevertheless, one should refrain from drinking alcohol during therapy with a drug in order to avoid oppression of the central nervous system.
A three-day “laundering” period is recommended before the appointment of allergological samples due to the fact that H1-histamines blockers inhibit the development of skin allergic reactions.
No medicinal interactions of cetyricin with other drugs were noted.
Based on the results of studies of the drug interaction of cetyrizin, in particular studies of the interaction with pseudoephedrine or theophyllin at a dose of 400 mg / day, there were no clinically significant interactions.
The simultaneous use of cetyrizin with alcohol and other drugs that depress the central nervous system can further reduce the concentration and speed of reactions, although cetrizin does not increase the effect of alcohol (at its concentration in the blood of 0.5 g / l).
It is not recommended to combine taking the drug Zinzet with other drugs without a doctor’s consultation. At the same time, taking with broncholithic drugs containing the theophylline as the active substance, an increase in the frequency of side effects of the drug Zincet. Data on the interaction of cetyricine with alcohol has not yet been received. Despite this, the use of alcoholic beverages in the treatment of Zincet is not recommended.
It is not recommended to combine the use of Cetirizina Genfar with other drugs without a doctor’s consultation. With simultaneous use with broncholithic agents containing theophylline as the active substance, an increase in the frequency of side effects of the drug Cetirizina Genfar. Data on the interaction of cetyricine with alcohol has not yet been received. Despite this, the use of alcoholic beverages in the treatment of Cetirizina Genfar is not recommended.
