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Method of action:
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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 16.03.2022
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Top 20 medicines with the same components:
treatment of symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis (such as itching, sneezing, nose congestion, rhinorea, lacrimation, conjunctiva hypermia);
hay fever (flaymaking) ;
urticaria;
allergic dermatoses, including.h. atopic dermatitis, accompanied by itching and rashes.
It is shown in adults and children with 6 months and older to facilitate :
- nasal and eye symptoms of year-round (persisting) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis: itching, sneezing, nasal congestion, rhinorea, tearing, conjunctival hyperemia ;
- symptoms of chronic idiopathic urticaria.
Symptomatic treatment of allergic rhinitis and conjunctivitis (including year-round and seasonal), hay fever (pollinosis), idiopathic urticaria and other allergic dermatoses, accompanied by itching and rashes.
Symptomatic treatment of allergic rhinitis and conjunctivitis (including year-round and seasonal), hay fever (pollinosis), idiopathic urticaria and other allergic dermatoses, accompanied by itching and rashes.
Usually the drug is well tolerated. In some cases, headache, drowsiness, dizziness, excitation, dry mouth are possible; disorders from the gastrointestinal tract: dyspepsia, abdominal pain, meteorism. As an exception, signs of hypersensitivity to the drug (short, swelling, shortness of breath) are possible. In this case, treatment with the drug should be stopped immediately and an urgent appeal to the doctor. It is necessary to inform the doctor about all side (unusual) effects.
Symptoms (when taking the drug in a dose of more than 5 tablets.): signs of intoxication in the form of drowsiness; in children - anxiety, increased irritability, the appearance of signs of anticholinergic action in the form of a delay in urine, dry mouth, constipation.
Treatment: taking the drug should be stopped, peeled, take activated carbon, immediately consult a doctor.
Cetirisin is an active substance of the drug Telarix® - is a metabolite of hydroxysine, belongs to the group of competitive antagonists of histamine and blocks H1histamine receptors.
Cetirisin warns development and facilitates the course of allergic reactions, and has antitudent and anti-exudative effect. Cetirisin affects the early histone-dependent stage of allergic reactions, limits the release of inflammation mediators at a late stage of an allergic reaction, and also reduces the migration of eosinophiles, neutrophils and basophiles, stabilizes the membranes of fat cells. Reduces the permeability of capillaries, prevents the development of tissue edema, relieves the spasm of smooth muscles. Eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). Reduces histin-induced bronchocongricia with bronchial asthma of the light current.
Cetirisin does not have an anti-cholinergic and anti-serotonin effect. In therapeutic doses, the drug has virtually no sedative effect. After taking cetyrizin in a single dose of 10 mg, its action develops after 20 minutes (in 50% of patients), after 60 minutes (in 95% of patients) and lasts more than 24 hours. Against the background of course treatment, tolerance for the antihistamine action of cetyrizin does not develop. After the cancellation of therapy, the effect persists up to 3 days.
Cetirisin is a metabolite of hydroxisin, belongs to the group of competitive antagonists of histamine and blocks N1- histamine receptors.
In addition to the antihistamine effect, cetyrizin prevents development and facilitates the course of allergic reactions: at a dose of 10 mg 1 or 2 times a day inhibits the late phase of the aggregation of eosinophiles in the skin and conjunctiva of patients exposed to atopia.
Clinical efficiency and safety. Studies in healthy volunteers have shown that cetirisin in doses of 5 or 10 mg significantly inhibits the reaction in the form of rash and redness to inject histamine into the skin at a high concentration, but a correlation with efficiency has not been established. A 6-week placebo-controlled study involving 186 patients with allergic rhinitis and concomitant bronchial asthma of mild to moderate currents shows that taking cetrizin at a dose of 10 mg 1 time per day reduces the symptoms of rhinitis and does not affect the function of the lungs.
The results of this study confirm the safety of the use of cetyrin in patients suffering from allergies and bronchial asthma of the mild and medium-lived course.
A placebo-controlled study showed that taking cetrizin at a dose of 60 mg / day for 7 days did not cause a clinically significant extension of the QT interval. Taking cetyrin in the recommended dose showed an improvement in the quality of life of patients with year-round and seasonal allergic rhinitis.
Children. In a 35-day study involving patients aged 5–12 years, there were no signs of immunity to the antihistamine effect of cetyrizin. The normal reaction of the skin to the histamine was restored within 3 days after the abolition of the drug when it was repeatedly used.
A 7-day placebo-controlled study of cetyricine in the form of syrups involving 42 patients aged 6 to 11 months demonstrated the safety of the drug.
Cetirizin was assigned at a dose of 0.25 mg / kg 2 times a day, which approximately corresponded to 4.5 mg per day (dose range ranged from 3.4 to 6.2 mg per day).
The use of children from 6 to 12 months is possible only by appointment of a doctor and under strict medical supervision.
When studying the drug interaction of cetyrizin with pseudoephedrine, cimetidine, ketokonazole, redytromycin, azithromycin, diazepam, glypidine and antipyrin, clinically significant unwanted interactions were not detected.
With simultaneous use with theophylline (400 mg / day), the total clearance of cetyrizin is reduced by 16% (theophylline kinetics does not change).
With simultaneous use with AUC ritonavir, cetyrizin increased by 40%, while the same indicator of the ritonavir slightly changed (−11%).
With simultaneous use with macrolides (azitromycin, red bloodmicin) and ketoconazole, changes to the ECG were not noted.
When using the drug in therapeutic doses, data on the interaction with alcohol were not obtained (at a blood alcohol concentration of 0.5 g / l). Nevertheless, one should refrain from drinking alcohol during therapy with a drug in order to avoid oppression of the central nervous system.
A three-day “laundering” period is recommended before the appointment of allergological samples due to the fact that H1-histamines blockers inhibit the development of skin allergic reactions.
No medicinal interactions of cetyricin with other drugs were noted.
Based on the results of studies of the drug interaction of cetyrizin, in particular studies of the interaction with pseudoephedrine or theophyllin at a dose of 400 mg / day, there were no clinically significant interactions.
The simultaneous use of cetyrizin with alcohol and other drugs that depress the central nervous system can further reduce the concentration and speed of reactions, although cetrizin does not increase the effect of alcohol (at its concentration in the blood of 0.5 g / l).
It is not recommended to combine taking the drug Zinzet with other drugs without a doctor’s consultation. At the same time, taking with broncholithic drugs containing the theophylline as the active substance, an increase in the frequency of side effects of the drug Zincet. Data on the interaction of cetyricine with alcohol has not yet been received. Despite this, the use of alcoholic beverages in the treatment of Zincet is not recommended.
It is not recommended to combine the use of Telarix with other drugs without a doctor’s consultation. With simultaneous use with broncholithic agents containing theophylline as the active substance, an increase in the frequency of side effects of the drug Telarix. Data on the interaction of cetyricine with alcohol has not yet been received. Despite this, the use of alcoholic beverages in the treatment of Telarix is not recommended.