Brustan

Brustan

Brustan is a combination medication that contains two active ingredients:

• Ibuprofen (400 mg) — a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, lowers temperature and relieves pain.

• Paracetamol (325 mg), also known as acetaminophen — an analgesic and antipyretic that enhances the pain-relieving effect of ibuprofen. This combination provides more powerful and rapid pain relief compared to taking each substance separately.

Brustan is available as film-coated tablets. Each tablet contains:

• ibuprofen — 400 mg;

• paracetamol — 325 mg. This form is suitable for adults and adolescents from 12 years of age. The package may contain 10 or 20 tablets — in blisters of 10 tablets each.

Brustan is used for short-term symptomatic treatment of pain and fever. It does not eliminate the cause of the disease but helps to cope with unpleasant symptoms.

Indications for use include:

• headache, including migraine;

• toothache (including after tooth extraction);

• muscle and joint pain, including pain from arthritis and injuries;

• menstrual pain (dysmenorrhea);

• cold and infectious diseases accompanied by elevated body temperature.

Brustan can be used as "first aid" for pain, but if symptoms persist for more than 3 days, you should consult a doctor.

Dosage and duration of use depend on the patient's age, severity of symptoms, and health condition.

Adults and adolescents (from 12 years):

• 1 tablet 1-3 times a day;

• interval between doses — at least 4 hours;

• maximum — 3 tablets per day.

Children under 12 years are not prescribed this medication — due to lack of data on safety and efficacy.

Special cases:

• for liver or kidney diseases, the dosage is reduced and intervals between doses are increased — under medical supervision;

• should not be taken on an empty stomach to avoid stomach irritation;

• tablets should be swallowed whole with water.

Duration of treatment — no more than 3 days. If pain or fever persists longer, this is a reason to seek medical help.

Brustan is a strong pain reliever, but it is not suitable for everyone. Before use, it is important to exclude conditions in which its use may be dangerous.

When the drug is contraindicated:

• allergy to ibuprofen, paracetamol, or any other component of the drug;

• stomach or duodenal ulcer in the acute stage;

• gastrointestinal bleeding in the past;

• inflammatory bowel diseases (Crohn's disease, ulcerative colitis);

• severe hepatic, renal, or cardiac failure;

• bronchial asthma triggered by aspirin or other NSAIDs;

• age under 12 years;

• pregnancy (3rd trimester) and lactation;

• blood disorders, including leukopenia, thrombocytopenia, hemophilia;

• glucose-6-phosphate dehydrogenase deficiency — may cause hemolysis.

If the patient has a history of severe allergic reactions to painkillers or GI bleeding — Brustan is absolutely unsuitable.

Although Brustan is effective for pain and fever, its use requires attentiveness and observance of a number of limitations.

What to consider:

• Elderly age, kidney, liver, heart diseases — require special caution.

• With prolonged use, it is necessary to monitor liver and kidney functions and blood parameters.

• Brustan should not be combined with other NSAIDs — this increases the risk of ulcers and bleeding.

• Alcohol enhances the toxic load on the liver and increases the risk of side effects — it should be avoided during treatment.

• Brustan can mask symptoms of infection, such as fever — do not delay seeking medical help.

• Women planning pregnancy should consult a doctor — some components of the drug can affect fertility.

If weakness, skin rash, abdominal pain, or black stool appear during treatment — stop taking the drug and seek medical help immediately.

Brustan can interact with other medications, enhancing side effects or reducing their effectiveness.

Not recommended to combine with:

• other NSAIDs (aspirin, diclofenac, naproxen) — risk of ulcers and bleeding;

• anticoagulants (warfarin, heparin) — increased risk of bleeding;

• antiplatelets (clopidogrel, ticlopidine) — same risk.

Caution is required when combined with:

• diuretics — their effect may be reduced, especially in kidney diseases;

• ACE inhibitors and beta-blockers — possible increase in blood pressure and reduced effectiveness of these drugs;

• glucocorticosteroids — increased risk of GI damage;

• lithium preparations — possible increase in its blood concentration;

• methotrexate — its toxicity is enhanced;

• cyclosporine — increased risk of nephrotoxicity;

• fluoroquinolones (ciprofloxacin, levofloxacin) — possible seizures.

Before starting Brustan, inform your doctor about all medicines you are using. It is especially important to mention painkillers, blood pressure medications, and any anti-inflammatory drugs.

Brustan is contraindicated in the 3rd trimester of pregnancy and during breastfeeding.

Pregnancy:

• In the last trimester, Brustan can cause premature closure of the ductus arteriosus in the fetus and increase the risk of complications during childbirth.

• In the 1st and 2nd trimesters, the drug may be prescribed only by doctor's decision if the expected benefit outweighs the risk.

Breastfeeding:

• The active substances of the drug pass into breast milk, so its use is contraindicated.

• If treatment is required, breastfeeding is temporarily discontinued.

Fertility:

• Ibuprofen can reduce fertility in women, especially with prolonged use.

• Women planning pregnancy are advised to avoid taking Brustan without consulting a doctor.

Brustan can cause side effects related to the nervous system:

• dizziness;

• drowsiness;

• impaired concentration.

During treatment, it is recommended:

• not to drive;

• not to work with potentially dangerous machinery;

• to avoid activities requiring quick reaction and high concentration — especially in the first hours after taking the drug.

If you feel sluggishness or drowsiness, it is better to postpone driving or work until your condition normalizes.

Like any combination drug, Brustan can cause side effects. They depend on the dose, duration of use, and individual sensitivity of the patient.

Gastrointestinal effects:

• common — nausea, vomiting, abdominal pain, discomfort;

• uncommon — diarrhea, constipation, heartburn, belching;

• rare — peptic ulcer, gastrointestinal bleeding (may manifest as bloody vomit or black stool).

Allergic reactions:

• uncommon — skin rash, itching, urticaria;

• rare — angioedema, bronchospasm;

• very rare — anaphylactic shock.

Blood-related:

• rare — anemia;

• very rare — leukopenia, thrombocytopenia.

Nervous system effects:

• common — headache, dizziness;

• uncommon — drowsiness, insomnia, irritability.

Kidney and urinary system effects:

• rare — kidney function impairment;

• very rare — acute renal failure.

Others:

• uncommon — increased blood pressure;

• rare — edema, vision problems.

If any of these symptoms appear — especially signs of stomach bleeding, urination problems, or sudden weakness — stop taking the drug and seek medical help immediately.

Exceeding the dose of Brustan can lead to serious complications, especially affecting the liver, kidneys, and nervous system. This is related to the action of both ibuprofen and paracetamol.

Symptoms of overdose:

• nausea, vomiting, abdominal pain;

• headache, dizziness, drowsiness, lethargy;

• seizures, respiratory distress;

• sharp drop in blood pressure;

• impaired liver and/or kidney function (in severe cases — liver failure).

What to do in case of overdose:

• seek medical help immediately;

• in the early stage — gastric lavage, administration of activated charcoal;

• for paracetamol poisoning — the antidote N-acetylcysteine is prescribed;

• symptomatic therapy is conducted — maintaining respiration, blood pressure, liver and kidney function.

Brustan overdose can be life-threatening, especially in children and when combined with alcohol.

Brustan is a combination drug combining the properties of two active components: ibuprofen and paracetamol. Their mechanisms of action are different but complement each other.

• Ibuprofen — belongs to non-steroidal anti-inflammatory drugs (NSAIDs). It blocks the enzyme cyclooxygenase (COX), which reduces the production of prostaglandins — substances that cause pain, inflammation, and fever. It has anti-inflammatory, analgesic, and antipyretic effects.

• Paracetamol — an analgesic-antipyretic. Its effect is related to its influence on pain centers and thermoregulation in the brain. It has virtually no anti-inflammatory action but effectively reduces temperature and enhances analgesia.

The combination of the two substances strengthens and prolongs the analgesic effect, while reducing the need for high doses of each component separately.

The components of Brustan act quickly and are metabolized independently of each other.

Ibuprofen:

• rapidly absorbed from the GI tract;

• maximum blood concentration — after 1-2 hours;

• plasma protein binding — 90-99%;

• metabolized in the liver;

• excreted by the kidneys as metabolites;

• half-life — 1.8-2 hours.

Paracetamol:

• rapidly absorbed, maximum concentration — after 30-60 minutes;

• protein binding — 10-25%;

• metabolized in the liver, forming active and inactive metabolites;

• excreted by the kidneys;

• half-life — from 1 to 4 hours.

In cases of liver or kidney function impairment, both components can accumulate — in such cases, dose adjustment is needed.

Brustan belongs to the group of:

• analgesics and antipyretics in combination — i.e., agents that relieve pain and fever;

• NSAIDs (ibuprofen) in combination with a non-narcotic analgesic (paracetamol).

Such a combination is often used for short-term relief of moderate to severe pain. It provides quick relief of symptoms without requiring the use of opioids.

In addition to active components, Brustan contains excipients that provide stability, form, and solubility of the tablet. They do not directly affect the therapeutic effect but may be significant in cases of allergies or intolerances.

Excipients may include:

• Microcrystalline cellulose — a filler that gives the tablet the necessary density.

• Corn starch — a binding agent and filler.

• Colloidal silicon dioxide — improves powder flow, prevents caking.

• Magnesium stearate — a lubricant, prevents sticking to press equipment.

• Talc — a texture stabilizer.

• Hypromellose, macrogol 400 — components of the film coating, regulate dissolution rate.

• Titanium dioxide (E171) — white colorant, protects from light.

The full composition is listed in the instructions for the specific batch of the drug. If you have intolerance to food additives or colorants — check this list in advance.

• The shelf life of Brustan is 3 years from the date of manufacture. It is indicated on the package (blister and cardboard box) — be sure to check the date before use.
• Do not use the drug after the expiration date.
• Over time, active substances can degrade or change, which reduces effectiveness and may increase the risk of adverse reactions.

Proper storage of the drug affects its safety and effectiveness:

• store at a temperature not exceeding 25°C;

• protect from direct light, moisture, and heat sources;

• do not freeze;

• keep the drug out of reach of children;

• do not remove tablets from the blister in advance — they are sensitive to air and moisture.

Observing storage conditions is an essential part of safe drug administration.

Brustan is available in film-coated tablets. Each tablet contains:

• ibuprofen 400 mg;

• paracetamol 325 mg.

Packaging:

• blisters of 10 tablets;

• 1 or 2 blisters per box (total of 10 or 20 tablets);

• the package includes instructions for use.

The package indicates: name, dosage, expiration date, batch number, and storage conditions.

Medications, including Brustan, should not be disposed of as regular waste or flushed down the drain — this can harm the environment.

Disposal recommendations:

• if possible — return remaining or expired drugs to a pharmacy participating in a disposal program;

• if this is not possible — mix the tablets with an inedible substance (such as coffee grounds or cat litter), place in a sealed bag, and dispose of in the trash;

• never flush medication down the toilet or sink;

• remove personal data from the package if returning it to a pharmacy.

Responsible disposal protects not only nature but also people — especially children and animals who might accidentally find discarded medication.

Brustan is registered and available for sale in India and some Central Asian countries.

• Sun Pharma (India)

Brustan is typically sold without a prescription, as it falls into the category of available analgesics.

However:

• it is advisable to consult a doctor before use, especially if you have chronic diseases or regularly take other medications;

• in some countries (e.g., in the EU), combination analgesics may be available only by prescription — depending on local legislation.

To ensure safe and effective use of Brustan, follow these recommendations:

• Do not take the drug for more than 3 days without consulting a doctor.

• Do not combine with other anti-inflammatory agents or antipyretics — this increases the risk of complications.

• Do not consume alcohol during treatment — it increases the load on the liver.

• For chronic kidney, liver, or GI diseases — discuss with your doctor whether this drug is suitable for you.

• If symptoms of allergy, abdominal pain, or blood in the stool appear — immediately stop taking the drug and consult a doctor.

• Women planning pregnancy should discuss taking Brustan with a gynecologist.

• The drug can mask symptoms of infection — do not delay seeking medical help if your condition does not improve.

Important: This information is for familiarization purposes. Before using the drug — refer to the official instructions and follow your doctor's prescriptions.

• M01AE51 — Ibuprofen in combination with other drugs

• G43.9 Migraine, unspecified

• K08.8.0* Toothache

• M25.5 Pain in joint

• M45 Ankylosing spondylitis

• M54 Dorsalgia

• M79.1 Myalgia

• M79.2 Neuralgia and neuritis, unspecified

• M89.9 Disorder of bone, unspecified

• R07.0 Pain in throat

• R50.0 Fever with chills

• R51 Headache

• R52.9 Pain, unspecified

• T14.0 Superficial injury of unspecified body region

• T14.2 Fracture of unspecified body region

• T14.3 Dislocation, sprain and strain of unspecified body region

• T14.9 Injury, unspecified

• T88.9 Complication of surgical and medical care, unspecified