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AB Broncol NF

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AB Broncol NF

AB Broncol NF_FR
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Method of action: Bactericidal

Treatment option: Abscess, Bronchitis, Bronchopneumonia, Gonorrhea, Influenza, Infection, Pertussis, Meningitis, Pneumonia, Salmonella

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of AB Broncol NF

Quick Facts

Property Description
Active ingredient Ampicillin, Lidocaine hydrochloride, Gomenol
Form Powder for injectable suspension (Vial)
Pharmacological class Antibiotic (Aminopenicillin), Local Anesthetic, Expectorant
Common use Combating bacterial infections and associated airway issues
Origin Semi-synthetic (Ampicillin component)
Status Prescription-only

What Type of Medicine is AB Broncol NF?

AB Broncol NF is a prescription-only, combination product that belongs to the aminopenicillin family, a highly effective subclass of penicillin antibiotics. This class of drug is a semi-synthetic derivative which is designed to provide bactericidal activity against a wide array of susceptible microorganisms. This specialized formulation, manufactured by MEDIFARMA, is differentiated by its tripartite structure.

It is uniquely categorized as an antibiotic-anesthetic-expectorant combination, a design clinically recognized for its ability to address both the infectious agent and two ancillary symptomatic issues concurrently. This composite nature offers simultaneous antimicrobial action and ancillary support related to localized discomfort and the management of airway congestion, moving beyond the scope of a simple single-ingredient penicillin.

The Unique Composition of AB Broncol NF

The formulation contains three active ingredients: the core antibiotic Ampicillin, the local anesthetic Lidocaine hydrochloride, and the expectorant Gomenol. The Ampicillin component is deliberately combined as two different salts, Ampicillin sodium and Ampicillin benzathine, to manage its absorption profile.

This specific composition ensures a dual-release action. The sodium salt provides rapid absorption to achieve high concentrations necessary for immediate bactericidal activity, while the benzathine salt acts as a depot form which results in a sustained-release effect in the muscle tissue. The medicine is supplied as a powder for injectable suspension that requires reconstitution prior to its intended intramuscular administration.

General Purpose and Broad-Spectrum Action

The general purpose of AB Broncol NF is to provide a comprehensive broad-spectrum therapeutic defense that rapidly targets the cause of bacterial infections while maintaining prolonged activity. The central benefit is the effective elimination of the infectious agent through inhibition of bacterial cell wall synthesis.

Furthermore, the unique multi-component design offers a practical advantage: the anesthetic component works to reduce injection site discomfort, and the expectorant assists with the thinning of thick bronchial secretions. This composition is geared toward treating infectious processes, especially those found in respiratory tract infections, with enhanced patient support, a typical neutral use scenario for this specific combination product.

Regulatory References

  1. NIH MedlinePlus on Ampicillin
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What side effects are possible with AB Broncol NF?

The official safety profile of AB Broncol NF is based on the documented risks associated with its three active components: Ampicillin, Lidocaine hydrochloride, and Gomenol. Regulatory agencies classify adverse reactions across specific System-Organ Classes (SOCs) to formally describe potential effects.

Frequency and Systemic Adverse Reactions

Adverse reactions are formally categorized by frequency in regulatory documentation:

  • Common Reactions may include effects on the Gastrointestinal Disorders system, such as diarrhea, nausea, and vomiting, as well as Skin and Subcutaneous Tissue Disorders, particularly rash.
  • Uncommon Reactions include urticaria and transient elevation of hepatic enzymes, reflecting potential effects on the Hepatobiliary Disorders.

Serious Adverse Reactions and Safety Constraints

The label documents specific serious adverse reactions that are considered rare but clinically significant:

  • Anaphylaxis is classified as a rare, potentially fatal hypersensitivity reaction associated with the penicillin component (Ampicillin).
  • Neurological effects, including seizures and convulsions, are documented risks, especially associated with high systemic levels of the antibiotic, often related to underlying renal impairment.
  • Severe colitis, specifically Clostridioides difficile-associated diarrhea (CDAD), is a serious gastrointestinal risk that may appear during or after treatment cessation.

Safety-related constraints require strict adherence to label guidelines. The medication is formally contraindicated in patients with a history of serious hypersensitivity to any penicillin or to local anesthetics of the amide type (Lidocaine). Additionally, the use of Gomenol-related derivatives has specific pediatric safety notes in infants and young children, focusing on the potential for respiratory and neurological spasms. These official classifications structure the understanding of the medicine’s risks, establishing the formal boundaries for its safe use.

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Overdose and Emergency Response

The official regulatory documents define the overdose profile of AB Broncol NF through the potential for serious, life-threatening systemic toxicity linked to its active components. Management is primarily symptomatic and supportive.

Documented Manifestations and Severe Outcomes

Overdose may present with severe neurological, cardiac, and respiratory signs. Documented neurological manifestations include seizures, confusion, dizziness, tinnitus, and coma. Cardiac signs include bradycardia, hypotension, and cardiovascular collapse. Respiratory effects include respiratory arrest.

Severe outcomes officially documented are Anaphylactoid Reactions, Methemoglobinemia, and the risk of fatal colitis linked to C. difficile-Associated Diarrhea (CDAD). Aspiration pneumonitis is also a documented risk.

Emergency Action and Monitoring Requirements

Regulators explicitly mandate that individuals experiencing signs of systemic toxicity seek immediate emergency treatment. Urgent medical help is required when manifestations such as lethargy, shallow breathing, seizure activity, or cardiovascular instability occur. The official management guidance requires procedures like Airway Management, the use of Injectable Lipids, and hospital observation with monitoring of vital signs and ECG. No specific antidote is known for the general toxicity. The elderly, acutely ill, and children are noted as populations requiring special consideration due to increased susceptibility to toxicity.

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Therapeutic Uses of AB Broncol NF

What AB Broncol NF Treats: Main Uses and Benefits

The medication is primarily used to address bacterial infections caused by susceptible microorganisms, often applied in clinical settings that involve acute or unstable symptom patterns. It plays a role in managing the infection by targeting the causative agent, which may assist with easing symptoms related to systemic imbalance, such as fever and general malaise. The therapeutic domain is relevant for infections affecting the blood, lungs, urinary tract, and other sites in the body.

Symptomatic Support for Comfort

The medicine is commonly used to help with conditions characterized by periods of heightened symptoms, such as severe bronchitis, pneumonia, or otitis media. The formulation may be part of symptomatic management for distressing manifestations, specifically targeting airway congestion and symptoms related to thick bronchial secretions that can create noticeable physiological strain. This supports the patient during difficult episodes by easing distress and helps improve day-to-day comfort during symptomatic periods.

Additionally, the formulation is applied in addressing the localized pain and soreness experienced at the site of the intramuscular injection, providing supportive relief that assists with maintaining functional stability and may help patients cope more steadily with the administration across adult and child patient groups.

Quick Fact: Symptom Management Context

Type of Support Symptom Addressed Primary Benefit
Antimicrobial Susceptible bacterial pathogens Supports the management of core infectious symptoms
Expectorant Thick bronchial secretions Assists with easing breathing difficulty and functional strain
Anesthetic Localized injection site pain Contributes to patient tolerance and comfort

Regulatory References

  1. NIH MedlinePlus overview of Ampicillin Injection
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Eligibility and Restrictions for Use

Who Can and Cannot Use AB Broncol NF

The eligibility for AB Broncol NF, a combination product containing Ampicillin and Lidocaine, is strictly defined by regulatory guidelines, focusing on absolute contraindications and conditional population restrictions.

Absolute Contraindications (Must Not Use):

  • Hypersensitivity: The medicine is strictly contraindicated for individuals with a known history of severe hypersensitivity or allergic reactions to penicillins (like Ampicillin) or to amide-type local anesthetics (like Lidocaine).
  • Specific Diseases: Use is not recommended or contraindicated in patients with infectious mononucleosis or lymphatic leukemia due to the high risk of a generalized rash.

Conditional Eligibility and Restrictions (Use with Caution):

Population Group Regulatory Status
Age Groups Adults and Children are generally eligible; however, neonates have specialized administration requirements, and older adults require caution due to potential decreased renal function.
Organ Function Patients with severe renal impairment require conditional modification of the administration frequency. Use in hepatic impairment should proceed with caution.
Pregnancy/Lactation Ampicillin is generally considered acceptable if clearly needed during pregnancy. Use during lactation is subject to caution and clinical assessment.
Cardiac Conditions Patients with pre-existing cardiac conduction issues (e.g., severe heart block) must use the medicine with caution due to the Lidocaine component.
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What should I know about interactions with other medicines?

AB Broncol NF contains ampicillin (an antibiotic), gomenol (an expectorant), and lidocaine (a local anesthetic). It is important to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting treatment.

Significant Drug Interactions

Drug Class or Medication Potential Effect of Interaction Action to Take
Tetracyclines, Chloramphenicol, Erythromycin, Sulfonamides May decrease the antibacterial effect of ampicillin. Concurrent use should generally be avoided or monitored closely by a doctor.
Methotrexate Ampicillin may decrease the clearance of methotrexate, potentially increasing its toxicity. Close monitoring and possible dose adjustment of methotrexate may be required.
Probenecid May increase and prolong the concentration of ampicillin in the blood. This combination is sometimes used intentionally to enhance ampicillin's effect, but requires a doctor's guidance.
Oral Contraceptives Penicillins, including ampicillin, may theoretically reduce the effectiveness of oral contraceptives. Use an alternative, non-hormonal method of birth control while on this medication.
Bentiromide Lidocaine may invalidate the results of pancreatic function tests using bentiromide. Inform the lab and your doctor if you are scheduled for this test.

Other Considerations

Alcohol and other central nervous system depressants (e.g., sedatives or tranquilizers) should be used with caution, as lidocaine may contribute to CNS effects.

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Mechanism of Action

The mechanism of AB Broncol NF involves the simultaneous influence of three distinct biological systems: bacterial metabolism, neural signaling, and pulmonary secretion dynamics.

Inhibition of Bacterial Peptidoglycan Synthesis

This domain describes the bactericidal action exerted by the aminopenicillin component. The mechanism involves the irreversible acylation and inhibition of essential bacterial Penicillin-Binding Proteins (PBPs), which are the enzymes responsible for cross-linking the peptidoglycan structure of the cell wall . This specific molecular interference leads directly to the structural compromise of the cell wall, causing bacterial lysis due to internal osmotic pressure.

Localized Sodium Channel Blockade

This secondary domain governs the conduction blockade mechanism of the anesthetic component. The molecule acts directly on voltage-gated sodium channels ( Na v) within peripheral nerve axons. By binding to these channels from the intracellular side, the anesthetic prevents the necessary influx of sodium ions required for cell depolarization, which results in the reversible interruption of sensory signal transmission and local conduction arrest.

Reflex Modulation of Airway Secretion Rheology

This third domain explains the secretagogue action mediated by Gomenol. The mechanism is primarily reflexive, initiating a signal, often via vagal receptors, which culminates in an efferent parasympathetic response to the bronchial glands. This signal enhances the volume and water content of the respiratory fluid, thereby lowering the viscosity of thick secretions and facilitating mucociliary action.

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Dosage and Administration Information

The use of AB Broncol NF is defined by specific procedural requirements for dosing, route, and administration.

Administration and Preparation

The medicine is administered exclusively by intramuscular (I.M.) injection, supplied as a powder for suspension that requires mandatory reconstitution. To ensure formulation integrity, the powder must be dissolved using only the provided solvent, and its dilution with water is explicitly prohibited, as this risks precipitation of components. Administration must occur immediately after the suspension is prepared.

Dosing and Schedule

The product's composition, which combines Ampicillin sodium for rapid effect and Ampicillin benzathine for sustained release, structures the dosing schedule. The typical adult regimen often involves a single daily administration, with available strengths being 300 mg, 600 mg, or 1200 mg total Ampicillin equivalent per dose unit. Treatment duration generally extends for a minimum of 48 to 72 hours after the resolution of clinical signs. For infections caused by beta-hemolytic streptococcus, the treatment course requires a minimum of 10 days.

Population Adjustments and Constraints

Dosing requires adjustment for specific patient populations. Patients with significant renal impairment require dose reduction, calculated based on the degree of reduced kidney function. Furthermore, an additional dose is specified following each hemodialysis session to compensate for drug clearance. When co-administering this medication with an aminoglycoside, the two must be injected at separate sites with a minimum interval of one hour between administrations.

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Recent Clinical Evidence

AB Broncol NF is a combination product containing ampicillin benzathine and ampicillin sodium, which are broad-spectrum, semi-synthetic penicillin antibiotics. The clinical evidence supporting its use is primarily focused on its established role in treating bacterial infections sensitive to these components.

Efficacy in Respiratory Tract Infections

Clinical application of AB Broncol NF is guided by the established bactericidal action of its active components, which inhibit bacterial cell wall synthesis. The combination is indicated in the treatment of various bacterial infections, including those affecting the respiratory tract. Efficacy data is consistent with the established profile of ampicillin against susceptible Gram-positive and Gram-negative bacteria. Studies on related antibiotic combinations highlight their use in managing conditions such as acute bacterial exacerbations of chronic bronchitis, though the specific efficacy profile of this fixed combination relies on appropriate identification of the causative organism and its sensitivity to ampicillin.

Safety and Tolerability

The safety profile of AB Broncol NF is generally reflective of the known risks associated with penicillin-class antibiotics. Clinical monitoring for serious adverse reactions, such as hypersensitivity and anaphylaxis, is standard practice. The formulation may also include a local anesthetic, such as lidocaine, which is incorporated to reduce pain at the injection site. This addition addresses a common issue associated with intramuscular penicillin injections, though it does not impact the antibiotic's overall systemic safety profile. As with all antibiotics, evidence supports prudent use to minimize the risk of bacterial resistance and related complications.

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Frequently Asked Questions (FAQ)

Common questions about AB Broncol NF (FAQ)

Q: What should I do if I miss a dose of AB Broncol NF?

Official regulatory guidance suggests that if a dose is missed, it can be administered by a healthcare professional as soon as it is feasible to re-schedule. The regular dosing schedule is typically resumed from that point to help ensure the necessary course of treatment is completed as prescribed.

Q: How long does it take for the medicine to start working against the bacteria?

While regulatory documents do not specify an exact time to the complete clinical effect, the antibiotic component is specifically formulated to provide both a rapid start to its action, through quick absorption, and a sustained effect over time. This dual strategy is intended to ensure appropriate therapeutic levels are quickly achieved and maintained.

Q: Why is lidocaine included in the AB Broncol NF injection?

According to the official product information, Lidocaine is a local anesthetic that is included in the formulation. It is incorporated to help minimize the pain and localized discomfort often associated with intramuscular antibiotic injections. This addition is intended to enhance tolerability and does not impact the antibiotic’s primary action against bacteria.

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How should AB Broncol NF be stored and disposed of?

The storage and disposal of AB Broncol NF powder for suspension must adhere strictly to regulatory requirements for injectable Ampicillin-based products to maintain stability and sterility.

Official Storage Conditions

Condition Requirement
Temperature Store the dry powder at controlled room temperature, between 68°F and 77°F (20°C and 25°C).
Protection Keep the medicine in its original, tightly closed container and protect it from moisture.
Prohibition The powder must not be frozen and should not be stored above 86°F (30°C).
Stability After the powder is mixed, the solution has a limited stability period and must be discarded if it shows discoloration or particulate matter.

Disposal and Safety Rules

The medicine must be kept out of the sight and reach of children. Unused or expired portions must not be flushed down the toilet or disposed of in household waste. Disposal should follow local regulations and utilize approved medication take-back programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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