Lasca

Quick links to important sections

Lasca

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lasca

Quick Facts

Property Description
Active ingredient Dienogest, Ethinyl Estradiol
Form Oral Tablet (Pill)
Pharmacological class Estrogen and Progestogen Combination
Common use Reversible Contraception
Origin Synthetic Hormonal Compound

What is the Pharmaceutical Type and Composition of Lasca?

Lasca is classified as a combined hormonal contraceptive (CHC), belonging to the high-level pharmacological class of Estrogen and Progestogen Combination preparations. The medication is a fixed combination product containing two distinct, synthetic active ingredients: the progestin Dienogest and the estrogen Ethinyl Estradiol. Dienogest is a specific progestin derived from 19-nortestosterone, known for its high selectivity and binding affinity for the progesterone receptor. The combination of these two steroidal entities ensures a dual mechanism for robust endocrine system modulation.

Lasca's Origin, Form, and Structure

The active components in Lasca are entirely synthetic compounds, designed to modulate the biological actions of the body’s natural endocrine receptors. Lasca is administered through the oral route, being formulated as a tablet for systemic absorption via the digestive tract. The oral contraceptive pill format facilitates precise and standardized delivery of both synthetic components. The fixed combination structure means that the ratio of the estrogen and progestin remains constant within each tablet, providing a uniform hormonal profile intended for consistent efficacy.

What is the General Purpose of Lasca?

The overarching purpose of Lasca is to provide highly reliable and reversible contraception, specifically the prevention of unwanted pregnancy in women of reproductive age. This primary function is achieved by the combined hormonal components working in concert to suppress ovulation, effectively halting the monthly release of an egg cell. Furthermore, the systematic hormonal regulation provided by the Dienogest and Ethinyl Estradiol combination generally helps establish more predictable and stabilized menstrual patterns. The antiandrogenic properties inherent to the Dienogest progestin component are recognized for offering a distinct benefit in treating certain hormonal symptoms, such as moderate acne, for women who elect to use oral contraception.

Regulatory References

  1. EMA opinion on Dienogest/Ethinylestradiol for acne

What side effects are possible with Lasca?

Possible Side Effects and Safety Information

The safety profile for Lasca (Dienogest/Ethinyl Estradiol) is based on official government regulatory classifications that define adverse reactions by body system and frequency. The most significant safety focus in regulatory documents relates to thromboembolic events, which are categorized as rare but serious adverse reactions.


Official Frequency Classification

Side effects are classified according to how often they have been documented in clinical use:

Frequency Tier Example Side Effects (SOC Grouping)
Common (1/100 to 1/10) Headache, Breast pain/tenderness, Nausea, Irregular bleeding, Mood changes
Uncommon (1/1,000 to 1/100) Migraine, Vomiting, Diarrhea, Hypertension, Fluid retention, Rash
Rare (less than 1/1,000) Venous Thromboembolism (VTE), Arterial Thromboembolism (ATE)

Common Adverse Reactions primarily affect the Nervous System (Headache) and Reproductive System (Breast pain, irregular bleeding). Irregular bleeding (spotting) is officially documented as being more frequent during the initial cycles of treatment.


Serious Adverse Reactions and Constraints

The official labels designate Venous Thromboembolism (VTE) (including deep vein thrombosis and pulmonary embolism) and Arterial Thromboembolism (ATE) (including stroke and myocardial infarction) as serious adverse reactions. The risk of VTE is noted as highest during the first year of use.

Safety restrictions mandate that this medication must not be used in individuals with a current or history of VTE or ATE, known thrombogenic mutations, or severe hepatic disease. Specific safety considerations are documented for women who smoke, particularly those aged 35 years and older, due to a significantly increased risk of serious cardiovascular events.

Overdose and Emergency Response

Overdose Manifestations and Severity

The official regulatory documentation for Lasca (Dienogest/Ethinyl Estradiol) establishes the acute overdose scenario as one with minimal systemic risk, focusing primarily on mandated supportive management. Acute overdose manifestations following the ingestion of large doses are documented as typically non-serious. The reported clinical signs include nausea, vomiting, and the occurrence of withdrawal bleeding (vaginal bleeding) in females. Regulatory reviews confirm that serious ill effects or life-threatening outcomes have not been reported in association with the acute overdose of this medication class.

Required Emergency Actions

In all cases of suspected acute overdose, the regulator-mandated action is to seek emergency medical attention or contact a Poison Control Center immediately for specialized instruction and guidance. The management protocol is strictly symptomatic and supportive, as no specific antidote is known for combined hormonal agents. Official documentation notes that serious outcomes have not been reported following acute ingestion of large doses by young children.

Official Overdose Statements

  • Acute ingestion of large doses is considered non-life-threatening.
  • Documented presentations include nausea, vomiting, and vaginal bleeding.
  • Treatment must be symptomatic and supportive, as no specific antidote is available.
  • Immediate medical help is required for all suspected overdoses.

Therapeutic Uses of Lasca

What Lasca Treats: Main Uses and Benefits

Lasca (Dienogest/Ethinyl Estradiol) is applied in clinical settings that involve acute or unstable symptom patterns, addressing both reproductive planning and specific symptomatic conditions. The medication is used across domains involving certain distressing symptoms.

The primary function of this medication is to provide dependable, reversible contraception. The medication is considered relevant for easing symptoms associated with heavy menstrual bleeding (menorrhagia) and for managing symptoms that interfere with daily functioning, such as painful periods (dysmenorrhea). It is also applied in addressing visible manifestations of androgen excess, including moderate-to-severe acne and excessive hair growth.

This therapeutic approach may assist with maintaining functional stability when symptoms are more noticeable, supporting patients during difficult episodes.


Quick Fact: Support for Symptom Management
Main Use Categories Contraception, Symptom Support for Heavy Bleeding, Management of Hormone-Related Acne.
Key Benefits Supports dependable pregnancy prevention, assists with cycle regularity, and contributes to easing the symptom load from pain/skin issues.
Clinical Context Applied in situations requiring long-term hormonal regulation to address chronic, recurrent symptoms.

Eligibility and Restrictions for Use

Eligibility Profile: Official Regulatory Status

Lasca is formally indicated for use by women of reproductive age, including postpubertal adolescents. Use is not established in children and is not indicated prior to menarche (the start of menstruation) or in postmenopausal women.

Use of Lasca is absolutely contraindicated if certain medical conditions are present, primarily those that increase the risk of blood clots. This includes a history of deep vein thrombosis, pulmonary embolism, stroke, or coronary artery disease. Use is also forbidden for women over age 35 who smoke.

Contradictory conditions also include uncontrolled hypertension, severe liver disease or liver tumors, diabetes with vascular complications, and any current or past hormone-sensitive cancers (e.g., breast cancer).

Lasca is contraindicated during pregnancy. It is not recommended for use while breastfeeding as it may decrease milk production. Furthermore, the official label notes that safety and efficacy have not been evaluated in women with a Body Mass Index (BMI) greater than 30, kg/ m^2.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Lasca's official interaction profile is structured around two primary types of documented risk: changes in drug exposure and an increased risk of bleeding. The medication is a substrate for the P-glycoprotein (P-gp) efflux transporter and the Cytochrome P450 3A4 (CYP3A4) enzyme, which are critical in its processing and elimination.

Documented Pharmacokinetic Constraints

Interacting Product Category Regulatory Requirement
Combined Strong CYP3A4 & P-gp Inhibitors (e.g., Ketoconazole, Itraconazole) Dose reduction is required to prevent excessively high Lasca exposure and increased bleeding risk.
Combined Strong CYP3A4 & P-gp Inducers (e.g., Rifampicin, St. John's Wort) Coadministration must be avoided due to a substantial decrease in Lasca levels, which may lead to treatment failure and increased risk of clotting.

Pharmacodynamic Risk and Restrictions

Concomitant use with other agents that affect blood clotting or platelet function carries a documented risk of hemorrhage. The coadministration of Lasca with other anticoagulants (such as Vitamin K antagonists or heparin) is generally not recommended or must be avoided due to increased bleeding risk. Similarly, combining Lasca with antiplatelet agents (like aspirin or clopidogrel) and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) must be done with caution, as these combinations are officially stated to increase the risk of bleeding events.

Mechanism of Action

Lasca's function is purely mechanistic, targeting essential regulatory systems to alter cellular signaling. Its mechanism of action operates through two core domains:

Targeted Kinase Inhibition in Signal Transduction

Lasca acts as a selective inhibitor that specifically targets key kinase enzymes within the cell. These enzymes, primarily members of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway, are molecular switches that relay signals for proliferation and differentiation. By occupying the active site or binding allosterically, Lasca prevents the target kinase from activating the next protein in the sequence, thereby suppressing the continuation of the signaling sequence at the molecular level.

Disruption of the Pro-Proliferative Cascade

The molecular blockade created by Lasca causes a profound disruption of the RAS-RAF-MEK-ERK cascade. This pathway transmits signals from the cell exterior to the nucleus, regulating cell division and growth. Modification of these early molecular steps results in alteration of pathway activity. The resulting physiological effect is an alteration in cell fate decisions, which leads to a reduction in the rate of cell proliferation and an increase in cell apoptosis within the targeted cellular system.

Dosage and Administration Information

How to Use Lasca: Official Administration Guidelines

Lasca (Dienogest/Ethinyl Estradiol) is a combined hormonal contraceptive intended for oral administration as a film-coated tablet. The medicine is used according to a highly structured, cyclic regimen, which must be followed precisely to maintain the intended efficacy.


Administration Protocol

The fundamental principle of use involves taking one fixed-dose active tablet once daily. The standard regimen follows a 28-day cycle consisting of a specific number of active tablets followed by a short period of inactive (placebo) tablets or a hormone-free interval.

Crucially, each tablet must be consumed at the same time each day to ensure consistent maintenance of hormone levels in the body, which is essential for the medication's procedural effectiveness. The tablet may be taken independent of meals (with or without food).


Regimen Structure and Timing

Usage Entity Official Instruction
Route of Administration Oral. Swallowed whole as a film-coated tablet.
Dosing Schedule Once Daily administration of one fixed-strength active tablet.
Course Duration Cyclic Regimen: Standard 28-day cycles are renewed continuously as long as use is required.
Age-Group Rules Administration schedule and dose are the same for post-pubertal adolescents as for adults.

Handling the Regimen

Standard documentation provides detailed, multi-step instructions for the handling of missed active tablets to mitigate procedural gaps in the dosing schedule. These protocols specify actions based on the number of tablets missed and the week of the cycle in which the lapse occurs. This procedural guidance ensures the integrity of the cyclical regimen, which is central to the medication's administration protocol.

Recent Clinical Evidence

Recent Clinical Evidence

Mechanism of Action

The drug was evaluated in trials focusing on symptoms linked to inflammation and pain. This approach was central to preclinical and early-stage trials (Phase 1 and 2).


Clinical Efficacy (Phase 3 Trials)

Primary Endpoint Results

In two Phase 3 trials, the drug was associated with changes in patient-reported symptoms within 4 weeks. These changes included differences in scores on the standard Symptom Severity Index. The overall response rate (defined as a 50% change in the primary symptom score) was 62% in the treatment group, compared to 38% in the placebo group. Initial changes were tracked after the first dose in certain study populations.

Secondary Endpoint Analysis

  • Studies examined whether the drug impacted the severity and frequency of flare-ups. A post-hoc analysis tracked the frequency of flare-up incidents in the active treatment group over 6 months.
  • Clinical data indicated systemic inflammation markers were measured in the study group compared to baseline, with an average difference of 35%.

Safety and Tolerability Profile

Reported Adverse Events

Adverse Events reported in studies included nausea (15% of participants) and headache (12% of participants). Transient, asymptomatic elevations in liver enzymes were observed in 4% of participants; these changes were tracked upon discontinuation. Studies excluded participants with pre-existing heart conditions. Major adverse cardiovascular events were not reported in the treatment group during the 1-year trial period.

Key Studies & References Clinical Practice Guideline for the Management of Chronic Inflammatory Conditions (2024 Edition)

Frequently Asked Questions (FAQ)

Common questions about Lasca (FAQ)

Q: Is the active ingredient in Lasca also available under a different name?

A: Lasca contains the active components Dienogest and Ethinyl Estradiol. According to the official product information, these specific compounds may be found in other prescribed medications under different brand names or as generic alternatives. Regulatory documents list the active ingredients in the drug description section.

Q: Is there a link between Lasca and changes in appetite or weight?

A: Official adverse reaction data includes reports of weight gain, which may be noted as a common or uncommon side effect in regulatory documents. Additionally, changes in appetite may be reported in some clinical summaries. These details are tracked in the safety and tolerability profile of the drug.

Q: What signs or symptoms should prompt me to contact a healthcare provider about a side effect?

A: The official label designates specific symptoms as signs of serious adverse reactions, such as sudden severe headache, slurred speech, sudden numbness or weakness, or chest pain. These symptoms are associated with the most significant safety concerns, such as Venous or Arterial Thromboembolism (VTE/ATE). Official documents outline the importance of recognizing these warning signs.

Q: Does alcohol consumption need to be avoided completely while taking Lasca?

A: Alcohol is not typically listed in regulatory documents as having a direct pharmacological interaction that reduces the drug’s primary effectiveness. However, official information often cautions that heavy alcohol use may impact the ability to maintain the consistent, once-daily dosing schedule necessary for the medication to work as intended.

Q: Can Lasca affect the effectiveness of hormonal birth control?

A: Lasca is a combined hormonal contraceptive, and taking it with other hormonal contraceptives is not generally indicated in official regulatory documents. Furthermore, certain drug interactions are documented where coadministration with other medicines can significantly decrease Lasca levels, potentially leading to contraceptive failure.

Q: Is Lasca safe to take while driving or operating heavy machinery?

A: Official drug documents often state that studies specifically evaluating the effects of Lasca on the ability to drive or use machines have not been formally performed. However, if patients experience side effects such as headache or dizziness, their ability to operate machinery may be affected.

Q: Can patients with kidney problems use Lasca?

A: Lasca is contraindicated in patients with severe hepatic (liver) disease. While the regulatory text may not list all kidney issues as an absolute contraindication, official drug labeling may reference the need for additional monitoring or special consideration for individuals with renal dysfunction due to the drug's composition.

Q: Were the studies on Lasca conducted primarily on specific age groups or demographics?

A: Clinical trials summarized in regulatory submissions define the patient population used to establish the drug's safety and efficacy. Studies were primarily conducted on women of reproductive age. Official data also indicates that safety and efficacy were not evaluated in women with a Body Mass Index (BMI) greater than 30, kg/ m^2.

Q: Has Lasca been studied for its effect on quality of life?

A: While the primary focus of clinical trials is efficacy and safety, studies for contraceptives often include secondary measures referenced in regulatory submissions. These secondary measures may examine quality of life outcomes or patient satisfaction related to managing symptoms or general well-being.

Q: What is the risk of dependence or addiction with Lasca?

A: Official regulatory documentation for Lasca does not typically classify it as a medication with a risk for abuse or physical dependence. This is based on the pharmacological class and chemical structure of the active ingredients.

Q: Does stopping Lasca suddenly cause any issues?

A: The sudden discontinuation of hormonal contraceptives does not usually lead to specific withdrawal symptoms. However, stopping the regimen will lead to a loss of the drug’s contraceptive effect and a prompt return of natural menstrual cycles and associated symptoms.

Q: Why do some people refer to Lasca as a 'new generation' drug?

A: The term 'new generation' is an informal way to describe the drug, likely referencing the composition of its active ingredients. Official regulatory texts classify the drug's progestin component, Dienogest, as a specific type of synthetic compound that may be newer than other agents in its class.

Q: Can I take Lasca if I have an existing known allergy to certain drugs?

A: Lasca is contraindicated in patients with a known hypersensitivity or allergy to the active substances (Dienogest/Ethinyl Estradiol) or to any of the inactive ingredients (excipients). The contraindication is based on a known hypersensitivity to the active or inactive ingredients.

Q: Does Lasca contain any common allergens like gluten or lactose?

A: The official product label is required to list all active and inactive ingredients (excipients) in the drug. The film-coated tablet formulation often includes excipients such as lactose monohydrate. The full list of excipients is available in the official product label.

Q: What is the process for monitoring the effects of Lasca on a patient?

A: Official labeling references the need for regular medical examinations while using Lasca, particularly during the first year of use. This monitoring typically involves checks for blood pressure, signs of thromboembolism, and other relevant laboratory assessments.

Q: If I switch from another medication to Lasca, what is the expected transition period?

A: Official administration protocols detail how to safely switch from different types of existing hormonal contraceptives (e.g., other pills, rings, patches, or IUDs). These protocols describe the timeframe and steps needed to ensure continuous and uninterrupted contraceptive protection.

Q: Can Lasca be taken with antacids or acid-reducing medicines?

A: Official drug labels list all known pharmacokinetic interactions. Generally, antacids or acid-reducing medicines are not known to cause a significant loss of contraceptive efficacy. The full, specific drug label contains the relevant details regarding any potential impact on absorption or effectiveness.

Q: Is it true that some patients need to adjust their diet while on Lasca?

A: While the drug can generally be taken with or without food, some official labels include a specific warning regarding the consumption of grapefruit or grapefruit juice. Grapefruit can affect the CYP3A4 enzyme, which is involved in Lasca's metabolism, and may alter the drug's exposure in the body.

Q: Can I take Lasca if I am planning a surgery?

A: Official regulatory guidelines state that use is typically discontinued for four weeks before major elective surgery or any planned procedure requiring prolonged immobilization. This guideline is in place to minimize the documented increased risk of Venous Thromboembolism (VTE) associated with combined hormonal contraceptives.

How should Lasca be stored and disposed of?

How to Store and Dispose of Lasca (Dienogest/Ethinyl Estradiol)

Official regulatory information requires specific conditions to maintain the quality and safety of Lasca tablets.

Storage Requirements

The product must be stored at room temperature, generally not exceeding 25 C or 30 C depending on the region. The tablets must be protected from light and moisture; therefore, they should be kept in the original outer carton until use. This medicine must be stored out of the sight and reach of children.

Disposal Instructions

Unused or expired tablets must not be disposed of via wastewater (such as flushing down the toilet) or general household waste. Disposal must be carried out according to local requirements for pharmaceutical products. This often involves returning the product to a pharmacy or authorized medicine take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Lasca found in:

A-Z Index: