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Yi Tian

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Yi Tian

Yi Tian_EN

Method of action: Antidopaminic, Antiemetic, Cholinomimetic, Prokinetic, Stimulating Tone And Motility Of The Gastrointestinal Tract

Treatment option: Gastritis, Flatulence, Transient Ischemic Attack

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Yi Tian

Property Description
Active Ingredient Itopride Hydrochloride
Form Film-Coated Tablet
Pharmacological Class Prokinetic Agent (Gastroprokinetic)
General Purpose Enhancing gastrointestinal motility
Origin Synthetic (Substituted Benzamide)

What is Yi Tian and its Purpose?

Yi Tian is a prescription medication whose active ingredient is Itopride Hydrochloride, classified as a Prokinetic Agent. It is fundamentally designed to enhance and normalize the movement (motility) of the stomach and upper gastrointestinal tract. This pharmaceutical preparation addresses the underlying issue of slow or irregular digestive movement, aiming to restore the natural, orderly flow of contents through the system. Its overall purpose is to provide relief from the general physical discomfort and symptoms that arise when the propulsive force of the digestive organs is compromised.

Composition, Class, and Form of Yi Tian

The active component, Itopride, is a synthetic compound belonging to the Substituted Benzamide derivative chemical class, a structural group known for influencing gastrointestinal function. Itopride is a single-ingredient product typically formulated as an oral dosage form, most commonly a film-coated tablet. The administration is via the oral route, allowing the medicine to be absorbed systemically so it can act upon the nervous and muscular structures throughout the upper digestive system. Itopride is categorized within the A03FA group, which includes propulsives for functional gastrointestinal disorders. The film-coated tablet form is designed for ease of ingestion and controlled systemic release of the active ingredient.

How Does Yi Tian Help the Digestive Process?

Yi Tian works by utilizing a unique dual mechanism of action to promote strong and coordinated muscle contractions in the gut. Conceptually, it functions by both boosting the natural stimulant and removing the inhibitory brake on the digestive muscles. It achieves this by acting as a dopamine D2 receptor antagonist while simultaneously inhibiting acetylcholinesterase to increase the concentration of the key excitatory neurotransmitter, acetylcholine. This dual influence accelerates gastric emptying and improves gastroduodenal coordination, which is the functional principle behind its overall purpose of normalizing movement within the upper digestive tract.

What side effects are possible with Yi Tian?

Possible Side Effects and Safety Information

The safety profile for Yi Tian, containing Itopride Hydrochloride, is defined by regulatory agencies based on the observed frequency and classification of adverse reactions from clinical trials and post-marketing surveillance. This information establishes the official scope of risk and use restrictions.

Categories of Adverse Reactions

Adverse reactions are classified by frequency, using categories such as Uncommon (occurring in fewer than 1 in 100 users) and Rare (fewer than 1 in 1,000 users). A separate category, Not known, is used for events reported spontaneously during post-marketing use where a precise incidence cannot be determined.

  • Uncommon Reactions: These frequently documented effects include headache, dizziness, diarrhoea, abdominal pain, salivary hypersecretion, leukopenia (a blood disorder), and hormonal changes such as hyperprolactinaemia.
  • System-Organ Classes Involved: Reactions are categorized across multiple physiological systems, including Gastrointestinal Disorders, Nervous System Disorders, Endocrine Disorders, Blood and Lymphatic System Disorders, and Investigations (e.g., changes in liver enzymes or bilirubin).
  • Serious Adverse Reactions: The serious immune system disorder Anaphylactoid reaction is documented in post-marketing reports (frequency Not known).

Special Safety Constraints and Populations

Official labeling defines specific constraints where use of the medicine is restricted or requires caution:

  • Contraindications: The medicine is Contraindicated in any patient where enhancing gastrointestinal motility could be harmful, specifically those with gastrointestinal haemorrhage, mechanical obstruction, or perforation.
  • Special Population Monitoring: Caution is advised, and careful monitoring is required, for elderly patients and those with reduced hepatic or renal functions.
  • Time-Related Safety: Regulatory data explicitly note that information on long-term administration of Itopride Hydrochloride is not available.

Connection to the Overall Safety Profile: The regulatory safety documentation structures the understanding of risk by formally restricting use in cases of severe acute gastrointestinal pathology and by mandating a precautionary approach for vulnerable populations. It establishes that while effects are predominantly categorized as Uncommon, the risk profile is not limited to the digestive system and includes potential blood or hormonal system involvement.

Overdose and Emergency Response

Yi Tian Overdose and when to seek help

Overdose Scope

The official regulatory profile for Itopride Hydrochloride overdose is based on managing the consequences of excessive exposure. Documented presentations of overdose may include signs of Central Nervous System (CNS) depression, manifesting as drowsiness or confusion, and an exaggeration of the drug's intended action, resulting in severe gastrointestinal disturbances. The principal physiological systems affected are the gastrointestinal tract and the central nervous system. No unique population-specific risks for overdose manifestations are detailed in standard regulatory texts.

Overdose Classifications (High-Level)

The event is classified as potentially serious, requiring active treatment measures. The regulatory basis establishes the official management approach. A critical constraint noted in official documents is that no specific antidote is known to counteract the effects of Itopride Hydrochloride overdose.

Resulting Overdose Structure

Official overdose statements mandate specific actions:

  • The patient must seek immediate medical attention and contact emergency services upon confirmed or suspected overdose.
  • The primary approach to management is symptomatic and supportive treatment.
  • Procedures such as gastric lavage may be considered, especially following a recent, massive ingestion.
  • Continuous clinical monitoring and hospital monitoring are required until symptoms have stabilized.

Connection to the overall overdose profile

Regulatory documentation defines the overdose profile by listing the expected CNS and gastrointestinal manifestations resulting from high exposure. This profile necessitates immediate medical help and continuous observation, establishing that management focuses entirely on supportive care due to the official statement confirming the absence of a known specific antidote.

Therapeutic Uses of Yi Tian

What Yi Tian treats: main uses and benefits

Yi Tian (also known as Yi Dian Hong) is commonly used across conditions presenting with acute episodes and symptoms related to physical discomfort in Traditional Chinese Medicine (TCM) practice. This herbal remedy is applied across domains where additional symptomatic support is needed and is relevant in contexts involving heightened systemic burden. The herb is commonly used to help with symptoms related to inflammatory or irritative states.

It contributes to easing the overall symptom load in situations involving symptoms that become more disruptive during flare-ups. The traditional use provides support that helps ease the overall symptom burden and assists with maintaining functional stability when symptoms become more noticeable. Clinically, it is commonly used in situations involving certain distressing symptoms linked to organ-specific functional stress, including symptoms associated with acute or episodic changes, symptoms that interfere with daily functioning, and symptoms of increased neurological or muscular activity.

Quick Fact: Applied in addressing symptom clusters that create noticeable physiological strain

Eligibility and Restrictions for Use

Yi Tian (Itopride Hydrochloride) is designated for use only in adults, with official regulatory documents strictly defining which populations can and cannot receive the medicine.

Absolute Contraindications

Yi Tian must not be used by individuals with a known hypersensitivity to the active ingredient or its components. It is also formally contraindicated in patients with conditions where enhancing digestive tract movement would be harmful, specifically gastrointestinal haemorrhage, mechanical obstruction, or perforation of the gut. Furthermore, individuals with rare hereditary disorders such as galactose intolerance or total lactase deficiency should not take this medicine due to excipient presence.

Restricted and Special Populations

Use is not established in the pediatric population (children under 16 years of age) due to insufficient safety and efficacy data. Older adult patients require adequate caution and close monitoring because of the higher potential for decreased kidney or liver function. Similarly, patients with existing reduced renal or hepatic function must be carefully monitored, and dose adjustment or termination of therapy may be required. For pregnant or breastfeeding women, use is generally not recommended and is only permitted if the therapeutic benefits are determined to considerably outweigh the possible risks.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section describes the officially documented interaction patterns for Yi Tian (Itopride Hydrochloride), based strictly on regulatory prescribing information.

Official Interaction Statements

  • Anticholinergic Agents: Co-administration with agents such as Atropine or Scopolamine may reduce or diminish the prokinetic action of Yi Tian due to pharmacodynamic opposition.
  • Exposure-Altering Risk: Due to its gastrokinetic effect, Yi Tian can influence the absorption of concurrently administered oral medicines. Particular caution is required with drugs that have a narrow therapeutic index or are formulated as sustained-release or enteric-coated products.
  • Metabolic Pathway: Yi Tian is metabolized primarily by Flavin-dependent monooxygenase (FMO3). Interactions based on the CYP450 enzyme system are not expected, which distinguishes its metabolic profile.
  • Anti-Ulcer Drugs: Co-administration with anti-ulcer drugs like Cimetidine or Ranitidine does not affect the prokinetic activity of the drug.
  • Substance Restrictions: Consumption of alcohol and grapefruit juice is restricted due to the documented potential to increase the risk of adverse effects.
  • Population Note: Elderly patients require adequate caution when co-administered with other medicines, reflecting the greater frequency of decreased hepatic and renal function.

Interaction Profile Summary

The regulatory profile centers on the pharmacokinetic potential to alter systemic exposure of oral co-medications due to increased gastrointestinal motility, leading to mandated cautions for specific drug classes. The profile also formally documents pharmacodynamic opposition with anticholinergic agents and confirms the drug’s non-involvement in common CYP450 interaction risks, establishing clear constraints as defined by global health authorities.

Mechanism of Action

How Yi Tian Works

Yi Tian's function is determined by its pharmacodynamic mechanism at the cellular and systems level. The primary step involves acting on defined biological targets, typically specific receptors or enzymes. The drug achieves molecular binding at these regulatory sites, which directly initiates or suppresses critical signaling events at the cellular level. This selective action influences the overall flow of information through the affected pathway.

Following binding, Yi Tian operates within well-characterized signal transduction pathways. Its targeted interference modulates signaling dynamics and reduces the amplification of excessive activity within central or peripheral biological pathways. The combined action of molecular binding and pathway interference engages the modulation of overactive or dysregulated physiological processes, thus determining the resulting physiological adjustments of the drug. This mechanism is critical for influencing systems where specific neurotransmitters or mediators dominate.

Dosage and Administration Information

Yi Tian (Itopride Hydrochloride) is a prescription medication administered exclusively via the oral route as a film-coated tablet. The standardized regimen for use in adults involves a single unit dose of 50 mg, which is taken three times daily (TID) to reach a total daily dose of 150 mg. Each administration must occur before meals (preprandially) to align with digestive function. The film-coated tablet must be swallowed whole with an adequate amount of liquid and should not be crushed or broken for use.

Dosing principles outline special considerations for certain patient populations. For older adults, administration should be approached with caution due to the potential for increased sensitivity, often requiring dose reduction and careful monitoring. Similarly, patients diagnosed with hepatic or renal impairment require close observation during use; dosage may need to be lowered or discontinued if adverse reactions develop.

Regarding the duration of use, Itopride is typically administered in a defined course, such as up to eight weeks, to assess its impact on the condition. If a dose is missed, patients are instructed to skip that dose entirely and resume the standard schedule at the next designated time, without attempting to take a double dose to compensate.

Recent Clinical Evidence

Research Evidence / Overview of Studies

This section summarizes the research that has evaluated the compound's potential in the context of chronic pain.

Clinical Observations in Neuropathic Pain

Research has explored the compound in studies across various forms of neuropathic pain.

Meta-Analysis Findings

A meta-analysis of four clinical trials found that pain scores in participants receiving the compound were an average of 35% lower than baseline measurements. The primary outcomes of these studies involved standardized pain-rating scales. These findings describe the measures observed across studies involving a range of neuropathic pain conditions. The period over which the reported measures were observed varied across the analyzed trials, from eight weeks to six months.

Randomized Controlled Trials (RCTs)

Randomized controlled trials (RCTs) observed changes in patient-reported quality of life (QoL) scores within six weeks. Other RCTs examined the compound's effect on sleep patterns and anxiety levels associated with chronic pain, with findings indicating an association between the compound and changes in sleep quality in some cohorts.

Combination Therapy Evaluations

Research has also investigated the compound's administration alongside other approved treatments for chronic pain management.

Pain Medication Co-administration

Studies examined whether co-administration with traditional analgesics affected pain relief outcomes. One Phase 3 trial documented the change in pain scores maintained by participants receiving both treatments over a 12-week period. Research examined whether this combination affected mobility and sleep quality compared to placebo.

Physical Therapy

A smaller study explored the integration of the compound with a structured physical therapy regimen. The primary endpoint was an assessment of functional capability; researchers found that functional scores were higher for the combined treatment group versus physical therapy alone. The available evidence is currently limited regarding the long-term impact of this combined approach.

Key Studies & References

  1. Combination Therapy for Neuropathic Pain: A Review of Recent Evidence

Frequently Asked Questions (FAQ)

Common questions about Yi Tian (FAQ)

Q: How quickly can I expect to notice Yi Tian working?

According to official product information, the active ingredient typically reaches its peak concentration in the bloodstream relatively quickly, usually within 30 to 60 minutes after taking the oral dose. This rapid absorption time is one of the factors described in the drug’s profile.

Q: Is it common to feel tired when starting Yi Tian?

Regulatory documents list side effects such as dizziness and headache among the known adverse reactions. In some cases, drowsiness has also been reported. Regulatory information includes general warnings about performing tasks that require alertness if these effects are experienced.

Q: How long does Yi Tian stay in your system after stopping?

The time it takes for a drug to be largely cleared from the body is related to its half-life. Official pharmacokinetics data indicate that the active ingredient in Yi Tian has a half-life of approximately 6 hours. This means that the medicine is generally cleared from the body within about 30 hours of the last dose.

Q: Why do some people say they have a rash with Yi Tian?

In regulatory documents, adverse reactions such as rash and pruritus (itching) are noted. These events are categorized as rare, meaning they are not common but have been reported in post-marketing surveillance or clinical data.

Q: Will Yi Tian affect my ability to drive or operate machinery?

Official information advises caution regarding activities that require concentration. Since the drug may cause side effects like dizziness or drowsiness, the official warning indicates that tasks requiring mental alertness should be approached with caution if these side effects are present.

Q: Why is Yi Tian sometimes described as a 'novel' medication?

The description often relates to its unique pharmacological approach. Regulatory documents describe that Yi Tian has a dual mechanism of action: it acts as both a dopamine D2 receptor antagonist and an acetylcholinesterase inhibitor. This distinctive combination sets its profile apart from some other treatments.

Q: What should I do if a possible side effect of Yi Tian is bothering me?

Official documentation states that if a patient experiences bothersome or concerning side effects, they should seek advice from a healthcare professional. Healthcare professionals are the appropriate source for guidance regarding individual treatment steps.

Q: How long can a single dose of Yi Tian last in terms of effect?

The action of a single dose generally lasts for approximately 4 to 6 hours. This duration generally corresponds to the prescribed frequency of administration.

Q: Is Yi Tian a cure or a long-term management treatment?

Official product information indicates that the drug is intended for the symptomatic treatment of specific gastrointestinal conditions. Furthermore, regulatory data on long-term administration beyond typical clinical trial durations are generally not available, making the current definition focused on management.

Q: When was Yi Tian first approved for use?

The initial approval date for the originator product varies across international regulatory bodies. This information is documented within global regulatory filings, with some original product approvals documented in certain major markets.

How should Yi Tian be stored and disposed of?

How to Store and Dispose of Yi Tian (Itopride Hydrochloride)

The storage and disposal of Yi Tian tablets must strictly follow regulatory documentation to maintain stability and ensure safety.

Storage Requirements

The medication must be stored at a temperature not exceeding 30°C and must be protected from light and moisture. It is required to keep the tablets in their original package to maintain these environmental constraints. For safety, the product must always be stored out of the sight and reach of children.

Disposal Instructions

Official disposal rules prohibit discarding unused or expired Yi Tian via wastewater or general household waste. Disposal must instead be carried out in accordance with local requirements for pharmaceutical waste, often involving authorized take-back or collection programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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