Xin Ping

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Xin Ping

Xin Ping is a trade name for a synthetic, prescription-only medication whose single active component is Irbesartan, primarily used in the long-term therapeutic management of cardiovascular conditions. This medicine is formally classified as an Angiotensin II Receptor Blocker (ARB), a major drug class targeting the body's natural pressure regulation system.

Property Description
Active Ingredient Irbesartan
Form Oral Tablet
Pharmacological Class Angiotensin II Receptor Blocker (ARB)
Common Use Sustained control of high blood pressure (Hypertension)
Origin Synthetic Compound

What Type of Medicine is Xin Ping?

Xin Ping contains the active ingredient Irbesartan, a non-peptide, synthetic compound that belongs to the Angiotensin II Receptor Blocker pharmacological class. This substance acts by a selective and competitive antagonism of the AT1 receptor, ensuring high purity and consistent action. Unlike Angiotensin-Converting Enzyme (ACE) inhibitors, ARBs do not block the enzyme that produces the Angiotensin II hormone; instead, they specifically block the receptor where the hormone would normally attach. This difference in mechanism is associated with a lower incidence of the common dry cough typically observed with ACE inhibitors. The medication is an oral formulation, delivered as a solid, single-agent tablet intended for consistent daily administration.

What is Irbesartan’s General Purpose?

The fundamental general purpose of Irbesartan is the sustained control of high blood pressure, or essential hypertension. It acts by interrupting the powerful vasoconstrictor signal mediated by Angiotensin II within the Renin-Angiotensin-Aldosterone System (RAAS). The mechanism of the drug provides sustained lowering of blood pressure, a factor in mitigating long-term risks associated with hypertension. By blocking the AT1 receptors, the medication facilitates the widening of blood vessels (vasodilation), leading to a decrease in systemic resistance and, consequently, a measurable reduction in arterial pressure. This targeted pressure reduction is utilized in adult patients requiring maintenance therapy for hypertension.

Regulatory References

  1. Irbesartan: MedlinePlus Drug Information

What side effects are possible with Xin Ping?

Possible side effects and safety information

The safety profile of Xin Ping, containing Irbesartan, is categorized by regulatory bodies based on the frequency and system-organ class of documented adverse reactions.

Classification Examples of Documented Reactions
Common (ge 1/100) Dizziness (including upon standing), fatigue, nausea, vomiting, diarrhea, indigestion, and musculoskeletal pain.
Common in specific groups Hyperkalaemia (high potassium levels) and orthostatic dizziness are reported more frequently in patients treated for diabetic kidney disease.
Uncommon (ge 1/1,000) Hypoglycaemia (low blood sugar), which is particularly noted in diabetic patients.
Not Known Reactions like Angioedema (swelling of the face, tongue, or throat) and Hepatitis have been reported from post-marketing surveillance.

Serious Adverse Reactions and Safety Constraints

The official labeling includes specific safety warnings for potentially serious outcomes and restrictions on use in certain populations.

  • Fetal Toxicity: Irbesartan is strictly contraindicated during the second and third trimesters of pregnancy due to documented risks of injury and death to the developing fetus.
  • Acute Renal Failure: The medicine carries a risk of worsening renal function, including acute renal failure, particularly in patients with pre-existing renal disease or with bilateral renal artery stenosis.
  • First-Dose Hypotension: Symptomatic low blood pressure may occur, especially after the first administration, in patients who are volume- or salt-depleted.
  • Dual RAAS Blockade: Concomitant use with aliskiren is contraindicated in patients with Type 2 diabetes or specific levels of renal impairment.

These official safety domains structure the official risk profile by distinguishing between common, expected effects and rare, severe complications, defining the precise conditions and patient groups that require caution or specific restrictions as mandated by regulatory documents.

Overdose and Emergency Response

Overdose and When to Seek Help

The official overdose profile for Xin Ping (Irbesartan) is characterized by an exaggerated effect of the medication, primarily involving the cardiovascular system. The most prominent and documented clinical sign of overexposure is profound hypotension (severely low blood pressure). Regulatory documents also note potential abnormalities in heart rhythm, specifically tachycardia (abnormally fast heart rate) or, less commonly, bradycardia (abnormally slow heart rate).

Overdose Manifestations Regulator-Mandated Action
Profound Hypotension, Tachycardia, Bradycardia Seek immediate medical attention for suspected overdose.
Collapse, Seizure, Trouble Breathing Contact emergency services immediately.

Treatment management described in official labeling is symptomatic and supportive. There is no specific antidote known for Irbesartan overdose. In cases of severe hypotension, documented procedural steps include placing the patient in the supine position and initiating an intravenous infusion of normal saline to restore circulating volume. Regulatory data indicates that hemodialysis is not effective for removing the active compound.

Therapeutic Uses of Xin Ping

Xin Ping, containing Irbesartan, is a prescription medication primarily applied for long-term therapeutic management within cardiovascular and renal health domains. Its use is generally considered relevant for addressing chronic conditions that require sustained physiological support. In clinical practice, the medication is indicated for two key therapeutic areas.

Sustained Management of Essential High Blood Pressure

The primary therapeutic use is to assist with consistent management of arterial pressure, which contributes to easing the overall symptom load of chronic systemic imbalance and is used in support of the clinical objective to reduce the long-term potential for severe cardiovascular events. It is applied in clinical settings that involve chronic pressure management.

Targeted Protection for Diabetic Kidney Disease

Xin Ping is also applied in a specific clinical scenario: patients with both high blood pressure and Type 2 Diabetes. This use addresses diabetic nephropathy (kidney damage) by managing associated biological markers like proteinuria (protein in the urine). For this specific patient group, the medicine assists with maintaining functional stability and may support general well-being in situations involving heightened systemic burden. For patients in situations where symptoms related to irritative states may become disruptive, Xin Ping may be part of symptomatic management, offering an option for consistent management of blood pressure.

Quick Fact: Relief for Systemic Imbalance
Xin Ping plays a role in managing conditions characterized by heightened physiological activity (high pressure) and is relevant for easing the symptoms related to systemic imbalance.

Eligibility and Restrictions for Use

Xin Ping, which may refer to traditional Chinese medicine formulas such as Xiyanping injection or Nao Xin Ping elixir, is used for a range of conditions, primarily infectious diseases or central nervous system disorders, respectively. Its suitability depends on the specific formulation.

Potential Users of Xin Ping

Condition (General) Notes
Infections (e.g., bronchitis, tonsillitis, viral pneumonia) Related to Xiyanping, which has antiviral/antimicrobial properties.
Cerebrovascular/Neurological Conditions Related to Nao Xin Ping, used for post-traumatic encephalopathy, dizziness, and memory issues.
Children Xiyanping is often used in pediatrics for infections, but safety should be carefully considered.

Who Should Avoid Xin Ping?

Contraindications vary by specific product, but general caution is necessary for the following:

  • Hypersensitivity: Individuals with a known allergy to Andrographis paniculata (the main component of Xiyanping) or any other ingredients should not use the product.
  • Allergic Reactions: Due to reports of severe allergic reactions, including anaphylaxis, Xiyanping should be used with extreme caution, particularly in combination with certain other drugs such as gentamicin, cefoperazone-sulbactam, or lidocaine.
  • Pregnancy and Breastfeeding: Use is generally not recommended or requires strict medical consultation due to insufficient safety data.
  • Immunosuppressant Use: Certain formulas with immunostimulant components may be contraindicated for those taking immunosuppressive medications.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory considerations identify that the concomitant use of Xin Ping (also known as Xiyanping injection) with certain other medicinal products is associated with an increased risk of suspected allergic reactions.

Documented Interacting Categories

Official data suggest that certain medicinal products should be administered with precaution when a patient is also receiving Xin Ping. These categories include:

  • Antibiotics: Specifically the aminoglycoside gentamicin and the combination antibiotic cefoperazone-sulbactam.
  • Local Anesthetics: The medication lidocaine.
  • Antivirals: The nucleoside analogue ribavirin.

Interaction Classification and Constraints

Interactions involving the listed medicines are classified under the guidance of Chinese regulatory-aligned safety surveillance, which recommends precautionary use for these combinations due to the clinically observed elevated risk of allergic reactions. The official regulatory advice is that gentamicin, cefoperazone-sulbactam, lidocaine, and ribavirin should be applied with precautions in patients receiving Xin Ping. The underlying mechanism by which these co-administrations increase the risk of allergic reactions remains under-explored and is officially stated as unknown.

Mechanism of Action

Mechanism of Action

Xin Ping is a small molecule antagonist of the Receptor Activator of NF-kappaB Ligand (RANKL). Xin Ping specifically binds to circulating and membrane-bound RANKL, thus preventing its essential interaction with the RANK receptor located on the surface of osteoclast precursor cells and mature osteoclasts.

This binding event results in the inhibition of downstream RANKL-mediated signal transduction. This cascade includes the suppression of the NF -kappa B and NFATc1 pathways, which are necessary for osteoclast function. The inhibition consequently reduces the differentiation, maturation, and survival of osteoclasts (bone-resorbing cells). The resultant system-level physiological effect is a decrease in overall osteoclastogenesis and bone resorption, which influences the balance of bone remodeling and decreases the rate of bone matrix breakdown.

Dosage and Administration Information

Xin Ping, which contains the active ingredient Irbesartan, is delivered exclusively via the oral route as a tablet and is intended for consistent daily administration. The tablets are available in strengths of 75 mg, 150 mg, and 300 mg. The administration process is straightforward: the tablet is swallowed whole with a sufficient amount of water, and its intake is flexible, as it may be taken with or without food.

The primary usage pattern is a once-daily regimen for long-term therapeutic management. For the sustained control of high blood pressure, the typical starting dose is 150 mg once daily. This dose may be adjusted toward the maximum recommended dose of 300 mg once daily. For patients being treated for diabetic kidney disease in conjunction with hypertension, the preferred maintenance dose is often the maximum, 300 mg once daily. The full antihypertensive effect is typically established within two to four weeks of starting treatment or following a dose adjustment.

Specific procedural adjustments are applied for certain populations. For patients over 75 years of age or those with volume depletion (for instance, due to high-dose diuretic therapy or haemodialysis), treatment is typically initiated with a lower dose of 75 mg once daily. This adjustment is a procedural measure for a controlled introduction to the medicine. The maximum allowed dose for all standard adult usage patterns remains 300 mg daily.

Recent Clinical Evidence

Research on Xin Ping (Irbesartan) has been studied across several large-scale trials, focusing on its evaluation for two primary conditions. This overview describes what the studies examined and what patterns were observed in the group data.


Evidence for Use in Managing Essential High Blood Pressure

The evidence is derived from a series of short-term Randomized Controlled Trials (RCTs). Researchers primarily monitored changes in systolic and diastolic blood pressure across various adult populations, including the elderly. Trials reported patterns where measurable changes in blood pressure readings were observed in the studied groups. However, the short duration of these core trials provides limited insight into the very long-term outcomes on major cardiovascular events.


Evidence for Targeted Protection in Diabetic Kidney Disease

Research exploring this application comes from large-scale, long-term randomized trials in patients with Type 2 Diabetes and high blood pressure with evidence of kidney damage. Studies tracked a composite primary outcome focusing on the progression of the kidney disease, such as the doubling of serum creatinine levels and the development of end-stage renal disease. Findings describe patterns where the rates of progression toward this serious renal endpoint were observed to be lower in the studied groups.


Long-Term Evidence and Durability of Follow-Up

For chronic kidney protection, the core research included long-term studies spanning over two to four years, contributing to the understanding of the durability of observed patterns. For general high blood pressure management, while measured changes were observed to be maintained during extended-use periods, long-term effects are not fully established based solely on these specific short-term trials.


Evidence in Specific Adult and Pediatric Populations & What the Research Landscape Does Not Yet Fully Characterize

Research has explored the medicine in the elderly and patients with obesity. Conversely, limited information is available concerning its use in children under 6 years of age. Furthermore, the overall research provides insight into what has been observed so far, but the comparative evidence is lacking for certain long-term, high-risk outcomes when measured against all available classes of other medications.

Key Studies & References

  1. Clinical Practice Guideline: Management of Hypertension in Patients with Chronic Kidney Disease

Frequently Asked Questions (FAQ)

Common questions about Xin Ping (FAQ)


Q: Do the common side effects of Xin Ping usually lessen or go away after a period of adjustment?

According to official product information, many common side effects of Xin Ping, such as initial dizziness or fatigue, are often temporary. These effects may lessen or resolve completely as the body adjusts to the medication.


Q: Can Xin Ping cause symptoms that users might mistake for an allergic reaction?

Official regulatory documents include rare but serious adverse reactions, such as Angioedema (swelling of the face, tongue, or throat). This type of reaction is a severe allergic-type event described in regulatory warnings. The official safety summaries describe this risk.


Q: What are the official guidelines regarding the use of alcohol while taking Xin Ping?

Regulatory documents indicate that alcohol may increase the blood pressure-lowering effect of the medicine. This combination can increase the risk of symptoms like dizziness, lightheadedness, or fainting. Regulatory documents note that caution is recommended, as this combination may increase the risk of low blood pressure symptoms.


Q: Does Xin Ping have known interactions with common over-the-counter (OTC) pain or cold medicines?

Official product information warns that using Xin Ping with certain non-steroidal anti-inflammatory drugs (NSAIDs), such as common over-the-counter pain relievers, is associated with a risk of worsening kidney function. Official information states this combination is associated with a risk and requires precautions.


Q: Is it necessary to avoid any specific foods, vitamins, or herbal supplements while taking Xin Ping?

Official safety information states that potassium supplements or salt substitutes that contain potassium are generally to be avoided. This is because Xin Ping can increase potassium levels in the blood (hyperkalaemia), and adding potassium from supplements further raises this risk.


Q: What is the approved age range for the use of Xin Ping?

The efficacy and safety of Xin Ping have not been established in children under 6 years of age. For some adult formulations, the product information states that use is not established for patients younger than 18 years, defining the lower boundary of approved use.


Q: Why is it important to continue using Xin Ping even after symptoms improve?

Xin Ping is intended for the long-term, sustained management of conditions like high blood pressure. Stopping the medication, even after symptoms have improved, may lead to a loss of therapeutic control, which is the management goal of the treatment.


Q: Is the active ingredient in Xin Ping available in other countries under different names?

Yes, regulatory and international drug databases confirm that the active ingredient, Irbesartan, is marketed and sold under various other brand names across different countries. Examples include Avapro and Aprovel.


Q: Is it known if Xin Ping interacts with consuming caffeine or large amounts of fluids?

Official safety information includes a warning about symptomatic low blood pressure in patients who are volume-depleted (lacking sufficient fluids). Substances like caffeine may also have properties that affect blood pressure, and such considerations are noted in safety information.


Q: Why do official documents warn against stopping Xin Ping suddenly?

As a medication used to control high blood pressure, official documents warn that abrupt cessation carries the risk of losing the medication’s therapeutic effect. This interruption may lead to a subsequent loss of blood pressure control.


Q: Is Xin Ping described as safe for use in individuals who have a history of heart rhythm issues?

Because Xin Ping can raise blood potassium levels (hyperkalaemia), which may cause an irregular heart rhythm, official guidance advises careful monitoring of electrolytes for patients with risk factors. This monitoring is advised due to the potential association.


Q: What are the reported effects of Xin Ping on a person's ability to drive or operate machinery?

Product information includes explicit warnings that the medicine may cause dizziness or tiredness. Official warnings state that caution is advised when driving or operating machinery due to the risk of these effects.


Q: Is it possible for Xin Ping to interact with other prescription medications not listed in the main interaction section?

Official information emphasizes that patients inform their healthcare provider of all current medications, including those not explicitly listed. This acknowledges that not every possible drug combination is formally documented in the primary warnings.


Q: Does official information clarify if Xin Ping is less effective for certain broad populations (e.g., based on weight or metabolism)?

Official dosing guidelines require specific adjustments for certain groups, such as initiating a lower dose for patients over 75 years of age. This indicates that population-specific factors, including age and volume status, are considered in determining effective use.


Q: What general expectations should a patient have about feeling slightly worse before getting better on Xin Ping?

It is a common expectation, based on official safety profiles, that temporary side effects like dizziness and fatigue may occur when first starting the medicine. These initial symptoms often improve as the body adjusts to the therapy.


Q: Are there any specific medical tests that are generally recommended while using Xin Ping?

Due to the medicine's effects, official product labeling notes that periodic monitoring of kidney function and serum potassium levels is generally advised. This is particularly important for patients with existing risk factors.


Q: What should be done if a patient accidentally takes more Xin Ping than their prescribed amount? (Factual, non-advisory)

In the event of a suspected overdose, the official guidance advises contacting a regional poison control center or seeking emergency medical assistance for suspected overdose management. This is the standard procedure described in product information.

How should Xin Ping be stored and disposed of?

Storage and Disposal of Xin Ping (Irbesartan)

Xin Ping tablets must be stored under specific conditions to maintain their stability, as mandated by official labeling.


Storage Requirements

Item Requirement
Temperature Store at controlled room temperature, 20 C to 25 C (68 F to 77 F). Do not freeze.
Protection Keep away from excess moisture and excessive heat. Must be kept in the original container, tightly closed.
Child Safety Must be stored out of the sight and reach of children.

Disposal Instructions

Do not keep outdated medicine or medicine no longer needed. Unused or expired Xin Ping must be disposed of according to local regulatory requirements. The medicine should generally not be flushed down the toilet or poured into a drain. Utilize official drug take-back programs when available.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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