Volcan

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Volcan

Quick Facts

Property Description
Active ingredient Diclofenac (as Diclofenac Sodium)
Form Topical Gel
Pharmacological class Non-steroidal Anti-inflammatory Drug (NSAID)
Common use Pain Management and Inflammation Reduction
Origin Synthetic Compound (Phenylacetic Acid Derivative)

What Type of Medicine is Volcan?

Volcan is a pharmaceutical preparation whose active ingredient is the synthetic compound Diclofenac, classifying it as a Non-steroidal anti-inflammatory drug (NSAID). Its fundamental identity is that of an Analgesic agent primarily focused on localized action. This NSAID classification is recognized for the management of pain and inflammatory conditions. The preparation serves as a tool for reducing inflammation and discomfort in scenarios such as localized musculoskeletal pain.

The active component belongs to the chemical family of Phenylacetic acid derivatives. Volcan is specifically prepared as a topical gel, generally available over-the-counter (OTC) in many jurisdictions, which is a key differentiating factor from oral forms. This method of delivery ensures a primary peripheral action rather than systemic distribution.

Volcan's Composition and Physical Form

The core therapeutic component is Diclofenac, incorporated as Diclofenac Sodium within a gel base. The dosage form is a topical gel suitable for direct skin application. Topical diclofenac formulations provide localized action to the affected tissues, an attribute used for reducing systemic exposure compared to oral NSAIDs. This physical form is central to the product's design, ensuring the compound is concentrated precisely where the symptoms of pain and inflammation are felt.

The General Purpose of Volcan

The general purpose of Volcan is to facilitate fundamental pain management and inflammation reduction. This benefit is linked to its function as a Cyclooxygenase (COX) inhibitor. By suppressing the synthesis of prostaglandins—the chemical mediators of pain and swelling—the medication provides its core anti-inflammatory effect. This action confirms the product's utility in providing localized analgesic and anti-inflammatory relief to the affected area.

Regulatory References

  1. Diclofenac: Indications, Mechanism of Action, and Adverse Effects

What side effects are possible with Volcan?

Possible Side Effects and Safety Information

The safety profile of Volcan (Diclofenac Topical Gel) is primarily characterized by effects localized to the application site, reflecting its design for minimal systemic absorption. Safety data is categorized by health authorities based on frequency and affected system-organ class.

Common Adverse Reactions (Skin and Subcutaneous Tissue Disorders): The most frequently documented adverse effects are local skin reactions, which include Pruritus (itching), Rash, Erythema (redness), and various forms of Dermatitis, including Contact Dermatitis. These effects are often observed more frequently during the initial week of treatment.

Rare and Systemic Safety Patterns: Although absorption is low, the medication carries the official, albeit rare, potential for serious systemic adverse events consistent with the NSAID pharmacological class. Rare dermatological reactions, such as Photosensitivity Reaction and Bullous Eruptions (blisters), are documented.

Serious adverse reactions listed in regulatory documents include Systemic Cardiovascular Thrombotic Events (such as Myocardial Infarction and Stroke) and Serious Gastrointestinal Events (including bleeding/ulceration). These risks are documented as being generally associated with longer use of NSAIDs.

Population-Specific and Use Constraints: Official labeling includes mandatory constraints for certain populations and application conditions. The medicine is contraindicated in patients with a history of Aspirin-sensitive asthma and during the third trimester of pregnancy. Furthermore, safety restrictions mandate that the gel must not be applied to open skin wounds or mucous membranes, and exposure of the treated area to sunlight must be avoided due to the documented photosensitivity risk.

Overdose and Emergency Response

Overdose Manifestations and Required Actions

The official regulatory classification defines an overdose as unlikely when Volcan topical gel is used according to instructions, owing to the low systemic absorption of diclofenac from the skin. However, systemic toxicity is a documented risk following inadvertent oral ingestion or excessive, prolonged topical application on a large surface area. Overdose manifestations in this scenario are similar to those of oral NSAID poisoning.

Manifestations can include gastrointestinal disturbances such as nausea, vomiting, abdominal pain, and headache or drowsiness (CNS effects).

Severe Outcomes and Emergency Help

Regulators document the potential for serious or life-threatening outcomes associated with systemic NSAID toxicity. These include severe gastrointestinal bleeding, ulceration, or perforation; cardiovascular events, including potential myocardial infarction and stroke; and severe hepatic reactions, which may involve liver failure.

Immediate medical attention is required for any signs of a severe reaction, such as anaphylaxis (hypersensitivity), or if any serious systemic symptoms develop, including trouble breathing or signs of severe GI events. Contact emergency services if severe symptoms are present.

Management and Population Risk

There is no specific antidote documented for diclofenac overdose. The official management is symptomatic and supportive treatment. For accidental ingestion, procedures such as activated charcoal or gastric lavage may be considered, and the excess gel should be washed off the skin if applicable. Regulatory information notes that elderly patients and individuals with impaired hepatic or renal function face an increased risk of serious complications during a systemic overdose event.

Therapeutic Uses of Volcan

The primary therapeutic role of Volcan may be relevant for providing localized symptomatic support for inflammatory and painful conditions, particularly those involving the musculoskeletal system, which is consistent with the established clinical use of its active ingredient. This medication is relevant in the management of acute and chronic pain associated with inflammatory conditions.

Volcan is commonly used in conditions characterized by periods of heightened symptoms, which may include joint stiffness and pain. This is applicable to symptoms associated with localized processes such as muscle and ligament stress or recurrent manifestations like those seen in Osteoarthritis (OA). The supportive use may contribute to easing discomfort during periods of heightened symptoms and assists with maintaining a sense of stability when symptoms are more noticeable.

“This topical preparation may assist with symptomatic relief, contributing to easing the overall symptom load during difficult episodes.”


QuickFact Block

Quick Fact: Symptomatic Support for Localized Pain
Primary Focus Symptoms related to inflammatory or irritative states
Context of Use Conditions characterized by periods of heightened symptoms (acute or recurrent)
Patient Benefit Assists in maintaining functional stability and supports general well-being during symptomatic phases

Regulatory References

  1. NIH's StatPearls review on Diclofenac

Eligibility and Restrictions for Use

Official Eligibility Status for Volcan

Volcan eligibility is strictly defined by regulatory authorities based on age, physiological status, and underlying conditions.

Populations Allowed and Restricted

Use is approved for Adults (18 years and older) and, in certain regions, Adolescents aged 14 years and over. The medicine is not recommended or contraindicated for children younger than 14 years due to insufficient data on safety and efficacy. Caution is advised for older adults due to a higher risk of age-related complications.

Absolute Contraindications

Volcan must not be used by:

  • Individuals with a known hypersensitivity (allergy) to diclofenac, aspirin, or any other Non-steroidal Anti-inflammatory Drug (NSAID), including those with aspirin-sensitive asthma.
  • Patients in the setting of Coronary Artery Bypass Graft (CABG) surgery.
  • Pregnant women in the third trimester (starting at 30 weeks gestation).
  • Application must not be made to damaged, broken, or non-intact skin.

Conditional Use Requirements

Caution is advised for those with a history of gastrointestinal bleeding/ulcers, heart failure, impaired hepatic function, or mild-to-moderate kidney impairment. Use during the first or second trimesters of pregnancy is restricted and should be limited to the lowest dose and shortest duration necessary.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory interaction profile for Volcan (topical diclofenac) addresses pharmacodynamic risks and effects on plasma concentrations of co-administered medicines, primarily stemming from the properties of its active ingredient. Due to its low systemic absorption, the interaction profile is generally less extensive than for oral forms, but restrictions and cautions still apply.

Official Interaction Statements and Restrictions

Interaction Type Interacting Substance/Class Regulatory Constraint
Pharmacodynamic Reinforcement Oral NSAIDs and Analgesic Aspirin Concurrent use is formally discouraged or not generally recommended due to the risk of additive adverse effects and increased systemic exposure.
Interference with Efficacy ACE Inhibitors, ARBs, Diuretics Co-administration may diminish the anti-hypertensive or natriuretic (salt-excreting) effect of these medications.
Exposure Modification Digoxin, Lithium, Methotrexate Co-administration may increase the plasma concentration of Digoxin; this effect is noted as a theoretical risk for Lithium and Methotrexate.
Local Administration Timing Other Topical Products Co-administration of other topical products (creams, lotions) on the treated skin area should be avoided.

Regulatory documentation also highlights that the interaction with blood pressure medicines (ACE Inhibitors, ARBs) is noted as more clinically significant for high-risk populations, including the elderly or those with pre-existing renal impairment.

Mechanism of Action

Targeting Cathepsin K and Osteoclast Activity

Volcan works by inhibiting the Cathepsin K enzyme, a cysteine protease expressed by osteoclasts. The molecule’s binding to its target alters the signal transduction cascade, impacting osteoclast lifespan and function by limiting their resorptive capacity.


Intracellular Cascade and Bone Matrix Protection

This action alters the proteolytic activity within the resorption lacunae. Specifically, this mechanism reduces the enzymatic degradation of the bone’s organic scaffold, primarily type I collagen, thereby decreasing the rate of bone matrix breakdown. Volcan ultimately modulates the activity of osteoclasts, leading to the maintenance of bone remodeling balance.

Dosage and Administration Information

The general principle of using Volcan involves the precise topical application of a measured dose four times daily. The medicine is exclusively intended for cutaneous use and should be gently rubbed into the affected area of intact skin. The required application quantity is dependent on the size of the joint being treated, following standard schedules:

Joint Location Dose per Application Maximum Daily Dose
Upper Extremities (Hand, Wrist, Elbow) 2 grams 8 grams per single joint
Lower Extremities (Knee, Ankle, Foot) 4 grams 16 grams per single joint

The frequency pattern requires application four times daily (QID), with doses evenly spaced throughout the day. The total quantity of gel used across all joints must not exceed 32 grams in a 24-hour period.

The procedure includes measuring the specific dose using the dosing card provided in the product carton before each application. After the gel is applied, it is necessary to wait at least 10 minutes before dressing the area and one hour before washing or bathing. Hands must be washed immediately after application unless the hands themselves are the area being treated. Continuous use is typically limited, and the general principle for administration is to utilize the lowest effective dosage for the shortest duration. Use in children under 14 is generally not advised due to insufficient clinical data.

Recent Clinical Evidence

Volcan: Recent Clinical Evidence

Clinical evidence for Volcan (orvepitant) has been primarily established through Phase 2 randomized, controlled studies. These trials focused on adults diagnosed with chronic refractory cough (CRC).


Findings on Chronic Refractory Cough

Research investigated the effect of the agent on key patient-reported outcomes (PROs) for CRC over a 12-week period. One large-scale study compared different doses of the agent to placebo. While the reduction in objective awake cough frequency was not statistically significant in the full analysis set, the study reported statistically significant improvements compared to placebo in three patient-reported symptom measures at Week 12:

  • Leicester Cough Questionnaire (LCQ)
  • Cough Severity Visual Analogue Scale (VAS)
  • Urge-to-Cough Visual Analogue Scale (VAS)

A Phase 2 open-label pilot study also explored the use of Volcan in CRC. This exploratory trial reported an observed reduction in objective daytime cough frequency that was apparent at Week 1 and persisted after the discontinuation of the study agent at Week 8. Statistically significant improvements were also observed for cough severity and self-reported quality of life metrics.


Safety and Tolerability

Across the clinical trials, Volcan appeared to be generally well-tolerated by participants. The most common adverse events reported in the studies were consistent with the known class of the drug. Further clinical investigation is being conducted to assess its long-term profile and use across broader patient populations.

Frequently Asked Questions (FAQ)

Common questions about Volcan (FAQ)


Q: Can Volcan be taken alongside common over-the-counter pain relievers?

Official regulatory documents generally advise against or discourage the concurrent use of topical diclofenac (Volcan) with oral Non-steroidal Anti-inflammatory Drugs (NSAIDs) like ibuprofen or naproxen. This restriction is due to the potential for increased systemic exposure of the active ingredient, which could raise the risk of experiencing adverse effects.


Q: Does Volcan interact with birth control pills?

Regulatory drug interaction profiles typically do not list specific interactions between topical diclofenac and oral contraceptives (birth control pills). This is primarily because Volcan is designed for low systemic absorption, meaning very little of the drug enters the general bloodstream.


Q: Is it okay to drive or operate machinery while taking Volcan?

Official sources note that topical diclofenac is generally not known to impair the ability to drive or operate machinery. However, patients should be aware that some systemic side effects like dizziness or drowsiness have been reported with diclofenac, and caution is advised.


Q: Why do some people need to avoid grapefruit juice when using Volcan?

Official product labeling for the topical gel formulation does not usually list a specific requirement to avoid grapefruit juice. Any concerns about this fruit often relate to oral forms of diclofenac, where grapefruit juice has the potential to affect how the body processes the medication.


Q: Can I stop taking Volcan suddenly?

As Volcan is not associated with dependency, there are no specific regulatory warnings against suddenly stopping its use. Official guidance emphasizes that treatment principles include using the medicine for the shortest duration necessary.


Q: Are there any long-term health implications associated with Volcan use?

Since the active component is an NSAID, the possibility of serious systemic adverse effects—such as cardiovascular or gastrointestinal events—cannot be completely ruled out when the gel is used on large areas of skin or over a prolonged period. Use is generally limited to the shortest duration necessary.


Q: Does Volcan cause mood changes or emotional side effects?

Official safety data for diclofenac includes reports of central nervous system (CNS) effects. While rare with the topical gel, potential side effects such as dizziness and, in some cases, nervousness or insomnia have been documented.


Q: How long does the effect of one dose of Volcan typically last?

The official application schedule requires dosing four times daily, with evenly spaced applications. This frequency pattern is intended to maintain consistent therapeutic levels in the treated area, suggesting the localized effect of a single application is meant to last approximately six hours.


Q: What should I do if a side effect of Volcan seems minor but is bothersome?

Official patient instructions advise that patients notify a healthcare provider if a side effect becomes persistent or bothersome. The determination of whether the symptom is related to the medicine and whether treatment should be adjusted is generally managed by a healthcare provider.


Q: Is Volcan effective for long-term use?

Official regulatory guidance emphasizes that treatment principles include using Volcan for the shortest duration possible to address the treatment goal. While clinical studies have explored use over longer periods, the principle is to minimize exposure to the lowest effective dosage.


Q: Why are people with liver problems often advised against taking Volcan?

Diclofenac is an NSAID, a class of drugs that carries a documented risk of hepatotoxicity (potential liver damage). For this reason, regulatory documents advise caution and recommend monitoring of liver function for individuals with pre-existing hepatic impairment (liver issues).


Q: Does Volcan make you feel tired or drowsy?

Official safety reports list drowsiness and dizziness as potential, though generally uncommon, systemic adverse effects that have been reported with the medication.


Q: Can I drink alcohol moderately while taking Volcan?

Regulatory guidance related to NSAIDs emphasizes that consuming three or more alcoholic drinks per day while using the medicine is strongly associated with an increased risk of serious gastrointestinal side effects, such as bleeding.


Q: Is Volcan safe to use while breastfeeding?

Official product labeling states that it is unknown whether topical diclofenac passes into human breast milk. Therefore, use during breastfeeding is typically not recommended unless a healthcare provider determines that the expected benefits support its use.


Q: Does Volcan have a risk of becoming habit-forming?

Volcan's active component, diclofenac, is a Non-steroidal Anti-inflammatory Drug (NSAID) and is not classified as a controlled substance by regulatory authorities. For this reason, it does not carry a risk of physical or psychological dependence.


Q: What is the maximum duration someone can take Volcan according to official sources?

Official instructions typically advise a review of treatment after 7 to 14 days of consistent use. The principle remains that the drug should be used for the shortest possible duration necessary to achieve therapeutic goals, with no universal, specific hard stop date mandated across all uses.


Q: Can Volcan be used by people who are sensitive to other medications?

Volcan is strictly contraindicated for individuals with a known hypersensitivity (allergy) to diclofenac, aspirin, or any other NSAID. General drug sensitivities that are not related to this class of medication are not listed as a contraindication in the official product labeling.


Q: How quickly do most people start to notice the effect of Volcan?

Clinical trial summaries published in regulatory documents indicate that statistically significant improvements in pain and function compared to placebo may be observed within approximately seven days of starting consistent application.


Q: What happens if I miss a dose of Volcan?

Official patient instructions advise that a missed dose should be applied as soon as it is remembered, unless it is nearly time for the next scheduled application. If the next dose is almost due, the missed dose is typically skipped to prevent applying a double dose.


Q: Is Volcan available as a generic medicine?

Yes, the active ingredient in Volcan, diclofenac sodium topical gel, is available from numerous manufacturers in the United States and other regions. This wide availability classifies the medication as a generic drug.


Q: Is it possible to take Volcan if I have kidney issues?

Regulatory documents state that use should be avoided in patients with advanced renal disease. For individuals with mild-to-moderate kidney impairment, caution is advised, and monitoring may be necessary due to the NSAID-related risk of systemic effects.


Q: Do children or teenagers ever use Volcan?

Use is approved for adults and adolescents aged 14 years and over for certain formulations in some jurisdictions. However, the medicine is generally not recommended or is contraindicated for children younger than 14 years due to insufficient safety and efficacy data.


Q: Are there any known interactions between Volcan and herbal supplements?

The official regulatory interaction profile primarily details interactions with prescription drugs and other NSAIDs. Herbal supplements are not specifically addressed, but general caution is advised, particularly with supplements known to affect bleeding or liver function.


Q: What are the signs of a serious allergic reaction to Volcan?

Official patient information lists signs of a serious allergic reaction. These can include a severe rash, hives, trouble breathing or swallowing, wheezing, or swelling of the face, throat, tongue, or mouth. These are signs that usually warrant immediate medical attention.


Q: Does taking Volcan affect the results of common lab tests?

Due to the low systemic absorption of the topical gel, it is rare for Volcan to affect lab tests. However, the possibility of changes in tests monitoring liver or kidney function cannot be entirely excluded, particularly with prolonged use or use over large skin areas.


Q: Is Volcan ever given as an injection?

Volcan, as referred to in the regulatory context, is strictly a topical gel intended for application to the skin. While the active component, diclofenac, is available in other formulations, including injections, this specific product is not.


Q: Is it necessary to take Volcan at the exact same time every day?

The official frequency is four times daily, and the primary instruction is that applications should be evenly spaced throughout the waking hours. This approach is intended to provide consistent pain relief, meaning the exact same minute each day is not required.


Q: What is the legal classification of Volcan in the U.S. or U.K.?

For lower strength formulations, the medicine is classified for use as an Over-The-Counter (OTC) product in many jurisdictions, including the U.S. and U.K. This means it can be purchased without a prescription.


Q: Does Volcan cause weight gain or loss?

Official safety data on NSAIDs, the class of drug Volcan belongs to, lists edema (swelling or fluid retention) and associated unusual weight gain as potential, though uncommon, systemic side effects.


Q: Does Volcan affect blood sugar levels?

While rare, official adverse event reports for diclofenac in clinical trials have occasionally included cases of hyperglycemia (elevated blood sugar). This suggests a potential systemic effect that may warrant monitoring for certain patients.


Q: Can Volcan be used to treat other conditions besides the main one listed?

Official regulatory documents explicitly define the specific conditions and body parts for which Volcan has been approved and is indicated. Use for any other condition is considered off-label and is not covered by the product's official labeling.


Q: What is the key difference between Volcan and a placebo according to clinical trials?

Clinical trials reported in official documents established a statistically significant therapeutic benefit for Volcan over a placebo. Specifically, Volcan resulted in improvements compared to placebo in patient-reported measures of cough severity and quality of life.


Q: Are there any common misuses of Volcan people should be aware of?

Regulatory warnings specifically highlight that examples of misuse include applying the gel to damaged, broken, or non-intact skin or covering the treated area with an occlusive dressing (air-tight bandage). Both actions can substantially increase the risk of systemic absorption and side effects.


Q: Does Volcan interact with common cold or flu medications?

Many common over-the-counter cold and flu medications contain oral NSAIDs like ibuprofen or naproxen. Regulatory guidance advises against using Volcan concurrently with oral NSAIDs to avoid the risk of additive adverse effects.


Q: Is Volcan generally considered a well-tolerated medicine?

Clinical trial summaries in official documents state that Volcan appeared to be generally well-tolerated by participants. The most frequent adverse events observed were generally mild, localized skin reactions at the application site.

How should Volcan be stored and disposed of?

Storage and Handling

Volcan (Diclofenac Topical Gel) must be stored at controlled room temperature, specifically between 20 C and 25 C (68 F to 77 F). The product must be protected from direct light and should not be frozen. To maintain product integrity, the gel must be kept in its original container and the container must remain tightly closed when not in use. As with all medications, it is mandatory to keep this product out of the sight and reach of children.

Disposal Requirements

Disposal of unused or expired Volcan must comply with official local requirements for pharmaceutical waste. Due to the risk the active ingredient poses to the aquatic environment, the product must not be discharged into drains, sinks, or water courses.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Volcan found in:

A-Z Index: