Tafluprost

Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. (elevated intraocular pressure;)

Tafluprost eye drops is used alone or together with other medicines to treat increased pressure in the eye caused by open-angle glaucoma or a condition called hypertension of the eye. Both conditions are caused by high pressure in the eye which can lead to pain or vision changes. Tafluprost is a prostaglandin.

Tafluprost is available only with your doctor's prescription.

Usual Adult Dose for Intraocular Hypertension

One eye drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:

-The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect.

-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.

-If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart.

-Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours.

Use:

-Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Usual Adult Dose for Glaucoma (Open Angle)

One eye drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:

-The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect.

-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.

-If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart.

-Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours.

Use:

-Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

-Store in refrigerator (2 to 8 C/36 to 46 F)

-After the pouch is opened, the single-use containers may be stored in the opened foil pouch for up to 28 days at room temperature (20 to 25 C/68 to 77 F).

-Protect from moisture

-Protect from light

-Discard an opened single-dose container with any remaining solution immediately after use.

Patient Advice:

-You should wipe off any excess solution from the skin to reduce the risk of darkening of the eyelid skin.

-As with any other eye drops, nasolacrimal occlusion or gently closing the eyelid after administration is recommended. This may reduce the systemic absorption of medicinal products administered via the ocular route.

-If more than one topical ophthalmic medicinal product is being used, each one should be administered at least 5 minutes apart

See also:
What is the most important information I should know about Tafluprost?

Hypersensitivity to Tafluprost or to any of the excipients of Tafluprost.

Use Tafluprost drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Tafluprost drops. Talk to your pharmacist if you have questions about this information.
• Use Tafluprost drops in the evening unless your doctor tells you otherwise.
• Do not open the pouch containing Tafluprost drops until you are ready to use the eye drops.
• To use Tafluprost drops in the eye, first, wash your hands. Tilt your head back. If you are unable to tilt your head, lie down. Using your index finger, pull the lower eyelid away from the eye to form a pouch and look up. Drop the medicine into the pouch and gently close your eyes. If a drop misses your eye, try again. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• There is enough medicine in one container for both of your eyes.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye.
• Use Tafluprost drops at least 5 minutes apart from any other medicine that you put in your eye.
• Each container of Tafluprost drops is intended for a single use only. Use right away after opening. After you have opened the container and used it, throw away any remaining medicine immediately. Do not save it to use at a later time.
• Continue to use Tafluprost drops even if you feel well. Do not miss any doses.
• If you miss a dose of Tafluprost drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tafluprost drops.

Tafluprost is used to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (such as ocular hypertension). Lowering high pressure inside the eye can help prevent blindness. This medication works by regulating the flow of fluid within the eye to maintain a normal pressure.

How to use Tafluprost (PF) ophthalmic

Read the Patient Information Leaflet if available from your pharmacist before you start using Tafluprost and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Apply this medication in the affected eye(s) as directed by your doctor, usually once daily in the evening. Do not use this medication more frequently than prescribed; using more can make it work less well.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out. Try not to blink or rub your eye. Repeat these steps for your other eye if so directed. Wait several minutes for your vision to clear before driving or operating machinery.

If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.

Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day. It is important to continue using Tafluprost even if you feel well. Most people with glaucoma or high pressure in the eye do not have symptoms.

No interactions are anticipated in humans, since systemic concentrations of Tafluprost are extremely low following ocular dosing. Therefore, specific interaction studies with other medicinal products have not been performed with Tafluprost. In clinical studies, Tafluprost was used concomitantly with timolol without evidence of interaction.

See also:
What are the possible side effects of Tafluprost?

Applies to Tafluprost ophthalmic: ophthalmic solution

As well as its needed effects, Tafluprost ophthalmic may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Tafluprost ophthalmic, check with your doctor immediately:

Less common:

• Blurred vision
• burning, dry, or itching eyes
• decreased vision
• eye discharge or excessive tearing
• eye pain
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Minor Side Effects

Some Tafluprost ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Headache
• stinging or irritation of the eye

• Cough
• darker color of the eyelashes
• dry eyes
• increased growth of the eyelashes

A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, Tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.