Quiflor

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Quiflor

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Quiflor

Quick Facts

Property Description
Active Ingredient Marbofloxacin
Pharmacological Class Fluoroquinolone Antibacterial
Available Forms Solution for injection, Flavoured tablets
General Purpose Bacterial Infection Defense
Origin Synthetic, Carboxylic acid derivative

What Type of Medicine is Quiflor, and What is its Composition?

Quiflor is a veterinary medicinal product classified as a synthetic third-generation fluoroquinolone antibacterial. Its composition relies on the single active substance, Marbofloxacin, which is a compound derived from carboxylic acid and is used to combat bacterial pathogens in animals such as dogs and cats. This medicine belongs to the high-level antibiotic class and is clinically recognized for its reliable efficacy across a broad spectrum of pathogens. Quiflor is notably presented in two forms: a solution for injection for parenteral administration and as palatable flavoured tablets for oral administration.

How Does Marbofloxacin Function to Offer a General Benefit?

Marbofloxacin operates as a powerful bactericidal agent, meaning it actively kills targeted bacteria rather than merely inhibiting their growth. This action involves directly interfering with the essential bacterial enzymes, such as DNA gyrase and topoisomerase IV, which are necessary for DNA replication and repair. This fundamental function provides a robust, systemic capability for clearing various bacterial infections, such as those impacting soft tissues or the urinary tract. Marbofloxacin is classified as a Category B antimicrobial within the antimicrobial arsenal. This classification indicates that the drug is considered critical for specific therapeutic uses.

Key Differentiators of the Fluoroquinolone Class

Marbofloxacin is positioned as a third-generation compound within the broader fluoroquinolone group. This structural evolution provides functional advantages, including increased potency and a broad-spectrum of efficacy against a greater variety of Gram-negative and Gram-positive pathogens compared to older agents. A key differentiating factor of the Quiflor product is its availability across multiple tablet strengths (5 mg, 20 mg, and 80 mg), allowing for precise therapeutic adjustment based on patient need.

What side effects are possible with Quiflor?

Possible Side Effects and Safety Information

Quiflor (Marbofloxacin) is associated with an official safety profile that defines potential side effects and constraints for its appropriate use. The majority of reported adverse events involve the Gastrointestinal Tract, where mild effects such as vomiting, diarrhea, and reduced appetite occasionally occur. These signs typically cease spontaneously after treatment and do not require ending the course of therapy.


Regulatory Safety Constraints

The regulatory documents establish major constraints concerning the Musculoskeletal System and specific patient populations. The medicine is not recommended or contraindicated in immature, rapidly growing dogs and cats due to the officially documented risk of erosion of articular cartilage (arthropathy), a serious concern associated with the fluoroquinolone class. Caution is also advised regarding the Nervous System; while severe reactions are rare at recommended doses, the potential for neurological disorders, including seizures, requires careful use in animals diagnosed with epilepsy.


Other Safety Considerations

Hypersensitivity reactions are possible, and the drug must not be used in animals with a known allergy to fluoroquinolones. Additionally, simultaneous oral intake of divalent cations (such as calcium or iron) can interfere with the drug’s absorption, potentially reducing its effectiveness. These constraints define the necessary safety boundaries for the use of Marbofloxacin.

Overdose and Emergency Response

Overdose Scope

Property Official Regulatory Statement
Documented Overdose Presentations Acute neurological disorders, tremors, anorexia, vomiting, dehydration, red skin, facial swelling, lethargy, weight loss, and bloody diarrhoea (at high doses).
Physiological Systems Affected Central Nervous System (CNS) and skeletal system (cartilage damage in joints).
Dose-related or Exposure-related Factors Signs like bloody diarrhoea were observed at high multiples of the recommended dose. Accidental ingestion (of the product by a human) is noted as an exposure factor.
Population-specific Overdose Notes Overdosage may cause an increased risk of joint cartilage damage (arthropathy) in young/growing animals.
Emergency-response Statements Overdose should be treated symptomatically. Seek medical advice immediately and show packaging or leaflet to the physician (in case of accidental human ingestion).
When immediate medical help is required When accidental human ingestion occurs, or when acute signs, such as neurological disorders, are observed.

Overdose Classifications (High-Level)

Property Official Regulatory Statement
Severity Classification Associated with severe outcomes, including cartilage damage in the joints and acute neurological disorders.
Regulatory Basis Based on the Summary of Product Characteristics (SmPC) and equivalent regulatory prescribing information.
Overdose-context Constraints No specific antidote is known.

Resulting Overdose Structure

Official Overdose Statements:

  • Overdosage may result in acute neurological disorders, including tremors, and various systemic signs.
  • The most serious documented outcome linked to overdosage is cartilage damage in the joints.
  • Management of overdose must be symptomatic, as no specific antidote is known.
  • A specific population consideration is the increased risk of joint cartilage damage in young, growing patients following an overdosage event.

Connection to the overall overdose profile: Regulatory documents define the Quiflor overdose profile by documenting specific acute clinical signs, including neurological disturbances, and listing the potential for serious outcomes, such as arthropathy. The official instructions mandate immediate contact with medical professionals for accidental human ingestion and establish that the resulting clinical state must be addressed with symptomatic treatment.

Therapeutic Uses of Quiflor

What Quiflor Treats: Main Uses and Benefits

Quiflor (Marbofloxacin) is used to address bacterial infections across several key organ systems in dogs and cats, applied across domains where additional symptomatic support is needed. This application contributes to easing the overall symptom load and is commonly used to help with symptoms related to physical discomfort and disruptive infection symptoms.

The medication is relevant for treating conditions where symptoms are driven by susceptible bacteria, particularly skin and soft tissue infections (like pyoderma and abscesses), urinary tract infections (UTI), and specific respiratory tract manifestations.

“It is commonly used to help with symptom clusters that may become intense or disruptive, supporting the patient during difficult episodes by easing distress.”

In these contexts, Quiflor is applied when infection-driven symptoms that interfere with daily functioning include inflammation, discharge, redness, or discomfort during urination and breathing. Treatment generally supports improved day-to-day comfort by easing the physical burden and helps maintain a sense of stability when symptoms are more noticeable.


Quick Fact: Relief for Infection-Driven Distress

Regulatory References

  1. UK Veterinary Medicines Directorate

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Quiflor — Official Regulatory Information

Category Regulatory Statement
Populations for whom use is allowed Dogs and Cats (The official target species)
Populations for whom use is contraindicated Animals with known hypersensitivity to marbofloxacin, other fluoroquinolones, or any excipients. Animals with known resistance against quinolones.
Age-related eligibility rules Dogs less than 12 months old (or less than 18 months for exceptionally large breeds, such as Great Danes). Cats less than 16 weeks old (due to risk of joint damage).
Condition-specific eligibility rules Cautious use is recommended in dogs and cats diagnosed with epilepsy or other central nervous system disorders.
Pregnancy and lactation eligibility status Safety has not been established; use is permitted only according to a documented benefit/risk assessment.
Eligibility-related restrictions Higher-strength tablets (20 mg or 80 mg) are contraindicated for use in cats; only the 5 mg strength is approved for the species.

Connection to the overall eligibility profile

Official regulatory documents define eligibility primarily through absolute contraindications based on age to mitigate the risk of articular cartilage damage during rapid growth. Eligibility is also prohibited by prior patient history, specifically allergy or bacterial resistance. Furthermore, use is subject to conditional precaution for animals with neurological disorders and a safety not established status for pregnant and lactating populations.

What should I know about interactions with other medicines?

Interactions with Other Medicines and Products

The interaction profile for Quiflor (Marbofloxacin) is defined by officially documented patterns that alter drug exposure or result in pharmaceutical incompatibility, based on regulatory information from government health authorities.

Pharmacokinetic Interference

Interacting Substance Official Regulatory Outcome Type of Interaction
Oral Multivalent Cations (Aluminum, Calcium, Magnesium, Iron) Reduces bioavailability of Marbofloxacin, requiring separation of administration time. Pharmacokinetic (Reduced Absorption)
Theophylline Leads to inhibited clearance of Theophylline, resulting in an increase in its plasma concentration. Pharmacokinetic (Reduced Clearance)

Restrictions and Co-Administration Cautions

Co-administration with Tetracyclines or Macrolides is restricted due to a documented potential for antagonist effects. The official label also notes that interactions with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), aside from Tolfemic acid, cannot be excluded due to a lack of specific studies. Furthermore, the Quiflor solution for injection must adhere to the rule of pharmaceutical incompatibility and must not be physically mixed with any other veterinary medicinal products in the same syringe or administration vessel.

Mechanism of Action

How Quiflor Works

Quiflor (Marbofloxacin) is an antibacterial agent whose mechanism of action centers on the irreversible destruction of the bacterial genome, which initiates a bactericidal action.


Targeting Bacterial DNA Maintenance Enzymes

The core of Quiflor's action lies in its specific affinity for two essential bacterial enzymes: DNA Gyrase (Topoisomerase II) and Topoisomerase IV. These enzymes are critical for regulating the supercoiling, unlinking, and replication of the bacterial chromosome. Quiflor acts as an inhibitor, selectively interfering with these bacterial systems to halt the processes required for cell replication and division. This targeted engagement with the bacterial machinery is the molecular starting point for the drug's effect.


Activating the Lethal DNA Damage Cascade

Once bound, Quiflor does not simply block the enzymes; it stabilizes the enzyme-DNA complex in its cleaved (cut) state. This trapping mechanism prevents the religation of the bacterial DNA strands, leading to a catastrophic accumulation of DNA double-strand breaks within the bacterial genome. This irreparable damage triggers the bacterial cell's self-destruct mechanism, resulting in a rapid, concentration-dependent bactericidal action. The functional consequence is the death and lysis of susceptible bacterial cells.

Dosage and Administration Information

The administration of Quiflor (Marbofloxacin) is characterized by specific parameters that define its route, dosing, and required duration of use.

Administration Scope

Quiflor is designed for administration via the oral route using flavoured tablets and the parenteral route via subcutaneous (SC) or intravenous (IV) injection. The established dosing schedule involves administration once daily. The standard regimen is 2 mg of marbofloxacin per kg of body weight, though alternative regimens up to approximately 5.5 mg/kg once daily are utilized in certain contexts. Dosing accuracy is dependent upon precise body weight determination.

Procedural Constraints

Specific timing requirements define the use of this medication: the tablets are generally administered on an empty stomach. Oral administration is separated by at least two hours from the intake of products containing divalent cations, such as calcium, iron, or magnesium, to avoid interfering with absorption. The full prescribed duration is intended to be completed.

Duration and Population Rules

Treatment duration is time-bound, typically starting with a minimum period (e.g., 10 days for certain infections) and extending up to a maximum of 30 or 40 days. Administration continues for two to three days past the resolution of clinical signs, regardless of the total course length. Furthermore, specifications include restrictions on the use of Quiflor based on age: it is generally not indicated for use in large breed dogs under 18 months of age or small/medium breeds under 12 months, which serves as a structural constraint on its application.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Quiflor

The clinical evaluation of Quiflor (Marbofloxacin) is primarily based on formal studies, including Randomized Controlled Trials (RCTs) and controlled field evaluations, which were conducted under regulatory review. The research explores how the medicine was evaluated in studies focusing on changes in symptoms and measured patterns of pathogen clearance across its labeled uses. The following overview describes the types of research available, what was observed in these studies, and what aspects of the evidence are still emerging or not fully established.


Research Evidence for Skin and Soft Tissue Infections (SSTI)

Research examining Quiflor in studies of skin and soft tissue infections involved various controlled study designs. These studies monitored individuals diagnosed with conditions characterized by acute or disruptive episodes. Researchers measured the Clinical Cure Rate (tracking physical signs like inflammation) and the Bacteriological Cure Rate (monitoring the measured clearance of the targeted susceptible pathogen).

Studies conducted during periods of increased symptom activity described patterns observed in the measured outcomes related to physical discomfort. Specifically, trials documented the achievement of bacteriological clearance following defined treatment courses, and field evaluations reported measurements related to visible signs of infection over the observed time intervals.


Evidence Base for Urinary Tract Infections (UTI)

The evidence foundation for Quiflor's application in lower urinary tract infections (UTI) consists of Randomized Controlled Trials (RCTs) and Observational Clinical Studies. Research focused on individuals where the presence of a susceptible bacterial strain was confirmed prior to evaluation. The core outcomes monitored were the Bacteriological Cure Rate (tracking urine culture results) and the Clinical Cure Rate (assessment of changes in urinary symptoms).

Comparative reports documented the measured symptom parameters and described patterns related to pathogen clearance observed in the urine. The research base provides limited data on measured outcomes in patients with concurrent, complex systemic health issues, as these groups are often excluded from efficacy trials.


Key Limitations and Areas of Uncertainty in the Research

Research provides insight into short-term changes, but several limitations exist. Evidence quality varies across studies, particularly when comparing results derived from small, highly specific trials with larger field studies. Data for certain groups remain insufficient, especially for long-term outcomes and for evaluating the product in individuals with specific, complex pre-existing health issues. Study results reflect the specific conditions under which they were conducted, and research provides context but not individual predictions about clinical response.

Frequently Asked Questions (FAQ)

Common questions about Quiflor (FAQ)

Q: How does Quiflor differ from other medicines that treat the same condition?

A: Official information describes Quiflor as a synthetic third-generation fluoroquinolone antibacterial. The classification is associated with broad-spectrum activity against a range of pathogens compared to some older agents within the same drug class.


Q: Does Quiflor need to be taken long-term?

A: Quiflor is defined for short-term use. Official documents define treatment as short-term, with a defined maximum duration of use (e.g., up to 40 days for certain conditions). It is not classified as a long-term or chronic medication.


Q: Are there any serious but rare side effects associated with Quiflor?

A: Regulatory safety documents highlight major constraints for use, such as the risk of erosion of articular cartilage (arthropathy) in immature, rapidly growing populations, and the potential for neurological disorders, including seizures. Caution is advised in populations with pre-existing conditions, such as epilepsy, as noted in the safety warnings.


Q: Can I take Quiflor if I also take a vitamin supplement?

A: The drug's absorption may be reduced if taken near certain supplements. Official warnings state that the medicine should be administered at least two hours apart from products containing multivalent cations such as calcium, iron, or magnesium, which are commonly found in vitamin or mineral supplements.


Q: Is Quiflor generally suitable for children?

A: Quiflor is a veterinary medicinal product. For its target species, official prescribing information provides specific age-related restrictions. For example, it is not indicated for use in large breed dogs under 18 months of age or cats under 16 weeks of age.


Q: Is it normal to feel tired when first starting Quiflor?

A: Mild signs of lethargy (tiredness) and decreased activity are among the potential side effects that have been reported. These signs, which affect the Gastrointestinal Tract and behavior, are reported to occur occasionally and have been observed to resolve without specific intervention.


Q: Are there any foods I should avoid while on Quiflor?

A: The official instructions advise separating the administration of the tablets from the intake of products containing multivalent cations (such as calcium or iron) by at least two hours. This includes intake of certain foods or milk products that may contain these minerals.


Q: Can Quiflor cause changes in mood?

A: The regulatory safety profile advises caution regarding the Nervous System. Due to the potential for neurological disorders, the official label notes that behavioral changes or nervous system issues may occur and requires consideration for use in susceptible populations.


Q: Has Quiflor been studied in elderly patients?

A: The overview of studies notes that research primarily focuses on short-term changes in symptoms. Furthermore, the evidence base is noted to have insufficient data for certain groups, and studies are limited when evaluating complex pre-existing health issues often seen in elderly populations.


Q: How is the effectiveness of Quiflor measured in clinical trials?

A: Effectiveness in formal studies is measured using two key parameters. Researchers track the Clinical Cure Rate (assessing changes in physical signs) and the Bacteriological Cure Rate (monitoring the measured clearance of the targeted pathogen).


Q: What if I have stomach issues—will Quiflor irritate them?

A: The most frequently reported adverse events involve the Gastrointestinal Tract, including mild effects such as vomiting, diarrhea, and reduced appetite. These signs are reported to occur occasionally and are often observed to resolve without specific intervention.


Q: How does Quiflor affect blood sugar levels?

A: Quiflor belongs to the fluoroquinolone class of antibacterials. Regulatory documents for human-use counterparts of this class note that disturbances in blood sugar levels, including both hypoglycemia (low blood sugar) and hyperglycemia, have occurred.


Q: Is there a maximum daily dose described for Quiflor?

A: Official prescribing information defines a standard dose rate of 2 mg per kg of body weight once daily. Alternative regimens are authorized up to a maximum daily amount of approximately 5.5 mg per kg once daily in certain regions.


Q: How long after stopping Quiflor will the drug be cleared from my system?

A: Pharmacokinetic data describes how the drug is processed. Regulatory documents report the elimination half-life of Marbofloxacin in dogs, for instance, as approximately 14 hours. The drug is predominantly eliminated in the active form via the urine and faeces.


Q: Is there clinical data on Quiflor use in breastfeeding women?

A: Official documents state that safety for use during lactation has not been established in formal studies. Use in nursing populations is permitted only according to a documented benefit/risk assessment.


Q: Is there alternative dosing described in the label, like once or twice daily?

A: The established dosing schedule in official information specifies once-daily administration.


Q: Is it safe to consume alcohol while taking Quiflor?

A: Quiflor is a veterinary medicinal product and its official label does not address human alcohol consumption. Consistent with safety requirements for all medicines, the product should be kept out of the sight and reach of children.


Q: Can people with kidney problems use Quiflor?

A: Cautious use is officially recommended in animals that have or are diagnosed with kidney problems or liver problems. This is because these conditions can potentially affect the clearance of the drug from the body.


Q: Can Quiflor be taken with or without food?

A: The official instructions define that the tablets should generally be administered on an empty stomach to avoid interference with the drug’s absorption. This is a key procedural constraint.


Q: What types of tests are needed before starting Quiflor?

A: Prior to using Quiflor, it is necessary to determine the animal’s precise body weight for dosing accuracy. Furthermore, it is required to confirm the presence of a susceptible bacterial strain to ensure appropriate use of the medicine.


Q: What is the latest research saying about the long-term use of Quiflor?

A: Research is noted to primarily provide insight into short-term changes and outcomes related to defined courses of therapy. The evidence base has limitations regarding long-term outcomes and for evaluating the medicine in individuals with complex pre-existing health conditions.


Q: Is nausea a very common initial experience with Quiflor?

A: Potential side effects involving the Gastrointestinal Tract, such as nausea, vomiting, and reduced appetite, are reported to occur occasionally. These effects are observed to resolve without specific intervention.

How should Quiflor be stored and disposed of?

How to Store and Dispose of Quiflor

Quiflor (marbofloxacin) tablets must be stored in the original package to ensure protection from light. When the product is packaged for sale, it generally does not require any special temperature storage conditions.

Stability and Child Safety

Condition Requirement
Shelf-Life of Sealed Product Up to 3 years.
Divided Tablets Must be stored below 25°C in the original blister and used within 5 days.
Child Safety Keep out of the sight and reach of children.

Disposal Requirements

Any unused Quiflor or waste materials must be disposed of in accordance with local requirements. Official regulations specify that the medicine should not be disposed of via wastewater.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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