Primodian Depot

Males:

replacement therapy in conditions associated with a deficiency or absence of endogenous Testosterone (Primodian Depot) :

•Primary hypogonadism (congenital or acquired) :

Testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy.

Hypogonadotropic hypogonadism (congenital or acquired) : Idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury..

Delayed puberty :

Females:

Advancing inoperable metastatic (skeletal) mammary cancer in patients who are 1 to 5 years post-menopausal. Androgen therapy occasionally appears to accelerate metastatic breast.

History of liver tumors, severe liver impairment, genital tract or breast carcinoma (unless progestogens are being used as part of the management of these conditions), arterial disease, undiagnosed vaginal bleeding and porphyria. Pregnancy, pregnancy testing, missed or incomplete abortion.

the doctor should know if the patient is taking any of the following:Acetaminophen,Amiodarone,Anabolic steroids,oxandrolone,oxymetholone,Anti-infectives by mouth or by injection,Antithyroid agents,Carbamazepine,Carmustine,Chloroquine,Dantrolene,Daunorubicin,Disulfiram,Divalproex Etretinate,Gold salts,Hydroxychloroquine,Mercaptopurine,Methotrexate,Methyldopa,Naltrexone,Phenothiazines,chlorpromazine,fluphenazine,mesoridazine,perphenazine,prochlorperazine,promazine,promethazine,thioridazine,trifluoperazine,triflupromazine,Phenytoin,Plicamycin,Valproic acid,Anticoagulants,Cyclosporine.

Tumors of the liver, liver cancer, and peliosis hepatis (a form of liver disease) have occurred during long-term, high-dose therapy with androgens. When androgens are used in women, especially in high doses, male-like changes may occur, such as hoarseness or deepening of the voice, unnatural hair growth, or unusual hair loss.also The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the uterus lining) in women after menopause. It is not yet known whether the use of estrogens increases the risk of breast cancer in women. Yellow eyes or skin,Uncontrolled jerky muscle movements; vomiting of blood (with long-term use or high doses).