Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Each tablet contains Aceclofenac (Painfree-MR) 100 mg, Chlorzoxazone (Painfree-MR) 500 mg and acetaminophen 375 mg.
Acute painful inflammatory conditions, which may include skeletal muscle spasm and pain associated with sprains, strains and other traumatic muscle injuries; myalgias; arthritis; low back pain; tension headache; tooth extraction; torticollis; fibrositis; spondylitis; cervical root and disc syndromes; postsurgical pain.
Usual Dose: Twice daily, orally.
Children: There are no clinical data on the use of Aceclofenac (Painfree-MR) in children.
Renal Insufficiency: There is no evidence that the dosage of Aceclofenac (Painfree-MR) needs to be modified in patients with mild renal impairment, but as with other NSAID, caution should be exercised.
Hepatic Insufficiency: There is some evidence that the dose of Aceclofenac (Painfree-MR) should be reduced in patients with hepatic impairment and it is suggested that an initial dose of 100 mg be used.
Hypersensitivity to Aceclofenac (Painfree-MR), Chlorzoxazone (Painfree-MR), acetaminophen or any of the components; severe heart failure; severely impaired hepatic or renal function; and acute porphyria. Aceclofenac (Painfree-MR) should not be administered to patients with active peptic ulcer or GI bleeding. Aceclofenac (Painfree-MR) should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used.
Drug interactions associated with Zifam Painfree-MR are similar to those observed with other NSAIDs. Aceclofenac (Painfree-MR) increase plasma concentration of lithium, digoxin and methotrexate, increase activity of anticoagulants, inhibit the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolones. The co-administration of Aceclofenac (Painfree-MR) with other NSAIDS or corticosteroids may result in increased frequency of adverse events. Potential hepatotoxicity of acetaminophen may be increased by large doses or long-term administration of barbiturates, carbamazepine, hydantoin, isoniazid, rifampin and sulfopyrazone.
GI effects.