Ovidac

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Ovidac

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ovidac

Quick Facts: Ovidac (hCG)

Property Description
Active Ingredient Chorionic Gonadotropin (hCG)
Form Lyophilized Powder for Solution for Injection
Pharmacological Class Gonadotropin
Route of Administration Intramuscular or Subcutaneous
Origin Biological (Glycoprotein Hormone)

What Type of Medicine is Ovidac?

Ovidac is a pharmaceutical product containing the active ingredient Chorionic Gonadotropin (hCG), which is classified within the pharmacological group of Gonadotropins and their analogues. This agent functions as a Luteinizing Hormone (LH) receptor agonist. This means the substance functionally mimics the action of the body's natural Luteinizing Hormone (LH). hCG is a complex glycoprotein hormone of biological origin. The product is supplied as a sterile lyophilized powder that requires reconstitution with an aqueous solvent before being administered via injection. Ovidac is a prescription-only medicine, and its form necessitates delivery through the intramuscular or subcutaneous route, as the peptide hormone is inactive if taken orally.

How is Chorionic Gonadotropin Generally Used?

The general purpose of Chorionic Gonadotropin is to provide a crucial hormonal signal that supports or initiates reproductive functions. Its primary action is to bind to LH receptors, thereby promoting the final maturation and release of an egg (ovulation) in women of reproductive age. This mechanism is clinically recognized for its reliability in triggering the LH surge needed for fertility cycles. In the male patient, this action stimulates the Leydig cells of the testes to produce testosterone and other androgens, a process essential for male reproductive capability. This medication is a fundamental component of hormonal strategies designed to manage reproductive processes where deficiencies in natural gonadotropin secretion exist.

What side effects are possible with Ovidac?

Possible Side Effects and Safety Information

The safety profile for Ovidac, which contains Chorionic Gonadotropin (hCG), is based on official government regulatory documents and is characterized by risks related to its hormonal action, primarily affecting the reproductive and vascular systems.

Frequency-Classified Adverse Reactions

Adverse reactions are officially categorized by frequency of occurrence in clinical trials and post-marketing surveillance:

  • Very Common (Affecting ge 1 in 10 patients): Headache, and reactions at the injection site, such as localized pain.
  • Common (Affecting 1 to 10 in 100 patients): Abdominal pain or distension, nausea, vomiting, peripheral swelling (edema), fatigue, and mild or moderate Ovarian Hyperstimulation Syndrome (OHSS). Mood changes such as irritability, restlessness, and depression are also documented.
  • Very Rare (Affecting < 1 in 10,000 patients): Serious events including thromboembolic events (blood clots) and severe anaphylactic reactions (shock) have been reported.

Serious Safety Considerations

The most significant risks documented in regulatory labels relate to the hormonal effects on the body. The serious adverse reaction Ovarian Hyperstimulation Syndrome (OHSS) is a known risk that can progress rapidly and may be more severe and protracted if pregnancy occurs. OHSS can lead to critical complications, including fluid accumulation, acute pulmonary distress, and hemoconcentration. Additionally, thromboembolic events (such as pulmonary embolism or stroke) are noted as a rare but serious risk.

Population-Specific Notes and Safety Restrictions

Specific safety statements address certain patient groups. For women undergoing Assisted Reproductive Technologies (ART), there is an increased incidence of multiple births and ectopic pregnancy. For pediatric male patients, there is a risk of precocious puberty (early onset of secondary sexual characteristics). Ovidac is officially contraindicated (should not be used) in patients with conditions like androgen-dependent neoplasms or a known history of severe allergic reactions to hCG.

Overdose and Emergency Response

The documented overdose profile for Chorionic Gonadotropin (Ovidac) is primarily defined by the development of Ovarian Hyperstimulation Syndrome (OHSS). This condition represents the chief clinical manifestation resulting from overexposure or excessive stimulation, and the risk is specifically associated with female patients undergoing ovulation induction.

Regulatory labels classify OHSS by severity. Mild to moderate presentations involve abdominal pain, nausea, vomiting, and ovarian enlargement. Severe OHSS is documented as a potentially life-threatening event characterized by a dramatic fluid shift leading to ascites (abdominal fluid accumulation), hydrothorax, and risks of thromboembolic events (blood clots), dyspnea (trouble breathing), and oliguria (decreased urine output).

Official regulatory documents mandate that if an overdose is suspected or if signs of severe OHSS develop (such as severe abdominal pain, rapid weight gain, or shortness of breath), patients must seek immediate medical attention and require hospital monitoring. In such severe cases, the administration of gonadotropins, including hCG, should be stopped. Overdose management is confined to symptomatic and supportive treatment, as regulatory constraints confirm that no specific antidote is known.

Therapeutic Uses of Ovidac

What Ovidac Treats: Main Uses and Benefits

Ovidac’s active ingredient, human chorionic gonadotropin (hCG), is commonly used across conditions presenting with acute episodes of reproductive dysfunction in both men and women. The drug is applied across domains where additional symptomatic support is needed for fertility and hormone regulation.

This medication is generally used for specific clinical scenarios, including supporting conditions involving episodic or fluctuating manifestations related to fertility in women; applied in addressing symptom clusters that may become intense or disruptive related to systemic imbalance in men; and relevant for easing symptoms that interfere with daily comfort associated with specific pediatric conditions. The medication may assist with contributing to easing the overall symptom load related to organ-specific functional stress and is relevant in contexts involving heightened systemic burden.

Quick Fact: Relief for symptoms related to systemic imbalance

“The support helps ease the overall symptom burden and contributes to improved comfort during periods of heightened symptoms.”

In these therapeutic domains, Ovidac assists with maintaining functional stability and provides supportive relief when symptoms interfere with routine activities. The treatment may be part of symptomatic management applied during phases when symptoms become more noticeable.

Regulatory References

  1. NIH DailyMed official drug label

Eligibility and Restrictions for Use

Who can and cannot use Ovidac?

The eligibility for Ovidac (Chorionic Gonadotropin) is strictly defined by official regulatory documentation to ensure appropriate use.

Populations for whom use is contraindicated:

  • Patients with hypersensitivity to hCG or formulation components.
  • Individuals with tumors of the hypothalamus, pituitary gland, or known sex hormone-dependent tumors (e.g., breast, prostate).
  • Women with primary ovarian failure (high FSH), abnormal uterine bleeding of undetermined cause, or reproductive conditions incompatible with pregnancy.
  • Use is contraindicated once pregnancy is established.

Age-Related Eligibility Rules

Age Group Regulatory Eligibility Status
Children Under 4 Use not established; safety and efficacy are not demonstrated.
Prepubertal Boys Contraindicated if signs of precocious puberty are present.

Condition-Specific Eligibility Restrictions

The medicine must be used with caution in patients with conditions aggravated by fluid retention, such as renal disease, hypertension, epilepsy, or migraine. It is not recommended for use by women who are breastfeeding. Treatment must be withheld if signs of impending Ovarian Hyperstimulation Syndrome (OHSS) are evident prior to administration.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The regulatory profile for Ovidac (Chorionic Gonadotropin, hCG) regarding interactions with co-administered medicinal products is defined by the findings documented in official governmental prescribing information.

Documented Drug and Substance Interactions

Official regulatory sources note that formal drug-drug interaction studies have not been conducted for Chorionic Gonadotropin. Consequently, there is no documented information from regulatory authorities regarding specific co-administered substances that may lead to pharmacokinetic interactions, such as those mediated by cytochrome P450 (CYP) enzymes, or pharmacodynamic interactions that result in additive or synergistic effects.

This absence of documented interaction studies means that no medicinal products are explicitly listed as formally contraindicated combinations due to metabolic or exposure-altering effects in the drug's interaction section.

Procedural and Timing Constraints

The only explicit interaction constraint specified in regulatory labeling is related to diagnostic testing. The administration of Chorionic Gonadotropin can cause interference with specific immunological laboratory assays, particularly those used to measure gonadotropins, including Luteinizing Hormone (LH), and assays used for pregnancy testing.

This interference can result in false positive results in immunological pregnancy tests or inaccurate LH determination for a period of approximately seven to ten days following administration. Therefore, a timing-based separation is required for these specific diagnostic procedures relative to the administration of Ovidac.

Mechanism of Action

How Ovidac Works

Ovidac, containing Chorionic Gonadotropin (hCG), functions as a high-affinity endocrine agonist. Its mechanism is strictly defined by the direct engagement of the Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR) on target cells within the gonads. This binding initiates a clear intracellular signal that drives the synthesis of sex hormones, directly influencing the endocrine environment.


Targeted Activation of the Gonadotropin Cascade

This domain covers the drug's molecular initiation: the binding to the LHCGR immediately activates the Gs protein and leads to a sustained surge in the second messenger cyclic Adenosine Monophosphate (cAMP) within the cell. This signal acts as a hormonal trigger, initiating heightened biochemical activity in the reproductive tissues.


Mechanism Driving Sex Steroidogenesis

The central consequence of the cAMP surge is the rapid upregulation of key enzymes and proteins, such as the Steroidogenic Acute Regulatory Protein (STAR). This mechanism accelerates the conversion of cholesterol into sex steroids (testosterone, progesterone), resulting in a sustained hormonal output that drives specific physiological maturation processes in the gonads.

Dosage and Administration Information

How to Use Ovidac: Official Administration Guidelines

Ovidac contains Chorionic Gonadotropin (hCG), and its use is governed by established protocols to ensure proper administration. The medication is not administered orally.


Administration Scope

Administration Property Official Instruction Details
Route of Administration The active ingredient is delivered via Intramuscular (IM) or Subcutaneous (SC) injection, depending on the specific product formulation and indication.
Dosing Schedule & Unit Dosing is standardized in USP Units or micrograms. The regimen is condition-specific, ranging from a single injection for ovulation induction to doses of 500 to 4,000 USP Units administered 2 to 3 times per week for long-term male hormonal support.
Preparation Lyophilized powder forms require reconstitution with the provided sterile diluent prior to administration. The solution should be gently prepared.

Procedural Timing and Use Patterns

The usage protocol for Chorionic Gonadotropin is defined by the treatment goal, resulting in two main patterns.

For ovulation induction in women, a single injection of 5,000 to 10,000 USP units is administered, which must be precisely timed to occur 24 to 48 hours after the last dose of follicular-stimulating agents.

In the management of hypogonadism in males, the medication is used in an intermittent, multi-month regimen, involving injections multiple times per week. Similarly, for prepubertal cryptorchidism, the protocol involves specific low-range doses administered over a short, defined period. These instructions ensure the medicine is used according to the method and timing established for therapeutic use.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Dapagliflozin


Evidence for use in Type 2 Diabetes Mellitus

Research exploring dapagliflozin for Type 2 Diabetes Mellitus includes numerous short-term and long-term randomized controlled trials (RCTs). These studies primarily focused on measuring HbA1c levels, fasting glucose, body weight, and blood pressure in adults with Type 2 Diabetes. Research so far indicates that studies monitored these glycemic measures and also described patterns related to the reported incidence of composite cardiovascular events and markers of kidney function. Findings highlight changes measured during the study period across several metrics, but data are still emerging regarding certain long-term effects, and evidence quality varies across studies.


Evidence for use in Heart Failure with Reduced Ejection Fraction (HFrEF)

Dapagliflozin was evaluated in large-scale randomized controlled trials for use in patients diagnosed with HFrEF (a heart function measure of leq 40%). The primary outcomes that were measured focused on the first event of cardiovascular death or hospitalization for heart failure. Studies reported patterns observed in the reported incidence for this composite outcome across the intermediate follow-up periods. Research also describes the changes measured in functional status and blood biomarkers ( NT-proBNP) compared to the control groups. Data are insufficient for certain groups, such as patients with severely low estimated glomerular filtration rate ( eGFR).


Evidence for use in Heart Failure with Mildly Reduced or Preserved Ejection Fraction ( HFmrEF and HFpEF)

Research examined the use of dapagliflozin in patients with heart failure who had better-preserved heart function (LVEF > 40%). The key composite outcome that was measured was the first event of cardiovascular death or hospitalization for heart failure. Findings describe patterns related to the reported incidence for the composite endpoint in these populations, as well as changes in patient-reported outcomes describing perceived discomfort. Subgroup findings are uncertain for certain groups, and comparative evidence against other specific treatments is lacking.

Frequently Asked Questions (FAQ)

Common questions about Ovidac (FAQ)

Q: Can Ovidac affect my monthly cycle?

According to the official product information, Ovidac (Chorionic Gonadotropin) functions to promote or initiate specific reproductive processes, such as ovulation or hormone synthesis. This action is inherently designed to regulate or influence the natural reproductive cycle.

Q: Does Ovidac work right away or does it take time?

Pharmacokinetic studies indicate that the active ingredient reaches its peak concentration in the bloodstream approximately 6 to 24 hours after administration. The exact timing depends on the specific injection route used.

Q: How long after using Ovidac will I see the intended effects?

For its use in ovulation induction, the medicine is timed precisely to trigger the release of an egg approximately 24 to 48 hours after the last dose of stimulating agents. The time frame for seeing other intended effects will vary depending on the specific condition being treated.

Q: Is weight gain a possible side effect of Ovidac?

Weight gain has been listed in some regulatory documents as an adverse reaction associated with the medication. It is also recognized as a key symptom of Ovarian Hyperstimulation Syndrome (OHSS), a serious safety consideration described in the product information.

Q: Is Ovidac suitable for someone with kidney or liver disease?

Official safety statements indicate that the medicine should be used with caution in individuals with conditions that are aggravated by fluid retention, such as cardiac or renal disease (kidney disease).

Q: What is the list of ingredients in Ovidac?

The main component is the active ingredient, Chorionic Gonadotropin (hCG). When the powder is mixed, the solvent typically contains water for injection, sodium chloride, and often the preservative Benzyl Alcohol, according to the official labeling.

Q: Where is the Ovidac research evidence published?

The official regulatory documents, such as the FDA Prescribing Information and the EMA Summary of Product Characteristics (SmPC), contain specific citations and references. These references point to the clinical studies and trials that were used to support the drug’s regulatory approval.

Q: Can people with a history of blood clots use Ovidac?

Regulatory warnings state that individuals with generally recognized risk factors for thrombosis (blood clots), such as a personal or family history, may have an increased risk of thromboembolic events while undergoing gonadotropin therapy.

Q: Can I use Ovidac if I have cysts?

According to official regulatory information, the medicine is contraindicated (should not be used) in women with pre-existing ovarian cysts or ovarian enlargement of an undetermined origin.

Q: Does Ovidac contain any animal-derived ingredients?

Chorionic Gonadotropin is classified as a glycoprotein hormone of biological origin. Depending on the manufacturer, the active ingredient is either purified from the urine of pregnant women (human origin) or produced using recombinant DNA technology.

Q: How quickly does Ovidac leave your system?

The pharmacokinetics summaries describe the terminal half-life—the time it takes for the concentration in the bloodstream to reduce by half—as being approximately 23 hours.

Q: Is it safe to drink alcohol while using Ovidac?

Regulatory labeling for Chorionic Gonadotropin does not contain an explicit warning against consuming alcohol. However, official information suggests that patients review the use of alcohol with a prescriber while undergoing therapy.

Q: Is Ovidac safe for people with a history of thyroid problems?

Official warnings state that the medicine should be used with caution in patients with a history of certain endocrine disorders. These may include conditions affecting the thyroid or adrenal glands, as described in the product label.

Q: What happens if I miss a scheduled time to use Ovidac?

Specific patient instructions detailing the procedure for a missed dose are provided in the manufacturer's official Patient Information Leaflet or Instructions for Use. This document is the required source for guidance regarding missed doses.

Q: What is the difference between Ovidac and other fertility drugs?

Ovidac, containing Chorionic Gonadotropin, is classified as a Gonadotropin that primarily mimics the action of Luteinizing Hormone (LH). Other fertility drugs may be classified as Follicle-Stimulating Hormone (FSH) mimics or combination agents.

Q: Why do some people mistakenly associate Ovidac with unapproved weight loss programs?

The FDA requires the official product labeling to include a strong disclaimer stating that Chorionic Gonadotropin is not approved as an effective treatment for obesity. This clarifies that there is no substantial evidence it increases weight loss beyond caloric restriction alone.

Q: How do I know if Ovidac is working as intended?

The FDA Prescribing Information indicates that successful use requires close monitoring by a physician. This monitoring typically involves measuring serum estradiol levels and using transvaginal ultrasound on a regular basis to check the body's response.

Q: What is the proper way to check the Ovidac expiry date?

As required for all prescription medications by regulatory standards, the product's official expiration date is printed clearly on the outer packaging and on the vial label for both the powder and the diluent.

Q: Is Ovidac approved by the FDA?

Yes, prescription products containing Chorionic Gonadotropin (hCG) are approved by the FDA and other international authorities. They are approved for specific fertility and hormonal indications as defined in their official regulatory labeling.

Q: Does Ovidac affect driving ability?

Official adverse reaction lists include common events such as headache and fatigue. These are effects that may, in some individuals, indirectly affect the ability to safely drive or operate heavy machinery.

Q: What type of healthcare professional usually prescribes Ovidac?

The medication is intended for use by physicians who are thoroughly familiar with the criteria for patient selection, contraindications, and warnings described in the official package insert for gonadotropins. This typically implies a specialist or highly experienced physician.

Q: Is Ovidac a controlled substance?

The medicine is generally classified as not a controlled substance under the U.S. Drug Enforcement Administration (DEA) schedules, although state-level regulations can sometimes vary.

How should Ovidac be stored and disposed of?

How to Store and Dispose of Ovidac?

The official requirements for storing Ovidac (Chorionic Gonadotropin) differ based on its state:

  • The unreconstituted powder must be stored at Controlled Room Temperature (20 C to 25 C), protected from light and excessive heat.
  • Once the powder is mixed, the reconstituted solution must be stored under refrigeration (2 C to 8 C) and must not be frozen.

The refrigerated solution is generally stable for up to 60 days, after which it must be discarded. The medication and all supplies must be kept out of the sight and reach of children. Used needles and syringes (sharps) must be placed immediately into a puncture-resistant container and disposed of according to local and state regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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