Нозефрин

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Нозефрин

Property Description
Active ingredient Mometasone Furoate
Form Nasal Spray (Aqueous Suspension)
Pharmacological class Glucocorticoid (Corticosteroid)
Common use Local anti-inflammation, anti-allergy
Origin Synthetic derivative

What Type of Medicine is Нозефрин?

Нозефрин is a medicinal product defined by its active ingredient, Mometasone Furoate, which is classified as a synthetic, powerful Glucocorticoid. This substance belongs to the broader pharmacological class of corticosteroids and is derived through chemical synthesis. The formulation is primarily available via prescription, aligning with the regulatory oversight typical of potent corticosteroids. This characteristic is clinically recognized for delivering a high anti-inflammatory effect directly to the nasal mucosa, minimizing systemic exposure.

Composition and Delivery Form (Nasal Spray Aqueous Suspension)

The physical form of Нозефрин is a Nasal Spray, formulated specifically as an Aqueous Suspension. This means the active ingredient, Mometasone Furoate Monohydrate, is finely dispersed within a water-based liquid carrier and administered intranasally. The intranasal route ensures the medicine is delivered directly to the nasal lining. The aqueous suspension is a single-component product delivered via a metered-dose pump, a mechanism designed to optimize the medication's adherence to the tissue for a sustained effect while limiting any undesired systemic absorption.

General Purpose: Anti-Inflammation and Anti-Allergy Action

The core purpose of Нозефрин is to provide robust, local anti-inflammatory and anti-allergic effects, typical of the Glucocorticoid class. By acting as a topical Glucocorticoid Receptor Agonist, the active substance works at a cellular level to inhibit the fundamental biological cascade of inflammation and allergic responses. This powerful action effectively manages symptoms in the nose due to inflammation. This mechanism is key to mitigating the tissue swelling and suppressing the underlying allergic reaction, providing comprehensive relief for patients experiencing persistent nasal congestion and irritation.

Regulatory References

  1. MedlinePlus

What side effects are possible with Нозефрин?

Possible Side Effects and Safety Information

Нозефрин (Mometasone Furoate) nasal spray has an official safety profile structured around the classifications established by regulatory authorities. The adverse reactions are categorized by frequency and the organ system affected, distinguishing between common local effects and rare, but clinically significant, systemic concerns inherent to its corticosteroid class.

Frequency-Classified Adverse Reactions

The most frequently reported adverse reactions, classified as Common or Very Common in regulatory documents, include local effects related to the nasal application and some systemic effects:

  • Respiratory, Thoracic, and Mediastinal Disorders: Epistaxis (nosebleeds), Nasal burning, Nasal irritation, and Nasal ulceration.
  • Nervous System Disorders: Headache.
  • Infections and Infestations: Pharyngitis and localized infection of the nose and pharynx with Candida albicans.

Reactions classified as having an Unknown Frequency (typically derived from post-marketing reports) include disturbances of taste and smell, and severe immune system disorders such as hypersensitivity reactions (e.g., Angioedema or Anaphylaxis).

Serious Adverse Reactions and Safety Constraints

The product's safety information includes specific constraints related to its glucocorticoid action. Potential Serious Adverse Reactions or important safety considerations include ocular effects, namely Glaucoma and Cataracts, which are recognized risks of long-term or excessive topical corticosteroid use. Furthermore, the potential for systemic effects like Adrenal Suppression and Hypercorticism is documented, requiring caution, particularly with prolonged use or use exceeding recommended regulatory dosages.

Population and Exposure-Related Safety

Specific Population-Specific Safety Considerations are noted in official labeling. In pediatric patients, there is a documented need to monitor for a potential reduction in growth velocity. For all patients undergoing long-term use, the label requires periodic monitoring for changes in the nasal mucosa (e.g., atrophy) and for the development of ocular conditions. The product should also be used with caution in patients with recent nasal surgery, trauma, or unhealed ulcers due to the inhibitory effect of corticosteroids on wound healing.

Overdose and Emergency Response

Overdose is a serious medical event that requires immediate intervention. Novoefrin is understood to belong to the benzodiazepine class of medications. Overdose of a benzodiazepine alone typically results in central nervous system (CNS) depression, ranging from mild drowsiness to profound lethargy or stupor.

Overdose Presentations

Symptoms of an overdose primarily involve the central nervous system, and can include:

  • Slurred speech and ataxia (lack of voluntary coordination).
  • Confusion and altered mental status.
  • Profound drowsiness or unresponsiveness (coma).

When to Seek Immediate Medical Help

Urgent medical attention is required if you suspect an overdose. Call emergency services immediately if the affected person exhibits any of the following serious symptoms, which may indicate a severe or mixed ingestion:

  • Respiratory depression (slowed, shallow, or stopped breathing).
  • Significant loss of consciousness or inability to awaken the person.
  • Hypotension (severely low blood pressure) or other signs of circulatory compromise.

Overdose risk is significantly increased when this medication is taken in combination with other Central Nervous System depressants, such as alcohol or opioids. Co-ingestion is the primary cause of life-threatening respiratory depression and fatality associated with this class of drugs. Treatment for overdose is primarily supportive, focusing on maintaining an airway, respiration, and hemodynamic support.

Therapeutic Uses of Нозефрин

Quick Facts

  • Relieves: Temporary nasal congestion and stuffiness.
  • Assists with: Symptoms associated with the common cold and allergies.
  • Supports: Addressing sinus pressure.

What Нозефрин treats: main uses and benefits

Нозефрин (Mometasone Furoate) nasal spray is used to manage and help relieve symptoms of certain nasal conditions. The medication works to reduce swelling and irritation in the nasal passages. This may assist in alleviating congestion and stuffiness associated with seasonal and year-round allergies, which can include hay fever. It is also utilized in the management of nasal polyps in adult patients.

Additionally, the medication is applied to address symptoms of inflammation of the lining of the sinuses (sinusitis) in specific instances, often alongside other treatments, to support the patient's condition. The therapeutic goal is to improve the patient's ability to breathe through the nose and to help manage associated discomfort. A healthcare provider can determine if this medication is appropriate for a patient’s specific condition and offer further guidance on its use.

Eligibility and Restrictions for Use

The eligibility for using Нозефрин (mometasone furoate nasal spray) is strictly defined by regulatory documents, focusing on age and specific health conditions. Minimum age varies by indication:

Condition Minimum Eligible Age (FDA/EMA)
Allergic Rhinitis Treatment 2 years (FDA) / 3 years (EMA)
Seasonal Rhinitis Prophylaxis 12 years
Nasal Polyps Treatment 18 years

The medicine is contraindicated for individuals with a known hypersensitivity or allergy to mometasone furoate or its ingredients.

Use is restricted or cautioned in the following situations, as the medicine may impair the body’s ability to fight infection or delay healing:

  • Patients with recent nasal surgery, nasal trauma, or sores in the nose should not use the spray until healing is complete.
  • Use is cautioned, or not recommended, in the presence of untreated localized nasal infections (such as herpes simplex) or systemic infections (including active or quiescent tuberculosis, fungal, bacterial, or viral infections).
  • Use during pregnancy is advised only if the potential benefit justifies the potential risk, as data are limited. For lactating women, a decision must be made to either discontinue breastfeeding or discontinue the therapy, as it is unknown if the drug passes into human milk.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Нозефрин (Mometasone Furoate) nasal spray has officially documented interaction patterns based on its partial metabolism and classification as a corticosteroid. The core interaction concerns involve two distinct mechanisms: pharmacokinetic and pharmacodynamic.


Drug–Drug Interactions and Exposure Increase

The most critical documented pharmacokinetic interaction involves substances that inhibit the enzyme Cytochrome P450 3A4 (CYP3A4). Mometasone Furoate is metabolized, in part, by this enzyme. The co-administration of potent CYP3A4 inhibitors, such as ritonavir or cobicistat-containing products, may significantly increase the plasma concentration and systemic exposure of the medicine. This interaction carries a formal risk of systemic corticosteroid effects, including Hypercorticism and Adrenal Suppression.

Pharmacodynamic and Additive Effects

Co-administration with any other form of corticosteroid (oral, inhaled, or topical) is considered a pharmacodynamic interaction. Regulatory documents note that this combination may lead to an additive steroid effect, increasing the potential for systemic corticosteroid-related outcomes.


Other Interactions and Population Notes

Interaction with alcohol is not generally expected. However, the potential for altered clearance exists in patients with hepatic impairment (liver disease), which may increase systemic effects. No specific mandatory timing separation rules are documented for co-administered medicines.

Mechanism of Action

Нозефрин (containing mometasone furoate) operates as a synthetic glucocorticoid receptor (GR) agonist. Upon topical application to the nasal mucosa, mometasone furoate diffuses across cell membranes and binds to the intracellular GR. This binding induces a conformational change, leading to the dissociation of chaperone proteins, and subsequent nuclear translocation of the receptor-ligand complex. In the nucleus, the complex modulates gene transcription by binding to glucocorticoid response elements (GREs) in the promoter regions of target genes, primarily leading to the transactivation of anti-inflammatory proteins. Concurrently, it engages in transrepression by interfering with pro-inflammatory transcription factors, such as NF-κB and AP-1. These actions result in the suppression of pro-inflammatory mediator synthesis, including certain cytokines (e.g., interleukins) and chemokines, and inhibition of inflammatory cell migration (e.g., eosinophils and mast cells). This molecular cascade ultimately yields a system-level physiological consequence of local vasoconstriction and diminished tissue exudation within the nasal microvasculature.

Dosage and Administration Information

Нозефрин (Mometasone Furoate) nasal spray is a medication used to treat symptoms of allergic rhinitis (such as hay fever) and nasal polyps, and it must be administered intranasally as directed by a healthcare professional.

Preparation and Priming

Before initial use, or if the spray has not been used for 7–14 days, the pump must be primed to ensure an accurate dose. To prime, gently shake the bottle and pump the spray ten times, or until a fine mist appears. If the spray is unused for a week or more, re-prime by actuating it twice or until a fine mist is produced. Do not attempt to unblock the nozzle with a sharp object, as this can damage the dosing mechanism and impair delivery.

Administration

  1. Clear the Nose: Gently blow your nose to clear the nostrils before use.
  2. Insert and Spray: Close one nostril by pressing a finger against the side of your nose. Insert the nozzle tip into the open nostril, tilting your head slightly forward while keeping the bottle upright. Breathe in slowly through your nose while pressing down firmly on the applicator to release one spray. Breathe out through your mouth.
  3. Repeat: If two sprays are prescribed, repeat this process in the same nostril. Repeat the entire process for the other nostril, if directed.

Dosing Schedule

The recommended dosage varies depending on the condition being treated and the patient’s age. For allergic rhinitis, the typical dose for adults and adolescents (12 years and older) is two sprays in each nostril once daily. For children aged 3–11 years, the dose is typically one spray in each nostril once daily. Use the spray regularly, as it may take 12 hours up to two weeks to achieve the full therapeutic benefit. If a dose is missed, take it as soon as you remember, unless it is almost time for the next scheduled dose. Do not use extra sprays to make up for a missed dose.

Recent Clinical Evidence

Research evidence / Overview of Studies for Нозефрин


Evidence for Use in Seasonal and Perennial Allergic Rhinitis

The research for this medicine has focused on conditions characterized by fluctuating or episodic manifestations, such as seasonal and year-round allergic rhinitis. The core of the evidence comes from Randomized Controlled Trials (RCTs) and subsequent Systematic Reviews that synthesize trial data. These studies were applied in research contexts involving fluctuating or unstable symptoms and used in research exploring how outcomes related to physical discomfort are measured over time.

Research examined how the medicine was measured in studies related to seasonal and year-round nasal allergies. Findings describe patterns observed in the studies related to measured symptom outcomes over the study period. Trials also assessed patient-reported outcomes describing perceived discomfort and overall health-related Quality of Life (QoL) metrics.


Evidence for Use in Nasal Polyps

The active ingredient was studied in research exploring outcomes related to nasal polyps, which are non-cancerous growths inside the nasal passages. This research involved Randomized Controlled Trials (RCTs) against an inactive control (placebo) and Meta-analyses that pool the results. These studies explored outcomes reflecting daily functioning or activity level in adults with bilateral nasal polyps.

Researchers primarily examined objective outcomes, such as the Total Polyp Size Scores (a measure of polyp volume), alongside patient-reported outcomes describing perceived discomfort, like nasal obstruction and changes in the sense of smell. Research examined follow-up durations extending into several months to observe outcomes related to polyp size scores.


What is Still Uncertain About Нозефрин

A key research limitation is that the evidence quality varies across studies, and data for certain groups remain insufficient. For instance, research surrounding acute rhinosinusitis includes a focus on how anatomical factors influence drug delivery. Research has explored both short-term symptom changes and extended follow-up durations. Follow-up durations were limited in certain studies, and long-term effects are not fully established across the entire spectrum of conditions. Comparative evidence, or research directly testing this specific formulation against other similar medicines, may sometimes be lacking, and outcomes were observed to vary across some studies, contributing to the overall research context.

Frequently Asked Questions (FAQ)

Common questions about Нозефрин (FAQ)


Q: How quickly can I expect Нозефрин to start working?

Official labeling suggests that relief may be noticed within 12 hours of starting the medicine. However, because this medicine works by reducing inflammation, the full therapeutic benefit is generally achieved only after using it consistently, once a day, for several days or up to two weeks.

Q: Does Нозефрин have a 'rebound effect' like some other nasal sprays?

This medicine is classified as a corticosteroid with an anti-inflammatory mechanism, which is distinct from traditional decongestant sprays. Decongestants are often associated with a 'rebound effect' (where symptoms worsen after stopping use), but this medicine is intended for regular use, as described in product information.

Q: What happens if I use Нозефрин for longer than the package says?

Regulatory documents state that the use of corticosteroids for prolonged periods or in doses exceeding recommendations may increase the potential for systemic corticosteroid effects. These effects include Hypercorticism and Adrenal Suppression, and a potential slowing of the growth rate in children. Patients on long-term use are monitored by a health professional for these concerns.

Q: What is the maximum recommended period for Нозефрин use as described in official documents?

For children aged 2 to 11 years, official labeling states that the medicine should be used for the shortest amount of time necessary to manage symptoms. Use for longer than two months per year suggests that a review with a health professional is warranted, as noted in the product information.

Q: Can Нозефрин cause changes to my sense of smell or taste?

Adverse reaction reports collected after the medicine's initial release (post-marketing experience) have included reports of disturbances to the sense of taste and smell. These effects are generally classified as having an unknown frequency in regulatory documents.

Q: What official information exists about Нозефрин use during pregnancy?

Official information advises that if a person is pregnant, a health professional should be consulted before use. Because regulatory data are limited on its use in pregnant people, a health professional determines whether the potential benefit justifies the potential risks to the fetus.

Q: Is Нозефрин safe to use while breastfeeding is generally described in official sources?

Official guidance states that it is unknown if the drug passes into human milk during breastfeeding. A decision must be made by a health professional regarding discontinuing breastfeeding or discontinuing the therapy, based on the specific circumstances of use.

Q: What are the common misunderstandings about using a steroid nasal spray?

Common misunderstandings may involve the medicine’s nature as a corticosteroid (anti-inflammatory) rather than an immediate decongestant. The product information suggests that this medicine requires regular, consistent daily use to reach its full therapeutic benefit, and that long-term use requires monitoring as described in official warnings.

Q: Can Нозефрин be used at the same time as other inhaled medications?

Official information warns that combining this nasal spray with any other medicine containing a corticosteroid (which can include some inhaled products) may lead to an additive steroid effect, increasing the potential for systemic side effects. No specific mandatory timing separation rules are documented for co-administered non-steroidal medicines.

Q: Is Нозефрин a type of antibiotic?

No, this medicine is classified as a synthetic glucocorticoid (corticosteroid). Its mechanism is to reduce inflammation and suppress the allergic response in the nasal passages; it is not a medicine used to treat bacterial infections.

Q: Is Нозефрин the same as a common decongestant spray?

No, this medicine is a corticosteroid used for anti-inflammatory and anti-allergic effects, which requires regular, consistent use to work fully. Common decongestants are a different class of medicine that provides immediate, temporary relief and are not intended for long-term treatment.

Q: Does Нозефрин help with a runny nose?

Regulatory labeling indicates the medicine is used to relieve symptoms associated with allergic rhinitis, which includes a runny nose (rhinorrhea). Its anti-inflammatory effect helps manage these allergy symptoms.

Q: Can Нозефрин be used for a common cold?

Official product information states that the medicine is indicated for allergic symptoms and nasal polyps, and is not intended for use to treat symptoms such as sneezing, stuffiness, or runny nose that are caused by the common cold.

Q: Is Нозефрин a prescription-only medicine?

The legal status of the medicine can vary by formulation and country. Regulatory information indicates that certain formulations of this medicine are available over-the-counter (OTC) for allergy symptom relief, while other forms, such as those prescribed for nasal polyps, may still require a prescription.

Q: What is the main difference between Нозефрин and other sprays for allergies?

This medicine is classified as a powerful glucocorticoid (corticosteroid). Its core action is to suppress the underlying allergic and inflammatory response at a cellular level, which is a different mechanism than other classes of allergy sprays, such as antihistamines or simple decongestants.

Q: What are the key findings from research on Нозефрин's long-term safety?

Research-related safety warnings for long-term use focus on the potential for systemic exposure effects. These include the potential for Hypercorticism and Adrenal Suppression, as well as the need to monitor children for a potential reduction in growth velocity, as stated in the product labeling.

Q: What does 'systemic absorption' mean in relation to Нозефрин?

Systemic absorption refers to the medicine entering the bloodstream and traveling through the body. This medicine is formulated for topical use in the nose to minimize systemic absorption and to concentrate its anti-inflammatory effects locally within the nasal passages.

Q: Can Нозефрин cause headaches or dizziness?

Regulatory documents list headache as one of the most common adverse reactions reported in studies. While dizziness is not listed among the most common effects, it could potentially be a symptom related to rare serious adverse reactions, such as Adrenal Insufficiency.

Q: Do the official documents mention any effects of Нозефрин on the eyes?

Yes, official labeling includes warnings that long-term or excessive use carries a recognized risk of serious ocular effects. These risks, associated with systemic corticosteroid effects, include the potential for developing Glaucoma or Cataracts.

Q: Is Нозефрин used for prevention or only for treating current symptoms?

According to official regulatory documents, the medicine is indicated for both purposes. It is approved for the prophylaxis (prevention) of nasal symptoms of seasonal allergic rhinitis in certain age groups, as well as for the treatment of established symptoms.

Q: What is the general duration of effect after one use of Нозефрин?

This medicine is intended for continuous, daily treatment. Official product information notes that initial symptom relief may begin within 12 hours, indicating an effect that builds over time with regular administration, rather than providing immediate, single-dose relief.

Q: Why is it important to use Нозефрин regularly instead of just when I feel symptoms?

Official directions indicate that the medicine is intended to be used regularly each day. This is because its anti-inflammatory mechanism takes time, and the full therapeutic benefit may require several days to two weeks of consistent use to achieve.

Q: Are there studies comparing the side effect profile of Нозефрин in adults versus children?

Official documentation highlights specific safety considerations for pediatric patients that differ from adults. These include the documented need to monitor for a potential reduction in growth velocity, which is a unique concern for children using the medicine.

How should Нозефрин be stored and disposed of?

The storage and disposal of Нозефрин (Mometasone Furoate Nasal Spray) must strictly follow official regulatory requirements. The product must be stored at controlled room temperature, typically 20 C to 25 C. It is mandatory to protect the spray from light and moisture, and it must not be frozen. The container should be kept tightly closed and stored out of the reach of children. Regarding stability, the medicine must be discarded 2 months (or 75 days) after first use, or after the maximum number of sprays has been dispensed. Any unused or expired product must be disposed of in accordance with local regulatory requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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