Нафтадерм

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Нафтадерм

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Нафтадерм

Quick Facts

Property Description
Active ingredient Petroleum Naphtalan
Form Ointment (Topical)
Pharmacological class Dermatotropic Agent
General purpose Anti-inflammatory, Skin Regeneration
Origin Natural (Refined heavy crude oil distillate)

What Type of Medicine is Нафтадерм and Where Does it Come From?

Нафтадерм is a non-prescription (OTC) medicinal preparation classified as a dermatotropic agent, indicating its primary therapeutic activity is directed specifically toward the skin. The drug contains a single active component: Petroleum Naphtalan, also known as refined Naftalan oil. As a differentiating factor, this particular preparation is commonly manufactured by the Yaroslavl Pharmaceutical Factory in Russia.

This medicine possesses a natural origin, as its active ingredient is derived from a specialized type of heavy crude oil traditionally sourced from the Naftalan region of Azerbaijan. The pharmaceutical product utilizes a highly refined distillate of the source material. This purification process, necessary for medicinal application, ensures the preparation contains the therapeutically beneficial naphthenic hydrocarbons while eliminating potentially irritating heavy aromatic components.

Composition and Physical Form of Нафтадерм

Нафтадерм is typically formulated as an ointment, making it a viscous, semi-solid preparation intended strictly for topical application onto the skin's surface. The product consists of the active ingredient, Petroleum Naphtalan, suspended within an ointment base that acts as the hydrophobic fatty vehicle. The choice of this dosage form is deliberate, as its consistency ensures sustained contact between the active naphthenic compounds and the skin barrier.

What is the General Therapeutic Purpose of Нафтадерм?

The general purpose of Нафтадерм is to support the recovery of compromised skin structures by stabilizing tissue and mitigating related symptoms. The key physiological actions associated with the Petroleum Naphtalan compound include anti-inflammatory, antipruritic (anti-itching), and keratoplastic (skin-regenerating) effects. The unique structure of the oil's hydrocarbons is responsible for these local biological activities.

By combining the mitigation of inflammation with a reduction in the sensation of persistent itching—a common issue in chronic dermatological conditions—the preparation is generally intended to help interrupt the cycle of irritation and support the natural processes of tissue renewal. This focused action promotes the structural and functional stabilization of the skin barrier.

What side effects are possible with Нафтадерм?

Possible Side Effects and Safety Information

The official safety profile for Нафтадерм (Petroleum Naphtalan Ointment) is characterized by localized reactions at the application site and specific systemic constraints, as documented in national regulatory prescribing information.

Adverse Reaction Scope

The adverse effects are primarily categorized under Skin and Subcutaneous Tissue Disorders. The regulatory label typically lists possible effects without using the standard frequency classifications (e.g., Common, Uncommon) found in EMA or FDA documents.

Officially documented local reactions include:

  • A local burning sensation at the application site.
  • Erythema (skin redness).
  • Xeroderma (dryness of the skin).
  • The potential for local hypersensitivity reactions.

In the event of pronounced local allergic or hypersensitivity reactions, official labeling states that the use of the preparation should be discontinued.


Safety-Related Restrictions and Limitations

The regulatory documentation outlines important restrictions for the use of the ointment, which extend beyond local skin tolerance:

  • Application Integrity: The preparation is strictly contraindicated for application to areas with acute inflammation or to non-intact skin, including open wounds.
  • Systemic Health: Constraints are officially documented for patients with specific, underlying severe health conditions. This includes contraindication for individuals diagnosed with severe renal impairment (such as nephritis or nephrosis) and certain systemic illnesses.
  • Specific Populations: Use during pregnancy and lactation, as well as in infants and young children, is subject to specific regulatory limitations defined in the official prescribing information.

Overdose and Emergency Response

Overdose and when to seek help

The following information on overdose is based on the known properties of the main active component, purified Naftalan oil, as documented in scientific literature and the general regulatory assessment of hydrocarbon exposure.

Overdose Scope

Classification Detail (Based on Hydrocarbon Regulatory Notes)
Documented overdose presentations Primarily symptoms related to accidental ingestion, including gastrointestinal upset (vomiting, diarrhea) and potential systemic effects if large amounts of the unrefined product are absorbed or ingested.
Physiological systems affected Gastrointestinal tract (upon ingestion); Dermatological system (with prolonged, unpurified, high-volume exposure)
Dose-related or exposure-related factors Overdose risk is associated primarily with ingestion or prolonged systemic absorption of large volumes of the substance, particularly the less-refined or native forms of Naftalan oil, which contain a higher percentage of potentially toxic hydrocarbons.
Population-specific overdose notes Specific regulatory notes for vulnerable populations (e.g., pediatric, renal/hepatic impairment) in an overdose scenario are generally not present in the non-systemic product labeling.

Emergency Response

Immediate medical help is required if a significant quantity of the product is accidentally swallowed. In cases of ingestion, symptoms may include severe vomiting, headache, or unusual lethargy. Urgent medical assessment is necessary to determine the nature and extent of the exposure and to initiate supportive measures, especially for products containing polycyclic aromatic hydrocarbons.

Resulting Overdose Structure

  • Overdose Classification: Classified as a localized risk; systemic toxicity primarily linked to ingestion of crude forms.
  • Official Overdose Statements: Emergency action is centered on symptomatic management following accidental ingestion.
  • Connection to the overall overdose profile: The overdose profile for products based on Naftalan oil is defined by the risks associated with hydrocarbon ingestion and not typically by an excessive dermal application of the refined product. Regulatory guidance focuses on treating exposure consequences, not on the product's therapeutic properties.

Therapeutic Uses of Нафтадерм

What Нафтадерм Treats: Main Uses and Benefits

The preparation is commonly used across domains where additional symptomatic support is needed for chronic inflammatory dermatoses, including Psoriasis, Eczema, Neurodermatitis, and certain forms of dermatitis. Such topical therapies may be part of symptomatic management in conditions characterized by periods of heightened symptoms to help with skin patches and ease symptoms related to scaling and itchiness. It is applied in clinical settings that involve acute or unstable symptom patterns, offering support that helps ease the overall symptom load of persistent irritation.

The preparation is relevant for easing the disruptive symptom of pruritus (intense itching), alongside manifestations like localized redness and swelling, which contributes to improved comfort during symptomatic periods. The medication assists with maintaining functional stability.

“The preparation provides support that helps ease the overall symptom burden when symptoms interfere with routine activities, helping patients cope more steadily.”


Quick Fact: Relevant for Easing Pruritus

Regulatory References

  1. NHS guidance on Psoriasis treatment

Eligibility and Restrictions for Use

Who Can and Cannot Use Нафтадерм?

Regulatory documentation for Нафтадерм (Petroleum Naphtalan Ointment) strictly defines which populations are eligible for use and which are excluded. The medicine is contraindicated and must not be used by individuals diagnosed with Renal Insufficiency (kidney failure), Hemorrhagic Syndrome, or Severe Anemia. Use is also prohibited in patients with known hypersensitivity to Naftalan oil or any other component of the ointment.

For several key populations, use is conditionally restricted, meaning application is not permitted without explicit physician guidance. These populations include children, for whom mandatory consultation with a healthcare professional is required prior to use. Similarly, use during pregnancy and lactation (breastfeeding) is only possible upon the prescription of, and consultation with, a physician.

Adults and older adults who do not possess any of the documented contraindications are the standard labeled population eligible to use the medicine. These official criteria establish a clear line between absolute exclusion and conditional use as determined by regulatory labeling.

What should I know about interactions with other medicines?

The interaction profile for Petroleum Naphtalan (Naftaderm) is highly specific, focusing only on local effects given its topical ointment formulation. Regulatory documentation establishes that this medicine is not associated with systemic drug-drug interactions. Co-administration is not documented to affect the clearance or plasma concentration of medicines taken orally or injected, as no interactions involving metabolic pathways (e.g., CYP enzymes) or drug transporters are formally established.


The primary and sole documented interaction pattern is a local pharmacodynamic effect. The official data notes that the preparation increases the permeability of the skin for other medicinal products.

Interaction Type Official Documented Outcome
Systemic PK Interactions Not established / Not documented
Local Pharmacodynamic Effect Increased absorption (exposure) of co-applied topical medicines

This increase in skin permeability results in the enhanced local exposure of any other topical agents applied to the same area. The official regulatory text does not classify any specific drug combinations as contraindicated due to interaction risk, nor does it mandate time-separation rules (e.g., separation by a specific number of hours) for co-administering topical agents. The interaction is limited exclusively to the local effect on dermal absorption and is not associated with any population-specific interaction considerations.

Mechanism of Action

The biological activity of Naftaderm (containing Naftalan oil) involves the modulation of key biological processes within the skin, particularly affecting mechanisms of cellular response regulation.

Modulating Inflammatory Signaling Pathways

This domain describes the interaction of Naftaderm with the cascade of pro-inflammatory mediators and associated signaling, including the modulation of activity and release of specific cytokines. Modification of these molecular steps affects the level of mediator activity, resulting in an alteration of physiological responses in the target tissue, such as vasodilation and tissue fluid retention.

Regulation of Epidermal Cell Proliferation

This mechanism involves the modulation of processes governing keratinocyte kinetics and differentiation. Naftaderm affects the regulation of cell processes associated with growth patterns, altering the skin cell cycle progression. This action is observed in cascades involving altered proliferation, resulting in changes to epidermal tissue morphology.

Local Modulation of Sensory Nerve Activity

This domain involves the localized influence on sensory nerve fibers, affecting the transmission of pruriceptive and nociceptive signals. It acts by modulating signaling within systems associated with pruriceptive and nociceptive transmission. This functional modulation alters the response mediated by excessive nerve activity, impacting the physiological mechanisms of cutaneous sensation.

Dosage and Administration Information

The administration of Нафтадерм (Petroleum Naphtalan Liniment) involves a precise set of instructions focusing on the proper external application of the product. The usage is structured around its formulation as a 10% liniment intended for topical administration.

Administration Scope

Category Instruction
Route of administration: Topical (External use only).
Dosing schedule: Apply a thin layer (тонким слоем) to the affected areas of the skin.
Frequency: Twice daily (2 раза/сут).
Age-group rules: Use in children requires consultation with a doctor.
Procedural condition: Application must be performed without rubbing in (не втирая).

Use Protocol and Duration

The standard protocol for this 10% liniment is based on a twice-daily frequency, applied directly to the site of concern. The preparation is to be spread without friction, which is a key procedural condition for the use of the liniment dosage form. The total duration of the treatment course is generally specified as 3 to 4 weeks, although the final length of the regimen is determined on an individualized basis. This framework defines the overall time-relationship concepts of how the medication is to be used. The rule requiring medical consultation for pediatric use represents the primary population-specific constraint for the preparation.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Нафтадерм


Evidence for Use in Chronic Plaque Psoriasis and Atopic Dermatitis

Research has explored the use of the refined petroleum naphtalan compound in individuals with chronic skin conditions, including plaque psoriasis and atopic dermatitis (eczema). Studies were primarily conducted as small-scale open-label trials or non-comparative observational studies focused on adult patients. Studies monitored physical signs, including erythema (redness), desquamation (scaling), and plaque infiltration (thickness), during defined time intervals, often using the Psoriasis Area Severity Index (PASI) to grade the extent of the condition. Findings describe patterns observed in these studies, where changes in the measured outcomes were documented over the short-term study period.

Research on Other Chronic Dermatoses and Skin Healing

The compound was studied in conditions characterized by fluctuating or episodic manifestations, such as general dermatitis and neurodermatitis. Studies explored the compound’s general properties, which are relevant in research contexts involving fluctuating or unstable symptoms. Evidence derived from observational settings describes measurements related to wound size and the rate of epithelialization (skin healing). Research indicates that data for these specific conditions are largely based on empirical evidence and historical clinical documentation rather than modern, large-scale comparative trials.


Long-Term Follow-up and Durability of Study Findings

Long-term effects are not fully established. The follow-up durations were limited in many of the core studies examining the refined ointment preparation. There is limited information for long-term outcomes regarding the durability of any observed response or the overall maintenance of skin status over periods of many months. The available data primarily describe short-term changes, and comprehensive evidence regarding long-term outcomes is not yet available.

What is Still Uncertain About the Research Evidence

Comparative evidence is lacking, as few published reports utilize large-scale randomized controlled trials (RCTs) to compare the ointment directly against modern standard-of-care topical preparations. The sample sizes were modest in many of the key clinical studies, meaning the results apply only to the populations studied. The overall certainty level remains low for definitive long-term outcomes, due to variations in study methodology and size.

Key Studies & References

  1. Psoriasis: assessment and management | Guidance (NICE guideline CG153)

Frequently Asked Questions (FAQ)

Common questions about Нафтадерм (FAQ)


Q: Is Нафтадерм considered a steroid-free treatment?

The active ingredient in Нафтадерм is Petroleum Naphtalan, which is classified as a dermatotropic agent. Official regulatory documentation identifies the active component as an oil derivative and does not categorize the product as a corticosteroid or contain any steroid components.

Q: Does Нафтадерм help with eczema and neurodermatitis?

Studies and official information indicate that the product has been researched for use in chronic skin conditions, including atopic dermatitis (eczema) and neurodermatitis. Its therapeutic actions include anti-inflammatory and antipruritic (anti-itching) effects. Studies monitored physical signs in individuals with these conditions.

Q: Can Нафтадерм be used for psoriasis on the scalp?

The official instructions specify applying the preparation to the affected skin areas. Use is subject to the general rule that the skin surface must be intact and free of acute inflammation. For specific application sites like the scalp, it is best to consult the prescribing physician.

Q: Can Нафтадерм cause skin dryness or irritation over time?

Yes, regulatory information lists local reactions at the application site. Officially documented adverse effects include Xeroderma (skin dryness), a local burning sensation, and the potential for local hypersensitivity reactions.

Q: Can Нафтадерм be used on sensitive areas of the body, like the face?

Official instructions do not specifically prohibit application to the face. However, it is strictly contraindicated (should not be used) on skin that has acute inflammation or is non-intact. Application to the face or other sensitive areas should be discussed with a healthcare professional.

Q: Are there any known interactions between Нафтадерм and oral antibiotics?

According to the official product information, Нафтадерм is a topical product and is not associated with systemic drug-drug interactions. This means it is not expected to affect the clearance or plasma concentration of medicines taken orally, such as antibiotics.

Q: Can Нафтадерм be used on broken or infected skin?

No, the official safety restrictions strictly contraindicate the preparation’s use on areas with acute inflammation or on non-intact skin, including open wounds. The official label specifies that the preparation must only be applied to intact skin surfaces.

Q: Does Нафтадерм thin the skin like some corticosteroid creams?

The mechanism of action involves the regulation of epidermal cell proliferation (how skin cells grow). Importantly, skin thinning (atrophy) is not listed as an officially documented local or systemic adverse effect in the regulatory safety profile.

Q: Is there a maximum recommended duration for using Нафтадерм?

The standard duration of the treatment course is generally specified as 3 to 4 weeks. However, the final length of the regimen is determined on an individualized basis by a healthcare professional.

Q: Can I apply makeup or sunscreen over an area treated with Нафтадерм?

The official label states the preparation increases the permeability of the skin for other medicinal products applied to the same area. This effect should be considered when applying any other product, including cosmetics or sunscreens, to the treated skin.

Q: What should I do if my skin gets worse after starting to use Нафтадерм?

If you experience a severe reaction, official labeling advises that the use of the preparation should be discontinued. This is specifically noted for pronounced local allergic or hypersensitivity reactions. Any worsening of symptoms should be discussed with a healthcare professional.

Q: Why do some people use Нафтадерм for problems other than eczema or psoriasis?

Beyond the most common indications, the compound has been studied in other contexts, including general dermatitis, neurodermatitis, and for effects related to the rate of epithelialization (skin healing).

Q: Why is Naftalan oil, the active component, used in skin treatment?

The therapeutic use is based on the oil's unique physiological actions. The compound is supported by pharmacological studies to have anti-inflammatory, antipruritic (anti-itching), and keratoplastic (skin-regenerating) effects.

Q: What scientific literature supports the use of Naftalan preparations in dermatology?

Research has included small-scale open-label trials and non-comparative observational studies. These studies tracked outcomes like the Psoriasis Area Severity Index (PASI) to grade the extent of improvement in patients with chronic skin conditions.

Q: Is Нафтадерм available without a prescription in some regions?

Yes, in the region of its primary regulation, the medicine is classified as a non-prescription (OTC) medicinal preparation.

Q: Is the effect of Нафтадерм permanent, or do symptoms return after stopping use?

Official regulatory texts note that long-term effects are not fully established. There is limited information available regarding the durability of any observed response or the overall maintenance of skin status in long-term follow-up.

Q: What kind of skin healing properties does Нафтадерм have?

The preparation is supported to have keratoplastic effects, meaning it helps normalize the renewal of the outer skin layer. Research has also explored the compound's relevance to the rate of epithelialization, or the process of skin healing.

Q: What are the typical expected results when using Нафтадерм for chronic eczema?

Studies monitored specific physical signs of chronic skin conditions. The results focused on changes in signs like erythema (redness), desquamation (scaling), and plaque infiltration (thickness) during the short-term study period.

Q: What patient groups should definitely avoid using Нафтадерм?

The medicine is strictly contraindicated for individuals diagnosed with severe systemic conditions such as Renal Insufficiency (kidney failure), Hemorrhagic Syndrome, Severe Anemia, or those with known hypersensitivity to the ingredients.

Q: Is there a concern about systemic absorption with long-term, large-area application of Нафтадерм?

Regulatory documents establish the medicine is not associated with systemic drug-drug interactions. However, constraints are listed for patients with specific systemic illnesses, such as severe renal impairment. Patients with concerns about large-area use should consult a healthcare professional.

Q: Where is the active ingredient in Нафтадерм sourced from?

The active ingredient, Petroleum Naphtalan, is a refined distillate of a specialized type of heavy crude oil. This source material has traditionally been obtained from the Naftalan region of Azerbaijan.

How should Нафтадерм be stored and disposed of?

How to Store and Dispose of Нафтадерм?

The storage of the topical preparation Нафтадерм is subject to specific regulatory requirements defined in the official labeling to ensure product stability.


Official Storage and Stability Requirements

Requirement Type Official Labeled Condition
Mandatory Temperature Storage is required in a refrigerated environment, specifically between 4 C and 8 C.
Prohibited Condition The medicine must not be allowed to freeze at any time.
Child Safety Keep out of the sight and reach of children is a mandatory rule.
Shelf-Life The preparation has an authorized stability period (shelf-life) of 5 years.

Disposal

The official regulatory documents for Нафтадерм do not contain specific, unique instructions on how to discard unused or expired product. Therefore, disposal should be carried out in accordance with local governing regulations for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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