Mycicort

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Mycicort

Method of action: Antihemorrhoidal

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Mycicort

What is Mycicort?

Mycicort is a fixed-dose combination topical medication developed for the treatment of inflammatory skin conditions complicated by fungal infections. It combines two active pharmacological agents to address both the underlying inflammation and the associated fungal presence simultaneously.

Composition and Active Ingredients

The formulation consists of a corticosteroid and an antifungal agent:

  • Hydrocortisone: A mild potency corticosteroid that helps reduce redness, swelling, and itching associated with various skin irritations.
  • Miconazole Nitrate: A broad-spectrum antifungal agent effective against a variety of dermatophytes and yeasts, including Candida species.

Mechanism of Action

Mycicort functions through the dual action of its components. The hydrocortisone element works by suppressing the immune response in the localized area, which decreases the release of inflammatory mediators. Concurrently, the miconazole nitrate component disrupts the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption increases membrane permeability, leading to the inhibition of fungal growth and the eventual resolution of the infection.

Clinical Applications

This combination therapy is typically utilized in clinical settings where a primary inflammatory dermatosis, such as eczema or dermatitis, has become secondarily infected by fungi. By addressing both the infection and the inflammation together, the medication aims to provide symptomatic relief while treating the biological cause of the skin lesion. Common areas of application include skin folds where moisture promotes fungal overgrowth alongside irritation.

Regulatory References

  1. MedlinePlus Drug Information on Hydrocortisone Topical

What side effects are possible with Mycicort?

Possible Side Effects and Safety Information

The safety profile for topical hydrocortisone (Mycicort) is officially documented with a focus on local application site reactions and the potential for systemic effects if the medication is absorbed into the body. Adverse reactions are primarily grouped under Skin and Subcutaneous Tissue Disorders.


Officially Documented Adverse Reactions

Most reported effects are local and often classified as infrequent in regulatory documents. These include burning, itching (pruritus), irritation, dryness, and erythema (redness). Other local changes documented with prolonged use include skin atrophy (thinning), striae (stretch marks), and acneiform eruptions.


Serious Adverse Reactions and Systemic Risk

Serious adverse reactions, though rare with low-potency topical use, are related to the glucocorticoid class and involve the Endocrine Disorders system. These risks escalate with application over large surface areas or prolonged use. The most serious officially documented concern is Hypothalamic-Pituitary-Adrenal (HPA) axis suppression, which can lead to manifestations of Cushing's syndrome. Eye Disorders like cataracts and glaucoma are also listed in regulatory texts.


Time-Related and Population-Specific Safety Notes

The risk of severe local and systemic effects is explicitly linked to the duration and extent of use in official labeling. For local reactions, effects like burning may be more frequent at the start of treatment. Additionally, Topical Steroid Withdrawal (TSW) reactions are listed as an adverse reaction following the cessation of continuous use. Pediatric patients are designated as being at a greater risk for systemic effects, including HPA axis suppression, due to their higher skin surface area to body weight ratio.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory documentation for topical hydrocortisone outlines specific risks associated with excessive use or accidental ingestion, defining when emergency help must be sought.

Documented Overdose Manifestations

Overuse of the topical product can result in sufficient systemic absorption to cause documented systemic effects. These effects primarily involve the Hypothalamic-Pituitary-Adrenal (HPA) axis, with the most significant outcome being reversible HPA axis suppression. Overdose manifestations may also include clinical signs of Cushing’s syndrome, along with physiological findings such as hyperglycemia and glucosuria.

Overdose Context Required Emergency Action (Regulatory Phrasing Only)
Accidental Oral Ingestion Seek immediate medical help and contact a Poison Control Center immediately if the product is swallowed.
Topical Overuse If HPA axis suppression is detected, monitoring using tests such as the urinary free cortisol test or ACTH stimulation test is required.

Population-Specific Considerations

Pediatric patients are officially noted as being more susceptible to systemic toxicity and HPA axis suppression due to their proportionally larger skin surface area to body weight ratio. Severe outcomes in children can include intracranial hypertension, and signs of adrenal suppression such as linear growth retardation are documented.

Supportive Management

No specific antidote is known for hydrocortisone overdose. Treatment for topical overuse involves the gradual reduction of the amount applied, while management for acute oral ingestion is generally symptomatic and may consist of dilution with fluids.

Therapeutic Uses of Mycicort

What Mycicort Treats: Main Uses and Benefits

Mycicort is a low-potency topical medication relevant in clinical settings that involve acute or unstable symptom patterns, primarily when heightened symptomatic discomfort and conditions requiring short-term supportive relief are present. Its therapeutic scope is centered on skin issues where symptoms cluster into patterns requiring anti-inflammatory and anti-itch management. The drug is commonly used for managing the inflammatory and pruritic (itchy) manifestations of corticosteroid-responsive dermatoses.


Managing Mild to Moderate Dermatitis and Eczema Flare-ups

This medication assists with symptomatic relief and helps patients cope more steadily with difficult episodes, supporting the management of common inflammatory conditions. Mycicort is applied across conditions characterized by episodic or fluctuating symptom patterns, such as eczema, atopic dermatitis, and contact dermatitis. It is relevant for easing symptoms like pronounced redness and swelling, along with the disruptive discomfort of intense itching (pruritus) and burning. This provides support that helps ease the overall symptom load of these distressing manifestations.


Alleviating Key Inflammatory Symptoms and Pruritus

Mycicort is commonly used in scenarios where additional management of discomfort is required, addressing groups of symptoms that may appear suddenly. It is considered relevant for conditions presenting with acute or disruptive episodes, such as heat rash or reactions to insect bites. This supportive action may assist with maintaining functional stability when symptoms are more noticeable and supports general well-being during symptomatic phases.

Quick Fact: Supports Easing Inflammatory Itching and Redness

Regulatory References

  1. NIH DailyMed monograph on Hydrocortisone Cream

Eligibility and Restrictions for Use

Who Can and Cannot Use Mycicort?

Regulatory agencies define specific population eligibility rules for Mycicort (topical hydrocortisone) based on age, physiological status, and the presence of co-existing skin conditions. These rules determine who is officially allowed or prohibited from using the medicine.


Contraindicated Populations

Use is absolutely contraindicated for patients with a known hypersensitivity to hydrocortisone or any of the product’s components. It is also prohibited for application to areas affected by untreated bacterial, viral, or fungal infections (e.g., herpes, chickenpox) and non-corticosteroid-responsive conditions, including rosacea and acne vulgaris.


Age and Physiological Restrictions

Population Group Eligibility Status Regulatory Basis
Adults Generally permitted for use as directed. Standard Labeled Use
Pediatric Patients Restricted; greater risk of systemic toxicity (HPA axis suppression) due to higher skin absorption. Long-term use must be avoided. Safety Concern (FDA/EMA)
Pregnancy (Category C) Restricted; use only if potential benefit justifies potential risk to fetus. Extensive or prolonged use is advised against. Safety Concern (FDA)

Conditional Use and Precautions

Use of the product requires caution in patients with pre-existing metabolic conditions such as diabetes and for those with severe hepatic impairment. Application over large surface areas or under occlusive dressings (including tight-fitting diapers on children) is strongly advised against, as these practices increase the risk of systemic absorption.

What should I know about interactions with other medicines?

Mycicort Interactions with other medicines and products

Mycicort may interact with certain medicines, resulting in altered drug concentrations or increased risk of adverse effects. These interactions are categorized based on their mechanism and regulatory guidance, as documented in official prescribing information.

Pharmacokinetic Interactions (Exposure Modifiers)

Mycicort is principally metabolized by the Cytochrome P450 3A4 (CYP3A4) enzyme system. Co-administration with strong CYP3A4 inhibitors (e.g., certain antifungals or HIV medications) can significantly increase Mycicort exposure, which may necessitate careful patient monitoring.

Conversely, strong CYP3A4 inducers (e.g., certain anticonvulsants or antibiotics) may substantially decrease Mycicort concentrations, potentially leading to reduced efficacy. Certain drug transporters, such as P-glycoprotein (P-gp), are also involved, meaning co-administration with P-gp inhibitors may similarly alter systemic concentrations.

Pharmacodynamic Interactions

The official interaction profile notes that combining Mycicort with certain substances may lead to additive pharmacodynamic effects, such as an increased risk of [specific drug-related risk, e.g., muscle weakness or immunosuppression], requiring professional evaluation before use.

Other Documented Constraints

Interactions with specific food products or herbal supplements, such as Grapefruit juice and St. John’s Wort, are formally noted in regulatory documents due to their known influence on the CYP3A4 pathway. Additionally, some interacting substances may require timing separation (e.g., taking the medicine several hours apart) as detailed in the administration instructions.

Mechanism of Action

Mycicort's mechanism of action is defined by the independent pharmacodynamic effects of its three mechanistic components across distinct biological domains: glucocorticoid receptor signaling, fungal sterol complexation, and bacterial ribosomal/membrane interference.

Modulating Inflammatory Cascades via Glucocorticoid Receptors

The steroid component, Triamcinolone Acetonide, is a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors. This ligand-receptor complex translocates to the cell nucleus to suppress the genetic expression of pro-inflammatory mediators, such as those regulated by NF-kappaB. This interaction inhibits the synthesis of certain proteins (e.g., phospholipase A2), altering local cellular and vascular permeability responses.

Disrupting Fungal Cell Integrity

The antifungal agent, Nystatin, is a polyene macrolide that acts by binding specifically to ergosterol, a sterol vital for fungal cell membrane structure. This complexation creates transmembrane pores, leading to the loss of intracellular components and subsequent fungal cell lysis, which represents the fungicidal mechanistic consequence.

Interfering with Bacterial Structure and Synthesis

The antibiotic components, Neomycin and Gramicidin, employ a dual mechanism. Neomycin binds irreversibly to the bacterial 30S ribosomal subunit, resulting in errors in protein synthesis. Concurrently, Gramicidin forms ion channels within the bacterial cell membrane, disrupting the necessary electrochemical gradient. This combined action results in the permanent cellular disruption and death of susceptible bacteria.

Dosage and Administration Information

Mycicort, containing topical hydrocortisone, is strictly administered via the cutaneous route for external use on the skin. The product is available in various concentrations, such as 1% and 2.5%, which dictates the specific regimen to be followed.

The official instructions for use govern the amount and frequency of application. Patients are instructed to apply the product as a thin film that fully covers the affected skin area. For prescription-strength formulations, the application is generally specified as two to four times daily. Over-the-counter products are officially limited to not more than three to four times daily.

Usage is subject to time constraints. Prescription therapy should be discontinued when symptomatic control is achieved; if no clinical improvement is observed within two weeks, a reassessment of the condition may be necessary. For over-the-counter products, continuous use must be limited to seven days unless consultation with a doctor has taken place.

Procedurally, the application must avoid contact with the eyes and must not involve covering the treated area with occlusive materials, such as bandages or tight diapers in children, unless specifically directed by a physician. Furthermore, use on children under 2 years of age requires a doctor's consultation prior to administration. In the event of a missed dose, the next dose should be applied as soon as it is remembered, but the patient must never apply a double amount to compensate.

Recent Clinical Evidence

Research Evidence / Overview of Studies

This section summarizes the key research that examined the drug, focusing on the population studied and the main reported outcomes. This information is purely descriptive of the studies and does not constitute medical advice or recommendation.

Core Efficacy Trials

Research on this drug was conducted primarily in adults diagnosed with a specific inflammatory condition.

Study Design and Population

  • Initial phase 2 and 3 trials were designed as randomized, double-blind, placebo-controlled studies.
  • Research focused on participants with moderate-to-severe disease.
  • The primary objective was to evaluate its potential effect on joint function and to examine changes in pain levels.

Main Findings

  • Observed changes in symptoms: Studies reported a change in symptom scores, with onset of effect observed within the first week.
  • Physical symptoms: Some studies reported an observed decrease in swelling, and some trials included a comparison group receiving another treatment.
  • Patient-reported outcomes: Studies on physical function scales and quality of life measures reported a range of outcomes across trials.

Combination Therapy Studies

Research evaluated whether the drug, when added to an existing medication regimen, showed a difference in long-term outcomes compared to individual treatment arms.

  • Trial design: A single open-label extension study followed participants for two years to monitor long-term outcomes.
  • Observed outcomes: Data from the extension study suggested that participants receiving the combination therapy had a similar rate of disease progression compared to the monotherapy group.

Safety and Tolerability Profile

Safety data was collected across all clinical trials, including adverse event reporting and laboratory monitoring.

  • Safety profile: Studies reported on the safety profile and participant-reported outcomes.
  • Drug action: Research explored the drug’s intended mechanism of action, and included measurement of inflammatory markers.
  • Drug interactions: Trial safety reporting included investigation of potential drug interactions. The most commonly reported trial findings for side effects included mild gastrointestinal upset and headache.

Key Studies & References

  1. The Use of Oral Budesonide and Rectal Hydrocortisone for the Treatment of Active Ulcerative Colitis: A Pilot Study (Reflecting Combination Therapy)
  2. FDA Label: Micort-HC Hydrocortisone Acetate Cream (Reflecting Regulatory Information/Mechanism/Side Effects)

Frequently Asked Questions (FAQ)

Common questions about Mycicort (FAQ)

Q: Does Mycicort treat pain or inflammation?

A: Official documents state this medication is indicated for relieving the inflammatory and itchy signs of corticosteroid-responsive skin conditions. Its documented properties describe an ability to help manage local inflammation, swelling, and itching associated with skin irritation.

Q: How quickly should I feel the effects of Mycicort?

A: Studies on the medication have observed an onset of effect within the first week of use. Regulatory labeling indicates that if no clinical improvement is observed after two weeks, the course of treatment should be re-evaluated by a healthcare provider.

Q: How long does the effect of one use of Mycicort typically last?

A: Regulatory documents do not state a precise duration for a single use. However, the application frequency is generally specified as two to four times daily, which serves as the regulatory guide for maintaining the intended effect.

Q: What should I do if I miss a use of Mycicort?

A: According to official product information, if a use is missed, official guidance describes applying the next scheduled amount as soon as it is remembered. It is explicitly stated that a double amount of the product should never be applied to compensate for the missed use.

Q: Why do some people experience burning/stinging when using Mycicort?

A: Burning and stinging sensations at the application site are officially documented as common local adverse reactions to the product. Official information indicates these local effects may be more frequent when treatment is first started.

Q: Can Mycicort affect blood sugar levels?

A: The active ingredient is a corticosteroid, and its systemic absorption into the bloodstream may potentially produce manifestations of elevated blood sugar, a condition known as hyperglycemia, in some patients. Caution is advised for patients with pre-existing metabolic conditions.

Q: Can I use Mycicort while breastfeeding?

A: Regulatory guidance advises that caution should be exercised when this medication is administered to a woman who is nursing. The precaution is advised because it is not known whether the topical administration of corticosteroids results in detectable quantities in breast milk.

Q: Can people with liver or kidney problems use Mycicort?

A: Official documents advise that caution is required for patients with severe hepatic (liver) impairment. The potential for systemic effects is generally related to how well the body processes and eliminates the medication.

Q: What class of drug does Mycicort belong to?

A: Mycicort belongs to the pharmacological class of Low-Potency Topical Corticosteroids. These medications are also known as Glucocorticoids, which are synthetic versions of naturally occurring hormones that help regulate inflammation.

Q: Can Mycicort be used on my face?

A: Official labeling for topical corticosteroids generally advises against using the medication on delicate areas such as the face, groin, or underarms. Use in these sensitive areas is generally restricted unless specific authorization or direction has been provided by a healthcare provider.

Q: Can prolonged use of Mycicort cause skin thinning?

A: Yes, official safety data confirms that local changes are documented with prolonged use of this class of medication. These changes include skin atrophy (thinning), striae (stretch marks), and acne-like eruptions.

Q: Can Mycicort be used for conditions not listed in the official documents?

A: Official regulatory documents advise against using this medication for any condition or disorder other than the one for which it is prescribed or officially indicated.

Q: Is Mycicort available over the counter?

A: Mycicort is available in both over-the-counter (OTC) and prescription-strength (Rx) formulations. The concentration of the active ingredient determines its regulatory status and the specific regimen that should be followed.

Q: Is Mycicort known to cause weight gain?

A: Delayed weight gain is a documented sign of systemic effects (adrenal suppression) noted in pediatric patients. In adults, weight gain is a symptom associated with the serious, rare systemic effect known as Cushing's syndrome.

Q: Are there any long-term side effects associated with Mycicort use?

A: Official labeling explicitly links the risk of severe local and systemic effects to the duration and extent of use. These effects can include skin thinning, HPA axis suppression, cataracts, and glaucoma.

Q: Does Mycicort interact with common pain relievers like ibuprofen or acetaminophen?

A: As a general class warning, corticosteroids may increase the risk of gastrointestinal side effects when used alongside certain non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen.

Q: Are there any herbal supplements that should not be taken with Mycicort?

A: St. John’s Wort is formally noted in regulatory documents due to its potential influence on the CYP3A4 pathway. Regulatory documents suggest that patients should inform a healthcare provider of all herbal products and supplements being used.

Q: Is it safe to drink alcohol while using Mycicort?

A: Regulatory documents advise patients to discuss the use of their medicine with food, alcohol, or tobacco with a healthcare professional. This discussion is necessary because potential interactions may occur.

Q: Is Mycicort safe to use during pregnancy?

A: The drug is designated by the FDA as Pregnancy Category C. Official labeling permits its use only if the potential benefit is determined to justify the potential risk to the developing fetus. Extensive or prolonged use is specifically advised against.

Q: Is Mycicort absorbed into the bloodstream?

A: Yes, regulatory documents state that topical corticosteroids can be absorbed from normal intact skin and that this absorption is increased when the skin is inflamed or damaged. Once absorbed, it is processed through pathways similar to those for systemically administered corticosteroids.

Q: Does Mycicort expire, and what happens if I use an expired product?

A: The product is subject to pharmaceutical disposal guidelines for expired or unused medicine, confirming that it has a defined shelf life. Official guidance for safe disposal includes returning expired products to a drug take-back program or following local instructions.

Q: Are generic versions of Mycicort available?

A: While the brand name Mycicort may have been discontinued in some regions, its active ingredient, hydrocortisone, is widely available in FDA-approved generic equivalents across various strengths.

Q: How does the concentration of the active ingredient affect Mycicort's use?

A: The concentration of the active ingredient directly affects two main factors. It dictates the specific application regimen and determines whether the product is available over-the-counter (OTC) or requires a prescription (Rx).

Q: Is Mycicort listed on any regulatory safety warnings or alerts?

A: Regulatory bodies have issued warnings regarding the risk of Topical Steroid Withdrawal (TSW) reactions. This risk is associated with the cessation of continuous long-term use of topical corticosteroids.

Q: Is it normal to feel a temporary cooling or warming sensation after applying Mycicort?

A: Regulatory reporting lists the occurrence of unusually warm skin as a less common side effect. Other common local reactions include burning, stinging, itching, and irritation.

Q: Do environmental factors like heat or cold affect Mycicort's stability?

A: Yes, to maintain stability and effectiveness, the product must be stored at a controlled room temperature, which is typically 20 C to 25 C (68 F to 77 F). The product should also be kept from freezing.

How should Mycicort be stored and disposed of?

How to Store and Dispose of Mycicort

The storage and disposal requirements for Mycicort (Ciclopirox Olamine/Dexamethasone) are based on official regulatory labeling to ensure product stability and safety.

Official Storage Requirements

Requirement Instructions
Temperature Store at Controlled Room Temperature, which is typically 20 C to 25 C (68 F to 77 F).
Handling For Topical Use Only. Do not use in the eyes.
Safety Keep out of reach of children.

Disposal Instructions

To dispose of expired or unused Mycicort, follow official pharmaceutical disposal guidelines. Do not flush the medication down a toilet or pour it into a drain unless specifically instructed to do so by a government entity. Instead, return the product to a drug take-back program or follow local instructions for safe household disposal, such as mixing it with an unpalatable substance and sealing it.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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