Overview of Motilat
Quick Facts
| Property | Description |
|---|---|
| Active ingredient | Domperidone (INN) |
| Form | Film-coated tablets, Oral suspension, Suppositories |
| Pharmacological class | Dopamine Antagonist, Prokinetic Agent |
| Common use | Relief of nausea, vomiting, and feelings of fullness |
| Origin | Synthetic organic compound |
Motilat: Definition and Pharmacological Classification
Motilat is a brand-name medicinal product whose active ingredient is Domperidone, an international non-proprietary name (INN) for a compound classified as a dopamine antagonist and functionally defined as a prokinetic agent. The substance is a synthetic organic compound and is formulated as a single-ingredient product. Domperidone is distinguished by its peripheral action, selectively blocking dopamine receptors primarily outside the central nervous system (CNS) in the chemoreceptor trigger zone and the gastrointestinal tract.
This mechanism is clinically recognized for its targeted effect on the digestive tract, as the substance exhibits minimal penetration of the blood-brain barrier at standard therapeutic concentrations. This peripheral selectivity is a characteristic of its pharmacological profile. Motilat, as a specific brand, is generally available as a prescription or over-the-counter medicine depending on the local regulatory entities, and is focused on symptomatic relief for adults and adolescents.
What Forms of Domperidone Are Available?
The Domperidone base is incorporated into several common dosage forms that allow flexibility in the route of administration. The most frequent pharmaceutical preparations are film-coated tablets and an oral suspension, both intended for oral administration. The composition involves the active drug combined with the necessary pharmaceutical base/vehicle (e.g., solid excipients or an aqueous vehicle) to facilitate stable delivery. The medicine may also exist as rectal suppositories for an alternative administration route. Various forms of domperidone-containing medicines are authorized for the management of the symptoms of nausea and vomiting. The availability of both solid and liquid forms ensures efficient delivery when conditions like acute nausea might impede the oral administration of a tablet.
General Purpose of Motilat as a Prokinetic Agent
The core therapeutic purpose of Motilat is the symptomatic relief of distress linked to disordered gastrointestinal motility, referring to the uncoordinated or slow muscle contractions of the upper digestive system. As a prokinetic agent, its function is to increase the tone and regularity of contractions, thereby promoting improved gastric emptying. This action is used in managing conditions where delayed stomach emptying contributes to discomfort. This generally helps to alleviate symptoms such as persistent nausea, episodes of vomiting, and feelings of abnormal epigastric fullness or abdominal distension after eating.
Regulatory References
