Metradol

Quick links to important sections

Metradol

Selected form

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Metradol

Quick Facts

Property Description
Active Ingredient Ibuprofen
Form Tablets, Capsules, Oral Solution (Oral Route)
Pharmacological Class Non-steroidal Anti-inflammatory Drug (NSAID)
General Purpose Relief from pain, inflammation, and fever
Origin Synthetic (Propionic Acid Derivative)

What Type of Medicine is Metradol and Its Core Ingredient?

The medicine Metradol is a medicinal entity based on the active compound Ibuprofen, which is officially categorized as a Non-steroidal anti-inflammatory drug (NSAID). Ibuprofen is chemically recognized as a Propionic acid derivative, highlighting its synthetic origin and placing it within a class of agents known for mitigating inflammatory processes. The comprehensive review of Ibuprofen confirms its status as a foundational over-the-counter pain and fever medication. This classification inherently assigns the drug its key pharmacological roles: it functions as an analgesic (to relieve pain), an antipyretic (to reduce fever), and an agent to suppress inflammation.

Formulation and General Purpose

The composition of this medicinal entity is designed for systemic absorption, commonly taking the physical dosage form of tablets or capsules for administration via the oral route. While Ibuprofen is widely available as a single-ingredient product, some preparations may utilize a Fixed-dose combination with other compatible analgesic agents. This approach suggests the formulation is engineered to provide enhanced relief when appropriate, a distinction often utilized in professional formulations for acute symptoms. The medicine achieves its purpose by reversibly inhibiting Cyclooxygenase (COX) enzymes, which limits the production of prostaglandins—chemical mediators that signal inflammation and pain. This mechanism is clinically recognized for successfully easing symptoms in scenarios such as managing discomfort following dental procedures.

Regulatory References

  1. MedlinePlus, NIH

What side effects are possible with Metradol?

Possible side effects and safety information

Metradol, as an opioid analgesic, carries a number of documented safety risks, including the potential for addiction, abuse, and misuse, which can lead to overdose and death. The most commonly reported side effects (Very Common or Common) involve the nervous and gastrointestinal systems, such as nausea, dizziness, somnolence (drowsiness), vomiting, constipation, and headache.


Serious and Clinically Significant Adverse Reactions

Regulatory warnings highlight several serious risks. The most critical is life-threatening respiratory depression, particularly during treatment initiation or following a dose increase. Concomitant use with other Central Nervous System (CNS) depressants, including alcohol, significantly increases the risk of profound sedation, respiratory depression, coma, and death.

The drug is also associated with an increased risk of seizures and Serotonin Syndrome, which can be life-threatening, especially when co-administered with other serotonergic medications. Prolonged use can result in physical dependence, tolerance, and neonatal opioid withdrawal syndrome if used during pregnancy.


Population-Specific Safety Considerations

Metradol is contraindicated in children younger than 12 years of age and for post-operative management of pain in children younger than 18 years following tonsillectomy and/or adenoidectomy. Caution is warranted in older adult patients and those with severe renal or hepatic impairment due to altered drug clearance. The drug is subject to safety programs, such as the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) in the United States, to manage the risks of abuse and misuse.

Overdose and Emergency Response

Metradol Overdose and When to Seek Help

An overdose of Metradol (Ibuprofen) requires immediate professional attention. The officially documented overdose profile identifies effects across multiple body systems, distinguishing between common manifestations and severe, life-threatening complications.

Documented Manifestations Severe Outcomes / Risks
Nausea, vomiting, abdominal pain, diarrhea. Acute renal failure, metabolic acidosis.
Drowsiness, dizziness, severe headache, tinnitus. Gastrointestinal bleeding, perforation, shock, coma.

Immediate Action Mandated by Regulators

Seek immediate medical attention or contact a Poison Control Center right away for any suspected overdose. This action is critical when severe symptoms are present, such as signs of internal stomach bleeding (bloody or black stools, vomiting material resembling coffee grounds) or sudden neurological symptoms (seizures, loss of consciousness). Elderly patients are officially noted to be at higher risk for serious gastrointestinal events following exposure.

Management Protocol

No specific antidote is available for Ibuprofen toxicity; therefore, management is symptomatic and supportive. Professional monitoring of vital signs, renal function, and acid-base status is required, and activated charcoal may be administered in specific circumstances.

Therapeutic Uses of Metradol

What Metradol Treats: Main Uses and Benefits

Metradol is commonly used across domains where relevant when supportive symptom management is appropriate for symptoms related to physical discomfort, systemic imbalance, or localized inflammation. Metradol (Ibuprofen) is commonly used to help with minor aches and pains, and to support the management of fever.

Metradol is relevant in conditions presenting with acute or disruptive episodes, including headache, muscular aches, toothache, backache, pain associated with arthritis, and menstrual cramps. It is applied when appropriate for managing symptoms that interfere with daily comfort, and may assist with maintaining functional stability by helping to ease the pain intensity.

The medication is relevant in contexts involving heightened systemic burden, specifically for managing fever and the body aches associated with the common cold. Used in situations involving certain distressing symptoms, this approach generally contributes to easing the overall symptom load during temporary physiological imbalance.


Quick Facts: Supportive Management of Key Symptoms

Symptom Type Example Context Primary Benefit
Pain Musculoskeletal aches, toothache Assists with maintaining comfort
Inflammation Pain associated with arthritis, soft tissue strain Supports easing of swelling/stiffness
Systemic Symptoms Common cold, immunization Contributes to reducing fever load

Eligibility and Restrictions for Use

Metradol (a tramadol/acetaminophen combination product) is an opioid-containing medicine with strict eligibility rules defined in regulatory labeling to prevent life-threatening risks, such as respiratory depression and liver toxicity.

Contraindicated Populations

Use of Metradol is prohibited in patients with a known hypersensitivity to the components, acute intoxication with central nervous system depressants, significant respiratory depression, or acute/severe asthma. It is also contraindicated for patients taking Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing them.

Age and Organ Restrictions

Metradol is contraindicated in children younger than 12 years of age and in children younger than 18 years following tonsillectomy or adenoidectomy. Caution and dose adjustment are required for older adults (over 75 years). Use is not recommended in patients with severe hepatic or renal impairment.

Pregnancy and Lactation Status

Pregnancy: Prolonged use during pregnancy can cause Neonatal Opioid Withdrawal Syndrome in the newborn. Lactation: Use is not recommended due to the risk of serious adverse reactions, including excessive infant sedation and respiratory depression, especially in mothers who are ultra-rapid metabolizers of tramadol.

What should I know about interactions with other medicines?

Official Prohibitions and Timing Rules

Metradol (Ibuprofen) is formally contraindicated for co-administration with other Non-steroidal Anti-inflammatory Drugs (NSAIDs) and high-dose Acetylsalicylic Acid (Aspirin) due to a documented, increased risk of gastrointestinal bleeding and ulceration. Use is also restricted for managing peri-operative pain associated with Coronary Artery Bypass Graft (CABG) surgery. A specific timing rule is noted for low-dose aspirin; separation of dosing is required to minimize the potential for Metradol to competitively inhibit the antiplatelet effect.


Pharmacodynamic and Exposure Interactions

The interaction profile documents that co-administration with Anticoagulants (e.g., Warfarin), Corticosteroids, and Selective Serotonin-Reuptake Inhibitors (SSRIs) is associated with an enhanced bleeding risk. Regulatory information also details Pharmacokinetic alterations for certain drugs. For instance, Metradol reduces the elimination of both Lithium and Methotrexate, which can lead to documented increased plasma concentrations of these co-administered medicines. Metradol may also reduce the efficacy of Antihypertensives (e.g., ACE inhibitors) and Diuretics.


Substance and Population Restrictions

Alcohol consumption is documented to increase the risk of gastrointestinal bleeding. Furthermore, the regulatory profile includes population-specific notes, indicating that elderly patients and those with impaired renal function carry a heightened susceptibility to interaction adverse effects, necessitating caution in combination therapy.

Mechanism of Action

How Metradol Works: The Mechanistic Blueprint

The mechanism of Metradol, driven by Ibuprofen, is centered on its ability to interfere with specific enzyme-mediated signaling pathways, which are responsible for generating chemical signals within the Prostanoid Pathway.


Blocking the Core Prostanoid Synthesis Pathway

This domain covers the drug's initial action: the competitive and reversible inhibition of the Cyclooxygenase ( COX) enzymes ( COX-1 and COX-2). By binding competitively to these primary molecular targets, the drug limits the production of key lipid signaling molecules like Prostaglandin E2 ( PGE2) and Thromboxane A2 ( TXA2). This limitation of mediator synthesis modifies early molecular steps that influence systemic physiological responses.


Modifying Peripheral and Central Signaling

The resulting physiological effect emerges across two distinct systems: Peripherally, the reduced PGE2 limits the sensitization of nociceptors (physiological pain receptors), modifying peripheral nociceptive signaling. Centrally, the inhibition of PGE2 in the hypothalamus prevents the abnormal elevation of the body’s temperature set-point. These actions collectively result in the modification of processes driven by distinct PGE2 signaling patterns across both central and peripheral systems.

Dosage and Administration Information

The official administration guidelines for Metradol (Ibuprofen) are defined by a structured usage protocol that establishes clear limits on the amount, frequency, and duration of intake. This framework ensures standardization across its different approved forms.

Metradol is approved for administration primarily via the Oral Route, encompassing forms such as tablets, capsules, and liquid suspensions. Specialized formulations are also approved for the Intravenous (IV) route, primarily for use within clinical settings. The general principle guiding all administration is the requirement to utilize the lowest effective dose for the shortest duration necessary to achieve the desired outcome.

Administration Detail Official Guideline
Oral Dosing Range 200 mg to 400 mg per dose. The maximum daily dose for self-treatment is typically 1200 mg, whereas prescription regimens for chronic use may be divided up to a maximum total of 3200 mg per 24 hours.
Frequency Pattern Doses must be separated by a minimum of 4 hours, generally administered every 4 to 6 hours as needed. For chronic conditions, the total daily dose is administered in 3 or 4 divided doses to maintain therapeutic effect.
Contextual Intake The medicine may be taken with food or milk if gastrointestinal discomfort is experienced. Liquid suspensions require vigorous shaking before measurement using a calibrated dosing device.
Duration Limit Self-treatment for pain is formally limited to 10 days, and for fever to 3 days, unless otherwise instructed by a healthcare provider.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Clinical Efficacy: Phase II and III Data

Monotherapy Trials

Studies have examined the use of this treatment as a standalone therapy for adults with active rheumatoid arthritis.

  • Phase II Findings: Initial dose-ranging studies explored different dosage levels and their potential effects on disease activity scores (DAS28) over a 12-week period. Findings were mixed, with some doses showing a larger reported difference in outcomes than others.
  • Phase III Trials: Larger trials reported findings that included improvements in mobility and a reduction in swelling over the study period. Trial reports indicated that a percentage of participants achieved a 20% improvement in the American College of Rheumatology (ACR20) response criteria after 24 weeks.
  • Acute Symptom Management: Research also investigated the drug's use during periods of intensified disease activity. In one study, participants reported a reduction in symptoms during acute flares.

Combination Therapy Trials

Research has examined the use of this treatment in combination with a standard disease-modifying anti-rheumatic drug (DMARD). Studies have explored whether the combination therapy is associated with differences in long-term disease management when compared to monotherapy.

  • Key Outcomes: Researchers focused on assessing joint damage progression via X-ray over a two-year period. While some initial data suggested a slower rate of progression in the combination group, long-term evidence remains limited, and further follow-up is ongoing.
  • Comparative Analysis: Notable anti-inflammatory effects were observed across both groups, and this finding was reported in the context of comparing the drug to other treatments.

Safety and Tolerability Profile

Reported Adverse Events

Across all major studies, the most frequently reported adverse events included mild to moderate gastrointestinal issues (nausea, diarrhea) and headaches. These events were typically temporary and led to study withdrawal in a small percentage of participants (less than 5% across Phase III).

Special Populations and Contraindications in Research

In research, individuals with chronic kidney issues were generally excluded from participation in the trials. The impact of the drug on patients with pre-existing cardiovascular conditions was also a specific focus of a post-hoc analysis.

Key Studies & References

  1. ACR Guidelines for the Management of Rheumatoid Arthritis

Frequently Asked Questions (FAQ)

Common questions about Metradol (FAQ)

Q: Can Metradol cause weird dreams or trouble sleeping?

A: Official product information for medications related to Metradol has noted trouble with sleeping (insomnia) and unusual dreams as possible side effects. If these effects are experienced, regulatory guidance suggests consulting a healthcare professional for further evaluation.

Q: How long does Metradol stay in your system after the last dose?

A: The length of time Metradol remains in the system is detailed in the Pharmacokinetics section of official prescribing information. This information documents the drug's half-life, which is a measure of how long it takes the body to reduce the amount of the drug by half.

Q: Are there any foods I should specifically avoid while on Metradol?

A: Regulatory documents do not typically list specific dietary foods to avoid while taking this medication. However, official labels often recommend taking Metradol with food or milk if gastrointestinal discomfort is a concern, to help reduce stomach upset.

Q: What should I do if I miss a dose of Metradol (general instruction, not specific to me)?

A: General guidelines published by regulatory bodies typically outline principles for managing a missed dose, such as taking it as soon as possible unless the next dose is due. Official guidance generally advises against taking two doses at once.

Q: Can you take Metradol if you are allergic to penicillin?

A: Official product labels list contraindications for known hypersensitivity to the components of Metradol itself. While the regulatory text does not usually detail cross-allergies with other medications, reviewing all known allergies with a healthcare provider is a standard step before initiating any new treatment.

Q: What are the most common reasons people have to stop taking Metradol?

A: Clinical trial data summarized in regulatory documents often list the most frequent adverse events that cause study participants to discontinue the medication. These commonly include mild to moderate side effects such as gastrointestinal issues (nausea, diarrhea) and headache.

Q: Can Metradol affect my mood or cause anxiety?

A: Official labels list side effects under the psychiatric and nervous system categories. Effects like nervousness or anxiety are sometimes noted in the safety profiles of similar medications that act on the central nervous system.

Q: What are some natural supplements that might interact with Metradol?

A: Regulatory warnings specifically include known interactions with certain herbal supplements. For example, some official documents caution that co-administration with St. John’s Wort may affect the drug’s metabolism or increase the risk of bleeding.

Q: Can Metradol be crushed or split if it's a tablet?

A: The administration section of the official drug label specifies whether a tablet can be safely altered (crushed, split, or chewed). If the product label does not specifically state that splitting or crushing is permissible, the tablet formulation is designed to be swallowed whole to ensure the medication works as intended.

Q: Why do doctors often tell patients not to share their Metradol?

A: Regulatory bodies strongly emphasize warnings related to the drug's abuse potential and risk of misuse. This guidance is given because sharing medication is unsafe, as the drug may have unintended and dangerous consequences for someone for whom it was not prescribed.

Q: What is the difference between brand-name Metradol and its generic equivalent?

A: According to regulatory standards, generic equivalents contain the same active ingredient as the brand-name product. They are required to meet the exact same government standards for strength, purity, quality, and performance.

Q: Does Metradol have any impact on blood sugar levels?

A: Official labels list changes to laboratory tests and specific adverse events. While uncommon, some regulatory documents note that NSAIDs may potentially lead to changes like hypoglycemia (low blood sugar), which may be a relevant piece of information for individuals with existing conditions like diabetes.

Q: How long is Metradol typically prescribed for? (range of days)

A: Regulatory documents establish the maximum duration for self-treatment, such as up to 10 days for pain or 3 days for fever. Prescribed use for chronic or inflammatory conditions is often monitored over a longer period, with the total duration based on the condition being treated.

Q: Are there different forms of Metradol, like capsules, tablets, or liquid?

A: Yes, official drug labels list all approved dosage forms available for the product. These typically include forms such as tablets, capsules, and oral solutions or suspensions.

Q: Can Metradol be used for prevention (prophylaxis) in certain situations?

A: The official Indications and Usage section defines the exact conditions the drug is approved to treat. Metradol is generally approved for relief from existing symptoms, and is not authorized for preventative use unless explicitly listed on the label.

Q: What kind of studies have been done on the long-term safety of Metradol?

A: Regulatory documents summarize the duration of clinical trials used to support the drug's approval, which may include studies lasting up to six months or two years. Official information also considers data collected from post-marketing surveillance to assess safety over time.

Q: If I get diarrhea while taking Metradol, is that a side effect or something serious?

A: Official product information lists diarrhea as a commonly reported (mild to moderate) adverse event in clinical trials. However, the regulatory text also details warnings about signs of more serious gastrointestinal events (like bleeding or ulceration) that are noted as requiring prompt clinical evaluation.

Q: Does Metradol interact with herbal remedies like St. John's Wort?

A: Regulatory documents often list specific herbal remedies as potential interaction risks. St. John's Wort, for example, is noted because it can affect the way the body processes the medication or increase the risk of bleeding.

Q: Does Metradol interact with Antihypertensives (blood pressure medicine)?

A: Yes, regulatory text warns that NSAIDs like Ibuprofen may reduce the antihypertensive effect of certain blood pressure medications. This includes drugs such as ACE inhibitors and diuretics.

Q: Is it true that you can't drink alcohol at all while taking Metradol?

A: Official regulatory warnings advise patients to avoid or limit alcohol consumption while taking Metradol. This caution is issued because alcohol intake is documented to increase the risk of serious side effects, such as gastrointestinal bleeding.

Q: What are the signs of a serious reaction to Metradol that I should look out for?

A: Regulatory information provides specific warnings about serious events, such as life-threatening respiratory depression or severe allergic reactions. These warnings detail symptoms that official information highlights as concerning and requiring prompt clinical evaluation.

Q: Does Metradol interact with blood thinners like warfarin?

A: Yes, regulatory documents specifically list anticoagulants such as Warfarin as a significant interaction risk. Combining Metradol with these medications is associated with an enhanced risk of bleeding.

Q: What is the research evidence supporting the use of Metradol for gum infections?

A: While the drug is primarily indicated for pain, inflammation, and fever, the official Indications section notes its use in managing discomfort following dental procedures. This indirectly supports its role in reducing symptoms related to dental pain and inflammation.

Q: Why is it important to take Metradol with food or a full glass of water?

A: Official administration guidelines state that taking the medication with food or milk is recommended to prevent stomach upset or lessen the chances of gastrointestinal discomfort. This minimizes the drug's direct irritation to the stomach lining.

How should Metradol be stored and disposed of?

Official Storage and Disposal Requirements

Regulatory documents mandate strict adherence to labeled storage and disposal protocols for Metradol (referring generally to products like methylprednisolone or tramadol).

Storage Conditions:

The medication must be stored at controlled room temperature, typically 20 C to 25 C (68 F to 77 F), away from excess heat and moisture. It is crucial to keep the product from freezing. The container must be kept tightly closed in its original packaging and stored out of the sight and reach of children. Specific preparations, like reconstituted solutions, may have limited in-use stability, often requiring use within 48 hours.

Disposal Rules:

Unused or expired Metradol should ideally be disposed of through a drug take-back program. If a program is unavailable, follow official guidelines for securing the medication (mixing with an unappealing substance like dirt or cat litter) in a sealed bag before placing it in household trash. Strong pain relievers are generally advised against flushing down the toilet unless explicitly directed by official government lists.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Metradol found in:

A-Z Index: