Lomudal

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lomudal

Quick Facts

Property Description
Active ingredient Cromoglicic acid (Cromolyn sodium)
Forms Eye drops, Nasal spray, Inhalation solution
Pharmacological class Mast Cell Stabilizer
Common Use Preventative allergy management
Origin Synthetic (inspired by khellin)

What Type of Medicine is Lomudal?

Lomudal's active ingredient is cromoglicic acid, which belongs to the pharmacological class known as a Mast Cell Stabilizer. This classification identifies the medicine's role as a single-ingredient preventative agent, helping to stabilize the immune cells involved in the allergic response before symptoms begin.

This preventative action is clinically recognized for providing effective support during predictable exposure to allergens. Unlike symptom relievers, Lomudal is used proactively to help minimize the release of inflammatory chemicals, making it a foundational component of ongoing allergy management.


Composition and Forms

Cromoglicic acid is a synthetic compound chemically inspired by the natural substance khellin, which ensures a consistent and high-purity composition. The drug is distinctively formulated for local application, which is its most effective route of administration.

Lomudal is typically offered in three primary forms: ophthalmic solutions (eye drops) for ocular symptoms, nasal sprays for the nasal passages, and solutions for inhalation for the airways. This targeted delivery system is key to its therapeutic success, focusing the protective effect precisely where allergen contact occurs and minimizing the amount of medicine required to circulate systemically.


What is Lomudal's General Purpose?

The primary purpose of Lomudal is to act as a protector against allergic symptoms. It provides continuous defense by stabilizing immune cells. It is generally intended for patients seeking to manage chronic or recurring allergic sensitivities by preventing the inflammatory process rather than treating existing symptoms.

Regulatory References

  1. Cromolyn Sodium Nasal Solution: MedlinePlus Drug Information
  2. Cromolyn Oral Inhalation: MedlinePlus Drug Information

What side effects are possible with Lomudal?

Possible Side Effects and Safety Information

The safety profile for cromoglicic acid (Lomudal) is defined primarily by its function as a locally applied medicine, meaning most reported adverse reactions occur at the application site. Regulatory documents categorize these effects based on frequency to objectively communicate risk.


Adverse Reaction Scope

Classification Examples of Officially Documented Effects
Common Transient stinging or burning sensation in the eye (ophthalmic form); nasal irritation, sneezing, cough, or throat irritation (nasal/inhalation forms). These effects are typically short-lived and occur immediately after use.
Uncommon Systemic effects such as headache and occasional nosebleeds (epistaxis).
Very Rare Serious systemic hypersensitivity reactions, including anaphylaxis and angioedema, which are documented in regulatory labeling but occur with extremely low frequency.

Safety Considerations

The most frequent local adverse effects are described as transient and occur immediately upon local application. The overall risk assessment for the drug's safety profile is therefore concentrated on managing common local discomfort rather than systemic issues.

From a regulatory standpoint, Lomudal is contraindicated in individuals with a known hypersensitivity to the active ingredient, cromoglicic acid, or any of the product's excipients. Due to minimal systemic absorption, official labeling generally does not recommend specific dose adjustments for patients with renal or hepatic impairment when using the localized eye, nasal, or inhalation forms.

Overdose and Emergency Response

Overdose Manifestations and Emergency Action

The official regulatory labeling for Cromoglicic acid (Lomudal) indicates that no specific clinical syndrome is associated with an overdose. This is consistent with acute toxicity testing in a wide variety of species, which has demonstrated an extremely low order of toxicity for the compound. The minimal systemic absorption from locally applied forms, such as eye drops, nasal sprays, and inhalation solutions, minimizes the risk of severe systemic outcomes.

Regulators mandate that in the event of accidental ingestion or suspected overdose, professional assistance must be sought immediately. This action is required regardless of the low systemic toxicity profile. The explicit guidance is to seek professional assistance or contact a Poison Control Center at once.

Overdose Component Regulatory Status
Documented Symptoms No distinct systemic symptoms listed (minimal toxicity)
Antidote Availability No specific antidote is known
Management Approach Symptomatic and supportive treatment is required
Urgent Help Trigger Suspected accidental ingestion/overdose mandates immediate contact with emergency services

Population and Organ Considerations

Official prescribing information notes that Cromoglicic acid is excreted via both biliary and renal routes. Due to this elimination pathway, consideration should be given to patients with impaired renal or hepatic function, as they may be at a theoretical higher risk for systemic accumulation should significant overdose occur.

Therapeutic Uses of Lomudal

What Lomudal Treats: Main Uses and Benefits

Lomudal is intended for the temporary relief of acute ocular symptoms associated with both seasonal and perennial allergic conjunctivitis. It may help manage common issues such as watery, irritated, and red eyes caused by hay fever and various airborne allergens. For those with chronic or persistent ocular allergies, the medication may be incorporated into a long-term treatment plan to manage and reduce the frequency of symptoms, including persistent eye itchiness and inflammation.

This therapeutic support may aid in promoting overall comfort and supports visual function. Lomudal is also used in the specialized management of specific, severe allergic eye conditions, including vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. The overall goal is to enhance the patient's daily quality of life by mitigating bothersome allergic responses.

Quick Fact: Relief for Eye Itchiness

Eligibility and Restrictions for Use

Lomudal's (cromolyn sodium) eligibility profile is strictly defined by official regulatory labeling, which establishes boundaries on who can and cannot use the medicine. The single absolute exclusion is hypersensitivity to cromolyn sodium or any component of the formulation, which is a formal contraindication.

Eligibility is primarily determined by age and specific physiological conditions. The medicine is generally established for adults and pediatric patients 2 years of age and over. Use is officially not established for most formulations in children below 2 years of age. For older adults, cautious dose selection is advised due to the frequency of decreased organ function.

Eligibility Status Specific Population Restriction
Contraindicated Hypersensitivity to cromolyn sodium or excipients
Conditional Use Impaired renal or hepatic function
Conditional Use Pregnancy (Category B) and Lactation

Populations with impaired renal or hepatic function require caution, and a dose decrease may be considered due to the drug’s dual excretion routes. Furthermore, use during pregnancy (Category B) is permitted only if clearly needed due to limited human data, and caution is advised in nursing mothers as excretion into human milk is unknown. The inhalation formulation is also restricted from use in the treatment of status asthmaticus.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents consistently confirm that the interaction profile for locally administered Lomudal (Cromoglicic acid, specifically ophthalmic, nasal, and inhaled forms) is characterized by a minimal potential for systemic drug-drug interactions.

Systemic and Metabolic Interaction Profile

Due to the medicine's limited absorption into the bloodstream, major regulatory labels report a general absence of clinically significant systemic interactions. This includes no officially documented role as a substrate, inhibitor, or inducer of Cytochrome P450 (CYP) enzymes or drug transporters at relevant plasma concentrations. Consequently, the topical and inhaled forms have no documented restrictions concerning co-administration with food, alcohol, or herbal products.

Documented Specific Interactions

The documented interactions are limited to specific local or procedural contexts:

  • Methacholine: Co-administration may decrease the effectiveness of Methacholine when used as a diagnostic agent in bronchial challenge testing, which is a pharmacodynamic interaction.
  • Oxymetazoline: Co-administration of the nasal form of Lomudal with Oxymetazoline (a nasal decongestant) may officially result in decreased absorption of the Cromoglicic acid component, a pharmacokinetic interaction.

Population-Specific Notes

Official labeling advises that due to the drug’s excretion via both renal and biliary routes, caution may be necessary in patients with impaired renal or hepatic function for considerations related to clearance, although this is not listed as an interaction with another substance.

Mechanism of Action

Lomudal (cromolyn sodium) functions as a mast cell stabilizer, modulating the allergic cascade by inhibiting the cellular processes that lead to mediator release. Its mechanism is primarily prophylactic and local, acting directly on the primary effector cells within mucosal tissues.

This action involves direct interaction with the mast cell membrane, preventing the structural changes required for the cell to undergo degranulation upon activation. This stabilization is achieved by specifically interfering with the molecular signal essential for this process: the influx of calcium ions (Ca^2+).

Blocking this influx breaks a crucial step in the cell's signaling sequence, resulting in the suppressed release of preformed and newly synthesized inflammatory mediators, including histamine and leukotrienes. This key pathway effect results in an adjustment of local microvascular permeability and smooth muscle tone in the targeted tissue.

Dosage and Administration Information

Lomudal (cromoglicic acid) is a prophylactic agent used via several routes. The efficacy of the medicine depends upon its administration at regular intervals throughout the required treatment period.


Official Administration Guidelines

Administration Route Standard Adult Dosing (Starting) Frequency and Timing
Ophthalmic (Eye Drops) 1 to 2 drops per eye 4 to 6 times a day at regular intervals
Intranasal (Nasal Spray) 1 spray into each nostril 3 to 6 times a day
Inhalation (Nebulizer) 20 mg (1 ampule) per dose 4 times a day (QID) at regular intervals
Oral Concentrate (Solution) 200 mg (2 ampules) per dose 4 times a day (QID)

Procedural and Age-Specific Instructions

  • Oral Dosing Preparation: The oral concentrate must be diluted in a glass of plain water and consumed immediately; it must not be mixed with juice, milk, or food. Oral doses are scheduled to be taken 30 minutes before meals and at bedtime.
  • Prophylactic Timing: For preventative use against acute triggers like exercise or environmental exposure, the dose must be administered shortly before exposure, typically within 10 to 60 minutes.
  • Pediatric Rules: The adult dose for ophthalmic administration is approved for children 4 years and older, and for nasal spray 2 years and older. The oral concentrate starting dose for children 2–12 years is 100 mg (1 ampule) four times daily.
  • Missed Dose: If a dose is missed, patients should resume the regular dosing schedule and not take a double dose to compensate. Continuous use is essential to maintain the protective effect.
  • Administration Constraints: Due to the risk of contamination, the tips of the ophthalmic dropper and nasal spray should not touch any surface during application.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Lomudal (Cromoglicic Acid Ophthalmic Solution)

This section provides context on the available clinical research for cromoglicic acid, including the types of studies conducted and what outcomes were monitored, without making any recommendations for use or personal clinical claims. Findings described here reflect group patterns in specific research settings and do not predict individual responses.


Evidence for Use in Seasonal and Perennial Allergic Conjunctivitis

Research for allergic conjunctivitis—conditions characterized by fluctuating or episodic manifestations of eye allergy symptoms—has primarily relied on short-term Randomized Controlled Trials (RCTs) and systematic reviews that combine data from numerous clinical studies. This research was used in trials assessing short-term or episodic symptom patterns.

The studies monitored a range of outcomes, including patient-reported outcomes describing perceived discomfort (such as ocular itching, tearing, and foreign body sensation) and physician-assessed outcomes linked to inflammatory or irritative states (like conjunctival redness and swelling). Research examines symptom changes over periods generally lasting up to four to six weeks during allergy seasons.

Findings describe patterns observed in the studies where changes in measured symptom scores were reported compared to a placebo. In some comparisons against other similar anti-allergic eye drops, research did not consistently describe a difference between active preparations for symptom control.

Evidence for Use in Severe Allergic Ocular Conditions

The evidence base for more chronic and severe conditions, such as vernal keratoconjunctivitis (VKC), was examined in randomized, double-masked, placebo-controlled multicenter studies. These conditions are associated with acute or disruptive episodes and are marked by functional limitations.

Research examined outcomes related to physical discomfort and objectively monitored physical signs of the disease, like the presence and severity of limbal and corneal inflammation. The research examined observed changes in the study participants and observed responses over defined time intervals, with follow-up durations often around six weeks.

Some studies reported patterns showing differences in overall assessments compared to placebo.


Long-Term Studies and Maintenance Follow-Up

Research describes its use in observational settings evaluating daily-life functioning over extended periods. These studies contribute to the broader evidence landscape but do not substitute for long-term placebo-controlled trials.

The follow-up durations for many primary controlled trials were limited, meaning there is limited information on outcomes tracked over many consecutive seasons. Long-term effects are not fully established, and evidence is limited regarding the use of the medicine for maintenance over multiple years.

Evidence in Children and Adolescents

Cromoglicic acid was studied for its use in children and adolescents, with research generally including those aged 4 years and older. Research examined observed changes and applied to study populations that included children with both common seasonal allergic conjunctivitis and the more severe conditions like VKC.

Findings describe group patterns related to symptom changes observed in these younger populations.


What is Still Uncertain About the Research

Evidence highlights what is known—and what is still uncertain—about this medicine. Study results reflect the specific conditions under which they were conducted and do not determine whether an individual will respond similarly.

  • Comparative evidence is lacking: Comparative evidence is lacking against all currently available, newer topical anti-allergic medications.
  • Sample sizes were modest: Many initial trials for allergic eye conditions involved sample sizes that were modest, and evidence quality varies across studies, which can influence the certainty of findings.
  • Uncertainty remains: Data are still emerging for some areas, particularly concerning the full pattern of long-term effects beyond the typical short-term study periods. Research has generally measured acute, episodic changes.

Frequently Asked Questions (FAQ)

Common questions about Lomudal (FAQ)

Q: How quickly can I expect Lomudal to start having an effect?

Studies and official product information indicate that while some symptom relief may be noticed within a few days of starting treatment, the full protective benefits may take longer. Regulatory data indicates that the full protective benefits may require up to six weeks of regular use to be established. This lag is a known expectation for preventative medicines.


Q: Why do some people say Lomudal takes a long time to show results?

Official documents describe Lomudal as a prophylactic or preventative agent, meaning its function is to protect cells from a reaction before symptoms begin. Since it does not act as an immediate reliever, continuous, regular use is required to build up the necessary cellular protection over several weeks. Therefore, the full results are not immediate.


Q: Are the side effects of Lomudal usually mild?

According to the official product information, the most frequent adverse reactions are transient local effects that occur at the site of application, such as stinging or irritation. These effects are generally short-lived and are not considered systemic or serious. The regulatory risk assessment focuses primarily on managing this common, local discomfort.


Q: Is Lomudal considered a long-term treatment option?

Treatment with this medicine is often continued for the duration of exposure to the triggering allergen, such as during an entire allergy season. Official documentation suggests that the determination for long-term use, especially across multiple seasons, should be made with the guidance of a qualified healthcare professional.


Q: Is it okay to stop using Lomudal suddenly?

Regulatory documents state that continuous use is essential to maintain the medicine's protective effect. Lomudal is designed to be a preventative medicine used at regular intervals. If use is stopped suddenly, the prophylactic protection will likely be lost.


Q: What is the purpose of the medicine's container or device?

The design of the special container, such as the nasal spray or eye drop device, is primarily to ensure the accurate, measured dose is delivered to the correct area. Official instructions define the proper application method, which typically includes precautions to prevent the device tip from touching any surfaces.


Q: Why is Lomudal not suitable for treating a sudden, severe issue?

Official indications state that Lomudal is strictly a prophylactic agent, meaning it is designed to prevent symptoms from starting. It works by stabilizing cells before a reaction occurs. Therefore, it is not indicated or effective for use as a rescue treatment for acute allergic attacks or other sudden, severe established conditions.


Q: What is the single most common side effect?

Official adverse reaction reports indicate that the most frequently reported side effect for the ophthalmic (eye drop) solution is a transient burning or stinging sensation in the eye upon application. Other common local effects may also occur depending on the formulation used.


Q: Is Lomudal available over the counter or do I need a prescription?

The classification varies by form and location, according to official regulatory information. The nasal spray form is commonly available as an over-the-counter (OTC) product in some regions. However, other forms, such as the ophthalmic or inhalation solutions, typically require a prescription.


Q: Can Lomudal cause drowsiness or affect my ability to drive?

Regulatory documents indicate that drowsiness (somnolence) and headache are listed as possible side effects, though they are generally reported as uncommon. Since cognitive impairment is a possible, though infrequent, effect, individuals should be aware of how they react to the medicine.


Q: Is a metallic taste in the mouth a common side effect of Lomudal?

Official adverse reaction reports mention that taste perversion, which can include a metallic taste, has been reported in a small percentage of patients using certain forms of the medicine. However, this is not listed as a common side effect in the primary regulatory documentation.


Q: What is the non-active ingredients list for Lomudal?

The full list of non-active ingredients, or excipients, is found on the official product label for each formulation. These typically include ingredients like edetate disodium and Water for Injection. The ophthalmic solution also commonly contains a preservative, such as benzalkonium chloride.


Q: Can I use Lomudal with contact lenses?

According to the official product information for the ophthalmic solution, patients are generally advised not to wear soft contact lenses during the course of treatment. This caution is due to the potential for the product’s preservative, like benzalkonium chloride, to be absorbed by the lenses.


Q: Is it common to have blurry vision when first starting Lomudal?

Studies and official information indicate that blurred vision has been reported in less than 5% of patients using the ophthalmic (eye drop) solution in clinical trials. It is not considered a common side effect.


Q: Does Lomudal contain alcohol or preservatives?

The ophthalmic solution contains a preservative, commonly benzalkonium chloride. In contrast, the official regulatory label for the oral solution specifies that it must be mixed with plain water for administration and does not mention alcohol content.


Q: Can Lomudal be used in conjunction with antihistamines?

Official documents state that the nasal solution may be used in conjunction with an antihistamine, particularly when treatment is first initiated. The decision to combine medications is typically made with the guidance of a healthcare provider.


Q: Is there a generic version of Lomudal available?

Yes, generic versions of the active ingredient, which is cromolyn sodium (or cromoglicic acid), are widely available. These generic alternatives exist for various formulations, including the ophthalmic solution and the nasal spray.

How should Lomudal be stored and disposed of?

How to Store and Dispose of Lomudal?

The storage and handling requirements for Lomudal (cromolyn sodium) are officially defined in regulatory labeling to ensure product stability.

Required Storage Conditions

Condition Requirement Formulation Context
Temperature Controlled Room Temperature (20 C to 25 C) or below 30 C Most Solutions and Concentrates
Protection Must be protected from light and must not be frozen All Liquid Forms
Container Store in the original container and keep tightly closed Ophthalmic and Nasal Solutions

Stability and Disposal Rules

All forms must be kept out of the sight and reach of children. Solutions must be inspected for discoloration or precipitate and discarded after the prescribed treatment period, if applicable. Unused or expired medicine must be disposed of according to local regulations and not via wastewater or general household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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