Ketanor

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ketanor

Property Description
Active Ingredient Ketorolac Tromethamine
Form Tablet, Injectable Solution, Ophthalmic Solution, Nasal Spray
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common Use Management of Moderately Severe Acute Pain
Origin Synthetic

The medicinal entity commonly known by the trade name Ketanor is a pharmaceutical preparation containing the synthetic active ingredient Ketorolac Tromethamine. It is classified as a potent, non-narcotic analgesic used for the short-term management of acute pain.


What Type of Medicine Is Ketanor?

Ketanor belongs to the Nonsteroidal Anti-inflammatory Drug (NSAID) class of medications, which are clinically recognized for their combined ability to relieve pain and reduce inflammation. As a derivative of pyrrolizine carboxylic acid, Ketorolac Tromethamine is a purely synthetic compound, chemically distinct from opioid narcotics. Ketorolac is primarily utilized for its pain-relieving effects and belongs to the therapeutic class of anti-inflammatory agents. Its classification as a potent NSAID sets it apart from milder, over-the-counter NSAID options, positioning it for use in acute pain scenarios where high efficacy is required, such as post-operative discomfort.


Composition and Available Forms of Ketorolac

The therapeutic action of the drug is based on a single-active-ingredient product containing Ketorolac Tromethamine. Due to its versatility in pain management, Ketorolac is available across various routes of administration. These preparations include the oral tablet for systemic administration, a sterile injectable solution for intramuscular or intravenous use, and specialized topical formulations such as the nasal spray and ophthalmic solution (eye drops), enabling localized therapeutic action depending on the clinical need. The various presentations of Ketorolac allow for its use in both systemic and localized pain and inflammation, a key differentiator from many standard oral-only NSAIDs.


How Does Ketorolac Work at a High Level?

Ketorolac works by inhibiting the biochemical process that causes pain and inflammation in the body. Its fundamental mechanism is the inhibition of prostaglandin synthesis, which it achieves by blocking the necessary Cyclooxygenase (COX) enzymes. By preventing the production of prostaglandins—the key chemical mediators of pain and inflammation—the medicine exerts a strong analgesic activity alongside significant anti-inflammatory properties. This dual action ensures that its general therapeutic purpose is the relief of moderately severe acute pain, accompanied by the reduction of swelling and fever.

What side effects are possible with Ketanor?

Ketorolac (the active ingredient in Ketanor) is a potent nonsteroidal anti-inflammatory drug (NSAID) with risks primarily related to cardiovascular, gastrointestinal, and renal systems. Due to the risk of serious, potentially fatal adverse events, use is limited by regulatory bodies to a maximum combined duration of five days.

Serious and Clinically Significant Risks

Official documents highlight the following as major, life-threatening risks:

  • Gastrointestinal (GI) Events: Risk of serious GI bleeding, ulceration, and perforation of the stomach or intestines, which may occur without warning symptoms. The risk increases with higher doses and longer duration of use.
  • Cardiovascular (CV) Thrombotic Events: Increased risk of serious CV events, including myocardial infarction (heart attack) and stroke. This risk may increase with the duration of use and is a contraindication in the setting of coronary artery bypass graft (CABG) surgery.
  • Hemorrhage: The drug inhibits platelet function, increasing the risk of bleeding. It is contraindicated in patients with a suspected or confirmed cerebrovascular hemorrhage or other conditions involving high bleeding risk.
  • Acute Renal Failure: May cause kidney damage or failure; it is contraindicated in patients with advanced renal impairment.
  • Hypersensitivity: Anaphylactic and other severe hypersensitivity reactions may occur, even without prior exposure.

Common Adverse Reactions

The most frequently reported adverse reactions, occurring in 1% to 10% of patients, often involve the gastrointestinal system or the central nervous system. These include headache, dizziness, drowsiness, nausea, abdominal pain, indigestion (dyspepsia), and fluid retention (edema).

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes a Ketanor (Ketorolac Tromethamine) overdose as requiring immediate medical attention. Treatment is universally defined as symptomatic and supportive, as there is no specific antidote documented in official labeling.

Documented Overdose Manifestations

Symptoms following acute overdose are typically reversible but can include:

  • Gastrointestinal: Nausea, vomiting, epigastric pain, abdominal pain, and potential gastrointestinal bleeding (e.g., peptic ulcers).
  • Systemic: Lethargy, drowsiness, and hyperventilation.

Serious Outcomes and Emergency Action

While uncommon, severe systemic outcomes are officially documented and include acute renal failure, coma, respiratory depression, and hypertension. Immediate medical help must be sought upon suspicion of an overdose to manage these risks.

Supportive Management Protocols

Official guidance for managing a large oral overdose seen within four hours may involve the use of activated charcoal and an osmotic cathartic. It is explicitly noted in official regulatory sources that procedures such as forced diuresis, hemodialysis, or hemoperfusion are generally not useful due to the drug's properties. Elderly patients and those with existing renal issues are noted to be generally more vulnerable to serious NSAID-related events.

Therapeutic Uses of Ketanor

What Ketanor Treats: Main Uses and Benefits

The medicine is commonly used for managing symptoms related to physical discomfort characterized by acute or episodic changes. This short-term symptomatic support is relevant in contexts involving heightened systemic burden, where symptoms relate to both physical discomfort and inflammatory states.

The medicine is applicable within clinical settings that involve acute or disruptive symptom patterns. These episodes may include symptoms related to physical discomfort, inflammatory or irritative states, and temporary functional strain. The medication supports the patient during difficult episodes by easing distress and may assist with maintaining a sense of stability when symptoms are more noticeable.

In its specialized form, the medication is applied across domains where additional symptomatic support is needed for localized, irritative states in the eye. It assists with managing post-procedural symptoms or is applied in addressing symptoms related to inflammatory or irritative states, thereby contributing to improved day-to-day comfort during symptomatic periods.


Quick Fact: Symptomatic Support Focus Ketanor is relevant when supportive symptom management is appropriate for symptoms that create noticeable physiological strain and is considered relevant during phases when symptoms related to inflammatory or irritative states become more noticeable.

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

The eligibility for Ketorolac Tromethamine (Ketanor) is strictly defined by regulatory authorities, restricting its use to certain populations and clinical conditions.

Populations for Whom Use is Contraindicated

The medicine is absolutely prohibited for the following populations, as stated in official labeling:

  • Patients with active peptic ulcer disease, recent Gastrointestinal (GI) bleeding or perforation, or a history of either (Source 1.1).
  • Individuals with a known hypersensitivity or allergic manifestations (e.g., asthma, urticaria) to aspirin or other NSAIDs (Source 1.1).
  • Patients with advanced renal impairment or those at risk for kidney failure due to volume depletion (Source 1.1).
  • Those at high risk of bleeding (e.g., suspected cerebrovascular bleeding, hemorrhagic diathesis) or receiving anticoagulant therapy (Source 1.1).
  • Use for peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (Source 1.1).
  • Use during pregnancy (especially from the 20th week gestation onward) and lactation (Source 2.1).
  • Patients currently taking aspirin or other NSAIDs due to increased cumulative risk (Source 1.2).

Age-Related and Conditional Restrictions

Category Official Regulatory Statement
Age Restriction Systemic use is not established in patients younger than 17 years and is generally not indicated for pediatric patients (Source 1.5).
Older Adults Patients 65 years of age and older and those weighing less than 50 kg are designated special populations and require the use of a reduced maximum daily dose (Source 1.1).
Duration The total combined duration of use (any route) must not exceed 5 days in adults (Source 1.1).

What should I know about interactions with other medicines?

Ketanor Interactions with other medicines and products

Official regulatory information for Ketorolac Tromethamine emphasizes interactions that affect bleeding risk, renal function, and drug clearance.

Contraindicated Combinations

Co-administration is strictly prohibited with several substances due to heightened risks of hemorrhage or toxicity. Contraindicated medicines include Warfarin and other Anticoagulants, Probenecid, Lithium salts, and Oxpentifylline (Pentoxifylline). Ketorolac must also not be co-administered with Aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs).

Clinically Significant Interactions

Interaction Domain Official Regulatory Statement
Bleeding Risk Concomitant use with Selective Serotonin-Reuptake Inhibitors (SSRIs), Anti-platelet agents, or Oral Corticosteroids increases the risk of gastrointestinal bleeding or ulceration.
Renal Function May reduce the natriuretic effect of Diuretics (e.g., Furosemide) and increases the risk of renal adverse effects when used with ACE Inhibitors or ARBs.
Drug Exposure May enhance the toxicity of Methotrexate by reducing its renal clearance. Salicylate may reduce Ketorolac protein binding, potentially increasing the unbound fraction.

Administration and Substance Restrictions

The injectable solution is physically incompatible with specific injection solutions, such as Morphine Sulfate, in a syringe due to precipitation. Regulatory documents note that the consumption of alcohol increases the risk of stomach bleeding. Ketorolac's plasma concentration is not affected by antacids, but a high-fat meal delays the time to maximum concentration.

Mechanism of Action

Inhibition of Prostaglandin Synthesis

The drug's action begins at the molecular level by functioning as a non-selective inhibitor of the Cyclooxygenase ( COX-1 and COX-2) enzymes. This inhibition blocks the conversion of Arachidonic Acid into Prostaglandins, which are key chemical mediators. By suppressing the synthesis of these mediators, Ketorolac initiates a sequence that decreases chemical sensitization and modulates prostaglandin-driven inflammation at the tissue level.


Modulating Nociceptive Signaling and Thermoregulation

The consequence of Prostaglandin suppression extends to two key physiological systems: pain signaling and thermoregulation. Ketorolac's mechanism dampens the chemical sensitization of peripheral nerve endings, contributing to the suppression of nociceptive signaling. Concurrently, its action in the brain's hypothalamus interrupts the Prostaglandin signal responsible for resetting the body's internal thermostat, resulting in the adjustment of the hypothalamic thermal set point.


Constraints of Non-Selective Action

Ketorolac engages mechanisms that regulate overactive processes; however, its non-selective nature means it also modulates pathways linked to constitutive, homeostatic functions mediated by COX-1. This constraint limits the mechanism to conditions primarily driven by Prostaglandins and renders the mechanism functionally irrelevant for signaling cascades not mediated by Prostanoids (e.g., certain neuropathic signals).

Dosage and Administration Information

The administration of Ketorolac Tromethamine, commonly known as Ketanor, is governed by the specific route, dose ranges, and total time frame of therapy. Systemic administration is utilized via Intravenous (IV), Intramuscular (IM) injection, and Oral tablet forms, while dedicated formulations are also available for intranasal and ophthalmic use.

The central usage principle is defined by its duration: the total combined use of all systemic forms (IV, IM, and Oral) is explicitly limited to five days in adults. The oral tablet is used as a continuation therapy following the injectable route and must not be used as an initial dose.

Standard dosing for non-elderly patients (≥50 kg) is typically 30 mg IV or IM every six hours (maximum 120 mg/day), transitioning to 10 mg oral tablets every four to six hours (maximum 40 mg/day). Prescribing guidelines may specify that continuous multiple daily doses of the injectable form should not exceed two days.

Specific dose adjustments are required for certain populations. Patients who are ≥65 years of age, under 50 kg body weight, or with moderately elevated serum creatinine are given a reduced parenteral dose of 15 mg every six hours, with the maximum daily injectable dose lowered to 60 mg. Procedurally, an IV bolus must be administered over no less than 15 seconds.

This structured approach to dosing and duration ensures the medicine is used according to established, time-limited protocols.

Recent Clinical Evidence

Research evidence / Overview of studies for Ketanor

Evidence for Systemic Use in Moderately Severe Acute Pain

The research base for the systemic forms of Ketorolac (tablets and injection) consists primarily of short-term Randomized Controlled Trials (RCTs) and meta-analyses that explored its role in the short-term management of acute, moderately severe pain. These studies were used in research exploring how outcomes related to physical discomfort change over time, often following operative procedures. Outcomes monitored included changes in pain intensity scores and the total level of symptom change reported by patients over a defined period. Research also tracked whether the use of Ketorolac was associated with a reduction in the need for supplemental opioid medications, known as the opioid-sparing effect.

Research so far indicates that results apply only to the populations studied and that follow-up durations were limited. Evidence is primarily derived from settings with varying symptom burdens over a strict period. In regulatory research, data show patterns related to use restricted to a maximum of five days for all forms combined. There is limited information for long-term outcomes related to chronic pain, as the medicine was evaluated exclusively for short-term acute management.


Evidence for Localized Ophthalmic Use

Research on Post-Procedure Eye Inflammation and Pain

The research supporting the ophthalmic solution focuses on its application following procedures like cataract extraction. The evidence is based on short-term, placebo-controlled RCTs that included Adults and children 2 years. Studies monitored objective measures of ocular inflammation and patient-reported outcomes describing perceived discomfort or eye pain. Findings describe patterns observed in the studies regarding the temporary management of symptoms in the eye following the procedure.

Research on Seasonal Allergic Ocular Itching

This application was also evaluated in RCTs and comparative studies. Research explored short-term symptom changes, focusing on the temporary reporting of intense ocular itching by patients. The evidence is focused purely on symptomatic relief during periods of heightened symptom activity, and comparative evidence is lacking regarding its potential to change the underlying allergic immune response itself.


Areas of Research Uncertainty and Study Limitations

The evidence is limited to the short-term management of acute pain; the outcomes of use for chronic conditions remain unstudied. Data for certain patient subgroups, including those with significant functional limitations, are insufficient, and the research does not determine whether an individual will respond similarly.

Frequently Asked Questions (FAQ)

Common questions about Ketanor (FAQ)


Q: Is Ketanor the same as an opioid or a narcotic painkiller?

No. According to regulatory documents, Ketorolac Tromethamine (Ketanor) is classified as a nonsteroidal anti-inflammatory drug (NSAID) and a non-narcotic analgesic. The active ingredient is chemically distinct and works differently in the body than opioid or narcotic painkillers.


Q: Is Ketanor used for chronic pain conditions?

Official prescribing information states that Ketorolac is indicated only for the short-term relief of moderately severe acute pain. It is explicitly noted that the medicine should not be used for pain from chronic (long-term) conditions, and its total duration of combined use is strictly limited, as defined in regulatory documents.


Q: Can Ketanor also help reduce fever and swelling?

Yes, as a Nonsteroidal Anti-inflammatory Drug (NSAID), its mechanism involves reducing the production of prostaglandins. These are chemical mediators involved in both pain signaling and processes that cause inflammation and fever. Additionally, official documents list swelling (edema) as a reported adverse reaction.


Q: Can Ketanor cause an upset stomach or indigestion?

Official safety information lists indigestion (dyspepsia) and abdominal pain as common adverse reactions that have been reported by patients. Official patient instructions often note that the oral tablets can be taken with food or an antacid, which may help lessen potential stomach upset.


Q: Is dizziness or drowsiness a possible side effect of Ketanor?

Yes, regulatory documents list both dizziness and drowsiness (somnolence) as common adverse reactions that have been reported. These central nervous system effects are generally reported as temporary adverse reactions.


Q: Can Ketanor interact with over-the-counter pain medicines like ibuprofen or naproxen?

Yes, regulatory product information states that the use of Ketanor is contraindicated, or prohibited, in patients who are currently receiving aspirin or any other NSAIDs. This restriction is in place because using multiple NSAIDs together increases the cumulative risk of serious related adverse events.


Q: Is there a known interaction between Ketanor and alcohol?

Yes, regulatory sources note that consuming alcohol while taking Ketorolac is associated with an increased risk of stomach bleeding. The consumption of alcohol is noted to potentially intensify some of the reported side effects.


Q: Is Ketanor a non-selective COX inhibitor, and what does that imply for side effects?

Ketorolac is described as a non-selective COX inhibitor. This means it blocks the COX enzymes that create pain and inflammation, but it also impacts pathways involved in the body's normal, homeostatic functions. It is this non-selective action that is linked to the potential for serious adverse events, such as gastrointestinal bleeding.


Q: Can Ketanor be taken with acid reflux or heartburn medications?

Official patient instructions often advise that the oral tablets can be taken with an antacid to help lessen stomach upset. While this addresses the use of antacids, official patient information does not typically detail the specific interaction profiles with other types of acid-reducing medicines.


Q: What happens if Ketanor is used for longer than the recommended time?

Regulatory documents explicitly limit the total combined use of the medicine to 5 days for adults. Exceeding this recommended duration is noted to significantly increase the frequency and severity of adverse reactions, including serious gastrointestinal and cardiovascular risks.


Q: Why is Ketanor sometimes used instead of or with opioid pain medication?

Ketorolac is indicated for moderately severe acute pain that requires analgesia at the opioid level but is not a narcotic. Official research evidence has supported its use due to its high potency, and studies show that its administration may be associated with a reduction in the need for supplemental opioid medications (known as an opioid-sparing effect).


Q: Can Ketanor affect blood pressure levels?

Yes, official safety information indicates that NSAIDs, including Ketorolac, have the potential to cause the onset of new hypertension (high blood pressure) or the worsening of pre-existing hypertension. For this reason, regulatory documents recommend blood pressure monitoring during the course of treatment.


Q: What kind of skin reactions or rashes have been reported with Ketanor?

Official documents report general skin reactions such as rashes and pruritus (itching). More seriously, severe dermatologic reactions, including life-threatening conditions like Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), have also been reported in regulatory background.


Q: Is Ketanor likely to cause weight gain or swelling (edema)?

Official product information notes that fluid retention (edema) is a reported adverse reaction in patients taking the medicine. Swelling due to fluid retention is a possible effect, and weight change is also noted as an adverse event.


Q: Does Ketanor have any potential to be habit-forming?

No, official regulatory documents classify the active ingredient as a non-narcotic analgesic. The drug is described as possessing no sedative or anxiolytic properties, indicating it does not carry the risk of dependence or habit formation associated with opioid medications.


Q: Can taking Ketanor affect my ability to drive or operate machinery?

Official information indicates that because drowsiness and dizziness are possible, patients should exercise caution regarding activities such as driving a car or operating machinery until they know how the medicine affects them.


Q: Are there specific symptoms of liver problems to watch out for while taking Ketanor?

Regulatory background reports elevated liver enzymes and rare cases of hepatitis. Patient counseling points suggest watching for signs of liver issues, such as jaundice (yellowing of the skin or eyes), dark-colored urine, or persistent nausea/vomiting.


Q: Does Ketanor interact with any medications used to treat depression or anxiety?

Yes, co-administration with a class of drugs known as Selective Serotonin-Reuptake Inhibitors (SSRIs) is noted as a clinically significant interaction. The combination is associated with an increased risk of gastrointestinal bleeding.


Q: Is it possible for Ketanor to affect my sleep?

Yes, official documents list both insomnia (difficulty sleeping) and somnolence (drowsiness) as adverse events reported in patients. These effects relate to how the central nervous system may be affected by the medicine.


Q: Is Ketanor sometimes used to treat menstrual pain (dysmenorrhea)?

While the primary indication is for moderately severe acute pain, some authoritative reference sources indicate that Ketorolac is also used to treat dysmenorrhea (menstrual pain). This use is based on its primary function as a potent anti-inflammatory agent.


Q: What research evidence supports the use of Ketanor for pain relief?

Official research evidence supports the use of Ketorolac for the short-term (up to 5 days) management of moderately severe acute pain. Studies were conducted to evaluate its effectiveness in situations where analgesia comparable to an opioid is typically required.


Q: Is it normal to feel a full or bloated feeling in the stomach after taking Ketanor?

Regulatory documents report that some patients experience a feeling of fullness in the abdominal area, as well as bloating or gas, as adverse reactions. These are typically related to the medicine's effect on the gastrointestinal system.


Q: Are there any signs of a severe side effect that require urgent medical attention?

Official safety information describes the signs of serious events that have been reported, such as symptoms related to GI bleeding (bloody, black, or tarry stools; vomiting blood), signs of a potential stroke (sudden weakness, slurred speech), and signs of a severe allergic reaction (trouble breathing or swelling of the face or throat).


Q: Is Ketanor available in forms other than tablets, such as injection or eye drops?

Yes, official regulatory documents confirm that Ketorolac Tromethamine is available in multiple formulations. These include oral tablets, an injectable solution (for IV or IM use), and specialized topical formulations such as a nasal spray and an ophthalmic solution (eye drops).


How should Ketanor be stored and disposed of?

How to Store and Dispose of Ketanor?

Ketorolac tromethamine (Ketanor) must be stored according to specific regulatory requirements to maintain its stability.

Storage Conditions

Constraint Requirement
Temperature Store at Controlled Room Temperature, 20 C to 25 C (68 F to 77 F).
Light/Moisture Protect from light; keep in the original carton and avoid excessive heat and moisture.
Security Keep the container tightly closed and stored securely out of the reach of children.

Disposal Instructions

Unused Ketorolac tromethamine and its containers must be disposed of in a manner consistent with all local and national regulations. This practice ensures proper waste management as defined by official regulatory bodies.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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