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Индоколлир

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Индоколлир

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Индоколлир

What is Индоколлир? (Indocollir)

Индоколлир is a prescription-only ophthalmic medication used to manage inflammation and discomfort in the eye. As a brand name for eye drops containing the active substance Indometacin, it is administered topically to the eye.

Quick Facts
Active ingredient Indometacin (Indomethacin)
Form Eye Drops (Aqueous Solution, typically 0.1%)
Pharmacological class Non-Steroidal Anti-Inflammatory Drug (NSAID)
General purpose Anti-inflammatory and pain-relieving action
Origin Synthetic compound

What Type of Medicine is Индоколлир?

Индоколлир is classified as a potent Non-Steroidal Anti-Inflammatory Drug (NSAID). This class is medically recognized for its ability to reduce inflammation and associated pain. Its specific formulation as a sterile aqueous solution distinguishes it, allowing the active component to be delivered directly and safely to the eye. Unlike oral NSAIDs, the topical route of administration is key, focusing the drug’s action locally.

What is the Active Ingredient and Its General Purpose?

The therapeutic efficacy of Индоколлир stems from its single active component, Indometacin (INN). Indometacin is a well-studied, synthetic substance that is highly effective at inhibiting key inflammatory pathways. This makes it valuable for achieving a powerful anti-inflammatory and analgesic effect in the ocular area. Its general purpose is therefore to provide symptomatic relief from pain and swelling caused by various inflammatory processes affecting the eye.

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What side effects are possible with Индоколлир?

Possible side effects and safety information

The safety profile of Indocollir (Indometacin ophthalmic solution) is primarily described by regulatory documents across two domains: local ocular effects and high-level systemic NSAID class constraints.


Adverse Reaction Scope

Category Details
Frequency-Classified Effects Most Common (Local): Burning sensation, stinging, and redness (conjunctival hyperaemia). Very Rare (Ocular): Severe corneal complications, including corneal melt and perforation.
System-Organ Classes Eye disorders are the primary focus. Systemic safety notes extend to Gastrointestinal disorders and Cardiac/Vascular disorders due to the drug’s classification.
Serious Adverse Reactions In addition to severe local effects, the drug’s active substance, Indometacin, requires the high-level NSAID class boxed warning regarding the risk of serious cardiovascular thrombotic events (e.g., stroke, myocardial infarction) and serious gastrointestinal adverse events (e.g., bleeding, ulceration, perforation) that can be fatal.

Population-Specific Constraints

The medicine is subject to specific regulatory limitations for certain patient groups. It is contraindicated from the sixth month of pregnancy onwards, and is generally not recommended during breast-feeding. The safety and efficacy of the drops have not been established for children. Additionally, patients with a known history of hypersensitivity to aspirin or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are formally contraindicated from use.


Safety Restrictions and Warnings

Regulatory documentation includes formal warnings that the use of an NSAID may potentially retard corneal healing. The product is also associated with a caution regarding the risk of increased ocular bleeding in patients with a known bleeding tendency, particularly during surgical procedures. The use of contact lenses is restricted during the course of treatment.

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Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation for Индоколлир (Indocollyre 0.1% eye drops) explicitly states that no specific data is available concerning overdose resulting from its topical administration. Therefore, the information provided below is based on the required emergency actions for any suspected overdose and the documented profile of accidental systemic (oral) ingestion of the active substance, Indometacin.

When to Seek Immediate Medical Help

Any suspected or accidental overdose of Индоколлир requires immediate emergency medical attention. Contact local emergency services or a poison control center right away for advice, as mandated by regulatory authorities.

Documented Systemic Manifestations

Accidental ingestion of the solution may result in symptoms associated with systemic Indometacin overdose. These manifestations, documented in regulatory sources, may include:

  • CNS Effects: Severe headache, mental confusion, unusual drowsiness, or lethargy.
  • Gastrointestinal Effects: Nausea, vomiting, and epigastric pain.
  • Severe Outcomes: In severe cases, documented complications include the potential for seizures, coma, or serious internal gastrointestinal bleeding.

Management and Support

The management of accidental systemic overdose is officially defined as symptomatic and supportive, as no specific antidote is listed in regulatory documentation. Procedural steps described in the event of recent, significant ingestion include gastric emptying (e.g., lavage) and administration of activated charcoal. Close monitoring of vital signs and potential complications is required in a healthcare setting.

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Therapeutic Uses of Индоколлир

What Индоколлир Treats: Main Uses and Benefits

Индоколлир eye drops, which contain indomethacin, are utilized to help manage symptoms associated with various non-infectious inflammatory conditions of the eye. Its primary use is in providing symptom relief, specifically reducing the discomfort linked to irritation, swelling, and pain.

Common clinical scenarios for the use of this medication include: the management of post-operative inflammation following cataract surgery or other anterior segment procedures, as well as the management of inflammation and pain after specific eye injuries. Индоколлир is indicated for inhibiting miosis during cataract surgery, and for the prophylaxis and management of inflammation following surgical interventions on the eyeball. It may also be utilized in the management of some types of non-infectious conjunctivitis, keratitis, keratoconjunctivitis, and post-traumatic inflammation. The medication may contribute to a more comfortable recovery process by addressing common symptoms.


Quick Fact: Relief for Inflammation and Pain

Regulatory References

  1. HPRA Summary of Product Characteristics for Indocollyre
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Eligibility and Restrictions for Use

Who Can and Cannot Use Индоколлир?

This section describes the officially documented population eligibility and restrictions for Индоколлир (Indometacin ophthalmic solution), as stated in governmental regulatory documents.

Contraindicated Populations and Conditions

Category Regulatory Status
Hypersensitivity Contraindicated in patients with known allergies to Indometacin or to other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), such as aspirin. This includes those who have previously experienced asthma attacks or urticaria with these substances.
Pregnancy Contraindicated from the sixth month of pregnancy onwards (third trimester).
Comorbidities Contraindicated in patients with active peptic ulcer, severe hepatocellular failure, or severe renal insufficiency.

Restricted and Special Populations

Population Group Eligibility Rule
Pediatric Use Not recommended for children and adolescents under 15 years old; safety and efficacy are not established.
Lactation Use is not recommended (should be avoided) while breastfeeding.
Specific Risks Caution is advised for patients with existing corneal epithelial damage or a history of coagulation disorders (bleeding risk).

Индоколлир is generally intended for use by adults who do not have any of the documented contraindications or high-risk systemic conditions.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

Индоколлир (Indometacin ophthalmic solution) is a topical Non-Steroidal Anti-Inflammatory Drug (NSAID) whose interaction profile, detailed in regulatory documents, requires considering the risks associated with systemic indometacin due to minimal absorption.

Formally Documented Interaction Restrictions

The combination of Diflunisal with Indometacin is strictly contraindicated. This pharmacokinetic interaction leads to elevated indometacin plasma concentrations and is associated with a high risk of fatal gastrointestinal bleeding.

Co-administration with Oral Anticoagulants, Parenteral Heparins, and Other NSAIDs poses a heightened pharmacodynamic risk of bleeding and gastrointestinal ulceration. Alcohol consumption is also noted as increasing the risk for GI bleeding.

Exposure and Efficacy Alterations

Indometacin can interfere with the elimination of certain drugs. For example, the renal clearance of Lithium and high-dose Methotrexate is reduced, potentially leading to toxic increases in their blood levels. Conversely, co-administration with Gastrointestinal Topical Salts (antacids) is documented to decrease the absorption of indometacin.

The medication may also diminish the therapeutic efficacy of Anti-Hypertensives (ACE Inhibitors, ARBs, Diuretics) and may increase the risk of renal function deterioration in susceptible patients, such as the elderly or those with existing impairment.

Timing Constraints

When using other eye-drop preparations, they must be administered at least 15 minutes apart from Индоколлир to prevent dilution. Antacids require administration to be separated by more than 2 hours to avoid reduced indometacin absorption.

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Mechanism of Action

The action of Индоколлир (Indometacin) is a focused modulation of the biochemical pathways that perpetuate inflammation, achieved through enzymatic inhibition of inflammatory mediator synthesis.

Enzymatic Blockade of Prostaglandin Synthesis

The drug acts primarily by functioning as an inhibitor of the Cyclooxygenase (COX) enzymes, specifically COX-2, which is activated during inflammation. This interaction blocks the conversion of arachidonic acid into pro-inflammatory prostaglandins, thereby reducing the local concentration of lipid mediators associated with the inflammatory cascade.

Modulation of Vascular Dynamics and Fluid Accumulation

By reducing the levels of prostaglandins (such as PGE2), the mechanism modulates the physiological responses of local ocular blood vessels. This effect reduces prostaglandin-induced vasodilation and decreases vascular permeability, resulting in less fluid and protein efflux into the ocular tissues (reduced tissue fluid accumulation).

Dampening Peripheral Nociceptor Sensitization

The reduction in local prostaglandin concentration extends to the nervous system by lowering the chemical sensitization of afferent pain nerves (nociceptors) in the ocular area. This desensitization results in an increased local nociceptive threshold, which represents the physiological basis for the drug's effect on sensory signaling.

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Dosage and Administration Information

How to Use Индоколлир

Индоколлир (Indometacin 0.1% ophthalmic solution) is administered exclusively via topical ocular instillation, meaning the drops are applied directly to the surface of the eye. The administration schedule is defined by the clinical purpose and is structured around the timing of surgical procedures.


Official Administration Regimens

The usage frequency is divided, requiring application multiple times daily across different scenarios:

  • For Pre-operative Miosis Inhibition: A loading regimen is used, typically requiring one drop four times the day before surgery, followed by one drop four times in the 3 hours immediately preceding the surgical procedure.
  • For Post-operative Inflammation Management: The standard regimen involves instilling one drop four to six times daily. This schedule often commences 24 hours prior to the surgery.
  • For Post-Keratectomy Pain: The prescribed use is typically one drop four times daily in the days following the procedure.

Procedural Instructions and Course Duration

When applying the solution, the drop must be placed into the conjunctival sac, and care must be taken to prevent the container tip from touching the eye or surrounding surfaces to maintain sterility. If other eye drops are required, a mandatory time interval of at least 15 minutes must separate the administration of the two solutions.

Treatment duration varies: for post-operative inflammation, the course generally continues until the complete resolution of symptoms. For acute pain, the course is typically short-term, lasting only for the first few days. The official label does not provide specific dose adjustment guidelines for older adults or patients with renal or hepatic impairment, nor has it established usage rules for the pediatric population.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for Индоколлир

Evidence for Use in Managing Post-operative Eye Inflammation

Research was evaluated in Randomized Controlled Trials (RCTs) and systematic reviews exploring the use of indometacin ophthalmic solution in adults following anterior segment procedures. The research examined outcomes linked to inflammatory or irritative states, such as aqueous flare and the incidence of cystoid macular oedema (MO). Research highlights findings describing patterns observed in patient-reported pain scales for the indometacin group compared to control groups over short periods. Research explored outcomes related to inflammatory states through measured values of biomarkers during the study period.

Evidence for Use in Maintaining Pupil Size During Surgery

Research was studied for its use in keeping the pupil wide during cataract surgery. These investigations used controlled studies, including placebo-controlled clinical trials. Studies monitored the pupil size in millimeters at various stages of the surgery. Data show patterns related to the pupil size measurements in patients who received the ophthalmic solution according to a pre-operative regimen. Studies describe how pupil size was monitored in the observed populations throughout the surgical process.

What is Still Uncertain About the Research for Индоколлир

There is a consistent limitation related to the lack of sufficient data on long-term outcomes. The majority of evidence highlights what is known about short-term symptom patterns and acute control. Certainty remains low for long-term clinical benefits. The subgroup findings are uncertain when trying to generalize results to all patients, especially those outside the main adult surgical populations. Data for certain groups remain insufficient, including pediatric populations and patients with multiple comorbidities.

Key Studies & References

  1. Summary of Product Characteristics (SPC): Indocollyre 0.1% Eye Drops
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Frequently Asked Questions (FAQ)

Common questions about Индоколлир (FAQ)

Q: Can Индоколлир cause blurry vision after I put it in?

A: Regulatory documents, including the official product information, list blurred vision as a possible, though typically temporary, side effect of the topical eye drops. Since the drops are applied directly to the eye, visual changes may occur. If any change in vision persists, it should be brought to the attention of a healthcare professional.

Q: How long can I use Индоколлир before I need to stop?

A: The treatment course for Индоколлир is generally short-term. For post-operative inflammation, the official guidelines state use continues until the condition resolves, as determined by the prescribing doctor. For acute pain following a procedure, the duration of use is typically limited to the first few days.

Q: Are there any long-term risks associated with using Индоколлир?

A: The active ingredient, Indometacin, is an NSAID. Regulatory information for NSAIDs includes warnings about the potential for serious systemic issues, such as cardiovascular thrombotic events (like heart attack or stroke) and gastrointestinal bleeding. These risks may be associated with the duration of NSAID use. Local long-term data for the topical drops are limited.

Q: What should I do if the bottle tip touches my eye while applying Индоколлир?

A: Official administration guidelines emphasize the need to prevent the container tip from touching the eye or any surrounding surfaces to maintain the solution's sterility and prevent infection. If the tip is compromised, the product's sterility may be affected, and its appropriate disposal should be determined by a healthcare provider.

Q: Can I drive after applying Индоколлир?

A: Regulatory warnings advise caution regarding driving or operating machinery immediately after application. Because the medication can temporarily cause visual disturbances, it is advised that individuals wait until their vision is completely clear before engaging in activities that require full visual capacity.

Q: Does alcohol consumption affect the use of Индоколлир eye drops?

A: The systemic forms of Indometacin carry a regulatory warning that alcohol consumption increases the risk of serious gastrointestinal bleeding. Although the drops are used topically with minimal systemic absorption, this is a serious class effect of the active substance that is noted in the regulatory information.

Q: Can I use Индоколлир if I have glaucoma?

A: Glaucoma is not listed as a formal contraindication, but regulatory information suggests that the active ingredient may potentially interfere with certain glaucoma medications. Therefore, the use of this medication by patients with glaucoma requires the close supervision of an eye doctor.

Q: What are the signs of an allergic reaction to Индоколлир?

A: As with any medication, severe hypersensitivity reactions (allergic reactions) are possible. Regulatory documents describe potential signs that may include hives, swelling of the face or throat, difficult breathing, and severe skin reactions. If signs of a severe allergic reaction are observed, immediate emergency medical attention is necessary.

Q: Can Индоколлир be used for non-surgical eye pain or redness?

A: The regulatory label specifies the use of Индоколлир for inflammation and pain primarily related to specific surgical procedures, such as post-operative inflammation and miosis inhibition during surgery. Use for general, non-surgical eye pain or redness is not a labelled indication.

Q: Are headaches a possible side effect of Индоколлир?

A: Regulatory documents for the active ingredient, Indometacin, list headache as a common side effect when the drug is taken systemically. While the risk is low with the topical drops due to minimal absorption, this should be noted as a possible side effect of the medicine class.

Q: Is Индоколлир used to prevent swelling after laser procedures?

A: While the primary approved indications relate to cataract surgery and keratectomy, some clinical studies support the use of Indometacin ophthalmic solution in the management of inflammation following certain other eye procedures, such as Argon Laser Trabeculoplasty.

Q: Can I travel with Индоколлир and does it need special handling?

A: The official product information specifies storage requirements that must be followed when traveling. The medication must be kept below 25 C, protected from light, and must not be frozen to ensure its quality and effectiveness.

Q: Is it common to have slight redness after using Индоколлир?

A: Yes, regulatory documents classify slight redness (conjunctival hyperaemia), along with stinging and a burning sensation, as among the most common local adverse reactions reported by patients using the drops.

Q: Is Индоколлир safe for patients with a history of corneal problems?

A: Official warnings advise caution for patients with existing corneal epithelial damage. The product information also notes that the use of NSAIDs may potentially retard corneal healing. The decision to use this medication in patients with a history of corneal problems is made based on a careful assessment by a healthcare professional.

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How should Индоколлир be stored and disposed of?

How to Store and Dispose of Индоколлир?

The storage and disposal of Индоколлир (Indocollir) must adhere strictly to regulatory requirements to ensure product quality and safety.

Storage and Stability

Condition Regulatory Requirement
Storage Temperature Store below 25 C (77 F).
Environmental Protection Protect from light; Do not freeze.
In-Use Shelf-Life Discard the solution 15 days after first opening the bottle.
Packaging Keep the medicine in its original container and outer carton.
Safety Keep the medicine out of the sight and reach of children.

Disposal Instructions

  • Unused or expired Индоколлир must be disposed of in accordance with local regulations for pharmaceutical waste.
  • The product must not be discarded in household waste or wastewater to prevent environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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