Godamed

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Godamed

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Godamed

Quick Facts

Property Description
Active ingredient Acetylsalicylic Acid (ASA) and Glycine
Form Oral tablet
Pharmacological class Platelet Aggregation Inhibitor, NSAID
Common use Long-term prophylaxis of cardiovascular events
Origin Synthetic compound and naturally occurring amino acid

Godamed is a specific fixed-dose combination product containing the active components Acetylsalicylic Acid (ASA) and the amino acid Glycine. It is administered as an oral tablet and its primary therapeutic classification is that of a Platelet Aggregation Inhibitor. The medicine's composition is designed to optimize its use in long-term preventive strategies.

What Type of Medicine is Godamed?

This medicine belongs fundamentally to the drug class known as Platelet Aggregation Inhibitors. Acetylsalicylic Acid, the component responsible for the core pharmacological action, is simultaneously categorized as a Nonsteroidal Anti-inflammatory Drug (NSAID) and a salicylate. This dual identity reflects ASA's ability to inhibit the Cyclooxygenase (COX) enzyme system, which affects both platelet function and the general reduction of inflammation.

Composition and Purpose: The Role of Acetylsalicylic Acid and Glycine

The core composition features Acetylsalicylic Acid, a synthetic compound, alongside Glycine, a naturally occurring amino acid. The inclusion of Glycine serves a distinct functional purpose, as it is intended to mitigate potential stomach discomfort often associated with regular ASA ingestion, thereby improving the overall tolerability profile of the medicine. ASA tablets with Glycine are used to improve long-term tolerability in antiplatelet drug therapy, showing an advantage over non-glycine-containing ASA alternatives.

The general purpose of Godamed is to help maintain the smooth flow of blood throughout the vascular system. It achieves this by working to inhibit the function of blood platelets, which prevents them from clumping together to form unwanted blood clots. This core action defines its role in preventive strategies aimed at supporting general vascular health.

Regulatory References

  1. long-term prophylaxis of cardiovascular events
  2. Cyclooxygenase (COX) enzyme system

What side effects are possible with Godamed?

Possible Side Effects and Safety Information

The safety profile of Godamed (Acetylsalicylic Acid/ASA) is primarily defined by risks associated with its effects on blood clotting and the gastrointestinal system.

Adverse reactions are classified by frequency, including Very Common (ge 1/10), Common (ge 1/100 to < 1/10), Uncommon, Rare, and Very Rare (lt 1/10,000).

Key Adverse Reactions and Safety Concerns

The most commonly reported side effects involve the gastrointestinal system (e.g., dyspepsia, heartburn) and increased bleeding tendencies. Serious, although less common, adverse reactions documented in regulatory sources include gastrointestinal hemorrhage, ulceration, and perforation, as well as severe allergic or hypersensitivity reactions (e.g., anaphylactic shock).

Other system-organ classes involved include Blood and Lymphatic System Disorders (hemorrhages, increased bleeding time) and Nervous System Disorders (tinnitus, dizziness, particularly at high doses).

Safety Restrictions and Contraindications

Godamed is contraindicated in several circumstances to minimize serious risks. These include known hypersensitivity to ASA or other NSAIDs, active gastrointestinal ulceration or hemorrhage, severe renal or hepatic failure, and severe uncontrolled heart failure.

Population-Specific Warnings

  • Children and Adolescents: Contraindicated for use in children and adolescents with viral infections (e.g., flu, chickenpox) due to the risk of Reye's syndrome, a rare but life-threatening condition.
  • Pregnancy: Contraindicated during the third trimester at daily doses above 150 mg.

Use requires particular caution in patients with a history of asthma, allergies, pre-existing ulcers, bleeding disorders, or gout predisposition, as low doses can reduce uric acid excretion.

Overdose and Emergency Response

Overdose and when to seek help: Official Regulatory Information

The official regulatory profile for Godamed overdose, attributed to its Acetylsalicylic Acid component, describes a progression of clinical manifestations requiring mandated emergency action.


Overdose Manifestations and Actions

Overdose Scope Regulatory Documentation
Documented Presentations Early signs of salicylate toxicity include tinnitus (ringing in the ears), nausea, vomiting, and hyperventilation. Severe intoxication may progress to confusion, seizures, and hyperthermia.
Physiological Systems Affected The overdose affects the Central Nervous System, Pulmonary System, and involves significant Metabolic disturbances, specifically metabolic acidosis.
Population-Specific Notes Overdose is potentially more serious in older adults and children, who may present with subtle or non-specific symptoms. Chronic ingestion can lead to more serious toxicity than acute overdose.
Immediate Emergency Action Seek immediate medical attention or contact a Poison Control Center immediately for any suspected overdose. Hospital admission is required if a toxic dose has been ingested.

Supportive Management and Monitoring

Treatment focuses on supporting vital functions and increasing drug elimination, as no specific antidote is known. Management procedures include the administration of activated charcoal and the use of sodium bicarbonate to correct acid-base disturbances. Hemodialysis is considered the required treatment for severe, life-threatening cases or critically high serum salicylate concentrations. Hospital monitoring is required for continuous assessment of serum salicylate levels and vital signs.

Therapeutic Uses of Godamed

The medicine is commonly used to help with symptoms related to physical discomfort and inflammatory or irritative states.

Its main therapeutic domain involves addressing symptoms related to inflammatory or irritative states. This therapeutic action supports the patient during difficult episodes by easing the overall symptom burden associated with chronic inflammatory conditions characterized by periods of heightened symptoms. These include clinical contexts where patients experience episodic or fluctuating manifestations associated with conditions such as osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS).

It helps address symptoms that interfere with daily functioning and is considered relevant in contexts marked by increased discomfort or tension, which may be part of symptomatic management in situations where patients experience episodic or fluctuating manifestations. It may assist with reducing swelling and stiffness. The medication may assist with maintaining functional stability during periods of heightened symptoms by providing supportive relief.

“The medication is applied in addressing scenarios where additional management of discomfort is required.”


Quick Fact: Applied across domains where additional symptomatic support is needed

Eligibility and Restrictions for Use

Official Eligibility and Non-Eligibility for Godamed

Regulatory documents define specific populations who are permitted to use this medicine and those who are strictly excluded or require special caution. Godamed (containing Acetylsalicylic Acid) is generally intended for use by adults aged 18 and over.

Category Regulatory Status
Populations for whom use is contraindicated: Individuals with known hypersensitivity to the active substance or other NSAIDs, those with bleeding disorders, active or history of peptic ulcer/haemorrhage, or severe heart, kidney, or liver failure.
Age-Related Exclusion: Children and adolescents under 16 must not be given the medicine unless explicitly prescribed for a specific indication (e.g., Kawasaki's disease). Use for fever in this age group is specifically restricted due to the established risk of Reye's Syndrome.
Pregnancy and Lactation Status: The medicine is contraindicated in the last trimester of pregnancy at higher doses. Use during the first and second trimesters is conditional and requires medical consultation. Low-dose use is allowed during breastfeeding; higher doses require discontinuation of breastfeeding.
Conditional Use/Caution: Special consideration and caution are required for older adults (due to increased risk of adverse events) and patients with impaired hepatic or renal function.

What should I know about interactions with other medicines?

The official interaction profile for Godamed is determined by the Acetylsalicylic Acid (ASA) component, which is classified as a Platelet Aggregation Inhibitor and a Nonsteroidal Anti-inflammatory Drug (NSAID). Regulatory authorities categorize certain combinations based on risk and documented mechanism.

A formal contraindication exists for co-administration with Methotrexate at doses of 15 mg/week or greater, as this combination is documented to increase Methotrexate exposure due to competition for renal clearance mechanisms.

The product carries significant pharmacodynamic warnings with Anticoagulants (such as Warfarin) and other Platelet Antiaggregants, leading to an officially documented additive risk of bleeding. This risk is also noted with Selective Serotonin-Reuptake Inhibitors (SSRIs) and is amplified by the co-ingestion of Alcohol (Ethanol), which increases the risk of gastrointestinal ulcers and bleeding.

Pharmacokinetic interactions include the inhibition of metabolism of Oral Hypoglycemics, officially increasing the risk of hypoglycemia. Furthermore, the regulatory label requires mandatory timing separation for certain co-administered NSAIDs. For immediate-release ASA, guidance advises that Ibuprofen must be taken at least 8 hours before or at least 30 minutes after the ASA dose to prevent interference with the anti-platelet effect. The risk of gastrointestinal toxicity from interactions is higher in elderly or debilitated patients.

Mechanism of Action

The primary mechanism of Godamed involves the action of Acetylsalicylic Acid (ASA), which performs an irreversible covalent inhibition of the Cyclooxygenase-1 ( COX-1) enzyme in blood platelets. This permanent molecular blockade prevents the platelet from synthesizing the potent aggregating agent, Thromboxane A2 ( TXA2). Since platelets lack a nucleus, they cannot create new COX-1, the state of impaired function persists for the platelet's 7–10 day lifespan. This core action modifies the system of Primary Hemostasis, resulting in a sustained reduction in platelet-mediated thrombus formation. The Glycine component does not directly influence the platelet aggregation mechanism but provides mechanistic support for sustained enzyme inhibition. ASA also inhibits COX-1 in the gastric lining, which can reduce the synthesis of protective prostaglandins. Glycine is included to reduce the localized inhibition of COX-1 in the gastric lining. This action enhances the feasibility of the sustained inhibition required to manage the continuous turnover of new platelets, thereby maintaining the sustained inhibition of platelet COX-1.

Dosage and Administration Information

Godamed is administered orally as a fixed-dose tablet. The medicine requires a specific administration procedure: the tablet must be swallowed whole with an ample amount of fluid and must not be crushed, broken, or chewed. The medicine is taken with or without food.

Two distinct dosing protocols govern the use of this medicine. For long-term, continuous use related to prophylaxis, the regimen involves a low-dose of Acetylsalicylic Acid (ASA), typically 75 mg to 100 mg, taken once daily. In contrast, the protocol for short-term, episodic use for symptomatic relief employs a higher dose range of 300 mg to 600 mg, taken every 3 to 4 hours as needed. The total intake for this episodic regimen must not exceed the maximum daily limit of 3.6 g.

The application of this medicine also features population-specific constraints. Use is generally not recommended for children under the age of 16 years. Furthermore, caution and regular medical review are warranted when the medicine is administered to older adults or individuals presenting with mild to moderate renal or hepatic impairment.

Recent Clinical Evidence

Evidence for Use in Long-Term Prophylaxis of Cardiovascular Events

Research examining the active component of Godamed, Acetylsalicylic Acid, has been applied in research exploring long-term cardiovascular outcomes. The most extensive data comes from large-scale, multi-year Randomized Controlled Trials (RCTs) and systematic reviews that pool data from thousands of participants. These studies monitored the incidence of major cardiovascular outcomes, such as nonfatal heart attack and stroke, in comparison groups over defined time intervals. Studies observed patterns where the measured incidence of cardiovascular events differed between the active and comparison groups, particularly in cohorts with a prior history of cardiovascular events. For those without a prior event (primary prevention), research findings were mixed, and studies reported varying measurements for specific event types. The full balance between the outcomes related to cardiovascular events and the measured risk of major bleeding is not fully established across all low-risk patient populations.

Evidence for Use in Symptomatic Management of Inflammatory States

Research was conducted in contexts involving outcomes linked to inflammatory or irritative states. Studies explored the use of the active component in examining symptoms related to conditions characterized by fluctuating or episodic manifestations, such as osteoarthritis and rheumatoid arthritis. These investigations used comparative trials and RCTs to assess short-term symptom patterns and examined patient-reported outcomes describing discomfort and daily functioning. Data for long-term outcomes remains limited, as research typically lasted only a few weeks to months, and many foundational trials utilized higher doses of the active component than are currently used for long-term therapy.

Evidence on Formulation and Research Gaps

Studies specifically examined patient-reported experiences related to gastrointestinal (GI) discomfort with the combination of Acetylsalicylic Acid and Glycine. Data show patterns related to patient-reported outcomes, and studies observed that the use of the Glycine formulation was associated with a lower frequency of GI complaints and higher tolerability ratings. This evidence is often based on non-interventional trials and short follow-up durations. Overall, the evidence landscape suggests that certain aspects remain uncertain. Data for special groups, such as pediatric populations, remain insufficient, and study results apply only to the specific populations studied.

Key Studies & References

  1. NICE Guideline NG185: Rheumatoid arthritis in adults: management (Summarized Evidence Base)

Frequently Asked Questions (FAQ)

Common questions about Godamed (FAQ)


Q: How quickly should I expect Godamed to start working?

A: For acute symptomatic relief of pain, official product information indicates that the therapeutic effects of the active component often begin within 30 minutes of taking an oral dose. The speed of action for cardiovascular prophylaxis is not described in the same way, as the purpose is long-term, sustained platelet inhibition.


Q: How long does the effect of one dose of Godamed typically last?

A: The duration of the pain-relieving component is typically short, with an elimination half-life of 2–3 hours for low doses. However, the medicine's antiplatelet function acts irreversibly on the affected blood platelets, meaning its effect on those specific cells lasts for their 7–10 day lifespan.


Q: Why do some people say they take Godamed when they don't have the condition it's approved for?

A: This practice is referred to as 'off-label use' in regulatory terms. It means the medicine is being used for an indication, dosage, or patient population that has not been specifically approved and documented on the official drug label by regulatory agencies.


Q: Is Godamed a scheduled or controlled substance?

A: According to regulatory classification, the active component, Acetylsalicylic Acid (ASA), is a Nonsteroidal Anti-inflammatory Drug (NSAID). It is generally not classified as a federally scheduled or controlled substance.


Q: Is it normal to feel tired after taking Godamed?

A: Official product information does not list tiredness or fatigue as a common side effect experienced at therapeutic doses. However, central nervous system effects such as dizziness or confusion are documented, particularly when the medication is taken at higher dose levels.


Q: Can Godamed affect my sleep pattern?

A: Sleep disturbance is not a side effect that is typically listed as a common adverse reaction in official product information. Regulatory documentation primarily focuses on common effects such as gastrointestinal upset and risks related to bleeding.


Q: Are there any major foods or drinks I should avoid while taking Godamed?

A: The co-ingestion of alcohol is strongly warned against on the regulatory label due to an increased risk of severe gastrointestinal bleeding. Outside of this warning, the medicine can typically be administered with or without food.


Q: What happens if I accidentally miss a dose of Godamed?

A: Regulatory guidance indicates that if a daily dose intended for prophylaxis is missed, the dose may be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the instruction is to skip the missed dose and not take a double amount.


Q: If I take Godamed for a long time, will my body become dependent on it?

A: The active component of this medication is an NSAID and is not classified as a controlled substance. Therefore, it is not generally associated with the potential for physical or psychological dependence.


Q: Is Godamed considered a high-risk medicine?

A: The medication carries documented warnings regarding the potential for serious risks, particularly gastrointestinal bleeding and ulceration. For children and adolescents with viral infections, official warnings also address the rare but serious risk of Reye's syndrome.


Q: Why did the regulatory body (like the FDA) give Godamed its specific safety classification?

A: The regulatory classification is based on the specific pharmacological action of the active component. This action involves the irreversible inhibition of the Cyclooxygenase (COX) enzyme system, which fundamentally affects platelet function and the body's inflammatory processes.


Q: Can I take Godamed if I am already taking an herbal supplement?

A: Regulatory guidance includes warnings that certain herbal supplements, such as Ginkgo Biloba or Garlic, may carry antiplatelet properties. Due to this potential, using them alongside this medication may increase the risk of bleeding.


Q: Is Godamed known to interact with birth control pills?

A: A specific, major interaction between this medication and oral contraceptive pills is not commonly listed on regulatory labels. However, conditions like severe vomiting or diarrhea caused by the medicine may indirectly reduce the effectiveness of the contraceptive pills.


Q: What kind of monitoring is recommended while taking Godamed?

A: Official product warnings advise cessation of use and seeking medical help if signs of stomach bleeding occur, such as bloody or black stools. Warnings are also issued if symptoms like ringing in the ears (tinnitus) or a loss of hearing develop.


Q: Are there any known long-term effects of using Godamed?

A: For long-term prophylaxis, use of the medication is common. The primary known long-term risks documented on regulatory labels include chronic gastrointestinal ulceration and blood loss. Prolonged blood loss can potentially lead to iron-deficiency anemia.


Q: What precautions are generally advised when starting Godamed?

A: Regulatory documents advise reviewing all contraindications and consulting a healthcare professional if there is a history of bleeding or stomach problems. Co-administration with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) is also explicitly discouraged.


Q: Does Godamed affect a person's ability to drive or operate machinery?

A: Official regulatory guidance advises users to be cautious when driving or operating machinery if they experience side effects that could cause impairment. The medication may cause dizziness or confusion, particularly when taken at high doses.


Q: How does Godamed's use condition change for patients with other chronic diseases?

A: Regulatory documents explicitly advise that a consultation with a healthcare professional is recommended before initiating use for patients with certain chronic conditions. These conditions include high blood pressure, heart disease, liver cirrhosis, or kidney disease.


Q: Can I take Godamed if I have high blood pressure?

A: Official guidance states that consultation with a healthcare provider is advised before use if an individual has high blood pressure (hypertension). This is because special caution or review may be necessary.


Q: What is the maximum time a person can take Godamed according to studies?

A: For short-term pain relief, over-the-counter use is generally limited to 3 to 10 days unless directed by a healthcare professional. For its use in cardiovascular prophylaxis, the medication is often recommended for long-term continuous use.


Q: What does the term 'off-label use' mean for a medicine like Godamed?

A: The term 'off-label use' refers to the practice of using a medicine outside of the indication, age group, dosage, or administration route that has been formally approved by the regulating body for the drug's official label.


Q: Is Godamed a cure or a treatment for the condition?

A: The medication is classified as a treatment used for symptomatic relief of inflammation and as a prophylactic (preventive) agent for the reduction of cardiovascular risk. Official documentation does not designate it as a cure for the underlying conditions.


Q: Does the body mass of a person affect how Godamed works?

A: Regulatory pharmacokinetics data indicates that patient factors such as body mass can influence the absorption and distribution of the active component. This may make patient review for individuals with extreme body weights a relevant consideration.


Q: Are there any contraindications related to mental health conditions?

A: There are no general mental health conditions listed as absolute contraindications in the official documentation. However, a documented interaction warning exists with Selective Serotonin-Reuptake Inhibitors (SSRIs), which are a common class of medication used to treat mental health conditions.


Q: Does Godamed contain lactose or gluten?

A: The inactive ingredients used in specific commercial formulations of Acetylsalicylic Acid may include excipients like lactose monohydrate. Verification of specific excipients is recommended by checking the individual product's label.

How should Godamed be stored and disposed of?

Storage and Disposal of Godamed

Godamed (Acetylsalicylic acid/Glycine) must be stored and handled according to regulatory requirements to ensure product stability and safety.

Storage Requirements

  • Store this medicine at a temperature under 25 C.
  • The product must be kept in a closed place and out of the reach and sight of children and/or babies.
  • Do not use the product after the expiration date that appears on the package.

Disposal Instructions

  • Unused or expired Godamed should generally not be thrown into wastewater or the household trash.
  • Official guidance recommends utilizing community drug 'take-back' programs for proper disposal.
  • If no take-back program is available, the medicine may be mixed with an undesirable substance (e.g., used coffee grounds), sealed in a container, and placed in the trash, following health authority recommendations for safe household disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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