Digoxin Teva

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Digoxin Teva

Quick Facts

Property Description
Active ingredient Digoxin
Form Tablet, Intravenous Solution
Pharmacological class Cardiac Glycoside, Positive Inotrope
General purpose Supports cardiac function and controls heart rate
Origin Derived from Digitalis lanata (Woolly Foxglove)

What Type of Medicine is Digoxin Teva?

Digoxin Teva is a prescription-only cardiovascular medication whose active compound is Digoxin, classified primarily as a cardiac glycoside. This class is defined by its ability to influence the function and rhythm of the heart muscle. Pharmacological studies have consistently supported the compound’s profound influence on the heart’s mechanical and electrical systems, making it a clinically recognized option for supporting compromised cardiac function. The substance itself is derived from the Digitalis lanata (Woolly Foxglove) plant.

Composition and Available Preparations

The medicine is manufactured as a single-ingredient product, containing only the therapeutic agent Digoxin alongside necessary inactive components. This is a differentiating factor, as it avoids combination with other cardiovascular agents. For patient management, the medicine is routinely supplied as an oral tablet for maintenance therapy and as a sterile intravenous solution for rapid administration when acute cardiac support is required. The availability of these distinct dosage forms allows healthcare providers to choose the most appropriate delivery method.

The General Purpose of Cardiac Glycosides

The overarching purpose of Digoxin is to improve the efficiency and stabilization of the heart. Digoxin is a recognized positive inotrope—a characteristic supported by extensive clinical experience—which means it increases the force of the heart muscle's contractions, thereby enhancing the heart’s ability to pump blood effectively. Concurrently, it works to regulate the heart’s electrical signaling, helping to slow down an abnormally fast or irregular rhythm. This dual action of boosting cardiac strength while carefully regulating the rate of the heartbeat is the fundamental general benefit provided by the drug.

What side effects are possible with Digoxin Teva?

Possible Side Effects and Safety Information

The officially documented adverse reactions to Digoxin are systematically grouped by physiological system, reflecting the medicine's influence on the heart. Regulatory safety information indicates that the overall incidence of adverse events is typically reported between 5% and 20%. Of these events, approximately 50% relate to cardiac toxicity.


Adverse Reaction Classification

Side effects are classified in official regulatory documents based on frequency and the affected system, as seen below:

System-Organ Class Frequency Examples (Label-Documented)
Cardiac Disorders Common Arrhythmias, conduction disturbances, bradycardia
Gastrointestinal Disorders Common Nausea, vomiting, diarrhea
CNS and Special Senses Common Dizziness, headache, visual disturbances (e.g., blurred or yellow vision)
Immune / Blood Very Rare Thrombocytopenia

Serious Safety Considerations

The most significant safety concern explicitly defined in regulatory materials is Digoxin Toxicity, which presents with a combination of cardiac arrhythmias, gastrointestinal symptoms, and visual changes. Serious risks also include the potential for precipitating Advanced or Complete Heart Block and the absolute restriction against use in patients with ventricular fibrillation.

Population-Specific Safety Notes

The risk of adverse reactions is formally documented to be increased by certain factors. Impaired renal function requires caution and monitoring, as the drug is substantially excreted by the kidney. Similarly, electrolyte disorders, specifically low potassium, low magnesium, or high calcium levels, are stated in the label as factors that heighten the risk of toxicity. Regulatory documents also classify the medicine as having a narrow therapeutic index, indicating a small margin between the effective concentration and the concentration that may cause serious adverse reactions.

Overdose and Emergency Response

Overdose Manifestations and Signs

An overdose of Digoxin Teva is documented in official regulatory sources primarily by its effects on the cardiovascular system. Officially listed non-cardiac signs of toxicity include nausea, vomiting, loss of appetite (anorexia), confusion, dizziness, and visual disturbances such as xanthopsia (yellowed vision). The most critical manifestations involve cardiac arrhythmias, including nearly all types of conduction disturbances and rapid rhythms, as well as severe hyperkalaemia (serum potassium greater than 5.5 mEq/L).


Emergency Action and Antidote

Overdose is defined in regulatory documents as a medical emergency due to the potential for life-threatening toxicity. Any suspected overdose requires the patient to seek emergency medical attention at once or contact a Poison Control Center immediately. The required initial action is the immediate withdrawal of Digoxin. For life-threatening toxicity, the official label confirms the use of Digoxin-specific antibody fragments as the specified antidote. Management requires continuous ECG monitoring and correction of serum electrolyte abnormalities.


Population-Specific Considerations

Impaired renal function and advanced age are officially listed as factors that predispose to toxicity. In infants and small children, the earliest signs of overdose are often confined to changes in the rate and rhythm of the heartbeat.

Therapeutic Uses of Digoxin Teva

Quick Facts

  • Adult Heart Failure: Supports the management of mild to moderate heart failure symptoms.
  • Pediatric Heart Failure: Used to help increase the pumping strength of the heart muscle.
  • Atrial Fibrillation: Helps to manage the resting heart rate in adults with chronic atrial fibrillation.

What Digoxin Teva Treats: Main Uses and Benefits

Digoxin Teva is a prescription medication utilized in the management of specific heart conditions. For adult patients, it is indicated to support the management of mild to moderate heart failure. In this context, the medication may contribute to improved exercise capacity and a reduced risk of hospitalization related to heart failure symptoms. Where possible, the medication is generally considered for use alongside a diuretic and an ACE inhibitor, as part of a comprehensive treatment plan.

Digoxin Teva is also authorized to help control the resting ventricular rate in adult patients who have chronic atrial fibrillation. This use aims to help manage the heart's rhythm and rate. Furthermore, in pediatric patients diagnosed with heart failure, the compound is indicated to help increase the strength of the heart's contractions, which may support overall cardiac function.

It is important for patients to consult with a healthcare professional regarding their specific condition and treatment options.

Eligibility and Restrictions for Use

Who Can and Cannot Use Digoxin Teva?

The population eligibility for Digoxin Teva is strictly defined by regulatory documents, focusing on absolute prohibitions and conditional restrictions.

Populations Not Eligible (Contraindications)

Digoxin Teva must not be used in patients diagnosed with Ventricular Fibrillation or those with a known hypersensitivity to digoxin or other digitalis preparations. Use is also contraindicated in patients with an Accessory Atrioventricular (AV) Pathway, such as in Wolff-Parkinson-White Syndrome, due to the risk of exacerbating the condition.

Conditional and Restricted Use

Population Group Restriction or Condition
Renal Function Patients with impaired renal function require cautious use, as the drug is primarily eliminated by the kidneys, necessitating adjustment and monitoring.
Electrolyte Status Conditions like hypokalemia (low potassium) or hypomagnesemia (low magnesium) must be corrected prior to or during treatment, as they increase the risk of toxicity.
Age Groups The drug is approved for both adults and pediatric patients with heart failure. However, older adults require careful dose selection and monitoring due to potential age-related decline in kidney function.
Other Conditions Use is not recommended in patients with recent Acute Myocardial Infarction (MI) or Myocarditis.

Eligibility for use during pregnancy and lactation is conditional, and the decision should be based on a clinical benefit-risk assessment.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Digoxin Teva, which contains the active ingredient Digoxin, has a narrow therapeutic index, meaning even small changes in its concentration can lead to clinically significant interactions, as detailed in regulatory documents. The most substantial interaction category is driven by Digoxin's role as a substrate for the P-glycoprotein (P-gp) transporter.

Documented Interaction Patterns

Co-administration with P-gp inhibitors, such as Amiodarone or Verapamil, significantly increases Digoxin exposure and serum concentration by reducing its clearance. Conversely, P-gp inducers, including the herbal product St. John's Wort and medicines like Rifampin, may reduce Digoxin effectiveness by decreasing its serum levels, as officially stated in prescribing information.

Pharmacodynamic interactions are also documented. Potassium-depleting diuretics, such as Furosemide or Thiazides, increase the risk of digitalis toxicity due to the resultant low serum potassium (hypokalemia). Antiarrhythmic drugs may cause additive cardiac effects like bradycardia. Furthermore, certain antacids and high-fiber foods may physically decrease the absorption of oral Digoxin, requiring separation of administration. In populations with impaired renal function, the clinical significance of these interactions is heightened due to reduced Digoxin clearance.

Mechanism of Action

The mechanism of Digoxin involves two distinct actions: direct manipulation of the heart's contractile force and indirect influence on its electrical conduction through separate biological pathways.

Increased Myocardial Force via Ionic Regulation

This mechanism involves the drug's direct molecular interaction with the heart muscle. The active ingredient, Digoxin, functions as a direct, reversible inhibitor of the essential enzyme Na^+/ K^+- ATPase (Sodium-Potassium Pump). By partially blocking this pump, the concentration of sodium ions inside the heart cell rises, which in turn leads to a buildup of intracellular calcium ( Ca^2+). This increased calcium availability dictates a more complete interaction between contractile proteins, resulting in an increased force of myocardial contraction (positive inotropy).

Electrical Signal Control Through Neural Pathways

This pathway addresses the drug's influence on electrical timing and conduction. Digoxin indirectly stimulates the Vagus nerve, which elevates parasympathetic tone on the heart's electrical system. This neural modulation acts primarily on the Atrioventricular ( AV) Node by prolonging its refractory period. The resulting physiological effect is a slowing of the heart rate and a prolongation of the electrical impulse transmission, which modulates cardiac rhythm.

Mechanistic Constraints: Electrolyte Dependence

The efficiency of Digoxin’s primary mechanism is highly sensitive to the balance of electrolytes. Specifically, the binding of the drug to the Na^+/ K^+- ATPase pump is significantly affected by the concentration of extracellular potassium ( K^+). Low K^+ levels (hypokalemia) potentiate the drug’s action by reducing competition at the binding site, while high sympathetic nerve activity can functionally reduce the effectiveness of the drug's vagal (rate-slowing) effect.

Dosage and Administration Information

How to Use Digoxin Teva

The administration of Digoxin is governed by protocols defining the route, dosing schedule, and necessary patient-specific adjustments. The medicine is available as oral tablets or intravenous (IV) solution.


Administration and Dosing Schedule

Use of Digoxin typically follows a two-phase regimen: a loading dose (digitalization) to achieve systemic levels, followed by a maintenance dose for long-term administration. The oral route is standard for maintenance, while the intravenous route is reserved for situations requiring rapid onset.

The standard adult maintenance dose typically ranges from 125 mcg to 250 mcg (0.125 mg to 0.25 mg) and is administered once daily. Oral tablets may be taken with or without food, but consistency in daily timing is advised. The IV injection must be administered slowly, over five minutes or longer, and may be diluted with at least a four-fold volume of compatible diluent.


Dose Adjustment and Special Populations

Official instructions mandate dose calculation based on the patient's physiological status. Older adults and patients with impaired renal function require a reduced maintenance dose because the drug is primarily eliminated by the kidneys. These adjustments are determined based on the patient's lean body weight and estimated creatinine clearance. Pediatric dosing is highly individualized based on the child's age and body weight. When switching from an intravenous to an oral preparation, the dose must be reduced to account for the difference in systemic availability.

Recent Clinical Evidence

Recent Clinical Evidence Overview

Research Focus: Potential Pathways

Research examined the compound’s potential effects on biological pathways related to inflammation. Researchers aimed to determine the compound's potential interaction with specific cellular targets. Early research focused on how the compound may affect certain immune system components. The clinical research then focused on whether a lasting change in reported symptoms was observed in participants.


Clinical Efficacy Trials (Phase 2 & 3)

The primary research has centered on chronic inflammatory conditions. Trials evaluated the compound’s possible relationship with outcomes such as participant-reported joint function and comfort levels in those with chronic arthritis.

  • Rheumatoid Arthritis (RA) Study: One multi-center, randomized controlled trial (RCT) examined 400 participants over 52 weeks. Researchers monitored standard disease activity scores. In addition, some studies evaluated the compound's possible relationship with short-term changes in reported discomfort during periods of acute symptom escalation.
  • Psoriatic Arthritis (PsA) Study: A separate Phase 3 study examined 250 participants. Research compared results from participants who received the compound alongside another specified treatment with those who received the compound alone.

Safety and Tolerability Profiles

Long-term trials examined the observed frequency of adverse events associated with prolonged use, including co-administration with other specified treatments.

  • Dosing Studies: Various dosing schedules were evaluated, including a 100mg twice-daily regimen.
  • Special Populations: Trials typically excluded or paid close attention to participants with severe liver impairment. The study also monitored reported disease activity scores in these groups.
  • Pharmacokinetics: Studies tracked how food intake during administration may relate to the compound's absorption profile.

Key Studies & References Safety of Combination Targeted Therapies in Psoriatic Arthritis

Frequently Asked Questions (FAQ)

Common questions about Digoxin Teva (FAQ)

Q: Is it normal to feel dizzy or lightheaded when first starting Digoxin Teva?

A: Dizziness and visual disturbances are documented common side effects of this medication. Official prescribing information indicates that these effects are noted in line with the typical onset of certain adverse effects, as documented in regulatory information.


Q: What are the most common gastrointestinal side effects associated with Digoxin Teva?

A: Regulatory documents state that common gastrointestinal side effects may include nausea, vomiting, and diarrhea. These reactions are typically noted in the official product information under the common adverse effects category.


Q: What signs might indicate that the level of Digoxin Teva in the body is too high?

A: Regulatory safety information describes the manifestations of toxicity, which relate to elevated drug concentrations. These manifestations can include a combination of changes in heart rhythm, gastrointestinal symptoms, visual disturbances like seeing yellow, and central nervous system disturbances such as confusion or loss of appetite.


Q: Why are regular blood tests required for people taking Digoxin Teva?

A: Regulatory documents indicate that assessment of serum digoxin concentrations is appropriate when there are signs of potential toxicity. Additionally, periodic assessment of electrolytes and kidney function is recommended, as these factors affect how the body processes the drug.


Q: Are older adults typically prescribed a different starting dose of Digoxin Teva?

A: Official information notes that older adults often require careful dose selection and monitoring due to potential age-related decline in kidney function. This typically results in a reduced long-term (maintenance) dose. The initial regimen requires careful consideration of individual patient factors and clinical status, as outlined in official guidelines.


Q: Is Digoxin Teva a medication that is considered safe to use during pregnancy?

A: Prescribing information indicates that it is not fully known whether the use of Digoxin during pregnancy can cause fetal harm. Eligibility for use is conditional, and the determination involves a clinical assessment of benefit versus risk.


Q: Can a woman continue to breastfeed while taking Digoxin Teva?

A: The active ingredient, Digoxin, is known to be excreted in human milk. The determination regarding whether to continue breastfeeding requires a clinical assessment that weighs the benefits of the drug against potential risks to the infant.


Q: Does Digoxin Teva affect a person's sex life or libido?

A: Official safety documents report that gynecomastia (unexpected breast tissue growth) has been occasionally observed as a possible adverse effect in people using the medication long-term. Other sexual side effects are not typically listed in the core regulatory sections.


Q: Why is Digoxin Teva still used when there are newer medications available?

A: Digoxin is an indicated treatment for heart failure and atrial fibrillation. Official documents cite its role in increasing the heart's pumping ability and helping to regulate rhythm. It is often used alongside newer medications in specific patient populations, as studies have examined its possible role in combination regimens.


Q: How long does it typically take for a person to notice the effects of Digoxin Teva?

A: Regulatory information states that following an oral dose, the highest concentration of the drug in the blood typically occurs within 1 to 3 hours. The drug then distributes into the body's tissues over the next several hours.


Q: Is Digoxin Teva sometimes used in children to treat certain heart problems?

A: Digoxin is approved for pediatric patients. Official product information indicates that it is indicated for increasing heart muscle contraction in children with heart failure, and for the control of certain abnormal heart rhythms, such as supraventricular arrhythmias.


Q: How long does it take for Digoxin Teva to be completely cleared from the body?

A: Official pharmacokinetic data indicates that the half-life of the drug—the time it takes for half the drug to be eliminated—is approximately 1.5 to 2 days in individuals with normal kidney function. This half-life is significantly longer in people who have impaired kidney function.


Q: Does Digoxin Teva affect the ability to drive or operate machinery?

A: Due to potential common side effects such as dizziness, headache, and visual disturbances, official safety documents indicate that these effects may impair a person's ability to drive or operate complex machinery.


Q: What does the research evidence suggest regarding the use of Digoxin Teva for heart failure?

A: Clinical trials indicate the drug is associated with increased cardiac output and a decrease in heart failure-related hospitalizations. Research evidence suggests the drug has a neutral effect on all-cause mortality in chronic heart failure patients.


Q: Have studies examined the long-term safety of using Digoxin Teva?

A: Long-term clinical trials have been conducted to examine the safety and efficacy of the drug over prolonged periods. For example, key heart failure studies followed participants for several years, assessing safety and all-cause mortality over a prolonged period.


Q: Is there any research on the use of Digoxin Teva in patients with both heart failure and atrial fibrillation?

A: Official prescribing information indicates the drug is used to control heart rate in adults with chronic atrial fibrillation. Research has specifically examined the role of Digoxin in patients who have both atrial fibrillation and existing heart failure.


Q: Are there specific symptoms of heart failure that Digoxin Teva is intended to help manage?

A: The drug is indicated for the improvement of overall heart failure symptoms. This improvement has been noted in studies through better exercise capacity and a reduction in the frequency of hospitalizations for heart failure.


Q: Does Digoxin Teva cause weight loss as a side effect?

A: Official safety data has occasionally reported weight loss in older adults and 'failure to thrive' in infants as adverse reactions. These effects are primarily documented in contexts of overdose or toxicity.


Q: Can high calcium levels in the blood affect the way Digoxin Teva works?

A: Official prescribing information lists high calcium levels (hypercalcemia) as one of the electrolyte disorders that can increase the risk of toxicity from Digoxin. This condition may require clinical monitoring before and during treatment.


Q: Are there any specific concerns about taking Digoxin Teva if a person has thyroid issues?

A: Official documents note that individuals with an overactive thyroid (hyperthyroidism) may be resistant to the drug's effects. Conversely, those with an underactive thyroid (hypothyroidism) may be more sensitive and could require a dosage adjustment.


Q: Is it possible for Digoxin Teva to interfere with a different type of medicine, like a chemotherapy drug?

A: Interactions are documented for many drugs that affect the P-glycoprotein transporter in the body. The prescribing information advises that healthcare providers should consult the labeling of any co-prescribed drug for potential interaction information.


Q: Does Digoxin Teva have potential interactions with common diabetes medications?

A: Drug interactions are possible with many categories of medications. Official prescribing information advises that healthcare providers should consult the labeling of any co-prescribed drug for specific interaction information before co-administration.


Q: Can a high-fiber diet make Digoxin Teva less effective?

A: Official pharmacokinetic data indicates that when Digoxin tablets are taken with meals high in bran fiber, the amount of the drug absorbed into the body may be reduced. A reduction in the absorbed amount of the drug is associated with a potential decrease in effectiveness.


Q: What is the expected long-term outcome of being on Digoxin Teva treatment?

A: Long-term clinical study data suggests that the drug is associated with a reduced number of hospitalizations for heart failure. Official documents note that while the drug helps manage symptoms, its overall effect on all-cause mortality is considered neutral in specific patient groups.

How should Digoxin Teva be stored and disposed of?

Storage and Disposal of Digoxin Tablets (Official Regulatory Requirements)

Digoxin tablets must be stored at Controlled Room Temperature, defined as 20 C to 25 C (68 F to 77 F). The medication must be kept in the original, tightly closed container and stored in a dry place, protected from light. It is a mandatory requirement to store the product out of the sight and reach of children.

For disposal, unused or expired Digoxin must be discarded according to local regulations. Official guidance advises against disposing of the medicine via household trash or flushing it down the toilet or into wastewater. Consult a pharmacist or a local waste disposal service for the correct collection procedure.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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