Deliproct

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Deliproct

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Deliproct

Property Description
Active Ingredients Cinchocaine (Local Anesthetic) & Prednisolone Acetate (Corticosteroid)
Form Rectal Ointment and Suppository
Pharmacological Class Topical Anti-hemorrhoidal (Combined Local Anesthetic/Corticosteroid)
Common Purpose Relief of pain, itching, and inflammation in the anorectal area
Origin Synthetic Compounds

What Type of Combined Medicine is Deliproct?

Deliproct is classified as a fixed-dose combination product, a multicomponent pharmaceutical preparation categorized as a Topical Anti-hemorrhoidal medicine intended for localized relief in the anorectal area. This medication’s strategic merging of two distinct, synthetic active compounds—a potent local anesthetic and an anti-inflammatory corticosteroid—establishes its differentiating feature: simultaneous action on pain and inflammation. This specific combination is clinically recognized for providing a comprehensive approach to symptomatic management of anorectal discomfort.

The Active Ingredients and Forms of Deliproct

Deliproct's active core consists of two key International Nonproprietary Name (INN) components: Cinchocaine and Prednisolone Acetate. Cinchocaine is a highly effective amide-type local anesthetic used for the fast-acting, temporary relief of pain and itching. Prednisolone Acetate is a corticosteroid derivative, known to reduce swelling and tissue irritation.

Deliproct is supplied in two primary dosage forms—a rectal ointment and a suppository—allowing for flexible and targeted topical administration. This dual format is crucial for managing symptoms that may affect either external or internal areas.

What is Deliproct’s General Purpose?

Deliproct’s overall general purpose is to offer fast-acting, comprehensive symptomatic relief by jointly targeting the pain and inflammatory swelling in the affected area. The medication is designed to quickly alleviate acute symptoms such as burning, persistent itching (pruritus), and pain. The unique synergy between the potent local anesthetic and the corticosteroid ensures the medicine provides sustained comfort by addressing the localized inflammatory response.

What side effects are possible with Deliproct?

Possible Side Effects and Safety Information

The safety profile for Deliproct, a combination of Cinchocaine and Prednisolone Acetate, is formally classified by regulatory authorities based on the nature and frequency of adverse reactions observed in clinical use and post-marketing surveillance.

Frequency-Classified Adverse Reactions

The majority of documented effects are local reactions due to the topical route of administration. These effects are categorized in official labeling:

  • Common (may affect up to 1 in 10 people): Local burning and application-site irritation.
  • Uncommon (may affect up to 1 in 100 people): Local pruritus (itching) and allergic skin reactions.
  • Frequency Not Known: Adverse effects such as skin atrophy (thinning) and telangiectasia (spider veins) are documented.

Systemic and Serious Adverse Reactions

Adverse effects are primarily classified under Skin and subcutaneous tissue disorders, reflecting the localized application. However, the corticosteroid component (Prednisolone Acetate) introduces the potential for Endocrine disorders following extensive or prolonged absorption.

The serious systemic reactions of Adrenal suppression (HPA axis suppression) and clinical manifestations of Cushing's syndrome are documented as risks primarily associated with prolonged and/or extensive use of the medication.

Safety Restrictions and Special Populations

Official regulatory documents define specific contraindications, including pre-existing local infections such as viral diseases (e.g., chickenpox, herpes) or tuberculous and syphilitic processes in the treatment area. Furthermore, regulatory safety statements note that paediatric patients may be more susceptible to systemic toxicity from topical corticosteroids.

Overdose and Emergency Response

Deliproct Overdose and When to Seek Help

The official regulatory documentation classifies the potential for overdose based on the route of exposure. Acute intoxication is not expected following a single, inadvertent overdose via the intended rectal or perianal administration. This route does not typically lead to systemic levels of the active ingredients high enough to cause acute toxicity.

The primary scenario for significant systemic toxicity is the accidental oral intake of the preparation, such as swallowing several suppositories or a large amount of ointment. In this critical scenario, the risk is attributed to the systemic absorption of the local anesthetic component, cinchocaine hydrochloride. Systemic effects of cinchocaine may manifest as severe cardiovascular depression, which is considered a dose-dependent effect. Depending on the accidental dose ingested, this depression has the potential to progress to a life-threatening outcome, including cardiac arrest.

When to Seek Immediate Medical Help

Immediate emergency medical assistance is necessary if accidental oral intake of the product occurs. Due to the formally documented potential for severe or life-threatening cardiovascular effects, urgent contact with emergency services is required if any symptoms of systemic intoxication or cardiovascular changes are observed. The official labeling does not explicitly detail a specific antidote or specific supportive management procedures for overdose.

Therapeutic Uses of Deliproct

Quick Facts

  • Therapeutic Domain: Proctology
  • Primary Indications: Painful and itchy anal symptoms
  • Specific Context: Management of hemorrhoidal crises

Deliproct: Main Uses and Therapeutic Action

Deliproct is a prescription medication utilized in the treatment of specific anal symptoms. Its primary therapeutic use is in the management of painful and itchy manifestations within the anal region, particularly those associated with a hemorrhoidal crisis. The product is formulated to help provide relief from these localized, acute symptoms.

The medication contains a combination of active agents: prednisolone caproate and cinchocaine hydrochloride. The corticosteroid component, prednisolone caproate, functions to reduce localized inflammation and swelling in the affected area. Concurrently, cinchocaine hydrochloride is a local anesthetic that acts to alleviate associated pain and itching, thereby providing symptomatic relief.

This topical application is intended for short-term use to manage the acute manifestations of the condition.


Disclaimer: Always follow the guidance of a qualified healthcare professional regarding prescription medications.

Eligibility and Restrictions for Use

Deliproct’s official eligibility profile defines specific populations who must not use the medicine, as well as groups for whom use is restricted or conditional according to regulatory documents.

Absolute Contraindications

Use is strictly prohibited for patients with known hypersensitivity to Cinchocaine, Prednisolone Acetate, related local anesthetics, or any other ingredient. It is also contraindicated in individuals with active local viral diseases (such as herpes or chickenpox) or untreated bacterial, fungal, or tuberculous infections in the area being treated.

Restricted and Conditional Use

  • Pregnancy: The medicine is contraindicated in the first trimester. For later stages, prolonged application must be avoided. Use is restricted while breastfeeding, as small amounts of the corticosteroid are excreted in milk.
  • Pediatrics: Long-term continuous therapy must be avoided in infants and small children due to the risk of systemic absorption.
  • Other Restrictions: Caution is advised for patients with Systemic Sclerosis. Additionally, the formulation may reduce the functional reliability of latex products like condoms.

What should I know about interactions with other medicines?

The official interaction profile for this combination product is primarily focused on the Prednisolone Acetate (corticosteroid) component, due to its potential for systemic absorption during topical use. The low systemic exposure of the Cinchocaine (local anesthetic) component generally results in no explicit systemic drug-drug interaction warnings in regulatory documents.

Official Interaction Statements

Interaction Type Interacting Agent or Class Documented Outcome or Restriction
Pharmacokinetic CYP3A Inhibitors (e.g., cobicistat-containing products, ritonavir) Co-treatment is officially restricted and generally advised to be avoided. This co-administration can reduce the clearance of the corticosteroid component, leading to increased systemic exposure and associated risks.
Pharmacodynamic Anti-diabetic Agents (e.g., Insulin, oral anti-diabetics) The corticosteroid component may increase blood glucose concentrations, which is documented to reduce the therapeutic effect of anti-diabetic agents.
Pharmacodynamic Vitamin K Antagonists (e.g., Warfarin) Corticosteroids may have a variable effect on these oral anticoagulants, requiring monitoring of coagulation indices due to potential changes in effect.
Pharmacodynamic Fluoroquinolones Concomitant use is associated with an increased clinical risk of tendonitis and, in rare instances, tendon rupture.

Co-administration with CYP3A inhibitors is classified as a high-level risk that mandates strict monitoring or avoidance, according to regulatory guidelines. This structure defines the product's official constraints based on the systemic potential of the corticosteroid component.

Mechanism of Action

Deliproct is a combination product containing prednisolone caproate and cinchocaine hydrochloride, each component mediating a distinct pharmacodynamic effect on local tissues.

Prednisolone caproate, a glucocorticoid, acts as an agonist for the intracellular glucocorticoid receptor (GR). Upon binding, the activated GR complex translocates to the nucleus, where it modifies gene transcription by binding to glucocorticoid response elements (GREs). This modulation results in the enhanced synthesis of anti-inflammatory proteins, such as lipocortin-1 (annexin A1), which inhibits phospholipase A2. Concurrently, GR activation suppresses the transcription of pro-inflammatory mediators, including cyclooxygenase-2 (COX-2) and various cytokines, thereby stabilizing mast cells and reducing capillary permeability. The systemic consequence is a localized reduction in the inflammatory cascade and vascular exudation.

Cinchocaine hydrochloride, an amide-type local anesthetic, exerts its effect by reversibly inhibiting voltage-gated sodium channels ( Nav) on neuronal membranes. This Nav channel blockade decreases the rapid influx of Na^+ ions necessary for depolarization, thus elevating the threshold for action potential initiation and propagation along afferent nerve fibers. The resulting failure of impulse conduction modulates neural signaling at the system level.

Dosage and Administration Information

How to use Deliproct: Administration Guidelines

Deliproct is a fixed-dose combination product intended for rectal and topical administration, supplied as an ointment and a suppository. The usage protocol defines a structured, short-term treatment course with a reduction in frequency over time.

Dosing Frequency and Pattern

Treatment begins with a higher frequency to address acute manifestations. The ointment may be applied up to three to four times daily on the first day, or the suppository up to two to three times daily. Following this initial phase, the standard regimen reduces to application twice daily, typically once in the morning and once in the evening. As the condition stabilizes, the frequency is tapered to once daily or one suppository every other day.

Administration Context and Technique

Application is recommended to occur after a bowel movement and after the anorectal area has been thoroughly cleaned and dried. For internal application of the ointment, the specialized rectal cannula must be utilized, and this cannula must be cleaned with warm water after each use. Suppositories must be inserted high into the rectum. If the suppository is soft, it should be briefly hardened in cold water prior to use to facilitate insertion.

Treatment Duration and Age Restrictions

The total duration of treatment is short-term and generally should not exceed four weeks due to the corticosteroid component. Furthermore, the product is not recommended for use in the pediatric population. After acute symptoms have resolved, the protocol includes continued administration at a reduced frequency for at least one week before complete cessation.

Recent Clinical Evidence

Research evidence / Overview of studies for Deliproct


Evidence for Use in Haemorrhoids

Research has explored this combination product's class (a local anesthetic and a corticosteroid) in research focused on symptoms associated with haemorrhoidal conditions. Studies monitored outcomes related to physical discomfort, such as pain, itching, and localized swelling, primarily measuring changes in acute symptoms over limited observation periods. Evidence describes short-term symptom evolution, but research exploring long-term outcomes remains not well characterized. The consistency of findings across different studies is an area of ongoing discussion.

Evidence for Use in Anal Fissures

The medication's components were evaluated in clinical investigations relevant to temporary physiological imbalance and localized discomfort associated with anal fissures. Studies reported observations regarding short-term changes and documented symptom patterns during the acute phase of the condition. However, the body of high-quality research specific to this formulation's long-term effect on the progression of anal fissures remains limited, and follow-up durations were constrained.

Evidence for Use in Proctitis

This combination was evaluated in research exploring symptoms associated with proctitis, a condition marked by localized inflammatory states. Studies examined the acute response to the product's components, focusing on the assessment of inflammation, swelling, and discomfort. The evidence remains limited and heterogeneous, particularly regarding large-scale comparisons, and data supporting use beyond very short-term episodes are not fully established.


Long-Term Studies and Follow-Up Data

The available research is predominantly focused on acute, short-term treatment scenarios, consistent with the limited follow-up intervals explored by researchers. Long-term outcomes are not fully established for any extended-duration effects, and limited information means that research provides limited insight regarding sustained changes in symptoms.

Research in Specific Populations

Research exploring the use of this specific combination product in certain patient groups—such as children, adolescents, and older adults—is limited in the published research record. For pregnant or breastfeeding women, evidence is constrained, and available research provides context but not individual predictions regarding expected results. Documented findings are limited to the adult populations studied.

Documented Research Gaps and Uncertainties

The evidence landscape is characterized by several documented limitations. Comparative evidence is often lacking, and sample sizes were modest in some foundational studies. Furthermore, long-term effects are not fully established, and evidence quality varies, highlighting what is known and what is still uncertain about this topical formulation.

Frequently Asked Questions (FAQ)

Common questions about Deliproct (FAQ)


Q: How quickly should I expect to feel a difference after starting Deliproct?

Official product documentation describes the local anesthetic component in Deliproct, known as cinchocaine, as providing quick relief from painful and itching symptoms. This part of the medication is designed to act fast to help manage acute discomfort in the area of application.


Q: How long does the effect of a Deliproct suppository typically last?

Regulatory guidance defines the treatment schedule needed to maintain the therapeutic effect. Official dosing guidelines generally recommend applying the product typically twice daily, once in the morning and once in the evening, after the initial high-frequency phase. This schedule indicates the frequency of application required to support a sustained therapeutic effect.


Q: Are there any specific safety warnings about using Deliproct with other topical creams?

Regulatory safety information notes that certain ingredients (excipients) in the Deliproct ointment may reduce the effectiveness of latex products, such as condoms. Official guidance notes that if an existing skin infection is present, co-administration with appropriate agents, such as topical antibiotics or antifungals, is defined as necessary.


Q: Can Deliproct be used by people who have diabetes?

Official interaction statements indicate that the corticosteroid component of Deliproct has the potential to slightly increase blood glucose concentrations. This effect is documented to reduce the therapeutic effect of medicines used to manage diabetes, such as insulin or oral anti-diabetic agents. This potential interaction necessitates that co-treatment is assessed by a healthcare provider.


Q: Can Deliproct cause changes in skin appearance with prolonged use, based on regulatory filings?

Official product labeling documents risks associated with the prolonged or extensive use of the corticosteroid component. Adverse effects such as skin atrophy (skin thinning) and telangiectasia (the appearance of spider veins) are documented in these regulatory filings. Due to these risks, official guidance states that use is generally limited to short-term durations.


Q: Is Deliproct the same as other hemorrhoid creams or suppositories?

Deliproct is classified as a fixed-dose combination product, which distinguishes it from medicines that contain only a single active ingredient. It merges a potent local anesthetic (cinchocaine) for fast pain relief and an anti-inflammatory corticosteroid (prednisolone acetate) for reducing swelling and inflammation.


Q: Is it normal to feel a mild burning sensation when applying Deliproct for the first time?

Yes, regulatory product labeling reports that local burning and application-site irritation are Common side effects, meaning they may be experienced by up to 1 in 10 people who use the product. If discomfort persists or becomes severe, official guidance notes that the condition should be reassessed.


Q: Is there any research looking at Deliproct use in older adults?

Research documents indicate that clinical investigations exploring the use of this specific combination product in certain patient groups, including older adults, is limited in the published record. The available research generally focuses on the adult population, and findings provide context but not individual predictions.


Q: Is Deliproct associated with any long-term safety concerns mentioned in official sources?

Serious systemic reactions related to the corticosteroid component are documented risks primarily associated with prolonged and/or extensive use. These include the possibility of Adrenal suppression (HPA axis suppression) and clinical manifestations of Cushing's syndrome. For this reason, the official treatment duration is restricted to short-term use.


Q: What should I do if I accidentally swallow a small amount of the Deliproct ointment?

The patient information leaflet states that in the event of accidental ingestion of the ointment or suppositories, urgent medical attention should be sought. This measure is noted to ensure proper medical assessment and guidance can be provided based on the amount ingested and any symptoms.


Q: Are there any official reports of Deliproct interacting with blood thinners?

Yes, official interaction statements indicate that the corticosteroid component may have a variable effect on Vitamin K Antagonists, a class of oral blood thinners. Official documents state that co-treatment may affect the blood thinner's action, which typically necessitates monitoring of coagulation indices.


Q: How long after the expiry date should Deliproct definitely not be used?

Regulatory instructions for pharmaceutical waste are clear that expired medicine must be disposed of according to local regulations. Official regulatory information states that the medicine is not authorized for use past the expiry date printed on its packaging, as the integrity and stability of the product may be compromised.


Q: Why are there warnings about using Deliproct near the eyes?

Warnings are generally related to the corticosteroid component, as both systemic and topical use has been associated with reports of visual disturbance. If any visual issues occur while using this medicine, such as blurred vision, official documentation describes the need for specialized evaluation.


Q: How does Deliproct compare to a product that only contains an anesthetic ingredient?

Deliproct is officially categorized as a combination product intended to provide two simultaneous actions. It combines the fast-acting pain relief from a local anesthetic with a corticosteroid to address underlying inflammation and swelling, offering a dual-mechanism approach to symptomatic management.


Q: Why is it important to use only a small amount of the Deliproct ointment?

The application of unusually large quantities of the topical corticosteroid is associated with an increased risk of absorption of the active ingredients. This higher absorption can lead to a greater risk of experiencing systemic side-effects, which affect the body beyond the application site.

How should Deliproct be stored and disposed of?

How to Store and Dispose of Deliproct?

The storage requirements for Deliproct are defined by regulatory documents and vary based on the specific dosage form. The medicine must always be stored out of the reach and sight of children.

Official Storage Conditions

Dosage Form Required Storage Temperature
Rectal Ointment 15 C to 22 C (59 F to 71.6 F)
Suppositories 8 C to 15 C (46.4 F to 59 F)

It is mandatory to avoid freezing the product, as this can compromise its physical stability. The medicine should be stored in its original container.

Disposal Instructions

Unused or expired Deliproct must be disposed of according to local regulations for pharmaceutical waste. Do not discard the medicine by flushing it down the toilet or pouring it into a drain. Individuals should consult a pharmacist or local waste disposal service for guidance on proper handling.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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