Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 21.04.2022
Attention! Information on this page is intended only for medical professionals! Information is collected in open sources and may contain significant errors! Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)® (Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)) injection is indicated for
- the management of mild to moderate pain
- the management of moderate to severe pain with adjunctive opioid analgesics
- the reduction of fever.
used to treat symptoms caused by the common cold, flu, allergies, hay fever, or other breathing illnesses (e.g., sinusitis, bronchitis). Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) is a cough suppressant that affects a certain part of the brain (cough center), reducing the urge to cough. Decongestants help relieve stuffy nose symptoms. Antihistamines relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Hypertension: this medicine is indicated for the treatment of hypertension.
Heart Failure:
this medicine is indicated for the treatment of chronic heart failure with reduction of systolic ventricular function, in combination with diuretics and when appropriate, digitalis and beta-blockers.
Myocardial Infarction:
-Short -term (4 weeks) treatment: this medicine is indicated in any clinically stable patients within the first 24 hours of an infarction.
-Long term prevention of symptomatic heart failure: this medicine is indicated in clinically stable patients with asymptomatic left ventricular dysfunction (ejection fraction <40%).
Type I Diabetic Nephropathy:
this medicine is indicated for the treatment of macroproteinuric diabetic nephropathy in patients with type I diabetes..
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) and hydrocodone is used to treat cough and reduce chest congestion caused by the common cold, flu, or allergies.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection is used together with other medicines (eg, narcotic pain relievers) to relieve moderate to severe pain.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is used to relieve mild to moderate pain and reduce fever in patients. It does not become habit-forming when taken for a long time. Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) may cause unwanted effects when taken in large doses, including liver damage.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is available only with your doctor's prescription.
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) is used to treat a cough.
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) will not treat a cough that is caused by smoking, asthma, or emphysema.
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) may also be used for purposes not listed in this medication guide.
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness and are sometimes used a sleep aids.
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) is also used as a short-term treatment for sleep problems (insomnia).
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) may also be used for purposes not listed in this medication guide.
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is used to reduce chest congestion caused by the common cold, flu, or chronic bronchitis.
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
There are many brands and forms of Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) available. Not all brands are listed on this leaflet.
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) may also be used for purposes not listed in this medication guide.
General Dosing Information
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) may be given as a single or repeated dose for the treatment of acute pain or fever. No dose adjustment is required when converting between oral Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) and Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) dosing in adults and adolescents who weigh 50 kg and above. Calculated maximum daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is based on all routes of administration (i.e., intravenous, oral, and rectal) and all products containing Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid). Exceeding the maximum mg/kg daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) as described in Tables 1 and 2 may result in hepatic injury, including the risk of liver failure and death. To avoid the risk of overdose, ensure that the total amount of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) from all routes and from all credits does not exceed the maximum recommended dose.
Recommended
Dosage: Adults and Adolescents
Adults and adolescents weighing 50 kg and over: the recommended dosage of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 4000 mg per day (includes all routes of administration and all Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)-containing products including combination products).
Adults and adolescents weighing under 50 kg: the recommended dosage of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 75 mg/kg per day (includes all routes of administration and all Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)-containing products including combination products).
Table 1: Dosing for Adults and Adolescents
Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (by all routes) |
Adults and adolescents (13 years and older) weighing ≥ 50 kg | 650 mg | 1000 mg | 1000 mg | 4000 mg in 24 hours |
Adults and adolescents (13 years and older) weighing < 50 kg | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3750 mg) |
Recommended
Dosage: Children
Children 2 to 12 years of age: the recommended dosage of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) of 75 mg/kg per day.
Table 2: Dosing for Children
Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (by all routes) |
Children 2 to 12 years of age | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3750 mg) |
Instructions For
Intravenous Administration
For adult and adolescent patients weighing ≥ 50 kg requiring 1000 mg doses of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid), administer the dose by inserting a vented intravenous set through the septum of the 100 mL vial. Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) may be administered without further dilution. Examine the vial contents before dose preparation or administering. DO NOT USE if particulate matter or discoloration is observed. Administer the contents of the vial intravenously over 15-minutes. Use aseptic technique when preparing Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) for intravenous infusion. Do not add other medications to the Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) vial or infusion device.
For doses less than 1000 mg, the appropriate dose must be withdrawn from the vial and placed into a separate container prior to administration. Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from an intact sealed Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) vial and place the measured dose in a separate empty, sterile container (e.g. glass bottle, plastic intravenous container, or syringe) for intravenous infusion to avoid the inadvertent delivery and administration of the total volume of the commercially available container. The entire 100 mL vial of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is not intended for use in patients weighing less than 50 kg. Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is a single-use vial and the unused portion must be discarded.
Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes using a syringe pump.
Monitor the end of the infusion in order to prevent the possibility of an air embolism, especially in cases where the Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) infusion is the primary infusion.
Once the vacuum seal of the glass vial has been penetrated, or the contents transferred to another container, administer the dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) within 6 hours.
Do not add other medications to the Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) solution. Diazepam and chlorpromazine hydrochloride are physically incompatible with Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid), therefore do not administer simultaneously.
How supplied
Dosage Forms And Strengths
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is a sterile, clear, colorless, non pyrogenic, preservative free, isotonic formulation of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) intended for intravenous infusion. Each 100 mL glass vial contains 1000 mg Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (10 mg/mL).
Storage And Handling
NDC 43825-102-01 - Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)® (Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)) Injection is supplied in a 100 mL glass vial containing 1000 mg Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (10 mg/mL) in cartons of 24 vials.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) should be stored at 20°C to 25°C (68°F to 77°F).
For single use only. The product should be used within 6 hours after opening. Do not refrigerate or freeze.
Manufactured for: Mallinckrodt Hospital Products Inc., Hazelwood, MO 63042 USA. Revised: Dec 2014
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral, as hydrobromide:
Robafen Cough: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]
Robitussin Lingering CoughGels: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, polyethylene glycol, propylene glycol]
Gel,
Oral, as hydrobromide:
ElixSure Cough: 7.5 mg/5 mL (120 mL) [alcohol free; contains carbomer 934p, propylene glycol, propylparaben; cherry bubblegum flavor]
Liquid,
Oral, as hydrobromide:
Buckleys Cough: 12.5 mg/5 mL (118 mL) [alcohol free, sugar free; contains butylparaben, menthol, propylparaben, saccharin sodium]
Little Colds Cough Formula: 7.5 mg/mL (30 mL) [alcohol free, dye free, saccharin free; contains sodium benzoate; grape flavor]
PediaCare Childrens Long-Act: 7.5 mg/5 mL (118 mL) [contains brilliant blue fcf (fd&c blue #1), saccharin sodium, sodium benzoate]
Robitussin Lingering LA Cough: 15 mg/5 mL (118 mL [DSC]) [contains alcohol, usp, fd&c red #40, menthol, saccharin sodium, sodium benzoate]
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid): 10 mg/5 mL (480 mL [DSC], 3780 mL [DSC]) [alcohol free, dye free, fructose free, sodium free, sorbitol free, sugar free]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL) [alcohol free, dye free, pseudoephedrine free; contains benzoic acid, propylene glycol]
Lozenge, Mouth/Throat, as hydrobromide:
Hold: 5 mg (10 ea)
Hold: 5 mg (10 ea) [cherry flavor]
Trocal Cough Suppressant: 7.5 mg (1 ea [DSC])
Strip,
Oral, as hydrobromide:
Triaminic Long Acting Cough: 7.5 mg (14 ea, 16 ea) [contains alcohol, usp, fd&c red #40; cherry flavor]
Triaminic Long Acting Cough: 7.5 mg (14 ea) [contains alcohol, usp, fd&c red #40, isopropyl alcohol]
Suspension Extended Release,
Oral:
Cough DM: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite; orange flavor]
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid): Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), disodium edta, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; grape flavor]
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid): Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; orange flavor]
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) Cough Childrens: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), edetate disodium, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; grape flavor]
Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) Cough Childrens: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; orange flavor]
GoodSense Cough DM: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
GoodSense Cough DM Childrens: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 (quinoline yellow), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough
Child: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Generic: Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex [equivalent to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrobromide 30 mg/5 mL] (89 mL)
Syrup,
Oral, as hydrobromide:
Creomulsion
Adult: 20 mg/15 mL (118 mL [DSC])
Creomulsion for Children: 5 mg/5 mL (118 mL [DSC]) [cherry flavor]
Robitussin Childrens Cough LA: 7.5 mg/5 mL (118 mL) [alcohol free; contains fd&c red #40, propylene glycol, saccharin sodium, sodium benzoate; fruit punch flavor]
Silphen DM Cough: 10 mg/5 mL (118 mL) [contains alcohol, usp; strawberry flavor]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL [DSC]) [alcohol free, dye free; contains benzoic acid, edetate disodium, propylene glycol]
Dosing: Adult
Cough suppressant:
Oral: 10 to 20 mg every 4 hours
or
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Safety and efficacy for the use of cough and cold products in infants and young children limited; the AAP warns against the use of these products for respiratory illnesses in infants and young children (AAP 2018; FDA 2017).
Cough suppressant:
Oral:
Oral syrup (immediate release):
Children 2 to <6 years: 5 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children 6 to <12 years: 10 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children ≥12 years and Adolescents: 20 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Long-acting liquid: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Oral capsule: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Extended-release suspension (Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) polistirex):
Children 4 to <6 years: 15 mg every 12 hours as needed; do not exceed 30 mg in 24 hours.
Children 6 to <12 years: 30 mg every 12 hours as needed; do not exceed 60 mg in 24 hours.
Children ≥12 years and Adolescents: 60 mg every 12 hours as needed; do not exceed 120 mg in 24 hours.
Usual Adult Dose for Allergic Rhinitis
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) 5 mg oral tablet, chewable:
10 mg orally every 4 to 6 hours not to exceed 6 doses daily.
Usual Adult Dose for Allergic Conjunctivitis
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) 5 mg oral tablet, chewable:
10 mg orally every 4 to 6 hours not to exceed 6 doses daily.
Usual Adult Dose for Insomnia
12 years of age and older: 25 mg orally 30 minutes before bed
Maximum dose: Take once daily or as directed by physician
Comments: Do not use 25 mg Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) in children under 12 years of age
Usual Pediatric Dose for Allergic Rhinitis
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) 5 mg oral tablet, chewable:
12 years or older: 10 mg orally every 4 to 6 hours not to exceed 6 doses daily
6 years to under 12 years: 5 mg orally every 4 to 6 hours not to exceed 6 doses daily
Usual Pediatric Dose for Allergic Conjunctivitis
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) 5 mg oral tablet, chewable:
12 years or older: 10 mg orally every 4 to 6 hours not to exceed 6 doses daily
6 years to under 12 years: 5 mg orally every 4 to 6 hours not to exceed 6 doses daily
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dialysis
Data not available
ORGANIDIN® NR (Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid))
Tablets — Adults and children 12 years of age and older: One to 2 tablets (200 mg to 400 mg) every four hours, not to exceed 2400 mg (12 tablets) in 24 hours.
PATIENTS SHOULD BE ADVISED TO KEEP THESE AND ALL DRUGS OUT OF THE REACH OF CHILDREN AND TO SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY IN CASE OF ACCIDENTAL OVERDOSE.
How supplied
ORGANIDIN® NR (Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid))
Tablets — Each round, scored, rose-colored tablet contains 200 mg Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) USP—available in bottles of 100 (NDC 0037-4312-01)
Storage
Store at controlled room temperature 20°-25°C (68°-77°F). Protect tablets from moisture. Keep bottle tightly closed.
To report SUSPECTED ADVERSE REACTIONS, contact Meda Pharmaceuticals Inc. at 1-800-526-3840 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Meda Pharmaceuticals Inc. Somerset, New Jersey 08873-4120. Rev. 11/09
See also:
What is the most important information I should know about Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)?
There are many brands and forms of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) available and not all brands are listed on this leaflet.
Do not take more of this medication than is recommended. An overdose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) can damage your liver or cause death.
Know the amount of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) in the specific product you are taking.
Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid).
Avoid drinking alcohol. It may increase your risk of liver damage while taking Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid).
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver disease or a history of alcoholism.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) which can lead to a fatal overdose. Check the label to see if a medicine contains Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) or APAP.
See also:
What is the most important information I should know about Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Do not use Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) before the MAO inhibitor has cleared from your body.
Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid).
See also:
What is the most important information I should know about Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
OTC labeling: Do not use in children <12 years of age.
Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) or any component of the formulation; narrow angle glaucoma; asthmatic attack; prostatic hypertrophy; stenosing peptic ulcer, pyloroduodenal obstruction; bladder-neck obstruction; concurrent use with monoamine oxidase-inhibitors.
See also:
What is the most important information I should know about Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.
If you wear contact lenses, remove them before applying Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic may contains preservative (benzalkonium chloride), which may cause discoloration of contact lenses.
Do not use Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.
Use caution when driving, operating machinery, or performing other hazardous activities. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.
Use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix other medicines (especially chlorpromazine or diazepam) in the same container or IV line as Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection. Contact your health care provider if you have any questions about how to give Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection with other medicines.
- Do not use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection within 6 hours after opening.
- If you miss a dose of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) injection.
Use Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) orally disintegrating strips as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) orally disintegrating strips by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not remove the strip from the pouch until you are ready to take Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) orally disintegrating strips. Be sure that your hands are dry when you touch the strip.
- Remove the strip from the pouch and place it onto the tongue. The strip dissolves quickly and can be swallowed with saliva. It may be taken with or without water.
- Use the strip right away after you open the pouch. Do not store it for future use.
- If you miss a dose of Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) orally disintegrating strips and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) orally disintegrating strips.
Use Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) by mouth with or without food.
- Chew thoroughly before swallowing.
- Use Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) exactly as directed on the package, unless instructed differently by your doctor. If you are taking Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) without a prescription, follow any warnings and precautions on the label.
- If you miss a dose of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid).
Use Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) by mouth with or without food.
- Drinking extra fluids while you are taking Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is recommended. Check with your doctor for instructions.
- Swallow Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
How to use Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) Extra Strength
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
There are many brands and forms of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) available. Read the dosing instructions carefully for each product because the amount of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) may be different between products. Do not take more Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) than recommended.
If you are giving Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.
For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.
For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (e.g., sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid). It is a cough suppressant that works by decreasing the feeling of needing to cough.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid)
Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.
Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.
If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Improper use of this medication (abuse) may result in serious harm (e.g., brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.
Tell your doctor if your symptoms persist or worsen after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Insomnia: Reduce difficulty falling asleep
Off Label Uses
Nausea and vomiting of pregnancy
Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) is usually given in combination with pyridoxine for the treatment of nausea and vomiting of pregnancy. Data from a randomized placebo-controlled trial supports the use of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) and pyridoxine (Diclectin) in the treatment of nausea and vomiting of pregnancy.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is used to treat coughs and congestion caused by the common cold, bronchitis, and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier.
If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold. To decrease the risk for side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use 2/G
Take this medication by mouth with or without food, as directed by your doctor, usually every 4 hours. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) may have a bitter taste. Do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
For powder packets, empty the entire contents of the packet onto the tongue and swallow. To prevent a bitter taste, do not chew.
Dosage is based on your age, medical condition, and response to treatment. Do not take more than 6 doses in a day. Do not increase your dose or take this drug more often than directed.
Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.
Tell your doctor if your cough is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem. Seek immediate medical attention if you think you may have a serious medical problem.
See also:
What other drugs will affect Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) and may decrease the action of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid). Doses of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) should be avoided during warfarin therapy
See also:
What other drugs will affect Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid)?
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) Lafayette Pharmaceutical Laboratory may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
See also:
What other drugs will affect Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
The simultaneous use of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) with psychotropic, anticonvulsant medications and ethanol is observed enhancement inhibitory action alprazolam on the CNS.
The simultaneous use with blockers of histamine H2-receptor reduce the clearance of alprazolam and increase the inhibitory effect of alprazolam on the CNS; macrolide antibiotics reduce the clearance of alprazolam.
The simultaneous use with hormonal oral contraceptives increased T1/2 of alprazolam.
Simultaneous administration of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) with dextropropoxyphene observed a more pronounced CNS depression than in combination with other benzodiazepines, as may increase the concentration of alprazolam in blood plasma.
Simultaneous treatment with digoxin increases the risk of intoxication by cardiac glycosides.
Alprazolam increases the concentration of imipramine in plasma.
Simultaneous administration with itraconazole, ketoconazole increases the effects of alprazolam.
Simultaneous administration with paroxetine may increases the effects of alprazolam due to the inhibition of its metabolism.
Fluvoxamine increases the concentration of alprazolam in plasma and risk of its side effects.
Simultaneous administration of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) with fluoxetine may increase the concentration of alprazolam in plasma by decreasing its metabolism and clearance under the influence of fluoxetine which is accompanied by psychomotor disorders.
It can not be exclude the possibility of strengthening effect of alprazolam for simultaneous administration with erythromycin.
See also:
What other drugs will affect Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)?
In vitro results suggest that methadone undergoes hepatic N-demethylation by cytochrome P450 enzymes, principally CYP3A4, CYP2B6, CYP2C19 and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with CYP inducers of these enzymes may result in a more rapid metabolism and potential for decreased effects of methadone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadones effects. Although antiretroviral drugs such as efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir+ritonavir combination are known to inhibit CYPs, they are shown to reduce the plasma levels of methadone, possibly due to their CYP induction activity. Therefore, drugs administered concomitantly with methadone should be evaluated for interaction potential; clinicians are advised to evaluate individual response to drug therapy.
Opioid Antagonists, Mixed Agonist/Antagonists, and Partial Agonists
As with other mu-agonists, patients maintained on methadone may experience withdrawal symptoms when given opioid antagonists, mixed agonist/antagonists, and partial agonists. Examples of such agents are naloxone, naltrexone, pentazocine, nalbuphine, butorphanol, and buprenorphine.
Anti-retroviral Agents
Abacavir, amprenavir, efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir+ritonavir combination - Coadministration of these anti-retroviral agents resulted in increased clearance or decreased plasma levels of methadone. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)-maintained patients beginning treatment with these antiretroviral drugs should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Didanosine and Stavudine - Experimental evidence demonstrated that methadone decreased the AUC and peak levels for didanosine and stavudine, with a more significant decrease for didanosine. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) disposition was not substantially altered.
Zidovudine - Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result in toxic effects.
Cytochrome P450 Inducers
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly. The following drug interactions were reported following coadministration of methadone with inducers of cytochrome P450 enzymes:
Rifampin - In patients well-stabilized on methadone, concomitant administration of rifampin resulted in a marked reduction in serum methadone levels and a concurrent appearance of withdrawal symptoms.
Phenytoin - In a pharmacokinetic study with patients on methadone maintenance therapy, phenytoin administration (250 mg b.i.d. initially for 1 day followed by 300 mg QD for 3 to 4 days) resulted in an approximately 50% reduction in methadone exposure and withdrawal symptoms occurred concurrently. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin administration.
St. Johns Wort, Phenobarbital, Carbamazepin/strong>Administration of methadone along with other CYP3A4 inducers may result in withdrawal symptoms. Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would be increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.g., ketoconazole) and macrolide antibiotics (e.g., erythromycin), with methadone should be carefully monitored and dosage adjustment should be undertaken if warranted. Some selective serotonin reuptake inhibitors (SSRIs) (e.g., sertraline, fluvoxamine) may increase methadone plasma levels upon coadministration with methadone and result in increased opiate effects and/or toxicity. Voriconazole - Repeat dose administration of oral voriconazole (400mg Q12h for 1 day, then 200mg Q12h for 4 days) increased the Cmax and AUC of (R)-methadone by 31% and 47%, respectively, in subjects receiving a methadone maintenance dose (30 to 100 mg QD). The Cmax and AUC of (S)-methadone increased by 65% and 103%, respectively. Increased plasma concentrations of methadone have been associated with toxicity including QT prolongation. Frequent monitoring for adverse events and toxicity related to methadone is recommended during coadministration. Dose reduction of methadone may be needed. Monoamine Oxidase (MAO) Inhibitors - Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. Similar reactions thus far have not been reported with methadone. However, if the use of methadone is necessary in such patients, a sensitivity test should be performed in which repeated small, incremental doses of methadone are administered over the course of several hours while the patients condition and vital signs are under careful observation. Desipramine - Blood levels of desipramine have increased with concurrent methadone administration. Extreme caution is necessary when any drug known to have the potential to prolong the QT interval is prescribed in conjunction with methadone. Pharmacodynamic interactions may occur with concomitant use of methadone and potentially arrhythmogenic agents such as class I and III antiarrhythmics, some neuroleptics and tricyclic antidepressants, and calcium channel blockers. Caution should also be exercised when prescribing methadone concomitantly with drugs capable of inducing electrolyte disturbances (hypomagnesemia, hypokalemia) that may prolong the QT interval. These drugs include diuretics, laxatives, and, in rare cases, mineralocorticoid hormones. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) may be expected to have additive effects when used in conjunction with alcohol, other opioids or CNS depressants, or with illicit drugs that cause central nervous system depression. Deaths have been reported when methadone has been abused in conjunction with benzodiazepines. Anxiety - Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients who are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals. The physician should not confuse such symptoms with those of narcotic abstinence and should not attempt to treat anxiety by increasing the dose of methadone. The action of methadone in maintenance treatment is limited to the control of narcotic withdrawal symptoms and is ineffective for relief of general anxiety. Acute Pain - Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should be administered analgesics, including opioids, in doses that would otherwise be indicated for non-methadone-treated patients with similar painful conditions. Due to the opioid tolerance induced by methadone, when opioids are required for management of acute pain in methadone patients, somewhat higher and/or more frequent doses will often be required than would be the case for non-tolerant patients. Abrupt opioid discontinuation can lead to development of opioid withdrawal symptoms. Presentation of these symptoms have been associated with an increased risk of susceptible patients to relapse to illicit drug use and should be considered when assessing the risks and benefit of methadone use. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy. If methadone is abruptly discontinued in a physically dependent patient, an abstinence syndrome may occur. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. In general, chronically administered methadone should not be abruptly discontinued. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) should be given with caution and the initial dose reduced in certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addisons disease, prostatic hypertrophy, or urethral stricture. The usual precautions appropriate to the use of parenteral opioids should be observed and the possibility of respiratory depression should always be kept in mind. See also: Applies to Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid): oral capsule, oral capsule extended release, oral elixir, oral liquid, oral packet, oral solution, oral syrup, oral tablet, oral tablet extended release In addition to its needed effects, some unwanted effects may be caused by Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) (the active ingredient contained in Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)). In the event that any of these side effects do occur, they may require medical attention. Some of the side effects that can occur with Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: Less common or rare: See also: Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in DOLOPHINE. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute bronchial asthma or hypercarbia. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is contraindicated in any patient who has or is suspected of having a paralytic ileus. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic causes constriction of blood vessels in the eyes. It also enlarges the pupils, reduces the production of fluid in the eyes, and increases the amount of fluid that drains from the eyes. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic available over-the-counter is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants. Prescription-strength Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic is used to constrict blood vessels in the eye and to dilate (make bigger) the pupil for conditions such as glaucoma, before surgery, and before eye examinations. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) ophthalmic may also be used for purposes other than those listed in this medication guide. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis). This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely. Use Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) as directed by your doctor. Check the label on the medicine for exact dosing instructions. Ask your health care provider any questions you may have about how to use Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid). Hypotension/shock: Treatment of hypotension, vascular failure in shock. Note: Not recommended for routine use in the treatment of septic shock; use should be limited until more evidence demonstrating positive clinical outcomes becomes available (Rhodes 2017). Guideline recommendations: Cardiogenic shock: The 2017 American Heart Association (AHA) scientific statement for the Contemporary Management of Cardiogenic Shock recommends Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid), if needed, be considered for initial vasoactive management of cardiogenic shock due to aortic stenosis, mitral stenosis, or dynamic left ventricular outflow tract (LVOT) obstruction (AHA [van Diepen 2017]). Hypotension during anesthesia: As a vasoconstrictor in regional analgesia Nasal congestion: As a decongestant [OTC] Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) is a pure alpha1 agonist that will increase systemic vascular resistance without increasing heart rate or contractility. This is advantageous in patients with obstructive hypertrophic cardiomyopathy and hypotension since increases in both heart rate and contractility may cause the obstruction to worsen, leading to a decrease in cardiac output. Other vasopressors like dopamine, epinephrine, and norepinephrine may increase contractility and/or heart rate. Additional trials may be necessary to further define the role of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) in this condition. Based on the American Urological Association guidelines for the management of priapism, due to the low risk of cardiovascular side effects intracavernous injection of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) is recommended for ischemic priapism that persists following aspiration/irrigation. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs. Prolonged exposure to air or strong light may cause oxidation and discoloration. Do not use if solution is brown or contains a precipitate. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 10 percent ophthalmic solutions are especially useful when rapid and powerful dilatation of the pupil and reduction of congestion in the capillary bed are desired. A drop of a suitable topical anesthetic may be applied, followed in a few minutes by 1 drop of the Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 10 percent ophthalmic solutions on the upper limbus. The anesthetic prevents stinging and consequent dilution of the solution by lacrimation. It may occasionally be necessary to repeat the instillation after one hour, again preceded by the use of the topical anesthetic. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 10 percent ophthalmic solutions may be used in patients with uveitis when synechiae are present or may develop. The formation of synechiae may be prevented by the use of the 10 percent ophthalmic solutions and atropine to produce wide dilatation of the pupil. It should be emphasized, however, that the vasoconstrictor effect of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride may be antagonistic to the increase of local blood flow in uveal infection. To free recently formed posterior synechiae, 1 drop of the 10 percent ophthalmic solutions may be applied to the upper surface of the cornea. On the following day, treatment may be continued if necessary. In the interim, hot compresses should be applied for five or ten minutes three times a day, with 1 drop of a 1 or 2 percent solution of atropine sulfate before and after each series of compresses. In certain patients with glaucoma, temporary reduction of intraocular tension may be attained by producing vasoconstriction of the intraocular vessels; this may be accomplished by placing 1 drop of the 10 percent ophthalmic solutions on the upper surface of the cornea. This treatment may be repeated as often as necessary. Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride may be used with miotics in patients with wide angle glaucoma. It reduces the difficulties experienced by the patient because of the small field produced by miosis, and still it permits and often supports the effect of the miotic in lowering the intraocular pressure. Hence, there may be marked improvement in visual acuity after using Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride in conjunction with miotic drugs. When a short-acting mydriatic is needed for wide dilatation of the pupil before intraocular surgery, the 10 percent ophthalmic solutions or 2.5 percent ophthalmic solution may be applied topically from 30 to 60 minutes before the operation. Prior to determination of refractive errors, Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent ophthalmic solution may be used effectively with homatropine hydrobromide, atropine sulfate, or a combination of homatropine and cocaine hydrochloride. For adults, a drop of the preferred cycloplegic is placed in each eye, followed in five minutes by 1 drop of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent ophthalmic solution and in ten minutes by another drop of the cycloplegic. In 50 to 60 minutes, the eyes are ready for refraction. For children, a drop of atropine sulfate 1 percent is placed in each eye, followed in 10 to 15 minutes by 1 drop of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent ophthalmic solution and in five to ten minutes by a second drop of atropine sulfate 1 percent. In one to two hours, the eyes are ready for refraction. For a “one application method,” Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent ophthalmic solution may be combined with a cycloplegic to elicit synergistic action. The additive effect varies depending on the patient. Therefore, when using a “one application method,” it may be desirable to increase the concentration of the cycloplegic. One drop of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent ophthalmic solution is placed in each eye. Sufficient mydriasis to permit examination is produced in 15 to 30 minutes. Dilatation lasts from one to three hours. Provocative Test for Angle Block in Patients with Glaucoma: The 2.5 percent ophthalmic solution may be used as a provocative test when latent increased intraocular pressure is suspected. Tension is measured before application of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride and again after dilatation. A 3 to 5 mm of mercury rise in pressure suggests the presence of angle block in patients with glaucoma; however, failure to obtain such a rise does not preclude the presence of glaucoma from other causes. Shadow Test (Retinoscopy): When dilatation of the pupil without cycloplegic action is desired for the shadow test, the 2.5 percent ophthalmic solution may be used alone. Blanching Test: One or 2 drops of the 2.5 percent ophthalmic solution should be applied to the injected eye. After five minutes, examine for perilimbal blanching. If blanching occurs, the congestion is superficial and probably does not indicate iritis. In Mono-Drop ® plastic dropper bottle: Low surface tension solutions 2.5 percent ophthalmic solution - Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 2.5 percent in a sterile, isotonic, buffered, low surface tension vehicle with sodium phosphate, sodium biphosphate, boric acid, and, as antiseptic preservative, benzalkonium chloride, NF, 1:7500. The pH is adjusted with phosphoric acid or sodium hydroxide. Bottles of 15 mL (NDC 0024-1358-01). 10 percent ophthalmic solution- Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 10 percent in a sterile, buffered, low surface tension vehicle with sodium phosphate, sodium biphosphate, and, as antiseptic preservative, benzalkonium chloride 1:10,000. The pH is adjusted with phosphoric acid or sodium hydroxide. Bottles of 5 mL (NDC 0024-1359-01). Viscous solution 10 percent ophthalmic solution- Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) hydrochloride ophthalmic solution) hydrochloride 10 percent in a sterile, buffered, viscous vehicle with sodium phosphate, sodium biphosphate, methylcellulose, and, as antiseptic preservative, benzalkonium chloride 1:10,000. The pH is adjusted with phosphoric acid or sodium hydroxide. Bottles of 5 mL (NDC 0024-1362-01). Store at 25° C (77° F); excursions permitted to 15° - 30° C (59° - 86° F) Manufactured for Sanofi-Synthelabo Inc. New York, NY 10016 by Abbott Laboratories North Chicago, IL 60064. Revised September 1999. FDA revision date: n/a See also: Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid): May increase the serum concentration of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic). Monitor therapy Alpha1-Blockers: May diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy Benzylpenicilloyl Polylysine: Alpha1-Agonists may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Management: Consider use of a histamine skin test as a positive control to assess a patient's ability to mount a wheal and flare response. Consider therapy modification Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy Chloroprocaine: May enhance the hypertensive effect of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic). Monitor therapy CloZAPine: May diminish the therapeutic effect of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic). Monitor therapy Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Monitor therapy Ergot Derivatives: May enhance the hypertensive effect of Alpha1-Agonists. Ergot Derivatives may enhance the vasoconstricting effect of Alpha1-Agonists. Exceptions: Ergoloid Mesylates; Nicergoline. Avoid combination FentaNYL: Alpha1-Agonists may decrease the serum concentration of FentaNYL. Specifically, fentanyl nasal spray serum concentrations may decrease and onset of effect may be delayed. Monitor therapy Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy Hyaluronidase: May enhance the vasoconstricting effect of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic). Management: Avoid the use of hyaluronidase to enhance dispersion or absorption of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid). Use of hyaluronidase for other purposes in patients receiving Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) may be considered as clinically indicated. Avoid combination Iobenguane Radiopharmaceutical Products: Alpha1-Agonists may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products. Management: Discontinue all drugs that may inhibit or interfere with catecholamine transport or uptake for at least 5 biological half-lives before iobenguane administration. Do not administer these drugs until at least 7 days after each iobenguane dose. Avoid combination Ioflupane I 123: Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic) may diminish the diagnostic effect of Ioflupane I 123. Monitor therapy Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Alpha1-Agonists. While linezolid is expected to interact via this mechanism, management recommendations differ from other monoamine oxidase inhibitors. Refer to linezolid specific monographs for details. Exceptions: Linezolid. Avoid combination Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification Propacetamol: May increase the serum concentration of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (Systemic). Management: Monitor patients closely for increased side effects of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) if propacetamol is used concomitantly. Patients with underlying blood pressure issues or arrhythmias may need closer monitoring and may warrant consideration of alternative therapies. Monitor therapy Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Monitor therapy Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy Tricyclic Antidepressants: May enhance the therapeutic effect of Alpha1-Agonists. Tricyclic Antidepressants may diminish the therapeutic effect of Alpha1-Agonists. Monitor therapy See also: Applies to Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid): intravenous solution In addition to its needed effects, some unwanted effects may be caused by Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) (the active ingredient contained in Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)). In the event that any of these side effects do occur, they may require medical attention. If any of the following side effects occur while taking Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid), check with your doctor or nurse immediately: Incidence not known: If any of the following symptoms of overdose occur while taking Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid), get emergency help immediately: Symptoms of overdose: Cytochrome P450 Inhibitors
Others
Potentially Arrhythmogenic Agents
Interactions with Alcohol and Drugs of Abuse
Risk of Relapse in Patients on Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) Maintenance Treatment of Opioid Addiction
Tolerance and Physical Dependence
Special-Risk Patients
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) side effects
What are the possible side effects of Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)?Minor Side Effects
Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) contraindications
What is the most important information I should know about Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid)?What is Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) indications
How should I use Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Uses of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) in details
Use: Labeled Indications
Off Label Uses
Hypotension in patients with obstructive hypertrophic cardiomyopathy
Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) description
Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) dosage
Vasoconstriction and Pupil Dilatation
Uveitis: Posterior Synechiae
Glaucoma
Surgery
Refraction
Ophthalmoscopic Examination
Diagnostic Procedures
How supplied
Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) interactions
What other drugs will affect Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)?Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) side effects
What are the possible side effects of Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Minor Side Effects
Some of the side effects that can occur with Phenylephrine (Dayquil/ NyQuil Severe Cold and Flu liquid) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Incidence not known:
- Heartburn
- itching skin
- nausea
- pain in the neck
- pain or discomfort in chest, upper stomach, or throat
See also:
What are the possible side effects of Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Applies to Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid): capsule, capsule liquid filled, elixir, liquid, powder, powder for solution, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet effervescent, tablet extended release
Other dosage forms:
- intravenous solution
Along with its needed effects, Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (the active ingredient contained in Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid)) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid):
Rare
- Bloody or black, tarry stools
- bloody or cloudy urine
- fever with or without chills (not present before treatment and not caused by the condition being treated)
- pain in the lower back and/or side (severe and/or sharp)
- pinpoint red spots on the skin
- skin rash, hives, or itching
- sore throat (not present before treatment and not caused by the condition being treated)
- sores, ulcers, or white spots on the lips or in the mouth
- sudden decrease in the amount of urine
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid):
Symptoms of overdose
- Diarrhea
- increased sweating
- loss of appetite
- nausea or vomiting
- stomach cramps or pain
- swelling, pain, or tenderness in the upper abdomen or stomach area
See also:
What are the possible side effects of Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Applies to Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid): oral capsule, oral capsule liquid filled, oral elixir, oral liquid, oral lozenge/troche, oral solution, oral suspension, oral suspension extended release, oral syrup, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) (the active ingredient contained in Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) HBr Adult Formula). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid), check with your doctor or nurse as soon as possible:
Symptoms of overdose:
- Blurred vision
- confusion
- difficulty in urination
- drowsiness or dizziness
- nausea or vomiting (severe)
- shakiness and unsteady walk
- slowed breathing
- unusual excitement, nervousness, restlessness, or irritability (severe)
Minor Side Effects
Some of the side effects that can occur with Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common or rare:
- Confusion
- constipation
- dizziness (mild)
- drowsiness (mild)
- headache
- nausea or vomiting
- stomach pain
See also:
What are the possible side effects of Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid)?
Undesirable effects reported for captopril and/or ACE inhibitor include:
Blood and lymphatic disorders:
Very Rare: neutropenia/agranulocytosis, pancytopenia particularly in patients with renal dysfunction, anaemia (including aplastic and haemolytic), thrombocytopenia, lymphadenopathy, eosinophilia, auto-immune diseases and/or positive ANA-titres.
Metabolism and nutrition disorders:
Rare: Anorexia
Very Rare: Hyperkalaemia, hypoglycaemia
Psychiatric disorders:
Common: Sleep disorders.
Very Rare: Confusion, depression.
Nervous system disorders:
Common: Taste impairment, dizziness.
Rare: Drowsiness, headache and paraesthesia.
Very Rare: Cerebrovascular incidents, including stroke, and syncope.
Eye disorders:
Very Rare: Blurred vision.
Cardiac disorders:
Uncommon: Tachycardia or tachyarrhythmia, angina pectoris, palpitations.
Very Rare: Cardiac arrest, cardiogenic shock.
Vascular disorders
Uncommon: Hypotension, Raynaud syndrome, flush, pallor.
Respiratory, thoracic and mediastinal disorders:
Common: Dry, irritating (non productive) cough and dyspnoea.
Very Rare: Bronchospasm, rhinitis, allergic alveolitis / eosinophilic pneumonia.
Gastrointestinal disorders:
Common: Nausea, vomiting, gastric irritations, abdominal pain, diarrhoea, constipation, dry mouth.
Rare: Stomatitis/aphthous ulcerations.
Very Rare: Glossitis, peptic ulcer, pancreatitis.
Hepato-biliary disorders:
Very Rare: Impaired hepatic function and cholestasis. (including jaundice), hepatitis including necrosis, elevated liver enzymes and bilirubin.
Skin and subcutaneous tissue disorders:
Common: Pruritus with or without a rash, rash and alopecia.
Uncommon: Angioedema
Very Rare: Urticaria, Stevens Johnson syndrome, erythema multiforme, photosensitivity, erythroderma, pemphigoid reactions and exfoliative dermatitis.
Musculoskeletal, connective tissue and bone disorders:
Very rare: Myalgia, arthralgia.
Renal and urinary disorders:
Rare: Renal function disorders including renal failure, polyuria, oliguria, increased urine frequency.
Very Rare: Nephrotic syndrome.
Reproductive system and breast disorders:
Very Rare: Impotence, gynaecomastia.
General disorders:
Uncommon: Chest pain, fatigue, malaise.
Very Rare: Fever
Investigations:
Very Rare: Proteinuria, eosinophilia, increase of serum potassium, decrease of serum sodium, elevation of BUN, serum creatinine and serum bilirubin, decreases in haemoglobin, haematocrit, leucocytes, thrombocytes, positive ANAtitre, elevated ESR.
Intestinal angioedema has also been reported very rarely in patients with ACE inhibitors and should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain.
Acetaminophen (Dayquil/ NyQuil Severe Cold and Flu liquid) (with the Optizorb formulation) also contains the following excipients: Pregelatinized maize starch, calcium carbonate, alginic acid, crospovidone, povidone, magnesium stearate, colloidal anhydrous silica, parahydroxybenzoates (sodium methyl, ethyl and propyl), OPADRY YS-1-7003 white, carnauba wax, purified water.
It contains no sugar, lactose or gluten.
The d-isomer of the codeine analog of levorphanol. Dextromethorphan (Dayquil/ NyQuil Severe Cold and Flu liquid) shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine (Dayquil/ NyQuil Severe Cold and Flu liquid) has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Guaifenesin (Dayquil/ NyQuil Severe Cold and Flu liquid) is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)